{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:53:00Z","timestamp":1788871980516,"version":"build-2803163510"},"reference-count":59,"publisher":"Informa UK Limited","issue":"1","funder":[{"name":"AiCuris GmbH & Co. KG"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.4155\/fmc.13.192","type":"journal-article","created":{"date-parts":[[2013,12,23]],"date-time":"2013-12-23T06:08:12Z","timestamp":1387778892000},"page":"45-55","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":15,"title":["Helicase\u2013Primase Inhibitors for Herpes Simplex Virus: Looking to the Future of Non-Nucleoside Inhibitors for Treating Herpes Virus Infections"],"prefix":"10.1080","volume":"6","author":[{"given":"Subhajit","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK"},{"name":"School of Life Sciences, University of Lincoln, LN6 7TS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumi","family":"Sukla","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK"},{"name":"School of Life Sciences, University of Lincoln, LN6 7TS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh J","family":"Field","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK"},{"name":"Queens\u2019 College, University of Cambridge, CB3 9ET, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2013,12,23]]},"reference":[{"key":"e_1_3_2_3_1_1","first-page":"121","article-title":"Experimental production of herpetic lesions in organs and tissues of the rabbit.","volume":"44","author":"Goodpasture EW","year":"1923","unstructured":"Goodpasture EW , TeagueO. Experimental production of herpetic lesions in organs and tissues of the rabbit.J. Med. Res.44, 121\u2013138 (1923).","journal-title":"J. Med. Res."},{"key":"e_1_3_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.57.4.379"},{"key":"e_1_3_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3002(59)90597-9"},{"key":"e_1_3_2_3_4_1","first-page":"58","article-title":"De Clercq E. Antiviral drugs: a short history of their discovery and development","volume":"31","author":"Field HJ","year":"2004","unstructured":"Field HJ , De Clercq E. Antiviral drugs: a short history of their discovery and development. Microbiol. Today31, 58\u201361 (2004).","journal-title":"Microbiol. Today"},{"key":"e_1_3_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1963.00960040632017"},{"key":"e_1_3_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.145.3632.585"},{"key":"e_1_3_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706446"},{"key":"e_1_3_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldt011"},{"key":"e_1_3_2_3_9_1","unstructured":"Oberg B . Inhibitors of Virus-Specific Enzymes in Problems of Antiviral Therapy. Stuart-Harris CH Oxford J (Eds). Academic Press London UK 35\u201369 (1983)."},{"key":"e_1_3_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-133-34528"},{"key":"e_1_3_2_3_11_1","unstructured":"Cheng YC NakayamaK DerseDet al. Herpes Virus Specific Enzymes: Properties Physiological Roles and Pharmacological Implications in Herpesviruses Clinical Pharmacological and Basic Aspects. Shiota H Cheng Y-C Prusoff WH (Eds). Excerpta Medica International Congress Series Amsterdam The Netherlands 47\u201356(1982)."},{"key":"e_1_3_2_3_12_1","first-page":"9","article-title":"Inhibition of virus-encoded thymidine kinase suppresses herpes simplex virus replication in vitro and in vivo.","volume":"9","author":"Watkins AM","year":"1998","unstructured":"Watkins AM , DunfordPJ, MoffattAMet al. Inhibition of virus-encoded thymidine kinase suppresses herpes simplex virus replication in vitro and in vivo. Antivir. Chem. Chemother. 9, 9\u201318(1998).","journal-title":"Antivir. Chem. Chemother."},{"key":"e_1_3_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.4.3.294"},{"key":"e_1_3_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/11.15.5287"},{"key":"e_1_3_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.210500"},{"key":"e_1_3_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199448020-00007"},{"key":"e_1_3_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01596-09"},{"key":"e_1_3_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2384"},{"key":"e_1_3_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.9.6979-6987.1998"},{"key":"e_1_3_2_3_20_1","doi-asserted-by":"crossref","unstructured":"Field HJ MickleburghI. The helicase-primase complex as a target for efective herpesvirus antivirals in DNA helicases and DNA motor proteins. In: DNA Helicases and DNA Motor Proteins. Spies M (Ed.). Springer Berlin Germany 145\u2013159(2013).","DOI":"10.1007\/978-1-4614-5037-5_7"},{"key":"e_1_3_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.11.28"},{"key":"e_1_3_2_3_22_1","doi-asserted-by":"crossref","unstructured":"Biswas S FieldHJ. Helicase\u2013Primase Inhibitors: A New Approach to Combat Herpes Simplex Virus and Varicella Zoster Virus in Antiviral Drug Strategies. De Clercq E (Ed.). Wiley-VCH Verlag GmbH & Co. KGaA Weinheim Germany 129\u2013146(2011).","DOI":"10.1002\/9783527635955.ch6"},{"key":"e_1_3_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq198"},{"key":"e_1_3_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0402-392"},{"key":"e_1_3_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0402-386"},{"key":"e_1_3_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.6.1798-1804.2003"},{"key":"e_1_3_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2004.02.007"},{"key":"e_1_3_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.11.006"},{"key":"e_1_3_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1766-1772.2002"},{"key":"e_1_3_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/095632020701800104"},{"key":"e_1_3_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-302062"},{"key":"e_1_3_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.05.020"},{"key":"e_1_3_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01690-10"},{"key":"e_1_3_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn057"},{"key":"e_1_3_2_3_35_1","unstructured":"Field HJ MickelburghI Huang M-L et al. Sensitivity of clinical isolates to helicase primase inhibitors and no detection of resistance mutations above background frequency. Presented at: 25th International Conference on Antiviral Research. Sapporo Japan 16\u201319 April 2012."},{"key":"e_1_3_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-007-0964-7"},{"key":"e_1_3_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/095632020801900101"},{"key":"e_1_3_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2010.11.002"},{"key":"e_1_3_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.1.469-479.1992"},{"key":"e_1_3_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.04.005"},{"key":"e_1_3_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.011221-0"},{"key":"e_1_3_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/095632020701800102"},{"key":"e_1_3_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm182"},{"key":"e_1_3_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq135"},{"key":"e_1_3_2_3_45_1","unstructured":"Biswas S SuklaS PaulsenDet al. Efficacious treatment of a helicase-primase inhibitor resistant herpes simplex virus-1 mutant with AIC316 in a murine infection model. Presented at: 36th Annual International Herpesvirus Workshop. Gdansk Poland 24\u201328 July 2011."},{"key":"e_1_3_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2010.04.008"},{"key":"e_1_3_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.04.010"},{"key":"e_1_3_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.02.031"},{"key":"e_1_3_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0806"},{"key":"e_1_3_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000149373"},{"key":"e_1_3_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.08.024"},{"key":"e_1_3_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.4.1105"},{"key":"e_1_3_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi9010144"},{"key":"e_1_3_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.14.9088-9096.2005"},{"key":"e_1_3_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00174-07"},{"key":"e_1_3_2_4_2_1","unstructured":"AiCuris successfully completed Phase I for novel herpes compound. www.aicuris.com\/index.php\/fuseaction\/download\/lrn_file\/20091104-press-release-hsv-phase-i-e-final.pdf (Accessed 26June2013)"},{"key":"e_1_3_2_4_3_1","unstructured":"AiCuris: no resistant herpes simplex virus (HSV) observed in Phase II trial with herpes drug AIC316. www.drugs.com\/clinical_trials\/aicuris-no-resistant-herpes-simplex-virus-hsv-observed-phase-ii-trial-herpes-aic316-12297.html (Accessed 26June2013)"},{"key":"e_1_3_2_4_4_1","unstructured":"AiCuris surpasses 50% enrollment milestone in Phase II. Superiority trial for herpes drug pritelivir. www.aicuris.com\/index.php\/fuseaction\/download\/lrn_file\/2013-01-29_pr_50percent-recruitment-aic316-press-release.pdf (Accessed 26June2013)"},{"key":"e_1_3_2_4_5_1","unstructured":"Clinical trials. http:\/\/clinicaltrials.gov\/ct2\/show\/NCT01658826?term=aic316&rank=1 (Accessed 26June2013)"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc.13.192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:52:56Z","timestamp":1716479576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc.13.192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,23]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.4155\/fmc.13.192"],"URL":"https:\/\/doi.org\/10.4155\/fmc.13.192","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,23]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2013-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}