{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:30:48Z","timestamp":1787031048139,"version":"build-2736575974"},"reference-count":106,"publisher":"Informa UK Limited","issue":"23","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.4155\/fmc-2022-0252","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T04:35:40Z","timestamp":1670560540000},"page":"1811-1830","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["Recent Advances in ATM Inhibitors As Potential Therapeutic Agents"],"prefix":"10.1080","volume":"14","author":[{"given":"Chao","family":"Dong","sequence":"first","affiliation":[{"name":"School of Science\rChina Pharmaceutical University\r639 Longmian Avenue\rNanjing\r211198\rPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Science\rChina Pharmaceutical University\r639 Longmian Avenue\rNanjing\r211198\rPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlin","family":"Tu","sequence":"additional","affiliation":[{"name":"School of Science\rChina Pharmaceutical University\r639 Longmian Avenue\rNanjing\r211198\rPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxue","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Science\rChina Pharmaceutical University\r639 Longmian Avenue\rNanjing\r211198\rPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Science\rChina Pharmaceutical University\r639 Longmian Avenue\rNanjing\r211198\rPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Science\rChina Pharmaceutical University\r639 Longmian Avenue\rNanjing\r211198\rPR China"},{"name":"State Key Laboratory of Natural Medicines\rChina Pharmaceutical University\r24 Tongjiaxiang\rNanjing\r210009\rPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2189-9356","authenticated-orcid":false,"given":"Yadong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Science\rChina Pharmaceutical University\r639 Longmian Avenue\rNanjing\r211198\rPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4075-7556","authenticated-orcid":false,"given":"Haichun","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Science\rChina Pharmaceutical University\r639 Longmian Avenue\rNanjing\r211198\rPR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2004.03.029"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2009.04.006"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210872"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.31.1.635"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2020.111695"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08467"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.09.019"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35077232"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.10.038"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2014.01.009"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804615"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05978"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/35043058"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaq0702"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2021.02.001"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.10.025"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3546"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010523"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat1719"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.12.001"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0176-1"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22016"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1700933"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2019.12.010"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(00)01563-2"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.05.015"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1666208"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200805154"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.914401"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.61.4.742"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091496"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.015"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2016.1158362"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1982"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601231"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.204065"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601446"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03096-0"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188453"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.11.025"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2017.06.022"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01368"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1677"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5383.1674"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.3.10556"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mju045"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/35036406"},{"issue":"6","key":"e_1_3_2_50_1","first-page":"7035","article-title":"Expression of ATM, CHK2 and BRCA1 predicts the clinical outcome of non-small cell lung cancer in patients receiving platinum-based chemotherapy","volume":"10","author":"Li Y","year":"2017","unstructured":"Li Y , HeL , WangYet al. Expression of ATM, CHK2 and BRCA1 predicts the clinical outcome of non-small cell lung cancer in patients receiving platinum-based chemotherapy. Int. J. Clin. Exp. Pathol.10(6), 7035\u20137043 (2017).","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.74218"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104944"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051923"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.03.006"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.13.4129-4139.2001"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000096"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-013-1106-5"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7344"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2812"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.07.002"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501026z"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(05)00089-4"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-2727"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0519"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm061121y"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm050444b"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm049526a"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.03.006"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3408"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.27723"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-022-09731-3"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-823144-9.00015-7"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01819"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00114"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.269134"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00519"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112290"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm201388p"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml500146d"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(97)10019-7"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00200"},{"key":"e_1_3_2_82_1","unstructured":"SUZHOU ZANRONG PHARMA LIMITED PR CHINA . WO2020052688 (2020)."},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.12.041"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abd5750"},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01896"},{"key":"e_1_3_2_86_1","unstructured":"Study to Assess the Safety and Preliminary Efficacy of AZD0156 at Increasing Doses Alone or in Combination With Other Anti-cancer Treatment in Patients With Advanced Cancer (AToM). www.clinicaltrials.gov\/ct2\/show\/NCT02588105 (Accessed:December 1 2022)."},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2014.03.012"},{"key":"e_1_3_2_88_1","unstructured":"A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer. www.clinicaltrials.gov\/ct2\/show\/NCT03423628 (Accessed:December 1 2022)."},{"key":"e_1_3_2_89_1","unstructured":"AZD1390 in Recurrent Grade IV Glioma Patients. www.clinicaltrials.gov\/ct2\/show\/NCT05182905 (Accessed:December 1 2022)."},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa238"},{"key":"e_1_3_2_91_1","unstructured":"Zhong W . WO2022060377 (2022)."},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114234"},{"key":"e_1_3_2_93_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087057113520325"},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01092"},{"key":"e_1_3_2_95_1","unstructured":"IMPACT THERAPEUTICS INC. PR CHINA . WO2018153365 (2018)."},{"key":"e_1_3_2_96_1","unstructured":"IMPACT THERAPEUTICS INC. PR CHINA . WO2018127195 (2018)."},{"key":"e_1_3_2_97_1","unstructured":"SHANGHAI IMPACT THERAPEUTICS INC. PR CHINA . CN112480120 (2021)."},{"key":"e_1_3_2_98_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-0975"},{"key":"e_1_3_2_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114196"},{"key":"e_1_3_2_100_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-19-0474"},{"key":"e_1_3_2_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2021.09.008"},{"key":"e_1_3_2_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23105770"},{"key":"e_1_3_2_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02384-w"},{"key":"e_1_3_2_104_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-3126"},{"key":"e_1_3_2_105_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-0966"},{"key":"e_1_3_2_106_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-12-1242"},{"key":"e_1_3_2_107_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142561"},{"key":"e_1_3_2_108_1","doi-asserted-by":"publisher","DOI":"10.1080\/23723556.2015.1012976"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc-2022-0252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:51:42Z","timestamp":1716479502000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc-2022-0252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":106,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.4155\/fmc-2022-0252"],"URL":"https:\/\/doi.org\/10.4155\/fmc-2022-0252","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}