{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:02:18Z","timestamp":1791669738445,"version":"4.3.4"},"reference-count":56,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.4158\/ep-2018-0097","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T13:46:15Z","timestamp":1532612775000},"page":"684-692","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Integrated Insulin Pump and Continuous Glucose Monitoring Technology in Diabetes Care Today: A Perspective of Real-Life Experience With the Minimed\u2122 670G Hybrid Closed-Loop System"],"prefix":"10.1016","volume":"24","author":[{"given":"Grazia","family":"Aleppo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly M.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.4158\/EP-2018-0097_bb0010","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1089\/dia.2015.0297","article-title":"The future of the artificial pancreas","volume":"17","author":"Thabit","year":"2015","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0015","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2337\/diab.23.5.397","article-title":"Clinical control of diabetes by the artificial pancreas","volume":"23","author":"Albisser","year":"1974","journal-title":"Diabetes"},{"key":"10.4158\/EP-2018-0097_bb0020","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1136\/bmj.1.6107.204","article-title":"Continuous subcutaneous insulin infusion: an approach to achieving normoglycaemia","volume":"1","author":"Pickup","year":"1978","journal-title":"Br Med J"},{"key":"10.4158\/EP-2018-0097_bb0025","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1056\/NEJM197903153001101","article-title":"Reduction to normal of plasma glucose in juvenile diabetes by subcutaneous administration of insulin with a portable infusion pump","volume":"300","author":"Tamborlane","year":"1979","journal-title":"N Engl J Med"},{"key":"10.4158\/EP-2018-0097_bb0030","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1399-5448.2011.00793.x","article-title":"Effectiveness of sensor-augmented pump therapy in children and adolescents with type 1 diabetes in the STAR 3 study","volume":"13","author":"Slover","year":"2012","journal-title":"Pediatr Diabetes"},{"key":"10.4158\/EP-2018-0097_bb0035","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1056\/NEJMoa1002853","article-title":"STAR 3 Study Group. Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes","volume":"363","author":"Bergenstal","year":"2010","journal-title":"N Engl J Med"},{"key":"10.4158\/EP-2018-0097_bb0040","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1056\/NEJMoa1303576","article-title":"Threshold based insulin-pump interruption for reduction of hypoglycemia","volume":"369","author":"Bergenstal","year":"2013","journal-title":"N Engl J Med"},{"key":"10.4158\/EP-2018-0097_bb0045","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4158\/EP14187.OR","article-title":"Patient behaviors associated with optimum glycemic outcomes with sensor-augmented pump therapy: insights from the STAR 3 study","volume":"21","author":"Tanenberg","year":"2015","journal-title":"Endocr Pract"},{"key":"10.4158\/EP-2018-0097_bb0050","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/dia.2012.0288","article-title":"Routine sensor-augmented pump therapy in type 1 diabetes: the INTERPRET study","volume":"15","author":"N\u00f8rgaard","year":"2013","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0055","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.2337\/dc13-2159","article-title":"A randomized trial of a home system to reduce nocturnal hypoglycemia in type 1 diabetes","volume":"37","author":"Maahs","year":"2014","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0097_bb0060","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.2337\/dc14-3053","article-title":"Predictive low-glucose insulin suspension reduces duration of nocturnal hypoglycemia in children without increasing ketosis","volume":"38","author":"Buckingham","year":"2015","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0097_bb0065","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1089\/dia.2016.0319","article-title":"evaluation of a predictive low-glucose management system in-clinic","volume":"19","author":"Buckingham","year":"2017","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0070","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2337\/cd16-0008","article-title":"Continuous glucose monitoring: a perspective on its past, present, and future applications for diabetes management","volume":"35","author":"Mariani","year":"2017","journal-title":"Clin Diabetes"},{"key":"10.4158\/EP-2018-0097_bb0075","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2337\/dc16-2482","article-title":"REPLACE-BG: a randomized trial comparing continuous glucose monitoring with and without routine blood glucose monitoring in adults with well-controlled type 1 diabetes","volume":"40","author":"Aleppo","year":"2017","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0097_bb0080","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1089\/dia.2014.0378","article-title":"The performance and usability of a factory-calibrated flash glucose monitoring system","volume":"17","author":"Bailey","year":"2015","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0085","unstructured":"U.S. Food and Drug AdministrationFDA Expands Indication for Continuous Glucose Monitoring System, First to Replace Fingerstick Testing for Diabetes Treatment Decisions. Available at: https:\/\/www.fda.gov\/newsevents\/newsroom\/pressannouncements\/ucm534056.htm. Accessed February 14, 2018."},{"key":"10.4158\/EP-2018-0097_bb0090","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1089\/dia.2017.0087","article-title":"Accuracy of a fourth-generation subcutaneous continuous glucose sensor","volume":"19","author":"Christiansen","year":"2017","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0095","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1089\/dia.2017.0012","article-title":"Future of automated insulin delivery systems","volume":"19","author":"Castle","year":"2017","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0100","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1177\/1932296815617968","article-title":"Artificial pancreas device systems for the closed-loop control of type 1 diabetes: what systems are in development?","volume":"10","author":"Trevitt","year":"2016","journal-title":"J Diabetes Sci Technol"},{"key":"10.4158\/EP-2018-0097_bb0105","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1056\/NEJMoa1509351","article-title":"Home use of an artificial beta cell in type 1 diabetes","volume":"373","author":"Thabit","year":"2015","journal-title":"N Engl J Med"},{"key":"10.4158\/EP-2018-0097_bb0110","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S2213-8587(14)70114-7","article-title":"Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study","volume":"2","author":"Thabit","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.4158\/EP-2018-0097_bb0115","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1056\/NEJMoa1314474","article-title":"Outpatient glycemic control with a bionic pancreas in type 1 diabetes","volume":"371","author":"Russell","year":"2014","journal-title":"N Engl J Med"},{"key":"10.4158\/EP-2018-0097_bb0120","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/dom.12427","article-title":"Unsupervised home use of an overnight closed-loop system over 3\u20134 weeks: a pooled analysis of randomized controlled studies in adults and adolescents with type 1 diabetes","volume":"17","author":"Thabit","year":"2015","journal-title":"Diabetes Obes Metab"},{"key":"10.4158\/EP-2018-0097_bb0125","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1089\/dia.2016.0333","article-title":"Feasibility of long-term closed-loop control: a multicenter 6-month trial of 24\/7 automated insulin delivery","volume":"19","author":"Kovatchev","year":"2017","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0130","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0140-6736(16)32567-3","article-title":"Home use of a bihormonal bionic pancreas versus insulin pump therapy in adults with type 1 diabetes: a multicentre randomised crossover trial","volume":"389","author":"El-Khatib","year":"2017","journal-title":"Lancet"},{"key":"10.4158\/EP-2018-0097_bb0135","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1007\/s00125-016-4022-4","article-title":"Coming of age: the artificial pancreas for type 1 diabetes","volume":"59","author":"Thabit","year":"2016","journal-title":"Diabetologia"},{"key":"10.4158\/EP-2018-0097_bb0140","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1089\/dia.2017.0174","article-title":"Impact of an automated bihormonal delivery system on psychosocial outcomes in adults with type 1 diabetes","volume":"19","author":"Weissberg-Benchell","year":"2017","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0145","unstructured":"Beta-BionicsIntroducing the iLet. Available at: https:\/\/www.betabionics.org\/. Accessed February 11, 2018."},{"key":"10.4158\/EP-2018-0097_bb0150","unstructured":"Available at: www.typezero.com\/. Accessed May 19, 2018."},{"key":"10.4158\/EP-2018-0097_bb0155","unstructured":"Bigfoot Biomedical. Available at: https:\/\/www.bigfootbiomedical.com\/. Accessed February 11, 2018."},{"key":"10.4158\/EP-2018-0097_bb0160","unstructured":"OpenAPS. Available at: https:\/\/openaps.org\/. Accessed February 11, 2018."},{"key":"10.4158\/EP-2018-0097_bb0165","unstructured":"Food and Drug Administration, Center for Devices and Radiological Health: MiniMed 670G System approval letter, September 28, 2016. Available at: https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm522974.htm Accessed May 19, 2018."},{"key":"10.4158\/EP-2018-0097_bb0170","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/dia.2017.0073","article-title":"Automated insulin delivery system nomenclature","volume":"19","author":"Cohen","year":"2017","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0175","unstructured":"Minimed\u00ae 670G System User Guide. Available at: www.medtronicdiabetes.com. Accessed May 17, 2018."},{"key":"10.4158\/EP-2018-0097_bb0180","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1001\/jama.2016.11708","article-title":"Safety of a hybrid closed-loop insulin delivery system in patients with type 1 diabetes","volume":"316","author":"Bergenstal","year":"2016","journal-title":"JAMA"},{"key":"10.4158\/EP-2018-0097_bb0185","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1089\/dia.2016.0421","article-title":"Glucose outcomes with the in-home use of a hybrid closed-loop insulin delivery system in adolescents and adults with type 1 diabetes","volume":"19","author":"Garg","year":"2017","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0190","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1089\/dia.2017.0208","article-title":"the effect of prior continuous glucose monitoring use on glycemic outcomes in the pivotal trial of the MiniMed\u2122 670G hybrid closed-loop system","volume":"19","author":"Cordero","year":"2017","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0195","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/dme.13567","article-title":"Psychosocial impacts of hybrid closed-loop systems in the management of diabetes: a review","volume":"35","author":"Farrington","year":"2018","journal-title":"Diabet Med"},{"key":"10.4158\/EP-2018-0097_bb0200","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1089\/dia.2016.0432","article-title":"In-home closed loop control for artificial pancreas: patient and provider perspective","volume":"19","author":"Ekhlaspour","year":"2017","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0205","unstructured":"Medtronic Smart Technology Best Practices. Available at: www.medtronicdiabetes.com. Accessed May 17, 2018."},{"key":"10.4158\/EP-2018-0097_bb0210","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/dme.13436","article-title":"Bolusing frequency and amount impacts glucose control during hybrid closed-loop","volume":"35","author":"Bally","year":"2018","journal-title":"Diabet Med"},{"key":"10.4158\/EP-2018-0097_bb0215","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.diabres.2012.10.024","article-title":"Carbohydrate counting accuracy and blood glucose variability in adults with type 1 diabetes","volume":"99","author":"Brazeau","year":"2013","journal-title":"Diabetes Res Clin Pract"},{"key":"10.4158\/EP-2018-0097_bb0220","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1932296816685475","article-title":"Bolus calculator safety mandates a need for standards","volume":"11","author":"Walsh","year":"2017","journal-title":"J Diabetes Sci Technol"},{"key":"10.4158\/EP-2018-0097_bb0225","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1089\/dia.2017.0216","article-title":"Relevance of bolus calculators in current hybrid closed loop systems","volume":"19","author":"Forlenza","year":"2017","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0230","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1056\/NEJMra040832","article-title":"Insulin analogues","volume":"352","author":"Hirsch","year":"2005","journal-title":"N Engl J Med"},{"key":"10.4158\/EP-2018-0097_bb0235","doi-asserted-by":"crossref","first-page":"934","DOI":"10.2337\/dc07-1967","article-title":"Fully automated closed-loop insulin delivery versus semiautomated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas","volume":"31","author":"Weinzimer","year":"2008","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0097_bb0240","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.2337\/dc13-1195","article-title":"Both dietary protein and fat increase postprandial glucose excursions in children with type 1 diabetes, and the effect is additive","volume":"36","author":"Smart","year":"2013","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0097_bb0245","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1089\/dia.2015.0118","article-title":"Bolus estimation\u2014rethinking the effect of meal fat content","volume":"17","author":"Laxminarayan","year":"2015","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0250","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.2337\/dc15-2855","article-title":"Optimized mealtime insulin dosing for fat and protein in type 1 diabetes: application of a model-based approach to derive insulin doses for open-loop diabetes management","volume":"39","author":"Bell","year":"2016","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0097_bb0255","doi-asserted-by":"crossref","first-page":"810","DOI":"10.2337\/dc12-0092","article-title":"Dietary fat acutely increases glucose concentrations and insulin requirements in patients with type 1 diabetes: implications for carbohydrate-based bolus dose calculation and intensive diabetes management","volume":"36","author":"Wolpert","year":"2013","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0097_bb0260","unstructured":"MiniMed 670G Hybrid Closed-Loop SystemMedical Education. Available at: www.medtronicdiabetes.com. Accessed May 17, 2018."},{"key":"10.4158\/EP-2018-0097_bb0265","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1177\/193229681300700324","article-title":"\u201cTurn it off!\u201d: diabetes device alarm fatigue considerations for the present and the future","volume":"7","author":"Shivers","year":"2013","journal-title":"J Diabetes Sci Technol"},{"key":"10.4158\/EP-2018-0097_bb0270","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jcjd.2017.07.004","article-title":"Insulin management strategies for exercise in diabetes","volume":"41","author":"Zaharieva","year":"2017","journal-title":"Can J Diabetes"},{"key":"10.4158\/EP-2018-0097_bb0275","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1089\/dia.2016.0461","article-title":"Closed-loop insulin delivery for adults with type 1 diabetes undertaking high-intensity interval exercise versus moderate-intensity exercise: a randomized, crossover study","volume":"19","author":"Jayawardene","year":"2017","journal-title":"Diabetes Technol Ther"},{"key":"10.4158\/EP-2018-0097_bb0280","unstructured":"MiniMed Outcomes. Available at: https:\/\/usminimedoutcomes.medtronic.com\/visualize#\/sensor-glucose-distribution-670G\/physicianGroup\/0\/0\/0\/gt3hrs\/all. Accessed April 5, 2018."},{"key":"10.4158\/EP-2018-0097_bb0285","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/dia.2017.0052","article-title":"Will the first approved automated insulin delivery system be a game-changer in type 1 diabetes management?","volume":"19","author":"Castle","year":"2017","journal-title":"Diabetes Technol Ther"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20353866?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20353866?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:04:52Z","timestamp":1761516292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X20353866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S1530891X20353866"],"URL":"https:\/\/doi.org\/10.4158\/ep-2018-0097","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated Insulin Pump and Continuous Glucose Monitoring Technology in Diabetes Care Today: A Perspective of Real-Life Experience With the Minimed\u2122 670G Hybrid Closed-Loop System","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.4158\/EP-2018-0097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}