{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:08:00Z","timestamp":1774969680367,"version":"3.50.1"},"reference-count":30,"publisher":"Informa UK Limited","issue":"9","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["10GRNT4470042, 14GRNT20380687"],"award-info":[{"award-number":["10GRNT4470042, 14GRNT20380687"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL56712, HL79389"],"award-info":[{"award-number":["HL56712, HL79389"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.4155\/fmc-2023-0039","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T07:26:22Z","timestamp":1685431582000},"page":"757-767","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["Design, Synthesis and Characterization of Lead Compounds as Anti-Inflammatory Drugs Targeting mPGES-1 Via Enzymelink Screening"],"prefix":"10.1080","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5313-5967","authenticated-orcid":false,"given":"Renzhong","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Pharmacological & Pharmaceutical Sciences, Center for Experimental Therapeutics & Pharmacoinformatics, College of Pharmacy, University of Houston, Houston, TX, 77204, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Akasaka","sequence":"additional","affiliation":[{"name":"Department of Pharmacological & Pharmaceutical Sciences, Center for Experimental Therapeutics & Pharmacoinformatics, College of Pharmacy, University of Houston, Houston, TX, 77204, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-2231","authenticated-orcid":false,"given":"Ke-He","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Pharmacological & Pharmaceutical Sciences, Center for Experimental Therapeutics & Pharmacoinformatics, College of Pharmacy, University of Houston, Houston, TX, 77204, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00339"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/1-4020-5688-5_1"},{"issue":"4","key":"e_1_3_2_4_1","first-page":"655","article-title":"Selective COX-2 inhibitors: a review of their structure\u2013activity relationships","volume":"10","author":"Zarghi A","year":"2011","unstructured":"Zarghi A , ArfaeiS. Selective COX-2 inhibitors: a review of their structure\u2013activity relationships. Iran. J. Pharm. Res.10(4), 655\u2013683 (2011).","journal-title":"Iran. J. Pharm. Res."},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986710790979980"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-8663(00)00254-X"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12484"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.38.1.97"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557043403710"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0614277"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06703.x"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2021-0056"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003505200"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M213290200"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.02.006"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-6100"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzp058"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(02)00043-6"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700200"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2008.00963.x"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.59.3.1"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13048"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2005.1.445"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23482-4"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8MD00497H"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67283-0"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm200135z"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104913"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00330"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.01.021"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.207449"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc-2023-0039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:52:34Z","timestamp":1716493954000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc-2023-0039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.4155\/fmc-2023-0039"],"URL":"https:\/\/doi.org\/10.4155\/fmc-2023-0039","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}