{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:23:13Z","timestamp":1791267793482,"version":"4.1.0"},"reference-count":78,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Pharm. Pat. Analyst"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.4155\/ppa.13.75","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T12:26:23Z","timestamp":1387542383000},"page":"65-85","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":38,"title":["Small-molecule Arginase Inhibitors"],"prefix":"10.1080","volume":"3","author":[{"given":"Yan A","family":"Ivanenkov","sequence":"first","affiliation":[{"name":"Moscow Institute of Physics &amp; Technology (State University) 9 Institutskiy lane Dolgoprudny city Moscow Region 141700 Russian Federation"},{"name":"ChemDiv 6605 Nancy Ridge Drive San Diego CA 92121 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina V","family":"Chufarova","sequence":"additional","affiliation":[{"name":"Moscow Institute of Physics &amp; Technology (State University) 9 Institutskiy lane Dolgoprudny city Moscow Region 141700 Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2013,12,20]]},"reference":[{"key":"e_1_3_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1515\/bchm2.1904.41.4.321"},{"key":"e_1_3_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.10.2760S"},{"key":"e_1_3_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00374.x"},{"key":"e_1_3_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3360001"},{"key":"e_1_3_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00291.x"},{"key":"e_1_3_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.03.018"},{"key":"e_1_3_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2011.07.012"},{"key":"e_1_3_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24448"},{"key":"e_1_3_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0860123"},{"key":"e_1_3_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-007-0537-9"},{"key":"e_1_3_2_2_11_1","first-page":"736319","author":"Benson RC","year":"2011","unstructured":"Benson RC , HardyKA, MorrisCR. Arginase and arginine dysregulation in asthma. J. Allergy (Cairo)736319 (2011).","journal-title":"J. Allergy (Cairo)"},{"key":"e_1_3_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00278.x"},{"issue":"12","key":"e_1_3_2_2_13_1","first-page":"3305","volume":"60","author":"Singh R","year":"2000","unstructured":"Singh R , PervinS, KarimiA, CederbaumS, ChaudhuriG. Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells. Cancer Res.60(12), 3305\u20133312 (2000).","journal-title":"Cancer Res."},{"key":"e_1_3_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2013.03.015"},{"key":"e_1_3_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24265"},{"key":"e_1_3_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000899"},{"key":"e_1_3_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.1.58"},{"key":"e_1_3_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32834d1a08"},{"key":"e_1_3_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja042913p"},{"key":"e_1_3_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.002956"},{"key":"e_1_3_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02783147"},{"key":"e_1_3_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V114.22.3846.3846"},{"issue":"3","key":"e_1_3_2_2_23_1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/S0022-3565(24)35048-7","volume":"290","author":"Baggio R","year":"1999","unstructured":"Baggio R , EmigFA, ChristiansonDW, AshDE, ChakderS, RattanS. Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitor. J. Pharmacol. Exp. Ther.290(3), 1409\u20131416 (1999).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_3_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.01.053"},{"key":"e_1_3_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-4533-5"},{"key":"e_1_3_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504027102"},{"key":"e_1_3_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00201a012"},{"key":"e_1_3_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/14929"},{"key":"e_1_3_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0491705"},{"key":"e_1_3_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/383554a0"},{"key":"e_1_3_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2010.02.004"},{"key":"e_1_3_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327777"},{"key":"e_1_3_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00755.2012"},{"issue":"9","key":"e_1_3_2_2_34_1","first-page":"1233","volume":"12","author":"Chow AK","year":"2012","unstructured":"Chow AK , NgL, Sing Li H et al. Anti-tumor efficacy of a recombinant human arginase in human hepatocellular carcinoma. Curr. Cancer Drug Targets12(9), 1233\u20131243 (2012).","journal-title":"Curr. Cancer Drug Targets"},{"key":"e_1_3_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2013.01.001"},{"key":"e_1_3_2_2_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400014c"},{"key":"e_1_3_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.02.024"},{"key":"e_1_3_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02058-12"},{"key":"e_1_3_2_3_2_1","unstructured":"Rijksunversiteit Groningen: WO2008061612."},{"key":"e_1_3_2_3_3_1","unstructured":"The Penn State Research Foundation: WO2012158518."},{"key":"e_1_3_2_3_4_1","unstructured":"Arginetix Inc. Johns Hopkins University: WO2010062366."},{"key":"e_1_3_2_3_5_1","unstructured":"Christian-Albrechts-Universitat zu Kiel: WO2010078865."},{"key":"e_1_3_2_3_6_1","unstructured":"The Trastees of University of Pennsylvania Arginetix inc.: WO2010085797."},{"key":"e_1_3_2_3_7_1","unstructured":"Mars Inc.: WO2011133653."},{"key":"e_1_3_2_3_8_1","unstructured":"Mars Inc.: WO2012058065."},{"key":"e_1_3_2_3_9_1","unstructured":"Corridor Pharmaceuticals Inc.: WO2012091757."},{"key":"e_1_3_2_3_10_1","unstructured":"Mars Inc.: WO2013059437."},{"key":"e_1_3_2_3_11_1","unstructured":"University Of Tartu (Tartu \u00dclikool): WO2010075863."},{"key":"e_1_3_2_3_12_1","unstructured":"Universitatsklinikum Freiburg: WO2008071242."},{"key":"e_1_3_2_3_13_1","unstructured":"Mars Inc. Regents of the University of California: EP2438915 (2012)."},{"key":"e_1_3_2_3_14_1","unstructured":"Imp Innovations Ltd: WO2008056114."},{"key":"e_1_3_2_3_15_1","unstructured":"Johns Hopkins University: WO2007005620."},{"key":"e_1_3_2_3_16_1","unstructured":"Lsu Medical Center: WO2003078578."},{"key":"e_1_3_2_3_17_1","unstructured":"Cornell Res Foundation Inc.: WO2008011083."},{"key":"e_1_3_2_3_18_1","unstructured":"Mars Inc. University of California: WO2008011173."},{"key":"e_1_3_2_3_19_1","unstructured":"Childrens Hospital Medical Center: WO2003073990."},{"key":"e_1_3_2_3_20_1","unstructured":"Res Foundation of City Univers Beth Israel Hospital: WO2001085981."},{"key":"e_1_3_2_3_21_1","unstructured":"The Board of Regents of the University of Texas System: WO2010051533."},{"key":"e_1_3_2_3_22_1","unstructured":"Wyeth Corp.: WO2005003164."},{"key":"e_1_3_2_3_23_1","unstructured":"Balaraman Kalyanaraman Srigiridhar Kotamraju: US0219208 (2007)."},{"key":"e_1_3_2_3_24_1","unstructured":"Vockley JG Dillon PJ: US20020119554 (2002)."},{"key":"e_1_3_2_3_25_1","unstructured":"Ahluwalia G Funkhouser M Handelman JH Henry J Shander D: WO1997019672."},{"key":"e_1_3_2_3_26_1","unstructured":"Childrens Hosp & Res Ct Oak Cleveland Clinic Foundation: WO2006060793."},{"key":"e_1_3_2_3_27_1","unstructured":"Kgaa H Stefan M Andrea S Angela V: WO2002024156."},{"key":"e_1_3_2_3_28_1","unstructured":"Nitromed Inc.: US0009498 (2008)."},{"key":"e_1_3_2_3_29_1","unstructured":"Lsu Medical Ct: WO2003078578."},{"key":"e_1_3_2_3_30_1","unstructured":"Orthologic Corp Texas A&M University System: WO2008036387."},{"key":"e_1_3_2_3_31_1","unstructured":"Abbott Cardiovascular Systems: WO2007120709."},{"key":"e_1_3_2_3_32_1","unstructured":"Nitrosystems Inc: WO2000062614."},{"key":"e_1_3_2_3_33_1","unstructured":"Nitromed Inc: WO2006102071."},{"key":"e_1_3_2_3_34_1","unstructured":"Nitromed Inc: WO2004004648."},{"key":"e_1_3_2_3_35_1","unstructured":"Altarex Medical Corp.: WO2008091643."},{"key":"e_1_3_2_3_36_1","unstructured":"Nitromed Inc.: US0009431 (2006)."},{"key":"e_1_3_2_3_37_1","unstructured":"Kaesemeyer Wayne H: US0212174 (2011)."},{"key":"e_1_3_2_3_38_1","unstructured":"Centre National de la Recherche Scientifique Elro Pharma Universite Paris: WO2012045751."},{"key":"e_1_3_2_3_39_1","unstructured":"Nitromed Inc.: EP1828155 (2007)."},{"key":"e_1_3_2_3_40_1","unstructured":"Kaesemeyer Wayne H: WO1996010910."},{"key":"e_1_3_2_4_2_1","unstructured":"Thomson Integrity Database. http:\/\/integrity.thomson-pharma.com"}],"container-title":["Pharmaceutical Patent Analyst"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/ppa.13.75","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T08:16:09Z","timestamp":1746087369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/ppa.13.75"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,20]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.4155\/ppa.13.75"],"URL":"https:\/\/doi.org\/10.4155\/ppa.13.75","relation":{},"ISSN":["2046-8954","2046-8962"],"issn-type":[{"value":"2046-8954","type":"print"},{"value":"2046-8962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,20]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ippa20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ippa20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2013-12-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}