{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:55:53Z","timestamp":1792803353557,"version":"4.5.0"},"reference-count":64,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutic Delivery"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.4155\/tde.12.130","type":"journal-article","created":{"date-parts":[[2012,12,24]],"date-time":"2012-12-24T11:49:18Z","timestamp":1356349758000},"page":"115-124","source":"Crossref","is-referenced-by-count":37,"title":["Drug Delivery to the Ear"],"prefix":"10.1080","volume":"4","author":[{"given":"E","family":"Hoskison","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery Nottingham University Hospitals NHS Trust\rNottingham\rNG7 2UH\rUK"},{"name":"NIHR Nottingham Hearing Biomedical Research Unit\rNottingham\rUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery Nottingham University Hospitals NHS Trust\rNottingham\rNG7 2UH\rUK"},{"name":"NIHR Nottingham Hearing Biomedical Research Unit\rNottingham\rUK"},{"name":"Biomaterials-Related Infection Group Division of Orthopaedic &amp; Accident Surgery University of Nottingham\rUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Al-Zahid","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery Nottingham University Hospitals NHS Trust\rNottingham\rNG7 2UH\rUK"},{"name":"Biomaterials-Related Infection Group Division of Orthopaedic &amp; Accident Surgery University of Nottingham\rUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KM","family":"Shakesheff","sequence":"additional","affiliation":[{"name":"The Wolfson Centre for Stem Cells Tissue Engineering &amp; Modelling (STEM) The University of Nottingham\rUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Bayston","sequence":"additional","affiliation":[{"name":"Biomaterials-Related Infection Group Division of Orthopaedic &amp; Accident Surgery University of Nottingham\rUK"},{"name":"Surgical Infection Head Biomaterials-Related Infection Group School of Clinical Sciences Nottingham University Hospitals\rUK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JP","family":"Birchall","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery Nottingham University Hospitals NHS Trust\rNottingham\rNG7 2UH\rUK"},{"name":"NIHR Nottingham Hearing Biomedical Research Unit\rNottingham\rUK"},{"name":"Department of Otorhinolaryngology Head &amp; Neck Surgery Nottingham University Hospitals NHS Trust\rNottingham\rNG7 2UH\rUK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2012,12,24]]},"reference":[{"key":"e_1_3_2_3_1_1","unstructured":"Scott-Brown\u2018s Otorhinolaryngology. In: Head and Neck Surgery (Seventh Edition). Gleeson M (Ed.). Hodder Arnold Ltd London UK (2008)."},{"key":"e_1_3_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde.11.43"},{"key":"e_1_3_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19970201)36:3<201::AID-JEMT8>3.0.CO;2-R"},{"key":"e_1_3_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894800890S323"},{"key":"e_1_3_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894800890S325"},{"key":"e_1_3_2_3_6_1","unstructured":"Scottish intercollegiate guidelines network. Diagnosis and Management of Childhood Otitis Media in Primary Care. Scottish intercollegiate guidelines network Edinburgh UK 66 (2006)."},{"key":"e_1_3_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470160081036"},{"key":"e_1_3_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/324525"},{"key":"e_1_3_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(09)60003-7"},{"key":"e_1_3_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200911040-00003"},{"key":"e_1_3_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2007.12.008"},{"key":"e_1_3_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.2.202"},{"key":"e_1_3_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.2004.00767.x"},{"key":"e_1_3_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2000.00350.x"},{"key":"e_1_3_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200112000-00001"},{"key":"e_1_3_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(10)60014-X"},{"key":"e_1_3_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1980.00790360050013"},{"key":"e_1_3_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948109000209"},{"key":"e_1_3_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310900408"},{"key":"e_1_3_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.07.005"},{"key":"e_1_3_2_3_21_1","first-page":"937861","author":"Huth ME","year":"2011","unstructured":"Huth ME , RicciAJ, ChengAG. Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection. Int. J. Otolaryngol.937861 (2011).","journal-title":"Int. J. Otolaryngol."},{"key":"e_1_3_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1959.00730030400002"},{"key":"e_1_3_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198010001-00001"},{"key":"e_1_3_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.9.2502-2509.2001"},{"key":"e_1_3_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-002-2036-8"},{"key":"e_1_3_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000224092.79635.ee"},{"key":"e_1_3_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.22362"},{"key":"e_1_3_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.10.88"},{"key":"e_1_3_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198406000-00013"},{"key":"e_1_3_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3530064"},{"key":"e_1_3_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200101000-00005"},{"key":"e_1_3_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200407000-00010"},{"key":"e_1_3_2_3_33_1","first-page":"10","volume":"6","author":"Shulman A","year":"2000","unstructured":"Shulman A , GoldsteinB. Intratympanic drug therapy with steroids for tinnitus control: a preliminary report. Int. Tinnitus J.6, 10\u201320 (2000).","journal-title":"Int. Tinnitus J."},{"key":"e_1_3_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00023-3"},{"key":"e_1_3_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00025-7"},{"key":"e_1_3_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31819bda66"},{"key":"e_1_3_2_3_37_1","first-page":"640","volume":"39","author":"Chen Y","year":"2010","unstructured":"Chen Y , WenL, HuP, QiuJ, LuL, QiaoL. Endoscopic intratympanic methylprednisolone injection for treatment of refractory sudden sensorineural hearing loss and one case in pregnancy. J. Otolaryngol. Head Neck Surg.39, 640\u2013645 (2010).","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"e_1_3_2_3_38_1","first-page":"111","volume":"8","author":"Cesarani A","year":"2002","unstructured":"Cesarani A , CapobiancoS, SoiD, GiulianoDA, AlpiniD. Intratympanic dexamethasone treatment for control of subjective idiopathic tinnitus: our clinical experience. Int. Tinnitus J.8, 111\u2013114 (2002).","journal-title":"Int. Tinnitus J."},{"key":"e_1_3_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2010.07.008"},{"key":"e_1_3_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.679"},{"key":"e_1_3_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2011.11.012"},{"key":"e_1_3_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31818658ea"},{"key":"e_1_3_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1126-1"},{"key":"e_1_3_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20074"},{"key":"e_1_3_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000235310.72442.4e"},{"key":"e_1_3_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000134438.91734.38"},{"key":"e_1_3_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215108002776"},{"key":"e_1_3_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130608500811"},{"key":"e_1_3_2_3_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480601126952"},{"key":"e_1_3_2_3_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000095897"},{"key":"e_1_3_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2011.07.010"},{"key":"e_1_3_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3182009d29"},{"key":"e_1_3_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20713"},{"key":"e_1_3_2_3_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31058"},{"key":"e_1_3_2_3_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000180174.81036.5a"},{"key":"e_1_3_2_3_56_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.09.41"},{"key":"e_1_3_2_3_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e3181c351f2"},{"key":"e_1_3_2_3_58_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4002043"},{"key":"e_1_3_2_3_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1418-5"},{"key":"e_1_3_2_3_60_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215111001125"},{"key":"e_1_3_2_3_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200403000-00017"},{"key":"e_1_3_2_3_62_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215110001155"},{"key":"e_1_3_2_3_63_1","doi-asserted-by":"publisher","DOI":"10.1159\/000046130"},{"key":"e_1_3_2_3_64_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556139707600813"}],"container-title":["Therapeutic Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/tde.12.130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T15:17:29Z","timestamp":1715959049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/tde.12.130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,24]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.4155\/tde.12.130"],"URL":"https:\/\/doi.org\/10.4155\/tde.12.130","relation":{},"ISSN":["2041-5990","2041-6008"],"issn-type":[{"value":"2041-5990","type":"print"},{"value":"2041-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,24]]}}}