{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:30:46Z","timestamp":1787031046582,"version":"build-2736575974"},"reference-count":114,"publisher":"Informa UK Limited","issue":"23","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.4155\/fmc-2020-0295","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T09:39:23Z","timestamp":1635241163000},"page":"2107-2124","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":23,"title":["Advances in the Application of 1,2,4-Triazole-Containing Hybrids as Anti-Tuberculosis Agents"],"prefix":"10.1080","volume":"13","author":[{"given":"Yingdong","family":"Cao","sequence":"first","affiliation":[{"name":"Zhengzhou Sias University, Xinzheng, 451100, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5996-3280","authenticated-orcid":false,"given":"Hong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastropidae, Zhuji Affiliated Hospital of Shaoxing University, Shaoxing, 311800, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.76"},{"issue":"1","key":"e_1_3_2_4_1","first-page":"a615","article-title":"The next pandemic \u2013 tuberculosis: the oldest disease of mankind rising one more time","volume":"6","author":"Saleem A","year":"2013","unstructured":"Saleem A , AzherM. The next pandemic \u2013 tuberculosis: the oldest disease of mankind rising one more time. Br. J. Med. Pract.6(1), a615 (2013).","journal-title":"Br. J. Med. Pract."},{"key":"e_1_3_2_5_1","unstructured":"World Health Organization . Global tuberculosis report 2019. https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/329368\/9789241565714-eng.pdf?ua=1"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1405427"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijtb.2020.02.005"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30307-X"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30271-3"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijtb.2020.07.017"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-040717-051150"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijtb.2017.08.011"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2020.101986"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.07.059"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21602"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103534"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.02.003"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2018.08.003"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.19-2-135"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9030133"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900107r"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/157017861010131126115448"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4QO00007B"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104841"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.03.020"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.01.095"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.128140"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112652"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jccs.201900304"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.7897\/2230-8407.087112"},{"issue":"12","key":"e_1_3_2_31_1","first-page":"5157","article-title":"Bioactive triazoles: a potential review","volume":"4","author":"Sharma J","year":"2012","unstructured":"Sharma J , AhmadS , ShamsherA. Bioactive triazoles: a potential review. J. Chem. Pharm. Res.4(12), 5157\u20135164 (2012).","journal-title":"J. Chem. Pharm. Res."},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.04.043"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.04.033"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026620666200128143230"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520615666150819121106"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871524915666150209100533"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.01.009"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.03.020"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2015.51.12.2421058"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.01.047"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.05.054"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.06.051"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12527"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.22159\/ijpps.2019v11i1.29428"},{"issue":"2","key":"e_1_3_2_45_1","first-page":"70","article-title":"Synthesis and research of the impact of new derivatives of 4-R-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thiol on cultural attributes of pathogenic M. Bovis","volume":"9","author":"Shcherbyna RO","year":"2018","unstructured":"Shcherbyna RO , ParchenkoVV , SafonovAAet al. Synthesis and research of the impact of new derivatives of 4-R-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thiol on cultural attributes of pathogenic M. Bovis. Res. J. Pharm. Biol. Chem. Sci.9(2), 70\u201379 (2018).","journal-title":"Res. J. Pharm. Biol. Chem. Sci."},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.05.042"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.08.039"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.7897\/2230-8407.097121"},{"issue":"1","key":"e_1_3_2_49_1","first-page":"1","article-title":"A review on 1,2,4-triazoles","volume":"1","author":"Raval K","year":"2012","unstructured":"Raval K , PatelK , PatelS , PatelR , PatelS. A review on 1,2,4-triazoles. J. Pharm. Res.1(1), 1\u20134 (2012).","journal-title":"J. Pharm. Res."},{"issue":"8","key":"e_1_3_2_50_1","first-page":"73","article-title":"1,2,4-Triazoles: synthetic strategies and pharmacological","volume":"6","author":"Namratha P","year":"2014","unstructured":"Namratha P , GaonkarSL. 1,2,4-Triazoles: synthetic strategies and pharmacological. Int. J. Pharm. Pharmaceut. Sci.6(8), 73\u201380 (2014).","journal-title":"Int. J. Pharm. Pharmaceut. Sci."},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10593-006-0255-3"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570193X15666180108152302"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201800261"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA04208K"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570193X15666180622144414"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.07.005"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557516666160630120725"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA19334F"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2018.07.006"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2012.11.011"},{"issue":"2","key":"e_1_3_2_61_1","first-page":"420","article-title":"Synthesis and biological evaluation of certain N-bridged 1,2,4-triazole analogues","volume":"10","author":"Udupi RH","year":"2018","unstructured":"Udupi RH , ManjunathCJ. Synthesis and biological evaluation of certain N-bridged 1,2,4-triazole analogues. J. Pharm. Sci. Res.10(2), 420\u2013424 (2018).","journal-title":"J. Pharm. Sci. Res."},{"issue":"1","key":"e_1_3_2_62_1","first-page":"44","article-title":"Synthesis and biological evaluation of certain N-bridged 1,2,4-triazole analogues","volume":"11","author":"Udupi RH","year":"2019","unstructured":"Udupi RH , ManjunathCJ. Synthesis and biological evaluation of certain N-bridged 1,2,4-triazole analogues. J. Pharm. Sci. Res.11(1), 44\u201349 (2019).","journal-title":"J. Pharm. Sci. Res."},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.08.023"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.01.045"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-012-0431-1"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-012-0092-0"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.09.037"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.06.031"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201000061"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.09.024"},{"issue":"4","key":"e_1_3_2_71_1","first-page":"783","article-title":"Novel thiazolidinone-azole hybrids: design, synthesis and antimycobacterial activity studies","volume":"15","author":"Eroglu B","year":"2016","unstructured":"Eroglu B , Ozadali-SariK , Unsal-TanO , SriramD , YogeeswariP , BalkanA. Novel thiazolidinone-azole hybrids: design, synthesis and antimycobacterial activity studies. Iran J. Pharm. Res.15(4), 783\u2013790 (2016).","journal-title":"Iran J. Pharm. Res."},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01562"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/open.201900227"},{"key":"e_1_3_2_74_1","first-page":"317","article-title":"Design and synthesis of some new imidazole and 1,2,4-triazole substituted fluorobenzimidazoles for antitubercular and antifungal activity","volume":"5","author":"Nandha B","year":"2013","unstructured":"Nandha B , NargundLVG , NargundSL. Design and synthesis of some new imidazole and 1,2,4-triazole substituted fluorobenzimidazoles for antitubercular and antifungal activity. Der Pharm. Chem.5, 317\u2013327 (2013).","journal-title":"Der Pharm. Chem."},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201600286"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.12991\/201216411"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.10.054"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573407215666190524101510"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.05.004"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201900380"},{"issue":"5","key":"e_1_3_2_81_1","first-page":"1302","article-title":"Synthesis, antibacterial and antimycobacterial activity of some novel 3-(6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)-2H-chromen-2-one","volume":"7","author":"Sudha BN","year":"2016","unstructured":"Sudha BN , SastryVG. Synthesis, antibacterial and antimycobacterial activity of some novel 3-(6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)-2H-chromen-2-one. Int. J. Pharm. Sci. Res.7(5), 1302\u20131307 (2016).","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201900013"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijtb.2016.11.012"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2020.105374"},{"key":"e_1_3_2_85_1","first-page":"1742","article-title":"Development of 1,2,4-triazole-5-thione derivatives as potential inhibitors of enoyl acyl carrier protein reductase (InhA) in tuberculosis","volume":"18","author":"Vora D","year":"2019","unstructured":"Vora D , UpahdhyayN , TilekarK , JainV , RamaaCS. Development of 1,2,4-triazole-5-thione derivatives as potential inhibitors of enoyl acyl carrier protein reductase (InhA) in tuberculosis. Iran. J. Pharm. Res.18, 1742\u20131758 (2019).","journal-title":"Iran. J. Pharm. Res."},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570180814666170727143806"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2018.07.020"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/hc.21008"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.3987\/COM-12-12436"},{"key":"e_1_3_2_90_1","first-page":"1149","article-title":"Synthesis of some 1,2,4-triazoles as potent anti-tubercular agents","volume":"54","author":"Vijayaraghavan S","year":"2015","unstructured":"Vijayaraghavan S , ShirodkarPY. Synthesis of some 1,2,4-triazoles as potent anti-tubercular agents. Indian J. Chem.54B, 1149\u20131543 (2015).","journal-title":"Indian J. Chem."},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.53879\/id.51.01.p0041"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13040"},{"key":"e_1_3_2_93_1","first-page":"2795","article-title":"Design, synthesis and evaluation of antitubercular activity of amino azetidinones from isoniazid","volume":"7","author":"Thomas B","year":"2016","unstructured":"Thomas B , HarindranJ. Design, synthesis and evaluation of antitubercular activity of amino azetidinones from isoniazid. Int. J. Pharm. Sci. Res.7, 2795\u20132804 (2016).","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.870"},{"key":"e_1_3_2_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/bkcs.10009"},{"key":"e_1_3_2_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.3241"},{"key":"e_1_3_2_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.01.080"},{"key":"e_1_3_2_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21498"},{"key":"e_1_3_2_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201702279"},{"key":"e_1_3_2_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.07.060"},{"key":"e_1_3_2_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-014-1243-2"},{"key":"e_1_3_2_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22071171"},{"key":"e_1_3_2_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.07.071"},{"key":"e_1_3_2_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.10.027"},{"key":"e_1_3_2_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11094-018-1714-8"},{"issue":"6","key":"e_1_3_2_106_1","first-page":"89","article-title":"Design and synthesis of substituted clubbed triazolyl thiazole as XDR & MDR antituberculosis agents Part-II","volume":"3","author":"Mundhe D","year":"2011","unstructured":"Mundhe D , ChandewarAV , ShiradkarMR. Design and synthesis of substituted clubbed triazolyl thiazole as XDR & MDR antituberculosis agents Part-II. Der Pharm. Chem.3(6), 89\u2013102 (2011).","journal-title":"Der Pharm. Chem."},{"issue":"1","key":"e_1_3_2_107_1","first-page":"131","article-title":"Synthesis and antitubercular activity of some novel N-methyl triazolone derivatives","volume":"6","author":"Patil PB","year":"2014","unstructured":"Patil PB , AwatiSS , KumbhojeSR , GhotaneRB , PatilSS. Synthesis and antitubercular activity of some novel N-methyl triazolone derivatives. Der Pharm. Chem.6(1), 131\u2013136 (2014).","journal-title":"Der Pharm. Chem."},{"key":"e_1_3_2_108_1","doi-asserted-by":"publisher","DOI":"10.1590\/s2175-97902018000300040"},{"key":"e_1_3_2_109_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8NJ00670A"},{"key":"e_1_3_2_110_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjps.galenos.2018.43660"},{"key":"e_1_3_2_111_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026619666190227183826"},{"key":"e_1_3_2_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-012-0112-0"},{"key":"e_1_3_2_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.07.051"},{"key":"e_1_3_2_114_1","doi-asserted-by":"publisher","DOI":"10.12991\/mpj.2015199639"},{"key":"e_1_3_2_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12939"},{"key":"e_1_3_2_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201803605"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc-2020-0295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:53:47Z","timestamp":1716479627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc-2020-0295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,26]]},"references-count":114,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.4155\/fmc-2020-0295"],"URL":"https:\/\/doi.org\/10.4155\/fmc-2020-0295","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,26]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}