{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T03:12:54Z","timestamp":1724469174965},"reference-count":98,"publisher":"Informa UK Limited","issue":"6","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Ther. Deliv."],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.4155\/tde.15.22","type":"journal-article","created":{"date-parts":[[2015,7,7]],"date-time":"2015-07-07T09:24:41Z","timestamp":1436261081000},"page":"685-703","update-policy":"http:\/\/dx.doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["Trends in the Development of Oral Anticoagulants"],"prefix":"10.1080","volume":"6","author":[{"given":"Bettina","family":"Ralay-Ranaivo","sequence":"first","affiliation":[{"name":"Institut Galien Paris-Sud CNRS UMR 8612, 5 rue JB Cl\u00e9ment92296Ch\u00e2tenay-Malabry CedexFrance"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Borgel","sequence":"additional","affiliation":[{"name":"EA 4531\u2013Ing\u00e9nierie des prot\u00e9ines de l'h\u00e9mostase \u00e0 potentiel th\u00e9rapeutique, 5 rue JB Cl\u00e9ment92296Ch\u00e2tenay-Malabry CedexFrance"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Couvreur","sequence":"additional","affiliation":[{"name":"Institut Galien Paris-Sud CNRS UMR 8612, 5 rue JB Cl\u00e9ment92296Ch\u00e2tenay-Malabry CedexFrance"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruxandra","family":"Gref","sequence":"additional","affiliation":[{"name":"Institut Galien Paris-Sud CNRS UMR 8612, 5 rue JB Cl\u00e9ment92296Ch\u00e2tenay-Malabry CedexFrance"},{"name":"Institut of Molecular Sciences, UMR CNRS 8214, Universit\u00e9 Paris-Sud, Orsay, 91405, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2015,7,7]]},"reference":[{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0761"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0678"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318214876d"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000140263.20897.42"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60202-0"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.162677"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0656"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.203117"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.12.007"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.3_suppl.188S"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(03)00078-6"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2294"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2002.tb00081.x"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.04.008"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S25791"},{"key":"e_1_3_2_18_1","first-page":"100","article-title":"Heparins: anionic polyelectrolyte drugs","volume":"31","author":"Jaques LB","year":"1980","unstructured":"Jaques LB . Heparins: anionic polyelectrolyte drugs. Pharmacol. Rev.31, 100\u2013166 (1980).","journal-title":"Pharmacol. Rev."},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(03)00030-6"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0670"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04321.x"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.12.014"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712803306420"},{"key":"e_1_3_2_24_1","first-page":"1","article-title":"New direct oral anticoagulants-current therapeutic options and treatment recommendations for bleeding complications","volume":"108","author":"Miesbach W","year":"2012","unstructured":"Miesbach W Seifried E . New direct oral anticoagulants-current therapeutic options and treatment recommendations for bleeding complications. Thromb. Haemost.108, 1\u20137 (2012).","journal-title":"Thromb. Haemost."},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20217"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14683"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(03)00250-0"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1617033"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3185"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23202"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm050101d"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01166.x"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-005-0043-5"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.06.011"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-09-0659"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-011-0561-1"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0109513"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-03-0183"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.019083"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02899.x"},{"key":"e_1_3_2_42_1","first-page":"445","article-title":"Development and clinical applications of novel oral anticoagulants. Part II. Drugs under clinical investigation","volume":"13","author":"Ahrens I","year":"2012","unstructured":"Ahrens I Peter K Lip GY Bode C . Development and clinical applications of novel oral anticoagulants. Part II. Drugs under clinical investigation. Discov. Med.13, 445\u2013450 (2012).","journal-title":"Discov. Med."},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.02.041"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.065"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-08-0712"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3102"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-06-288522"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-01-0063"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-009-0411-6"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-10-0659"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9751-8"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1067"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/10611860500471906"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012160703533"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(97)00101-6"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012192115828"},{"key":"e_1_3_2_57_1","first-page":"148","article-title":"Oral SNAC-heparin vs, enoxaparin for preventing venous-thromboembolism following total hip replacement","volume":"100","author":"Hull R","year":"2001","unstructured":"Hull R Kakkar AK Marder VJ Baughman R Leone-Bay A Goldberg M . Oral SNAC-heparin vs, enoxaparin for preventing venous-thromboembolism following total hip replacement. Blood100, 148 (2001).","journal-title":"Blood"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2004.03.007"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-9560-4-6"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.16.1610"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00340.x"},{"key":"e_1_3_2_62_1","first-page":"38","article-title":"Oral low molecular weight absorption from solution and solid dosage form in rat, dog and monkey models","author":"Leone-Bay A","year":"2002","unstructured":"Leone-Bay A O'Shaughnessy C Agarwal R Rivera-Schaub T Rosado-Gray C Gerspach L . Oral low molecular weight absorption from solution and solid dosage form in rat, dog and monkey models. Pharm. Technol.38\u201346 (2002).","journal-title":"Pharm. Technol."},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00231-9"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013055120007"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023803706746"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015345827091"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(03)00126-3"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.08.030"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6017(200101)90:1<38::AID-JPS5>3.0.CO;2-3"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.11.002"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9226-8"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011949521144"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.10097"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1081\/DDC-120014740"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0202.101988"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.1080\/713840325"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.03.020"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.11.025"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.10.048"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.08.004"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.07.013"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.02.020"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.3.5.685"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.02.056"},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2003.11.013"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026474919869"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc5001.100627"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2005.12.011"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2005.03.018"},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2005.03.027"},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.03.008"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc100594v"},{"key":"e_1_3_2_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199316713"},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.1997.tb00321.x"},{"key":"e_1_3_2_95_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241002-00001"},{"key":"e_1_3_2_96_1","first-page":"335","article-title":"Le pentasaccharide (fondaparinux sodium, Arixtra\u00ae): avantage \u00e0 la synth\u00e8se","volume":"16","author":"Cariou R","year":"2004","unstructured":"Cariou R . Le pentasaccharide (fondaparinux sodium, Arixtra\u00ae): avantage \u00e0 la synth\u00e8se. STV16, 335\u2013338 (2004).","journal-title":"STV"},{"key":"e_1_3_2_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2010.08.001"},{"key":"e_1_3_2_98_1","unstructured":"Leonard TW Coughlan DC Cullen A . Pharmaceutical compositions of selective Factor Xa inhibitors for oral administration. WO 2011\/120033 A1 (2011)."},{"key":"e_1_3_2_99_1","unstructured":"Meissonnier J Sicre N Sabate G Dubreucq G Nancy-Portebois V Petitou M . Pharmaceutical oral dosage form containing a synthetic oligosaccharide. WO 2011\/073408 A2 (2011)."},{"key":"e_1_3_2_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.07.060"}],"container-title":["Therapeutic Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/tde.15.22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T19:14:29Z","timestamp":1715973269000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/tde.15.22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":98,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.4155\/tde.15.22"],"URL":"https:\/\/doi.org\/10.4155\/tde.15.22","relation":{},"ISSN":["2041-5990","2041-6008"],"issn-type":[{"value":"2041-5990","type":"print"},{"value":"2041-6008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itde20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=itde20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2015-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}