{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:10:09Z","timestamp":1772935809321,"version":"3.50.1"},"reference-count":27,"publisher":"Informa UK Limited","issue":"10","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Future Med. Chem."],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.4155\/fmc-2017-0239","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T15:09:13Z","timestamp":1526051353000},"page":"1177-1189","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":24,"title":["Anticancer Properties of the Abietane Diterpene 6,7-dehydroroyleanone Obtained by Optimized Extraction"],"prefix":"10.1080","volume":"10","author":[{"given":"Catarina","family":"Garcia","sequence":"first","affiliation":[{"name":"Research Center for Biosciences &amp; Health Technologies (CBIOS)\rUniversidade Lus\u00f3fona de Humanidades e Tecnologias\r1749\u2013024\rLisbon\rPortugal"},{"name":"Department of Biomedical Sciences\rFaculty of Pharmacy\rUniversity of Alcal\u00e1\rCtra. A2\rKm 33.600 \u2013 Campus Universitario\r28871\rAlcal\u00e1 de Henares\rSpain"}]},{"given":"Catarina Oliveira","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences\rFaculty of Pharmacy\rUniversity of Alcal\u00e1\rCtra. A2\rKm 33.600 \u2013 Campus Universitario\r28871\rAlcal\u00e1 de Henares\rSpain"}]},{"given":"Carlos M","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa)\rFaculdade de Farm\u00e1cia\rUniversidade de Lisboa\r1649\u2013003\rLisbon\rPortugal"}]},{"given":"Marisa","family":"Nicolai","sequence":"additional","affiliation":[{"name":"Research Center for Biosciences &amp; Health Technologies (CBIOS)\rUniversidade Lus\u00f3fona de Humanidades e Tecnologias\r1749\u2013024\rLisbon\rPortugal"}]},{"given":"Ana","family":"Viana","sequence":"additional","affiliation":[{"name":"CQB\rFaculdade de Ci\u00eancias\rUniversity of Lisbon\rCampo Grande 1749\u2013016\rLisbon\rPortugal"}]},{"given":"Joana M","family":"Andrade","sequence":"additional","affiliation":[{"name":"Research Center for Biosciences &amp; Health Technologies (CBIOS)\rUniversidade Lus\u00f3fona de Humanidades e Tecnologias\r1749\u2013024\rLisbon\rPortugal"},{"name":"Department of Biomedical Sciences\rFaculty of Pharmacy\rUniversity of Alcal\u00e1\rCtra. A2\rKm 33.600 \u2013 Campus Universitario\r28871\rAlcal\u00e1 de Henares\rSpain"}]},{"given":"Isabel","family":"Barasoain","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biol\u00f3gicas Consejo Superior de Investigaciones Cient\u00edficas Ramiro de Maeztu\r9\rMadrid\r28040\rSpain"}]},{"given":"Tijana","family":"Stankovic","sequence":"additional","affiliation":[{"name":"Institute for Biological Research \u2018Sini\u0161a Stankovi\u0107\u2019\rUniversity of Belgrade\rDespota Stefana 142\rBelgrade\r11060\rSerbia"}]},{"given":"Jos\u00e9","family":"Quintana","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology\rInstituto Universitario de Investigaciones Biom\u00e9dicas y Sanitarias\rUniversity of Las Palmas de Gran Canaria\rPaseo Blas Cabrera Felipe s\/n\r35016\rLas Palmas de Gran Canaria\rSpain"}]},{"given":"Inmaculada","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology\rInstituto Universitario de Investigaciones Biom\u00e9dicas y Sanitarias\rUniversity of Las Palmas de Gran Canaria\rPaseo Blas Cabrera Felipe s\/n\r35016\rLas Palmas de Gran Canaria\rSpain"}]},{"given":"Ignacio","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology\rInstituto Universitario de Investigaciones Biom\u00e9dicas y Sanitarias\rUniversity of Las Palmas de Gran Canaria\rPaseo Blas Cabrera Felipe s\/n\r35016\rLas Palmas de Gran Canaria\rSpain"}]},{"given":"Francisco","family":"Est\u00e9vez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology\rInstituto Universitario de Investigaciones Biom\u00e9dicas y Sanitarias\rUniversity of Las Palmas de Gran Canaria\rPaseo Blas Cabrera Felipe s\/n\r35016\rLas Palmas de Gran Canaria\rSpain"}]},{"given":"Ana M","family":"D\u00edaz-Lanza","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences\rFaculty of Pharmacy\rUniversity of Alcal\u00e1\rCtra. A2\rKm 33.600 \u2013 Campus Universitario\r28871\rAlcal\u00e1 de Henares\rSpain"}]},{"given":"Catarina P","family":"Reis","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa)\rFaculdade de Farm\u00e1cia\rUniversidade de Lisboa\r1649\u2013003\rLisbon\rPortugal"}]},{"given":"Carlos AM","family":"Afonso","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa)\rFaculdade de Farm\u00e1cia\rUniversidade de Lisboa\r1649\u2013003\rLisbon\rPortugal"}]},{"given":"Milica","family":"Pesic","sequence":"additional","affiliation":[{"name":"Institute for Biological Research \u2018Sini\u0161a Stankovi\u0107\u2019\rUniversity of Belgrade\rDespota Stefana 142\rBelgrade\r11060\rSerbia"}]},{"given":"Patr\u00edcia","family":"Rijo","sequence":"additional","affiliation":[{"name":"Research Center for Biosciences &amp; Health Technologies (CBIOS)\rUniversidade Lus\u00f3fona de Humanidades e Tecnologias\r1749\u2013024\rLisbon\rPortugal"},{"name":"Instituto de Investiga\u00e7\u00e3o do Medicamento (iMed.ULisboa)\rFaculdade de Farm\u00e1cia\rUniversidade de Lisboa\r1649\u2013003\rLisbon\rPortugal"}]}],"member":"301","published-online":{"date-parts":[[2018,5,11]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-143784"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.03.070"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.04.005"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.10.35"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401738"},{"issue":"3","key":"e_1_3_2_7_1","first-page":"214","article-title":"Synthesis of novel 1,8-acridinediones derivatives: investigation of MDR reversibility on breast cancer cell lines T47D and tamoxifen-resistant T47D","volume":"10","author":"Moallem SA","year":"2015","unstructured":"Moallem SA Dehghani N Mehri S Shahsavand S Alibolandi M Hadizadeh F . Synthesis of novel 1,8-acridinediones derivatives: investigation of MDR reversibility on breast cancer cell lines T47D and tamoxifen-resistant T47D. Res. Pharm. Sci.10 (3), 214 \u2013 221 (2015).","journal-title":"Res. Pharm. Sci."},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.09.011"},{"key":"e_1_3_2_9_1","first-page":"922","article-title":"Antimicrobial natural products from Plectranthus plants","volume":"2","author":"Rijo P","year":"2013","unstructured":"Rijo P Faustino C Sim\u00f5es MF . Antimicrobial natural products from Plectranthus plants. Formatex Research Center2, 922 \u2013 931, (2013).","journal-title":"Formatex Research Center"},{"key":"e_1_3_2_10_1","volume-title":"Phytochemical Study and Biological Activities of Diterpenes and Derivatives from Plectranthus Species [PhD thesis].","author":"Rijo P","year":"2011","unstructured":"Rijo P . Phytochemical Study and Biological Activities of Diterpenes and Derivatives from Plectranthus Species [PhD thesis].University of Lisbon, Lisbon, Portugal (2011)."},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1394809"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50063a016"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.4236\/abc.2014.42015"},{"key":"e_1_3_2_14_1","unstructured":"The Plant List (2013). Version 1.1.www.theplantlist.org\/ ."},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666151211094521"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17078196"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.08.001"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ed074p1222"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2012.12.005"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2014.08.022"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrc.1245"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165419"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2015-0011"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144454"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2006.18.1.66"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112536"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.13.1107"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0791"}],"container-title":["Future Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4155\/fmc-2017-0239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T19:53:35Z","timestamp":1716494015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4155\/fmc-2017-0239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.4155\/fmc-2017-0239"],"URL":"https:\/\/doi.org\/10.4155\/fmc-2017-0239","relation":{},"ISSN":["1756-8919","1756-8927"],"issn-type":[{"value":"1756-8919","type":"print"},{"value":"1756-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ifmc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2017-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}