{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:39:06Z","timestamp":1761597546885},"reference-count":75,"publisher":"Informa UK Limited","issue":"4","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Pharm. Pat. Anal."],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.4155\/ppa.14.24","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T16:40:07Z","timestamp":1412700007000},"page":"375-386","update-policy":"http:\/\/dx.doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":16,"title":["Recent Advances in Irreversible Kinase Inhibitors"],"prefix":"10.1080","volume":"3","author":[{"given":"Adam M","family":"Gilbert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2014,10,7]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3410"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.10.21"},{"key":"e_1_3_3_4_1","first-page":"31","article-title":"The role of binding kinetics in therapeutically useful drug action","volume":"12","author":"Swinney DC","year":"2009","unstructured":"Swinney DC . The role of binding kinetics in therapeutically useful drug action. Curr. Opin. Drug Discov.12, 31\u201339 (2009).","journal-title":"Curr. Opin. Drug Discov."},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.113.007450"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx980249i"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm8008597"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2012.688744"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm3003203"},{"key":"e_1_3_3_10_1","first-page":"413","volume-title":"Annual Report in Medicinal Chemistry.","author":"Noe MC","year":"2012","unstructured":"Noe MC Gilbert AM . Chapter 27: targeted covalent enzyme inhibitors. In:Annual Report in Medicinal Chemistry.ManojCD(Ed.). Academic Press, Amsterdam, The Netherlands, 413\u2013439 (2012)."},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.10.003"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.07.031"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0111-6"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2012.37.6.1813476"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1517\/21678707.2013.850413"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2559"},{"key":"e_1_3_3_17_1","unstructured":"Pharmacyclics Inc .: US20080108636 (2008)."},{"key":"e_1_3_3_18_1","unstructured":"Avila Therapeutics Inc .: WO2009158571 (2009)."},{"key":"e_1_3_3_19_1","unstructured":"Avila Therapeutics Inc .: WO2011090760 (2011)."},{"key":"e_1_3_3_20_1","unstructured":"Celgene Avilomics Research Inc .: WO2013084216 (2013)."},{"key":"e_1_3_3_21_1","unstructured":"University of Utah Research Foundation: WO2012135801 (2012)."},{"key":"e_1_3_3_22_1","unstructured":"Beta Pharma Canada Inc .: WO2013113097 (2013)."},{"key":"e_1_3_3_23_1","unstructured":"Locus Pharmaceuticals Inc .: WO2010126960 (2010)."},{"key":"e_1_3_3_24_1","unstructured":"Merck GmbH: WO2012170976 (2012)."},{"key":"e_1_3_3_25_1","unstructured":"MSD Oss BV : WO2013010868 (2013)."},{"key":"e_1_3_3_26_1","unstructured":"MSD Oss BV : WO2013010869 (2013)."},{"key":"e_1_3_3_27_1","unstructured":"Pharmacyclics Inc .: WO2013003629 (2013)."},{"key":"e_1_3_3_28_1","unstructured":"Pharmacyclics Inc .: WO2013155347 (2013)."},{"key":"e_1_3_3_29_1","unstructured":"Pharmacyclics Inc .: WO2010009342 (2010)."},{"key":"e_1_3_3_30_1","unstructured":"Pharmacyclics Inc .: WO2011046964 (2011)."},{"key":"e_1_3_3_31_1","unstructured":"Pharmacyclics Inc .: WO2013116382 (2013)."},{"key":"e_1_3_3_32_1","unstructured":"Boehringer Ingelheim Pharma : WO2002050043 (2002)."},{"key":"e_1_3_3_33_1","unstructured":"Wyeth John and Brother Ltd : US20050059678 (2005)."},{"key":"e_1_3_3_34_1","unstructured":"Pfizer Inc .: US20050250761 (2005)."},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2582"},{"key":"e_1_3_3_36_1","unstructured":"ACEA Biosciences Inc .: WO2013106792 (2013)."},{"key":"e_1_3_3_37_1","unstructured":"AstraZeneca AB : WO2013014448 (2013)."},{"key":"e_1_3_3_38_1","unstructured":"Ariad Pharmaceuticals Inc .: WO2013169401 (2013)."},{"key":"e_1_3_3_39_1","unstructured":"Pfizer Inc .: WO2013042006 (2013)."},{"key":"e_1_3_3_40_1","unstructured":"Astellas Pharma Inc .: WO2013108754 (2013)."},{"key":"e_1_3_3_41_1","unstructured":"Avila Therapeutics Inc .: WO2012061299 (2012)."},{"key":"e_1_3_3_42_1","unstructured":"Celgene Avilomics Research: WO2013138495 (2013)."},{"key":"e_1_3_3_43_1","unstructured":"Avila Therapeutics Inc .: WO2012061303 (2012)."},{"key":"e_1_3_3_44_1","unstructured":"Avila Therapeutics Inc .: WO2012064706A1 (2012)."},{"key":"e_1_3_3_45_1","unstructured":"Dana Farber Cancer Institute: WO2010129053 (2010)."},{"key":"e_1_3_3_46_1","unstructured":"Gatekeeper Pharmaceuticals Inc .: WO2011140338 (2011)."},{"key":"e_1_3_3_47_1","unstructured":"Guangzhou Institute of Biomedicine and Health: WO2012167415 (2012)."},{"key":"e_1_3_3_48_1","unstructured":"Hanmi Holdings Co .: WO2011162515A2 (2011)."},{"key":"e_1_3_3_49_1","unstructured":"Shanghai Allist Pharmaceuticals Inc .: WO2011095053 (2011)."},{"key":"e_1_3_3_50_1","unstructured":"Auckland Uniservices Limited : WO2010104406 (2010)."},{"key":"e_1_3_3_51_1","unstructured":"Shanghai Hengrui Pharmaceutical Co .: WO2013131424A1 (2013)."},{"key":"e_1_3_3_52_1","unstructured":"Shenzhen Neptunus Pharmaceutical Co .: CN102942561 (2013)."},{"key":"e_1_3_3_53_1","unstructured":"National Health Research Institutes: US20100120805 (2010)."},{"key":"e_1_3_3_54_1","unstructured":"Principia Biopharma Inc .: WO2010065898 (2010)."},{"key":"e_1_3_3_55_1","unstructured":"Taiho Pharmaceutical Co .: WO2013125709 (2013)."},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm401490p"},{"key":"e_1_3_3_57_1","unstructured":"Cellzome Limited: WO2013041605 (2013)."},{"key":"e_1_3_3_58_1","unstructured":"Cellzome Limited: WO2013092854 (2013)."},{"key":"e_1_3_3_59_1","unstructured":"Hanmi Pharm Co .: WO2013118986 (2013)."},{"key":"e_1_3_3_60_1","unstructured":"Hanmi Pharm Co .: WO2013100631 (2013)."},{"key":"e_1_3_3_61_1","unstructured":"Merck Sharp & Dohme Corp.: WO2013085802 (2013)."},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2014.851670"},{"key":"e_1_3_3_63_1","unstructured":"Reaction Biology Corp .: WO2010093808 (2010)."},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00248-4"},{"key":"e_1_3_3_65_1","unstructured":"Avila Therapeutics Inc .: WO2011031896 (2011)."},{"key":"e_1_3_3_66_1","unstructured":"Celgene Avilomics Research Inc .: WO2012122383 (2012)."},{"key":"e_1_3_3_67_1","unstructured":"Oncothyreon Inc .: WO2010118250 (2010)."},{"key":"e_1_3_3_68_1","unstructured":"Oncothyreon Inc .: WO2011153495 (2011)."},{"key":"e_1_3_3_69_1","unstructured":"Xiamen Amoy Diagnostics Co .: CN101824029 (2010)."},{"key":"e_1_3_3_70_1","unstructured":"Avila Therapeutics Inc .: WO2010028236 (2010)."},{"key":"e_1_3_3_71_1","unstructured":"Avila Therapeutics Inc .: WO2011034907 (2011)."},{"key":"e_1_3_3_72_1","unstructured":"Taiho Pharmaceutical Co .: WO2013108809 (2013)."},{"key":"e_1_3_3_73_1","unstructured":"Universidad de Barcelona : WO2012113967 (2012)."},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm1016279"},{"key":"e_1_3_3_75_1","unstructured":"Glaxo Group Limited : WO2012035055 (2012)."},{"key":"e_1_3_3_76_1","unstructured":"The University of California : WO2011153553 (2011)."}],"container-title":["Pharmaceutical Patent Analyst"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/ppa.14.24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T17:11:16Z","timestamp":1715965876000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/ppa.14.24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":75,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.4155\/ppa.14.24"],"URL":"https:\/\/doi.org\/10.4155\/ppa.14.24","relation":{},"ISSN":["2046-8954","2046-8962"],"issn-type":[{"value":"2046-8954","type":"print"},{"value":"2046-8962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ippa20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ippa20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2014-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}