{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:53:57Z","timestamp":1776750837278,"version":"3.51.2"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.4158\/ep-2018-0461","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T13:10:31Z","timestamp":1553605831000},"page":"254-262","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Markedly Delayed Insulin Secretion and a High Rate of Undetected Overt Diabetes Characterize Glucose Metabolism in Adult Patients with Cystic Fibrosis After Lung Transplantation"],"prefix":"10.1016","volume":"25","author":[{"given":"Yvonne","family":"Winhofer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Fellinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Tura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hillebrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Staufer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Jaksch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Murak\u00f6zy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Kautzky-Willer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Pacini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Luger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Kazemi-Shirazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.4158\/EP-2018-0461_bb0010","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2337\/dc09-1215","article-title":"Diabetes as a determinant of mortality in cystic fibrosis","volume":"33","author":"Chamnan","year":"2010","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0461_bb0015","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.2337\/diacare.28.9.2141","article-title":"Diabetes is associated with dramatically decreased survival in female but not male subjects with cystic fibrosis","volume":"28","author":"Milla","year":"2005","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0461_bb0020","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00592-015-0791-3","article-title":"The 1-h oral glucose tolerance test glucose and insulin values are associated with markers of clinical deterioration in cystic fibrosis","volume":"53","author":"Coriati","year":"2016","journal-title":"Acta Diabetol"},{"key":"10.4158\/EP-2018-0461_bb0025","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2337\/dc09-0585","article-title":"Insulin therapy to improve BMI in cystic fibrosis-related diabetes without fasting hyperglycemia: results of the cystic fibrosis related diabetes therapy trial","volume":"32","author":"Moran","year":"2009","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0461_bb0030","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.2337\/dc09-0586","article-title":"Cystic fibrosis-related diabetes: current trends in prevalence, incidence, and mortality","volume":"32","author":"Moran","year":"2009","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0461_bb0035","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.2337\/dc10-1768","article-title":"Clinical care guidelines for cystic fibrosis-related diabetes: a position statement of the American Diabetes Association and a clinical practice guideline of the Cystic Fibrosis Foundation, endorsed by the Pediatric Endocrine Society","volume":"33","author":"Moran","year":"2010","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0461_bb0040","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jcf.2016.02.005","article-title":"Glycated hemoglobin cannot yet be proposed as a screening tool for cystic fibrosis related diabetes","volume":"15","author":"Boudreau","year":"2016","journal-title":"J Cyst Fibros"},{"key":"10.4158\/EP-2018-0461_bb0045","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1399-0012.2005.00420.x","article-title":"Incidence and prevalence of diabetes mellitus in patients with cystic fibrosis undergoing lung transplantation before and after lung transplantation","volume":"19","author":"Hadjiliadis","year":"2005","journal-title":"Clin Transplant"},{"issue":"suppl 1","key":"10.4158\/EP-2018-0461_bb0050","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.2337\/dc18-S002","article-title":"Classification and diagnosis of diabetes: standards of medical care in diabetes-2018","volume":"41","author":"American Diabetes Assocaition","year":"2018","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0461_bb0055","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2337\/dc10-1604","article-title":"Elevation of 1-hour plasma glucose during oral glucose tolerance testing is associated with worse pulmonary function in cystic fibrosis","volume":"34","author":"Brodsky","year":"2011","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0461_bb0060","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jcf.2015.03.001","article-title":"Characterization of patients with cystic fibrosis presenting an indeterminate glucose tolerance (INDET)","volume":"15","author":"Coriati","year":"2016","journal-title":"J Cyst Fibros"},{"key":"10.4158\/EP-2018-0461_bb0065","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2337\/db16-0394","article-title":"Reduced beta-cell secretory capacity in pancreatic-insufficient, but not pancreatic-sufficient, cystic fibrosis despite normal glucose tolerance","volume":"66","author":"Sheikh","year":"2017","journal-title":"Diabetes"},{"key":"10.4158\/EP-2018-0461_bb0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2174\/157339910790442600","article-title":"Cystic fibrosis related diabetes mellitus - diagnostic and management challenges","volume":"6","author":"Lek","year":"2010","journal-title":"Curr Diabetes Rev"},{"key":"10.4158\/EP-2018-0461_bb0075","first-page":"3","article-title":"Cystic fibrosis-related diabetes is caused by islet loss and inflammation","author":"Hart","year":"2018","journal-title":"JCI Insight"},{"key":"10.4158\/EP-2018-0461_bb0080","doi-asserted-by":"crossref","first-page":"823","DOI":"10.2337\/dc17-1387","article-title":"Islet interleukin-1beta immunoreactivity is an early feature of cystic fibrosis that may contribute to beta-cell failure","volume":"41","author":"Hull","year":"2018","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0461_bb0085","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1007\/s00125-016-3936-1","article-title":"Islet-intrinsic effects of CFTR mutation","volume":"59","author":"Koivula","year":"2016","journal-title":"Diabetologia"},{"key":"10.4158\/EP-2018-0461_bb0090","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1055\/s-0035-1547319","article-title":"Clinical updates in cystic fibrosis-related diabetes","volume":"36","author":"Brennan","year":"2015","journal-title":"Semin Respir Crit Care Med"},{"key":"10.4158\/EP-2018-0461_bb0095","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s00125-015-3522-y","article-title":"Reduction of insulinotropic properties of GLP-1 and GIP after glucocorticoid-induced insulin resistance","volume":"58","author":"Eriksen","year":"2015","journal-title":"Diabetologia"},{"key":"10.4158\/EP-2018-0461_bb0100","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.2337\/dc12-2617","article-title":"Effects of low-dose prednisolone on hepatic and peripheral insulin sensitivity, insulin secretion, and abdominal adiposity in patients with inflammatory rheumatologic disease","volume":"36","author":"Petersons","year":"2013","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0461_bb0105","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/clinchem\/41.5.717","article-title":"Direct measurement of high-density lipoprotein cholesterol in serum with polyethylene glycol-modified enzymes and sulfated alpha-cyclodextrin","volume":"41","author":"Sugiuchi","year":"1995","journal-title":"Clin Chem"},{"key":"10.4158\/EP-2018-0461_bb0110","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/clinchem\/38.1.150","article-title":"Measurement of low-density-lipoprotein cholesterol in serum: a status report","volume":"38","author":"Rifai","year":"1992","journal-title":"Clin Chem"},{"key":"10.4158\/EP-2018-0461_bb0115","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2337\/diacare.24.3.539","article-title":"A model-based method for assessing insulin sensitivity from the oral glucose tolerance test","volume":"24","author":"Mari","year":"2001","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0461_bb0120","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1210\/jcem.85.7.6661","article-title":"Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans","volume":"85","author":"Katz","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP-2018-0461_bb0125","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1507\/endocrj.EJ16-0298","article-title":"Insulin resistance and beta-cell dysfunction in people with prediabetes according to criteria based on glycemia and glycosylated hemoglobin","volume":"64","author":"Tura","year":"2017","journal-title":"Endocr J"},{"key":"10.4158\/EP-2018-0461_bb0130","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.diabres.2005.10.005","article-title":"Insulinogenic indices from insulin and C-peptide: comparison of beta-cell function from OGTT and IVGTT","volume":"72","author":"Tura","year":"2006","journal-title":"Diabetes Res Clin Pract"},{"issue":"suppl 1","key":"10.4158\/EP-2018-0461_bb0135","doi-asserted-by":"crossref","first-page":"S221","DOI":"10.2337\/diabetes.51.2007.S221","article-title":"Assessing insulin secretion by modeling in multiple-meal tests: role of potentiation","volume":"51","author":"Mari","year":"2002","journal-title":"Diabetes"},{"key":"10.4158\/EP-2018-0461_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112578","article-title":"High variability in oral glucose tolerance among 1,128 patients with cystic fibrosis: a multicenter screening study","volume":"9","author":"Scheuing","year":"2014","journal-title":"PloS One"},{"key":"10.4158\/EP-2018-0461_bb0145","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1464-5491.2004.01219.x","article-title":"Conventional measures underestimate glycaemia in cystic fibrosis patients","volume":"21","author":"Dobson","year":"2004","journal-title":"Diabet Med"},{"key":"10.4158\/EP-2018-0461_bb0150","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2337\/diacare.22.1.112","article-title":"Metabolic alterations in middle-aged and elderly obese patients with type 2 diabetes","volume":"22","author":"Meneilly","year":"1999","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0461_bb0155","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2337\/diab.34.9.861","article-title":"Insulin resistance and impaired insulin secretion in subjects with histories of gestational diabetes mellitus","volume":"34","author":"Ward","year":"1985","journal-title":"Diabetes"},{"key":"10.4158\/EP-2018-0461_bb0160","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.2337\/diacare.20.11.1717","article-title":"Pronounced insulin resistance and inadequate beta-cell secretion characterize lean gestational diabetes during and after pregnancy","volume":"20","author":"Kautzky-Willer","year":"1997","journal-title":"Diabetes Care"},{"issue":"suppl 1","key":"10.4158\/EP-2018-0461_bb0165","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.2337\/diabetes.51.2007.S117","article-title":"Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?","volume":"51","author":"Gerich","year":"2002","journal-title":"Diabetes"},{"key":"10.4158\/EP-2018-0461_bb0170","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1038\/ncomms5420","article-title":"Glucose-induced electrical activities and insulin secretion in pancreatic islet beta-cells are modulated by CFTR","volume":"5","author":"Guo","year":"2014","journal-title":"Nat Commun"},{"key":"10.4158\/EP-2018-0461_bb0175","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jcf.2017.11.016","article-title":"Effect of Lumacaftor\/Ivacaftor on glucose metabolism and insulin secretion in Phe508del homozygous cystic fibrosis patients","volume":"17","author":"Thomassen","year":"2018","journal-title":"J Cyst Fibros"},{"key":"10.4158\/EP-2018-0461_bb0180","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jcf.2007.02.005","article-title":"Increased glucose excursion in cystic fibrosis and its association with a worse clinical status","volume":"6","author":"Costa","year":"2007","journal-title":"J Cyst Fibros"},{"key":"10.4158\/EP-2018-0461_bb0185","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.endonu.2014.08.002","article-title":"Insulin resistance, beta-cell dysfunction and differences in curves of plasma glucose and insulin in the intermediate points of the standard glucose tolerance test in adults with cystic fibrosis &lsqb;in English, Spanish]","volume":"62","author":"Cano Meg\u00edas","year":"2015","journal-title":"Endocrinol Nutr"},{"key":"10.4158\/EP-2018-0461_bb0190","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/imj.13963","article-title":"High prevalence of diabetes before and after lung transplantation: target for improving outcome?","volume":"48","author":"Fazekas-Lavu","year":"2018","journal-title":"Intern Med J"},{"key":"10.4158\/EP-2018-0461_bb0195","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.2337\/dc16-0020","article-title":"Does beta-cell autoimmunity play a role in cystic fibrosis-related diabetes? Analysis based on the German\/Austrian Diabetes Patienten Verlaufsdokumentation Registry","volume":"39","author":"Konrad","year":"2016","journal-title":"Diabetes Care"},{"key":"10.4158\/EP-2018-0461_bb0200","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jcf.2018.03.009","article-title":"Prevalence of hypoglycemia during oral glucose tolerance testing in adults with cystic fibrosis and risk of developing cystic fibrosis-related diabetes","volume":"17","author":"Mannik","year":"2018","journal-title":"J Cyst Fibros"},{"key":"10.4158\/EP-2018-0461_bb0205","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1210\/jc.2010-2729","article-title":"Continuous monitoring of circadian glycemic patterns in patients receiving prednisolone for COPD","volume":"96","author":"Burt","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP-2018-0461_bb0210","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.2337\/diabetes.48.5.1082","article-title":"Hepatic insulin resistance and defects in substrate utilization in cystic fibrosis","volume":"48","author":"Hardin","year":"1999","journal-title":"Diabetes"},{"key":"10.4158\/EP-2018-0461_bb0215","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.metabol.2004.06.015","article-title":"Insulin regulation of free fatty acid kinetics in adult cystic fibrosis patients with impaired glucose tolerance","volume":"53","author":"Moran","year":"2004","journal-title":"Metabolism"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20358894?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20358894?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:06:18Z","timestamp":1761516378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X20358894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1530891X20358894"],"URL":"https:\/\/doi.org\/10.4158\/ep-2018-0461","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Markedly Delayed Insulin Secretion and a High Rate of Undetected Overt Diabetes Characterize Glucose Metabolism in Adult Patients with Cystic Fibrosis After Lung Transplantation","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.4158\/EP-2018-0461","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}