{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:41:27Z","timestamp":1782963687280,"version":"3.54.5"},"reference-count":113,"publisher":"Informa UK Limited","issue":"6","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Ther. Deliv."],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.4155\/tde-2018-0060","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T15:58:01Z","timestamp":1560268681000},"page":"383-396","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":51,"title":["Skin Toxicity of Topically Applied Nanoparticles"],"prefix":"10.1080","volume":"10","author":[{"given":"Sara","family":"Hashempour","sequence":"first","affiliation":[{"name":"Dermatology &amp; Dermopharmacy Research Team, Student Research Committee &amp; Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Ghanbarzadeh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard I","family":"Maibach","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Ghorbani","sequence":"additional","affiliation":[{"name":"Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Hamishehkar","sequence":"additional","affiliation":[{"name":"Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"key":"e_1_3_2_3_1","volume-title":"Toxicogenomics: Principles and Applications","author":"Omenn GS","year":"2004","unstructured":"Omenn GS . Toxicogenomics: Principles and Applications. HamadehHK, AfshariCA (Eds). National Institute of Environmental Health Science, Wiley-Liss, NJ, USA (2004)."},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2016.04.024"},{"key":"e_1_3_2_5_1","volume-title":"A Guide to Practical Toxicology: Evaluation, Prediction, and Risk","author":"Woolley D","year":"2008","unstructured":"Woolley D , WoolleyA. A Guide to Practical Toxicology: Evaluation, Prediction, and Risk. CRC Press, London, UK (2008)."},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623314548765"},{"key":"e_1_3_2_7_1","volume-title":"OECD Guidelines for the Testing of Chemicals","author":"OECD","year":"1994","unstructured":"OECD . OECD Guidelines for the Testing of Chemicals. Organization for Economic Cooperation and Develoment, Paris, France (1994)."},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.09.012"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-373593-5.00060-4"},{"key":"e_1_3_2_10_1","first-page":"1","volume-title":"Issues in Toxicology","author":"Stephens ML","year":"2014","unstructured":"Stephens ML , MakNS. History of the 3Rs in toxicity testing: from Russell and burch to 21st century toxicology. In:Issues in Toxicology. Allen D, Walters M (Eds).Cambridge, UK,1\u201343 (2014)."},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/026119290503301s11"},{"issue":"6","key":"e_1_3_2_12_1","first-page":"1157","article-title":"Monitoring of skin penetration and absorption with a new in vivo experimental model","volume":"62","author":"Berk\u00f3 S","year":"2014","unstructured":"Berk\u00f3 S , Bal\u00e1zsB , S\u00fct\u0151Bet al. Monitoring of skin penetration and absorption with a new in vivo experimental model. Farmacia62(6), 1157\u20131163 (2014).","journal-title":"Farmacia"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-010-9522-9"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-003-0384-9"},{"issue":"3","key":"e_1_3_2_15_1","first-page":"239","article-title":"Evaluation of fentanyl transdermal patches in rabbits: blood concentrations and physiologic response","volume":"51","author":"Foley PL","year":"2001","unstructured":"Foley PL , HendersonAL , BissonetteEA , WimerGR , FeldmanSH. Evaluation of fentanyl transdermal patches in rabbits: blood concentrations and physiologic response. Comp. Med.51(3), 239\u2013244 (2001).","journal-title":"Comp. Med."},{"key":"e_1_3_2_16_1","article-title":"Nanotechnology: a research strategy for addressing risks","author":"Maynard AD","year":"2006","unstructured":"Maynard AD . Nanotechnology: a research strategy for addressing risks. Woodrow Wilson International Center for Scholars: Project on emerging nanotechnologies. 2006. [Cited on Nov 10, 2008]. Nordon, President, Lux Research, Inc. (2006). http:\/\/www.nanotechproject.org\/file download\/files\/PEN3 Risk.pdf","journal-title":"Nordon, President, Lux Research, Inc."},{"issue":"1","key":"e_1_3_2_17_1","first-page":"1","article-title":"Nanotechnology: safety paradigms","volume":"4","author":"Rastogi ID","year":"2012","unstructured":"Rastogi ID . Nanotechnology: safety paradigms. J. Toxicol. Environ. Health Sci.4(1), 1\u201312 (2012).","journal-title":"J. Toxicol. Environ. Health Sci."},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2008.01.001"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2004.013243"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114397"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1116\/1.2815690"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12204-014-1567-6"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apgeochem.2011.09.009"},{"issue":"8","key":"e_1_3_2_24_1","first-page":"1","article-title":"Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy","volume":"2","author":"Oberdorster G","year":"2005","unstructured":"Oberdorster G , MaynardA , DonaldsonKet al. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part. Fibre Toxicol.2(8), 1\u201335 (2005).","journal-title":"Part. Fibre Toxicol."},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-3155-2-12"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2011.10.001"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2001.9240"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/089426802320282338"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/08958370050166796"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.12.015"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/la300819u"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-51254-1.00010-5"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471669040"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-002-1_17"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8977-2-8"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj099"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm240"},{"key":"e_1_3_2_38_1","volume-title":"Toxicity Testing in the 21st Century: a Vision and a Strategy","author":"Council NR","year":"2007","unstructured":"Council NR . Toxicity Testing in the 21st Century: a Vision and a StrategyNational Academies Press, Washington, DC, USA (2007)."},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000257263"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja107583h"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4886"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0nr00618a"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm240"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.05.020"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S170745"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.07.007"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600731028"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1967.11"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2006.07.005"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-007-0788-z"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1142\/S1793984414400042"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20175481"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2012.01181.x"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2015.1062896"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt920"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfi293"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2010.1146"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2013.01.020"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700733"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.05.020"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901398"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2003.10.002"},{"key":"e_1_3_2_63_1","unstructured":"R\u00fchle M DoschH MittemeijerE Vande Voorde M. European white book on fundamental research in materials science. Max-Planck-Institut fur Metallforschung Stuttgart Germany (2001)."},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.12.022"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2004.06.015"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-011-0561-z"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2005.08.008"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2016.04.022"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16908"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-009-9694-y"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235554"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq243"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.20.5.051006"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2012.09.007"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2012.00656.x"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmi.12179"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2016.06"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.11.001"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16908"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2015.074"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1nr11109d"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.11.001"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-009-9694-y"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.39.897"},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs60064e"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1082"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.11.007"},{"issue":"2","key":"e_1_3_2_88_1","first-page":"105","article-title":"From inflammation to sickness: historical perspective","volume":"51","author":"Plytycz B","year":"2003","unstructured":"Plytycz B , SeljelidR. From inflammation to sickness: historical perspective. Archivum Immunologiae et Therapiae Experimentalis51(2), 105\u2013109 (2003).","journal-title":"Archivum Immunologiae et Therapiae Experimentalis"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01280.x"},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S17065"},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800670602"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.2217\/17435889.1.4.399"},{"key":"e_1_3_2_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.05.005"},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553000110104065"},{"key":"e_1_3_2_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2006.00265.x"},{"key":"e_1_3_2_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.01.008"},{"key":"e_1_3_2_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl0489586"},{"key":"e_1_3_2_98_1","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2010.482751"},{"key":"e_1_3_2_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200400093"},{"issue":"25","key":"e_1_3_2_100_1","first-page":"1","article-title":"Impact of nanosilver on various DNA lesions and HPRT gene mutations \u2013 effects of charge and surface coating","volume":"12","author":"Huk A","year":"2015","unstructured":"Huk A , Izak-NauE , ElYamani Net al. Impact of nanosilver on various DNA lesions and HPRT gene mutations \u2013 effects of charge and surface coating. Part Fibre Toxicol.12(25), 1\u201320 (2015).","journal-title":"Part Fibre Toxicol."},{"key":"e_1_3_2_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/met5020934"},{"key":"e_1_3_2_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/713853956"},{"key":"e_1_3_2_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl051748o"},{"key":"e_1_3_2_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2004.11.004"},{"key":"e_1_3_2_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.08.011"},{"key":"e_1_3_2_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.01.008"},{"key":"e_1_3_2_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13530-012-0112-y"},{"key":"e_1_3_2_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13273-012-0014-8"},{"key":"e_1_3_2_109_1","first-page":"1","article-title":"Cosmetics, nanotoxicity and skin penetration \u2013 a brief summary of the toxicological and skin penetration literature","author":"Miller G","year":"2006","unstructured":"Miller G . Cosmetics, nanotoxicity and skin penetration \u2013 a brief summary of the toxicological and skin penetration literature. Friends Earth1\u20138 (2006).","journal-title":"Friends Earth"},{"key":"e_1_3_2_110_1","doi-asserted-by":"publisher","DOI":"10.1080\/17435390902788086"},{"key":"e_1_3_2_111_1","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2014.968889"},{"key":"e_1_3_2_112_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652048.2017.1296500"},{"key":"e_1_3_2_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2011.05.022"},{"key":"e_1_3_2_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.08.042"},{"key":"e_1_3_2_115_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2009.1053"}],"container-title":["Therapeutic Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/tde-2018-0060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T18:17:13Z","timestamp":1715969833000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/tde-2018-0060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":113,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.4155\/tde-2018-0060"],"URL":"https:\/\/doi.org\/10.4155\/tde-2018-0060","relation":{},"ISSN":["2041-5990","2041-6008"],"issn-type":[{"value":"2041-5990","type":"print"},{"value":"2041-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itde20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itde20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}