{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T03:29:55Z","timestamp":1784086195270,"version":"3.55.0"},"reference-count":51,"publisher":"Informa UK Limited","issue":"7","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Princess Nourah bint Abdulrahman University Researchers","award":["PNURSP2024R95"],"award-info":[{"award-number":["PNURSP2024R95"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.4155\/fmc-2023-0336","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T10:21:03Z","timestamp":1709547663000},"page":"601-622","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["Design, Synthesis and Mechanistic Study of New Dual Targeting HDAC\/Tubulin Inhibitors"],"prefix":"10.1080","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1521-4581","authenticated-orcid":false,"given":"Mona S","family":"El-Zoghbi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0588-0073","authenticated-orcid":false,"given":"Amr KA","family":"Bass","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3908-1832","authenticated-orcid":false,"given":"Gamal El-Din","family":"A Abuo-Rahma","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt"},{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New Minia, Minia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7046-1799","authenticated-orcid":false,"given":"Mamdouh FA","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, 82524, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3596-1664","authenticated-orcid":false,"given":"Mohamed","family":"Badr","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3253-9698","authenticated-orcid":false,"given":"Hanan A","family":"AL-Ghulikah","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, PO Box 84428, Riyadh, 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0078-5261","authenticated-orcid":false,"given":"El-Shimaa MN","family":"Abdelhafez","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.013"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2017.08.020"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114807"},{"key":"e_1_3_6_6_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/290685","article-title":"Current and emerging therapeutics for cutaneous T-cell lymphoma: histone deacetylase inhibitors","volume":"2012","author":"Rodd AL","year":"2012","unstructured":"Rodd AL , VerverisK, KaragiannisTCJ. Current and emerging therapeutics for cutaneous T-cell lymphoma: histone deacetylase inhibitors. Lymphoma2012, 1\u201310 (2012).","journal-title":"Lymphoma"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00830"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.08.016"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.106181"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.115054"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114634"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12384"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.114058"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557516666160505115324"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00706"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.05.072"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112323"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113531"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115794"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2024.2302320"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00413"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm500002k"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c18-00269"},{"issue":"2","key":"e_1_3_6_24_1","first-page":"81","article-title":"3-Cyano-2-oxa-pyridines: a promising template for diverse pharmacological activities","volume":"4","author":"Bass AK","year":"2021","unstructured":"Bass AK , AbdelhafezE, El-ZoghbiMet al. 3-Cyano-2-oxa-pyridines: a promising template for diverse pharmacological activities. J. Adv. Biomed. Pharmaceut. Sci.4(2), 81\u201386 (2021).","journal-title":"J. Adv. Biomed. Pharmaceut. Sci."},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-014-0112-x"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-015-0176-7"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA19917H"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.07.045"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.10.066"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00413"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.03.049"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.106112"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114573"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.105625"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.115022"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105564"},{"key":"e_1_3_6_37_1","unstructured":"NCI-60 Screening Methodology | NCI-60 Human Tumor Cell Lines Screen | Discovery & Development Services | Developmental Therapeutics Program (DTP). cancer.gov"},{"key":"e_1_3_6_38_1","unstructured":"Abcam . HDAC Inhibitor Drug Screening Kit (Fluorometric). www.biovision.com\/documentation\/datasheets\/K340.pdf"},{"key":"e_1_3_6_39_1","unstructured":"BPS Bioscience . HDAC1 Assay. www.bpsbioscience.com\/pub\/media\/wysiwyg\/HDACs\/53001_1.pdf"},{"key":"e_1_3_6_40_1","unstructured":"BPS Bioscience . Fluorogenic HDAC6 Assay. www.bpsbioscience.com\/pub\/media\/wysiwyg\/HDACs\/50076-1_96_Reactions_.pdf"},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic701735q"},{"key":"e_1_3_6_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-080-5_20"},{"key":"e_1_3_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104019"},{"key":"e_1_3_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)34062-1"},{"key":"e_1_3_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-012-0972-4"},{"key":"e_1_3_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104020"},{"key":"e_1_3_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2017.03.005"},{"key":"e_1_3_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103127"},{"key":"e_1_3_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105076"},{"key":"e_1_3_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(95)00072-I"},{"key":"e_1_3_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103797"},{"key":"e_1_3_6_52_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S237957"},{"key":"e_1_3_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.06.003"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc-2023-0336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T14:23:22Z","timestamp":1726755802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc-2023-0336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,4]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.4155\/fmc-2023-0336"],"URL":"https:\/\/doi.org\/10.4155\/fmc-2023-0336","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}