{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:19:21Z","timestamp":1790911161627,"version":"4.1.0"},"reference-count":94,"publisher":"Informa UK Limited","issue":"4","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.4155\/fmc.13.214","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T17:26:57Z","timestamp":1395077217000},"page":"447-462","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":87,"title":["Challenges and Opportunities in Targeting the Menin\u2013MLL Interaction"],"prefix":"10.1080","volume":"6","author":[{"given":"Tomasz","family":"Cierpicki","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Grembecka","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2014,3,17]]},"reference":[{"key":"e_1_3_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08782-2"},{"key":"e_1_3_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.8.13.8924"},{"key":"e_1_3_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10040"},{"key":"e_1_3_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20430"},{"key":"e_1_3_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404150"},{"key":"e_1_3_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-007-0009-8"},{"key":"e_1_3_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.2.617-628.2004"},{"key":"e_1_3_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1041"},{"key":"e_1_3_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503630102"},{"key":"e_1_3_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1602107"},{"key":"e_1_3_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.20-5-364"},{"key":"e_1_3_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210760"},{"key":"e_1_3_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31861"},{"key":"e_1_3_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng765"},{"key":"e_1_3_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1111603"},{"key":"e_1_3_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.739"},{"key":"e_1_3_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.09.025"},{"key":"e_1_3_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510347103"},{"key":"e_1_3_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5311.404"},{"key":"e_1_3_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.4.1630"},{"key":"e_1_3_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2369"},{"key":"e_1_3_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.172783"},{"key":"e_1_3_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(04)00081-4"},{"key":"e_1_3_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.773"},{"key":"e_1_3_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-429274"},{"key":"e_1_3_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.13.5639-5649.2004"},{"key":"e_1_3_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07609.x"},{"key":"e_1_3_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2008.002436"},{"key":"e_1_3_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-051710-134100"},{"key":"e_1_3_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1128"},{"key":"e_1_3_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.04.031"},{"key":"e_1_3_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408836102"},{"key":"e_1_3_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100760"},{"key":"e_1_3_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.12.034"},{"key":"e_1_3_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.05.003"},{"key":"e_1_3_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01742-12"},{"key":"e_1_3_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10806"},{"key":"e_1_3_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037952"},{"key":"e_1_3_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020051"},{"key":"e_1_3_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-486647"},{"key":"e_1_3_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1610"},{"key":"e_1_3_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/89.9.653"},{"key":"e_1_3_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0060449"},{"key":"e_1_3_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.4.820"},{"key":"e_1_3_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.3.1118"},{"key":"e_1_3_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0154"},{"key":"e_1_3_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20605"},{"key":"e_1_3_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.15.6569-6580.2004"},{"key":"e_1_3_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.02055.x"},{"key":"e_1_3_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.258186"},{"key":"e_1_3_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80967-8"},{"key":"e_1_3_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204529"},{"key":"e_1_3_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061358098"},{"issue":"19","key":"e_1_3_2_3_54_1","first-page":"6135","article-title":"Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex.","volume":"63","author":"Kim H","year":"2003","unstructured":"Kim H , LeeJE, ChoEJ, LiuJO, YounHD. Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex.Cancer Res.63(19), 6135\u20136139 (2003).","journal-title":"Cancer Res."},{"key":"e_1_3_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4461"},{"key":"e_1_3_2_3_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-009-0581-0"},{"key":"e_1_3_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0724"},{"issue":"14","key":"e_1_3_2_3_58_1","first-page":"4204","article-title":"Menin associates with FANCD2, a protein involved in repair of DNA damage.","volume":"63","author":"Jin S","year":"2003","unstructured":"Jin S , MaoH, SchneppRWet al. Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res. 63(14), 4204\u20134210 (2003).","journal-title":"Cancer Res."},{"key":"e_1_3_2_3_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.2.493-509.2003"},{"key":"e_1_3_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.04.011"},{"key":"e_1_3_2_3_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2013.05.005"},{"key":"e_1_3_2_3_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.08.002"},{"key":"e_1_3_2_3_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.12.032"},{"key":"e_1_3_2_3_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(99)00089-5"},{"key":"e_1_3_2_3_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-1664-8_3"},{"key":"e_1_3_2_3_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2174"},{"key":"e_1_3_2_3_67_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-06-0123"},{"key":"e_1_3_2_3_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016119"},{"issue":"1","key":"e_1_3_2_3_69_1","first-page":"96","article-title":"SUMO modification of menin.","volume":"3","author":"Feng ZJ","year":"2013","unstructured":"Feng ZJ , GurungB, JinGH, YangXL, HuaXX. SUMO modification of menin.Am. J. Cancer Res.3(1), 96\u2013106 (2013).","journal-title":"Am. J. Cancer Res."},{"key":"e_1_3_2_3_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl282"},{"key":"e_1_3_2_3_71_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399408000641"},{"key":"e_1_3_2_3_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm3015298"},{"key":"e_1_3_2_3_73_1","unstructured":"Manka J DanielsRN DawsonEet al. Inhibitors of the menin-mixed lineage leukemia (MLL) interaction. In: Probe Reports from the NIH Molecular Libraries Program . Bethesda MD USA (2013)."},{"key":"e_1_3_2_3_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200300907"},{"key":"e_1_3_2_3_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/378505a0"},{"key":"e_1_3_2_3_76_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503072102"},{"key":"e_1_3_2_3_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.18.10632"},{"key":"e_1_3_2_3_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.06895.x"},{"key":"e_1_3_2_3_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07055.x"},{"key":"e_1_3_2_3_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.352"},{"key":"e_1_3_2_3_81_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65566"},{"key":"e_1_3_2_3_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1312022110"},{"key":"e_1_3_2_3_83_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-1881"},{"key":"e_1_3_2_3_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.109"},{"key":"e_1_3_2_3_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.05.011"},{"key":"e_1_3_2_3_86_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0755"},{"key":"e_1_3_2_3_87_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02302"},{"key":"e_1_3_2_3_88_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e06-11-1060"},{"key":"e_1_3_2_3_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12050"},{"key":"e_1_3_2_3_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203291"},{"key":"e_1_3_2_3_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2867-10-13"},{"key":"e_1_3_2_3_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.263"},{"key":"e_1_3_2_3_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346730"},{"key":"e_1_3_2_3_94_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2012.10"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc.13.214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:53:03Z","timestamp":1716493983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc.13.214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":94,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.4155\/fmc.13.214"],"URL":"https:\/\/doi.org\/10.4155\/fmc.13.214","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2014-03-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}