{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:16:22Z","timestamp":1787314582219,"version":"build-2736575974"},"reference-count":77,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T00:00:00Z","timestamp":1450656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"NIH National Cancer Institute","doi-asserted-by":"crossref","award":["R01CA197398"],"award-info":[{"award-number":["R01CA197398"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.4155\/fmc.15.166","type":"journal-article","created":{"date-parts":[[2015,12,21]],"date-time":"2015-12-21T09:49:04Z","timestamp":1450691344000},"page":"73-86","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":50,"title":["Leaving the Lysosome Behind: Novel Developments in Autophagy Inhibition"],"prefix":"10.1080","volume":"8","author":[{"given":"Abigail R","family":"Solitro","sequence":"first","affiliation":[{"name":"Center for Cancer &amp; Cell Biology, Van Andel Research Institute, 333 Bostwick Avenue, Grand Rapids, MI49503, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey P","family":"MacKeigan","sequence":"additional","affiliation":[{"name":"Center for Cancer &amp; Cell Biology, Van Andel Research Institute, 333 Bostwick Avenue, Grand Rapids, MI49503, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"e_1_3_3_3_1","article-title":"Leading causes of death","author":"CDC","year":"2015","unstructured":"CDC . Leading causes of death. FastStats (2015). www.cdc.gov\/nchs\/fastats\/leading-causes-of-death.htm.","journal-title":"FastStats"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-0759-2"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.136044.111"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235122"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4184"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1254721"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10738"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13600"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2662"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201490784"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.26123"},{"key":"e_1_3_3_15_1","volume-title":"Antimalarial Chemotherapy: Mechanisms of Action, Resistance and New Directions in Drug Discovery","author":"Meshnick SRD","year":"2001","unstructured":"Meshnick SRD , MaryJ. Antimalarial Chemotherapy: Mechanisms of Action, Resistance and New Directions in Drug Discovery. Humana Press, Inc., NJ, USA (2001)."},{"issue":"4","key":"e_1_3_3_16_1","first-page":"305","article-title":"Chloroquine: novel uses & manifestations","volume":"127","author":"Cooper RG","year":"2008","unstructured":"Cooper RG , MagwereT. Chloroquine: novel uses & manifestations. Indian J. Med. Res.127 (4), 305\u2013316 (2008).","journal-title":"Indian J. Med. Res."},{"key":"e_1_3_3_17_1","first-page":"71","article-title":"Studies on the treatment of malignant tumors with fibroblast-inhibiting agent. 3. Effects of chloroquine on human cancers","volume":"18","author":"Hiraki K","year":"1964","unstructured":"Hiraki K , KimuraI. Studies on the treatment of malignant tumors with fibroblast-inhibiting agent. 3. Effects of chloroquine on human cancers. Acta Med. Okayama18, 71\u201385 (1964).","journal-title":"Acta Med. Okayama"},{"issue":"2","key":"e_1_3_3_18_1","first-page":"307","article-title":"[The protective effect of chloroquine diphosphate on the survival rate of mice following whole body irradiation]","volume":"133","author":"Bielicky T","year":"1967","unstructured":"Bielicky T , ZakM. [The protective effect of chloroquine diphosphate on the survival rate of mice following whole body irradiation]. Strahlentherapie133 (2), 307\u2013311 (1967).","journal-title":"Strahlentherapie"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/215194a0"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(70)90049-3"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(73)90197-4"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.63.2.430"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)34446-0"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(98)00012-6"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206622"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501586m"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(86)90567-7"},{"key":"e_1_3_3_28_1","volume-title":"Lupus: The Facts","author":"Hughes GRV","year":"2000","unstructured":"Hughes GRV . Lupus: The Facts. Oxford University Press, Oxford, UK (2000)."},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.3.1025-1040.2005"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.80"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e32832f4e50"},{"issue":"44","key":"e_1_3_3_32_1","first-page":"2187","article-title":"[On the pathogenesis of pseudo-cystic primary pulmonary carcinogenic caverns. Possible role of a phenomenon of neoplastic autophagy]","volume":"60","author":"Omodei Zorini A","year":"1969","unstructured":"Omodei Zorini A . [On the pathogenesis of pseudo-cystic primary pulmonary carcinogenic caverns. Possible role of a phenomenon of neoplastic autophagy]. Minerva Med.60 (44), 2187\u20132204 (1969).","journal-title":"Minerva Med."},{"issue":"5","key":"e_1_3_3_33_1","first-page":"1349","article-title":"Mammary tumor regression. II. Autophagy of neoplastic cells","volume":"49","author":"Gullino PM","year":"1972","unstructured":"Gullino PM , LanzerottiRH. Mammary tumor regression. II. Autophagy of neoplastic cells. J. Natl Cancer Inst.49 (5), 1349\u20131356 (1972).","journal-title":"J. Natl Cancer Inst."},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287397909529757"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6398"},{"issue":"2","key":"e_1_3_3_36_1","first-page":"298","article-title":"Vinblastine-induced autophagic vacuoles in mouse liver and Ehrlich ascites tumor cells as assessed by freeze-fracture electron microscopy","volume":"27","author":"Hirsimaki Y","year":"1982","unstructured":"Hirsimaki Y , HirsimakiP, LounatmaaK. Vinblastine-induced autophagic vacuoles in mouse liver and Ehrlich ascites tumor cells as assessed by freeze-fracture electron microscopy. Eur. J. Cell Biol.27 (2), 298\u2013301 (1982).","journal-title":"Eur. J. Cell Biol."},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(84)90066-2"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(90)90061-H"},{"issue":"2","key":"e_1_3_3_39_1","first-page":"439","article-title":"A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles","volume":"61","author":"Paglin S","year":"2001","unstructured":"Paglin S , HollisterT, DeloheryTet al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res.61 (2), 439\u2013444 (2001).","journal-title":"Cancer Res."},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/45257"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.5.15066"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0047"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.350"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.11.046"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.06.001"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400917"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0397"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28833"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33700"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0086"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.29165"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.29264"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.29119"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.29118"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.29231"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.28984"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4566-4"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0597-3"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5774"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.156"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.07.029"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.28594"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/not119"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(03)90084-1"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118193109"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12138"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2425"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1247\/csf.23.33"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb500835z"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C114.627778"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.05.031"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm401675a"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087057110392996"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4MD00420E"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1681"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3053"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20141218"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1033601"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm5013352"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc.15.166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T15:50:39Z","timestamp":1716479439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc.15.166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,21]]},"references-count":77,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.4155\/fmc.15.166"],"URL":"https:\/\/doi.org\/10.4155\/fmc.15.166","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,21]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2015-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}