{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:00:13Z","timestamp":1788667213768,"version":"build-2803163510"},"reference-count":128,"publisher":"Informa UK Limited","issue":"9","funder":[{"name":"EU-COST Action","award":["TD1004"],"award-info":[{"award-number":["TD1004"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.4155\/fmc.14.56","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T13:52:20Z","timestamp":1406555540000},"page":"1017-1029","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Multitarget Ligands and Theranostics: Sharpening the Medicinal Chemistry Sword Against Prion Diseases"],"prefix":"10.1080","volume":"6","author":[{"given":"Salvatore","family":"Bongarzone","sequence":"first","affiliation":[{"name":"Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028Barcelona, Spain"},{"name":"Institut de Biologia Molecular de Barcelona (CSIC), Barcelona Science Park, Baldiri Reixac 10, 08028Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Staderini","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica y Farmac\u00e9utica, Universidad Complutense, 28040Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Bolognesi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy &amp; Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2014,7,28]]},"reference":[{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03909.x"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.519"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/15680266113136660167"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.11.001"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.23.13363"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070442"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/128_2011_157"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00006.2009"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.05.041"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03268-4"},{"key":"e_1_3_3_13_1","unstructured":"The national CJD research and surveillance unit . www.cjd.ed.ac.uk"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222951"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.326.5958.1337"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.337.6099.1172-a"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12481"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/15680266113136660172"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2094"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.143420"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.173"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2012.672409"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/9781849734912-00290"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867311320130007"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm7009364"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.04.010"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20248"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867311320130001"},{"key":"e_1_3_3_29_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/9781118098141.ch22","volume-title":"Polypharmacology in Drug Discovery.","author":"Cavalli A","year":"2012","unstructured":"Cavalli A , BolognesiML. Multitargeted drugs for treatment of alzheimer\u2019s disease. In : Polypharmacology in Drug Discovery.PetersJU(Ed.).John Wiley & Sons, Inc., NJ, USA, 441\u2013458 (2012)."},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc200151q"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200019c"},{"key":"e_1_3_3_32_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/9783527677252.ch09","volume-title":"Medicinal Chemistry Approaches to Personalized Medicine.","author":"Bolognesi ML","year":"2013","unstructured":"Bolognesi ML . Amyloid chemical probes and theranostics: steps toward personalized medicine in neurodegenerative diseases. In : Medicinal Chemistry Approaches to Personalized Medicine.LackeyK, RothBD(Eds).Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 211\u2013226 (2013)."},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.09.001"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl150"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm301182j"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ct900257t"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0796"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2003.08.003"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070881"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-013-1030-4"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic102331x"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.5012\/bkcs.2010.31.04.1029"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2013.11.009"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.2174\/15680266113136660176"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020863921840"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000133"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2011.550914"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.01.149"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102883200"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200700427"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm100882t"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710152105"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656560902781907"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.11.006"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.02.001"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(13)70032-4"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.5607\/en.2013.22.1.1"},{"key":"e_1_3_3_58_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/9781118098141.ch12","volume-title":"Polypharmacology in Drug Discovery","author":"Morphy R","year":"2012","unstructured":"Morphy R . Selective multitargeted drugs.In : Polypharmacology in Drug Discovery, PetersJ-U(Ed.). John Wiley & Sons, Inc., NJ, USA, 245\u2013262 (2012)."},{"key":"e_1_3_3_59_1","volume-title":"RSC Drug Discovery.","author":"Morphy JR","year":"2012","unstructured":"Morphy JR , HarrisCJ. Designing multi-target drugs. In : RSC Drug Discovery.Royal Society of Chemistry, Cambridge, UK (2012)."},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0603015"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2010.09.014"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm010158"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0342358"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(04)03163-0"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm058225d"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2006.12.006"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161209787315594"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05294"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1100195"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2002.0496"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00512-3"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.10.006"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250289197"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.07.009"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2628"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(02)00295-8"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200206000-00020"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1584"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871526510909010048"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000308955.25760.c2"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar050068p"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871526510909010003"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.5.4.613"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871526510909010081"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.05919.x"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200300704"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2006.05.002"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2007.02.018"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0612719"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702671104"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.2174\/15680266113136660170"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.07.054"},{"key":"e_1_3_3_93_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2627988100"},{"key":"e_1_3_3_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm060773j"},{"key":"e_1_3_3_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050895"},{"key":"e_1_3_3_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00150-3"},{"key":"e_1_3_3_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(01)00019-3"},{"issue":"10","key":"e_1_3_3_98_1","first-page":"579","article-title":"Free radicals, oxidative stress, oxidized low density lipoprotein (LDL), and the heart: antioxidants and other strategies to limit cardiovascular damage","volume":"59","author":"Sinatra ST","year":"1995","unstructured":"Sinatra ST , DemarcoJ. Free radicals, oxidative stress, oxidized low density lipoprotein (LDL), and the heart: antioxidants and other strategies to limit cardiovascular damage. Conn. Med.59 (10), 579\u2013588 (1995).","journal-title":"Conn. Med."},{"key":"e_1_3_3_99_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015909787602823"},{"key":"e_1_3_3_100_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955706778742731"},{"key":"e_1_3_3_101_1","doi-asserted-by":"publisher","DOI":"10.1179\/135100005X21624"},{"key":"e_1_3_3_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2002.10719189"},{"key":"e_1_3_3_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02205-4"},{"key":"e_1_3_3_104_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043365387"},{"key":"e_1_3_3_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm049112h"},{"key":"e_1_3_3_106_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901123n"},{"key":"e_1_3_3_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100072"},{"key":"e_1_3_3_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072656"},{"key":"e_1_3_3_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64705-0"},{"key":"e_1_3_3_110_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/150952"},{"key":"e_1_3_3_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.05.028"},{"key":"e_1_3_3_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharma.2013.04.001"},{"key":"e_1_3_3_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.05.005"},{"key":"e_1_3_3_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70001-2"},{"key":"e_1_3_3_115_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.065284"},{"key":"e_1_3_3_116_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920311795860151"},{"key":"e_1_3_3_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1085"},{"key":"e_1_3_3_118_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9047043"},{"key":"e_1_3_3_119_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-112168"},{"key":"e_1_3_3_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200500845"},{"key":"e_1_3_3_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06917"},{"key":"e_1_3_3_122_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19754-0"},{"key":"e_1_3_3_123_1","doi-asserted-by":"publisher","DOI":"10.2174\/15680266113136660178"},{"key":"e_1_3_3_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml3003605"},{"key":"e_1_3_3_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0708-7"},{"key":"e_1_3_3_126_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja404850u"},{"key":"e_1_3_3_127_1","doi-asserted-by":"publisher","DOI":"10.2174\/1875692110806020108"},{"key":"e_1_3_3_128_1","unstructured":"Merck and Luminex Corporation Enter Agreement to Develop Companion Diagnostic to Support Investigational BACE inhibitor Clinical Development Program for Alzheimer\u2019s Disease . www.merck.com\/licensing\/our-partnership\/luminex-partnership.html"},{"key":"e_1_3_3_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0704-86"},{"key":"e_1_3_3_130_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29999"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc.14.56","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:49:24Z","timestamp":1716493764000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc.14.56"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":128,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.4155\/fmc.14.56"],"URL":"https:\/\/doi.org\/10.4155\/fmc.14.56","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2014-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}