{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:18:06Z","timestamp":1791191886917,"version":"4.1.0"},"reference-count":80,"publisher":"Informa UK Limited","issue":"7","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AG029481"],"award-info":[{"award-number":["AG029481"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.4155\/fmc.12.51","type":"journal-article","created":{"date-parts":[[2012,5,9]],"date-time":"2012-05-09T12:29:47Z","timestamp":1336566587000},"page":"915-925","source":"Crossref","is-referenced-by-count":84,"title":["Is RAGE Still A Therapeutic Target For Alzheimer\u2019s Disease?"],"prefix":"10.1080","volume":"4","author":[{"given":"Richard J","family":"Deane","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, School of Arts & Sciences, University of Rochester, NY14642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2012,5,9]]},"reference":[{"key":"e_1_3_3_3_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/382685a0"},{"key":"e_1_3_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2010.05.017"},{"key":"e_1_3_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2011.08.008"},{"key":"e_1_3_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42138-2"},{"key":"e_1_3_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm890"},{"key":"e_1_3_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2010.01.013"},{"key":"e_1_3_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42137-0"},{"key":"e_1_3_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0773-2"},{"key":"e_1_3_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.11.016"},{"key":"e_1_3_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0409230"},{"key":"e_1_3_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22217"},{"key":"e_1_3_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.28"},{"key":"e_1_3_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002253"},{"key":"e_1_3_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780116"},{"key":"e_1_3_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.05.020"},{"key":"e_1_3_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4878-07.2008"},{"key":"e_1_3_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-109033"},{"key":"e_1_3_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-117739"},{"key":"e_1_3_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2029"},{"key":"e_1_3_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600415"},{"key":"e_1_3_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/76216"},{"key":"e_1_3_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1030"},{"issue":"1","key":"e_1_3_3_3_23_1","first-page":"9","volume":"24","author":"Baiguera S","year":"2009","unstructured":"Baiguera S , FioravanzoL, GrandiC, Di Liddo R, Parnigotto PP, Folin M. Involvement of the receptor for advanced glycation-end products (RAGE) in beta-amyloid-induced toxic effects in rat cerebromicrovascular endothelial cells cultured in vitro. Int. J. Mol. Med.24(1), 9\u201315 (2009).","journal-title":"Int. J. Mol. Med."},{"key":"e_1_3_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2005.08.003"},{"key":"e_1_3_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20644"},{"key":"e_1_3_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20736"},{"key":"e_1_3_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.01.006"},{"key":"e_1_3_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.212217"},{"key":"e_1_3_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-006-0078-9"},{"issue":"7","key":"e_1_3_3_3_30_1","first-page":"672","article-title":"The role of RAGE in amyloid-beta peptide-mediated pathology in Alzheimer\u2019s disease.","volume":"10","author":"Schmidt AM","year":"2009","unstructured":"Schmidt AM , SahaganB, NelsonRB, SelmerJ, RothleinR, BellJM. The role of RAGE in amyloid-beta peptide-mediated pathology in Alzheimer\u2019s disease.Curr. Opin. Investig. Drugs10(7), 672\u2013680 (2009).","journal-title":"Curr. Opin. Investig. Drugs"},{"issue":"12","key":"e_1_3_3_3_31_1","first-page":"1515","article-title":"Glycation and diabetes: the RAGE connection.","volume":"83","author":"Hudson BI","year":"2002","unstructured":"Hudson BI , HofmannMA, BucciarelliLet al. Glycation and diabetes: the RAGE connection. Curr. Sci. 83(12), 1515\u20131521 (2002).","journal-title":"Curr. Sci."},{"key":"e_1_3_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9909com"},{"key":"e_1_3_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.169276"},{"key":"e_1_3_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi7003735"},{"key":"e_1_3_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.02.032"},{"key":"e_1_3_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030800"},{"key":"e_1_3_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801622200"},{"key":"e_1_3_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.223438"},{"key":"e_1_3_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2011.02.013"},{"key":"e_1_3_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2011.02.011"},{"key":"e_1_3_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/539581"},{"key":"e_1_3_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.CPJ04005X"},{"key":"e_1_3_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0909142"},{"key":"e_1_3_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06181.x"},{"key":"e_1_3_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000143452.85382.d1"},{"key":"e_1_3_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/77397"},{"key":"e_1_3_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10498"},{"issue":"5","key":"e_1_3_3_3_48_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0896-6273(04)00533-1","article-title":"Clearance of Alzheimer\u2019s Abeta peptide: the many roads to perdition.","volume":"43","author":"Tanzi RE","year":"2004","unstructured":"Tanzi RE , MoirRD, WagnerSL. Clearance of Alzheimer\u2019s Abeta peptide: the many roads to perdition.Neuron43(5), 605\u2013608 (2004).","journal-title":"Neuron"},{"key":"e_1_3_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.01.003"},{"key":"e_1_3_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.07.017"},{"key":"e_1_3_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0115-3"},{"key":"e_1_3_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.06.124"},{"key":"e_1_3_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e3181c8ad2f"},{"key":"e_1_3_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.12.029"},{"key":"e_1_3_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21252"},{"key":"e_1_3_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(99)00065-2"},{"key":"e_1_3_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00730-4"},{"key":"e_1_3_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200000001-00008"},{"issue":"9","key":"e_1_3_3_3_59_1","first-page":"1005","article-title":"Inflammation in Alzheimer disease: driving force, bystander or beneficial response?","volume":"12","author":"Wyss-Coray T","year":"2006","unstructured":"Wyss-Coray T . Inflammation in Alzheimer disease: driving force, bystander or beneficial response?Nat. Med.12(9), 1005\u20131015 (2006).","journal-title":"Nat. Med."},{"issue":"1","key":"e_1_3_3_3_60_1","first-page":"307","article-title":"Microglial response to amyloid plaques in APPsw transgenic mice.","volume":"152","author":"Frautschy SA","year":"1998","unstructured":"Frautschy SA , YangF, IrrizarryMet al. Microglial response to amyloid plaques in APPsw transgenic mice. Am. J. Pahol. 152(1), 307\u2013317 (1998).","journal-title":"Am. J. Pahol."},{"key":"e_1_3_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0616-08.2008"},{"key":"e_1_3_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2432"},{"key":"e_1_3_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3158-09.2009"},{"key":"e_1_3_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1808-05.2005"},{"key":"e_1_3_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1555"},{"key":"e_1_3_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.279.6.C1772"},{"key":"e_1_3_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080528"},{"key":"e_1_3_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.034504"},{"key":"e_1_3_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4371-06.2007"},{"key":"e_1_3_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20924"},{"key":"e_1_3_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07207.x"},{"key":"e_1_3_3_3_72_1","unstructured":"Deane R SinghI SagareAPet al. Tertiary amide preferentially blocks A\u03b2\/RAGE interaction without causing toxicity. Presented at: Society for Neuroscience. Washington DC USA 12\u201316 November 2011."},{"key":"e_1_3_3_3_73_1","unstructured":"Deane R SinghI SagareAet al. Tertiary amide reduced BACE1 activity and A\u03b2 production in a mouse model of AD. Presented at: Society for Neuroscience. San Diego CA USA 13\u201317 November 2010."},{"key":"e_1_3_3_3_74_1","unstructured":"Deane R SinghI LoveRet al. Differential action of lipophilic and hydrophilic tertiary amide-based RAGE\/A\u03b2 blockers in a mouse model of AD. Presented at: Society for Neuroscience. Chicago IL USA 17\u201321 November 2009."},{"key":"e_1_3_3_3_75_1","unstructured":"Deane R SagareA PaquetteNet al. Tertiary amide improves cerebral blood flow and behavioral performance in a mouse model of AD by blocking RAGE\/A\u03b2 interaction. Presented at: Society for Neuroscience. Washington DC USA 15\u201319 November 2008."},{"key":"e_1_3_3_3_76_1","unstructured":"Deane R PerryS SagareAet al. Tertiary amides block RAGE-mediated A\u03b2 transport into brain in a mouse model of AD. Presented at: Society for Neuroscience. Atlanta GA USA 14\u201318 October 2006."},{"key":"e_1_3_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58642"},{"key":"e_1_3_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008309"},{"key":"e_1_3_3_4_2_1","unstructured":"A Phase II Study Evaluating the Efficacy and Safety of PF 04494700 in Mild to Moderate Alzheimer\u2019s Disease. http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00566397"},{"key":"e_1_3_3_4_3_1","unstructured":"6-Month Safety and Efficacy Study of TTP488 in Patients With Type 2 Diabetes and Persistent Albuminuria. http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00287183"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc.12.51","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:49:31Z","timestamp":1716479371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc.12.51"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":80,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.4155\/fmc.12.51"],"URL":"https:\/\/doi.org\/10.4155\/fmc.12.51","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}