{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:53:40Z","timestamp":1761663220542},"reference-count":94,"publisher":"Informa UK Limited","issue":"2","funder":[{"name":"ISTP Canada","award":["#ICRD08\u201315"],"award-info":[{"award-number":["#ICRD08\u201315"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.4155\/fmc.13.198","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T12:02:55Z","timestamp":1390910575000},"page":"165-177","update-policy":"http:\/\/dx.doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":6,"title":["Design of Inhibitors of Odcase"],"prefix":"10.1080","volume":"6","author":[{"given":"Sourabh","family":"Mundra","sequence":"first","affiliation":[{"name":"Center for Molecular Design &amp; Preformulations, &amp; Toronto General Research Institute, University Health Network, Toronto, Ontario, M5G 1L7, Canada"},{"name":"Birla Institute of Technology &amp; Science, Pilani, Rajasthan, 333031, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi P","family":"Kotra","sequence":"additional","affiliation":[{"name":"Center for Molecular Design &amp; Preformulations, &amp; Toronto General Research Institute, University Health Network, Toronto, Ontario, M5G 1L7, Canada"},{"name":"Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, M5S 3M2, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2014,1,28]]},"reference":[{"key":"e_1_3_3_3_1","first-page":"263","article-title":"The enzymatic synthesis of pyrimidines.","volume":"21","author":"Reichard P","year":"1959","unstructured":"Reichard P . The enzymatic synthesis of pyrimidines.Adv. Enzymol. Mol. Biol.21, 263\u2013294 (1959).","journal-title":"Adv. Enzymol. Mol. Biol."},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2007.07.004"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7809611"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809838105"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cs400272x"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.156.2.620-624.1983"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(84)90109-7"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.5950"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.110601.135446"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.04.017"},{"issue":"2","key":"e_1_3_3_13_1","first-page":"467","article-title":"Purines and pyrimidines in malarial parasites.","volume":"16","author":"Gero AM","year":"1990","unstructured":"Gero AM , O\u2018SullivanWJ. Purines and pyrimidines in malarial parasites.Blood Cells16(2\u20133), 467\u2013484 (1990).","journal-title":"Blood Cells"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)41283-0"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00561a024"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955708783744065"},{"issue":"5","key":"e_1_3_3_17_1","first-page":"2324","article-title":"Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-l-aspartic acid","volume":"43","author":"Casper ES","year":"1983","unstructured":"Casper ES , ValeK, WilliamsLJ, MartinDS, YoungCW. Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-l-aspartic acid. Cancer Res.43(5), 2324\u20139 (1983).","journal-title":"Cancer Res."},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00428a035"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00387a047"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00465a007"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi015758p"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi992553w"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(00)00148-2"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202362200"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi000987h"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.050417797"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.427252"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5314.942"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja011096f"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.142307099"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00163a026"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.259441296"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja102408k"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja076222f"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi400190v"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja710384t"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3058474"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja201734z"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi900623r"},{"issue":"12","key":"e_1_3_3_40_1","first-page":"3842","article-title":"Structure and inhibition of orotidine 5\u00b4-monophosphate decarboxylase from","volume":"47","author":"Langley DB","year":"2008","unstructured":"Langley DB , ShojaeiM, ChanCet al. Structure and inhibition of orotidine 5\u00b4-monophosphate decarboxylase from Plasmodium falciparum. Biochemistry 47(12), 3842\u20133854 (2008).","journal-title":"Plasmodium falciparum. Biochemistry"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/b94537"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi301491r"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi301650d"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm700968x"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm301176r"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986708784221449"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.025866"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm801224t"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)30098-4"},{"issue":"3","key":"e_1_3_3_50_1","first-page":"682","article-title":"Clinical, biological and biochemical effect of Pyrazofurin.","volume":"38","author":"Cadman EC","year":"1978","unstructured":"Cadman EC , DixDE, HandschumacherRE. Clinical, biological and biochemical effect of Pyrazofurin.Cancer Res.38(3), 682\u2013698 (1978).","journal-title":"Cancer Res."},{"key":"e_1_3_3_51_1","unstructured":"Williams RH GerzonK HoehnM GormanM deLongDC. Abstract# MICR 38 158th American Chemical Society National Meeting. NY USA 7\u201312 September 1969."},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar0000509"},{"issue":"11","key":"e_1_3_3_53_1","first-page":"2619","article-title":"Experimental antitumor activity of pyrazomycin.","volume":"33","author":"Sweeney MJ","year":"1973","unstructured":"Sweeney MJ , DavisFA, GutowskiGE, HamillRL, HoffmanDH, PooreGA. Experimental antitumor activity of pyrazomycin.Cancer Res.33(11), 2619\u20132623 (1973).","journal-title":"Cancer Res."},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb29257.x"},{"issue":"7","key":"e_1_3_3_55_1","first-page":"2043","article-title":"Pharmacological and biochemical effects of pyrazofurin in humans.","volume":"37","author":"Ohnuma T","year":"1977","unstructured":"Ohnuma T , RobozJ, ShapiroML, HollandJF. Pharmacological and biochemical effects of pyrazofurin in humans.Cancer Res.37(7, Pt1), 2043\u20132049 (1977).","journal-title":"Cancer Res."},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(85)90085-8"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.030409797"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm060202r"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1006\/bioo.1999.1140"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/095632029400500402"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.10.1535"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00013-X"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(93)90085-W"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(89)90017-X"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.2.382-397.2001"},{"issue":"17","key":"e_1_3_3_66_1","first-page":"5268","volume":"33","author":"Seymour KK","year":"1994","unstructured":"Seymour KK , LyonsSD, PhillipsL, Rieckmann,KH, ChristophersonRI. Cytotoxic effects of inhibitors of de novo pyrimidine biosynthesis upon Plasmodium falciparum. Biochemistry33(17), 5268\u20135274 (1994).","journal-title":"Plasmodium falciparum. Biochemistry"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(86)90045-9"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1081\/NCN-200067421"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(88)90080-6"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(87)90175-4"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.140.9.3249"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(88)90284-5"},{"issue":"6","key":"e_1_3_3_73_1","first-page":"647","article-title":"Cytokines involved in the augmentation of murine natural killer cell activity by pyrimidinones in vivo","volume":"6","author":"Richard KA","year":"1987","unstructured":"Richard KA , MortensenRF, TraceyDE. Cytokines involved in the augmentation of murine natural killer cell activity by pyrimidinones in vivo. J. Biol. Response Mod.6(6), 647\u2013663 (1987).","journal-title":"J. Biol. Response Mod."},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00150a018"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.28.4.485"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(85)90048-8"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(86)90433-8"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00958-13"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-264"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1970.19.202"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/mr.43.4.453-495.1979"},{"key":"e_1_3_3_82_1","unstructured":"Scheibel LW SchermanIW. Malaria: Principles and Practice of Malariology. Wernsdorfer WH McGreggor I (Eds). Churchill Livingstone London UK 234\u2013242 (1988)."},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2010.08.005"},{"issue":"17","key":"e_1_3_3_84_1","first-page":"5268","volume":"33","author":"Seymour KK","year":"1994","unstructured":"Seymour KK , LyonsSD, PhillipsL, RieckmannKH, ChristophersonRI. Cytotoxic effects of inhibitors of de novo pyrimidine biosynthesis upon Plasmodium falciparum. Biochemistry33(17), 5268\u20135274 (1994).","journal-title":"Plasmodium falciparum. Biochemistry"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0219720013500030"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm060827p"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm7010673"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.02.037"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja054865u"},{"key":"e_1_3_3_90_1","unstructured":"Copeland RA . Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists. John Wiley and Sons. Inc. Hoboken NJ USA (2005)."},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm301678j"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12376"},{"key":"e_1_3_3_93_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi700796t"},{"key":"e_1_3_4_2_1","unstructured":"Williams RH Hoehn MM: US3674774 (1972)."},{"key":"e_1_3_4_3_1","unstructured":"Kotra LP Pai EF Bello AM Fujihashi M: US8067391 (2009)."},{"key":"e_1_3_5_2_1","unstructured":"Protein database. www.rcsb.org\/pdb\/home\/home.do"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc.13.198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:52:59Z","timestamp":1716493979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc.13.198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,28]]},"references-count":94,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.4155\/fmc.13.198"],"URL":"https:\/\/doi.org\/10.4155\/fmc.13.198","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,28]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2014-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}