{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:30:50Z","timestamp":1771039850415,"version":"3.50.1"},"reference-count":114,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutic Delivery"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.4155\/tde.10.9","type":"journal-article","created":{"date-parts":[[2011,2,20]],"date-time":"2011-02-20T15:52:47Z","timestamp":1298217167000},"page":"91-107","source":"Crossref","is-referenced-by-count":7,"title":["Nucleic Acid Therapeutics: Concepts for Targeted Delivery to Solid Tumors"],"prefix":"10.1080","volume":"1","author":[{"given":"Manfred","family":"Ogris","sequence":"first","affiliation":[{"name":"Department of Pharmacy Center for Drug Research Pharmaceutical Biotechnology Ludwig-Maximilians-University Butenandstr. 5\u201313\rMunich\rD-81377\rGermany and Center for NanoScience (CeNS) Ludwig-Maximilians-University\rMunich\rGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2010,6,25]]},"reference":[{"key":"e_1_3_3_3_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"e_1_3_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/sonc.2002.37263"},{"key":"e_1_3_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/14796694.4.3.323"},{"key":"e_1_3_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1074"},{"key":"e_1_3_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.039719"},{"key":"e_1_3_3_3_6_1","first-page":"1","volume":"596","author":"Baguley BC","year":"2009","unstructured":"Baguley BC . Multidrug resistance in cancer. Methods Mol. Biol.596, 1\u201314 (2009).","journal-title":"Methods Mol. Biol."},{"key":"e_1_3_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2004.05.004"},{"key":"e_1_3_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1651"},{"key":"e_1_3_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318174e96e"},{"key":"e_1_3_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2008.12.006"},{"key":"e_1_3_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2006.07.005"},{"key":"e_1_3_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1208\/aapsj0902015"},{"key":"e_1_3_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP43588"},{"key":"e_1_3_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685539"},{"key":"e_1_3_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-008-0813-8"},{"key":"e_1_3_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-2254(200005\/06)2:3<148::AID-JGM105>3.0.CO;2-Q"},{"key":"e_1_3_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2660(05)54010-0"},{"key":"e_1_3_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.288"},{"key":"e_1_3_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920107782109985"},{"key":"e_1_3_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0144"},{"key":"e_1_3_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/35888"},{"key":"e_1_3_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.03.004"},{"key":"e_1_3_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2742"},{"key":"e_1_3_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.200900023"},{"key":"e_1_3_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr050266u"},{"key":"e_1_3_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(98)00005-2"},{"key":"e_1_3_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5235.475"},{"key":"e_1_3_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5466.669"},{"key":"e_1_3_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35700"},{"key":"e_1_3_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652308784746440"},{"key":"e_1_3_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652306778520647"},{"key":"e_1_3_3_3_32_1","first-page":"67","volume":"323","author":"Freimuth P","year":"2008","unstructured":"Freimuth P , PhilipsonL, CarsonSD. The coxsackievirus and adenovirus receptor. Curr. Top. Microbiol. Immunol.323, 67\u201387 (2008).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/10430340152712719"},{"key":"e_1_3_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566523043346372"},{"key":"e_1_3_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.03.006"},{"key":"e_1_3_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300321"},{"key":"e_1_3_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700547"},{"key":"e_1_3_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2005.16.1014"},{"key":"e_1_3_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(67)90324-5"},{"key":"e_1_3_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(68)90293-3"},{"key":"e_1_3_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00836a014"},{"key":"e_1_3_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.21.7413"},{"key":"e_1_3_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(16)41445-0"},{"key":"e_1_3_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1399"},{"key":"e_1_3_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.08.006"},{"key":"e_1_3_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920010791110827"},{"key":"e_1_3_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-00477-3_1"},{"issue":"11","key":"e_1_3_3_3_48_1","first-page":"4879","article-title":"Efficacy of ligand-based targeting for the egf system in cancer.","volume":"29","author":"Yotsumoto F","year":"2009","unstructured":"Yotsumoto F , SanuiA, FukamiTet al. Efficacy of ligand-based targeting for the egf system in cancer. Anticancer Res. 29(11), 4879\u20134885 (2009).","journal-title":"Anticancer Res."},{"key":"e_1_3_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2660(09)67004-8"},{"key":"e_1_3_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568011053174855"},{"key":"e_1_3_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-360-2_19"},{"key":"e_1_3_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656730701840147"},{"key":"e_1_3_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.01.006"},{"key":"e_1_3_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656730802149570"},{"key":"e_1_3_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707461104"},{"key":"e_1_3_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652308786071023"},{"key":"e_1_3_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302803"},{"key":"e_1_3_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920107783018354"},{"key":"e_1_3_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656730150201552"},{"key":"e_1_3_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(02)00818-5"},{"key":"e_1_3_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02471444"},{"key":"e_1_3_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656730500204487"},{"issue":"1","key":"e_1_3_3_3_63_1","first-page":"63","volume":"3","author":"Hauck ML","year":"1997","unstructured":"Hauck ML , DewhirstMW, BignerDD, ZalutskyMR. Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model. Clin. Cancer Res.3(1), 63\u201370 (1997).","journal-title":"Clin. Cancer Res."},{"issue":"16","key":"e_1_3_3_3_64_1","first-page":"4440","volume":"60","author":"Kong G","year":"2000","unstructured":"Kong G , BraunRD, DewhirstMW. Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size. Cancer Res.60(16), 4440\u20134445 (2000).","journal-title":"Cancer Res."},{"key":"e_1_3_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/026567399285558"},{"key":"e_1_3_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-006-0037-1"},{"key":"e_1_3_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2005.16.435"},{"key":"e_1_3_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-2254(200003\/04)2:2<89::AID-JGM90>3.0.CO;2-J"},{"key":"e_1_3_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880080120"},{"key":"e_1_3_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0350068"},{"key":"e_1_3_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.1997.34"},{"key":"e_1_3_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.1211\/002235703765951311"},{"key":"e_1_3_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300900"},{"key":"e_1_3_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.187"},{"key":"e_1_3_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.16.7297"},{"key":"e_1_3_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300418"},{"key":"e_1_3_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300717"},{"key":"e_1_3_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301227"},{"key":"e_1_3_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(03)75004-8"},{"key":"e_1_3_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.598"},{"key":"e_1_3_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.237"},{"key":"e_1_3_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152006778699158"},{"key":"e_1_3_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.05.013"},{"key":"e_1_3_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014861900478"},{"key":"e_1_3_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1775"},{"key":"e_1_3_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2006.08.002"},{"key":"e_1_3_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3303046"},{"key":"e_1_3_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.09.003"},{"key":"e_1_3_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-0851"},{"key":"e_1_3_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2008.064"},{"key":"e_1_3_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc050292z"},{"key":"e_1_3_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0764862"},{"key":"e_1_3_3_3_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030006"},{"key":"e_1_3_3_3_94_1","author":"Takeda K","year":"2007","unstructured":"Takeda K , AkiraS. Toll-like receptors. Curr. Protoc. Immunol. Chapter 14, Unit 14.12 (2007).","journal-title":"Curr. Protoc. Immunol."},{"key":"e_1_3_3_3_95_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199606000-00006"},{"key":"e_1_3_3_3_96_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1982.2.1"},{"key":"e_1_3_3_3_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-008-9705-3"},{"key":"e_1_3_3_3_98_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02257"},{"key":"e_1_3_3_3_99_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1358"},{"key":"e_1_3_3_3_100_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-11020"},{"key":"e_1_3_3_3_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2008.172"},{"key":"e_1_3_3_3_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-2254(199903\/04)1:2<111::AID-JGM22>3.0.CO;2-Y"},{"issue":"11","key":"e_1_3_3_3_103_1","first-page":"1515","article-title":"Comparison of two different non-viral gene delivery vectors for systemic sodium iodide symporter gene transfer in HCC.","volume":"20","author":"Klutz K","year":"2009","unstructured":"Klutz K , RussV, WillhauckMet al. Comparison of two different non-viral gene delivery vectors for systemic sodium iodide symporter gene transfer in HCC. Hum. Gene Ther. 20(11), 1515\u20131515 (2009).","journal-title":"Hum. Gene Ther."},{"key":"e_1_3_3_3_104_1","doi-asserted-by":"crossref","unstructured":"Roth JA (Ed.). Gene-Based Therapies For Cancer. Springer Heidelberg Germany (2010).","DOI":"10.1007\/978-1-4419-6102-0"},{"issue":"17","key":"e_1_3_3_3_105_1","first-page":"4968","article-title":"Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer.","volume":"62","author":"Freytag SO","year":"2002","unstructured":"Freytag SO , KhilM, StrickerHet al. Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer. Cancer Res. 62(17), 4968\u20134976 (2002).","journal-title":"Cancer Res."},{"key":"e_1_3_3_3_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2009.37"},{"key":"e_1_3_3_3_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp900015y"},{"key":"e_1_3_3_3_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08956"},{"key":"e_1_3_3_3_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-561-9_4"},{"key":"e_1_3_3_3_110_1","author":"Klein-Marcuschamer D","year":"2010","unstructured":"Klein-Marcuschamer D , YadavVG, GhaderiA, StephanopoulosGN. De novo metabolic engineering and the promise of synthetic DNA. Adv. Biochem. Eng. Biotechnol. (2010) (Epub ahead of print).","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"key":"e_1_3_3_4_2_1","unstructured":"Challenges in the process development of a novel Zero-CpG CFTR plasmid for human clinical use www.users.ox.ac.uk\/\u223cgenemed\/Publications\/pdf\/HebelASGT08.pdf"},{"key":"e_1_3_3_4_3_1","unstructured":"Glucocorticoid modulation of nucleic acid-mediated immune stimulation www.freepatentsonline.com\/20070054873.pdf"},{"key":"e_1_3_3_4_4_1","unstructured":"Clinicaltrials.gov \u2013 study NCT00393809 www.clinicaltrials.gov\/ct2\/show\/NCT00393809"},{"key":"e_1_3_3_4_5_1","unstructured":"Clinicaltrials.gov \u2013 study NCT00788307 www.clinicaltrials.gov\/ct2\/show\/NCT00788307"}],"container-title":["Therapeutic Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/tde.10.9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T15:40:37Z","timestamp":1715960437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/tde.10.9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,25]]},"references-count":114,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.4155\/tde.10.9"],"URL":"https:\/\/doi.org\/10.4155\/tde.10.9","relation":{},"ISSN":["2041-5990","2041-6008"],"issn-type":[{"value":"2041-5990","type":"print"},{"value":"2041-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,25]]}}}