{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:18:50Z","timestamp":1773155930602,"version":"3.50.1"},"reference-count":106,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.4158\/ep.13.3.300","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T21:46:55Z","timestamp":1365198415000},"page":"300-312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["The Multifaceted Associations of Hepatobiliary Disease and Diabetes"],"prefix":"10.1016","volume":"13","author":[{"given":"David S.H.","family":"Bell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Allbright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.4158\/EP.13.3.300_bb0005","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF00253736","article-title":"Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus","volume":"23","author":"DeFronzo","year":"1982","journal-title":"Diabetologia."},{"key":"10.4158\/EP.13.3.300_bb0010","doi-asserted-by":"crossref","first-page":"570","DOI":"10.2337\/diabetes.48.3.570","article-title":"Resistance to insulin\u2019s acute direct hepatic effect in suppressing steady-state glucose production in individuals with type 2 diabetes","volume":"48","author":"Lewis","year":"1999","journal-title":"Diabetes."},{"key":"10.4158\/EP.13.3.300_bb0015","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00125-004-1342-6","article-title":"Incretins, insulin secretion and type 2 diabetes mellitus","volume":"47","author":"Vilsboll","year":"2004","journal-title":"Diabetologia."},{"issue":"Suppl 1","key":"10.4158\/EP.13.3.300_bb0020","doi-asserted-by":"crossref","first-page":"M17","DOI":"10.1007\/s00125-002-0932-4","article-title":"Post-challenge hyperglycaemia is associated with premature death and macrovascular complications","volume":"46","author":"Qiao","year":"2003","journal-title":"Diabetologia."},{"key":"10.4158\/EP.13.3.300_bb0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1365-2362.2007.01755.x","article-title":"The metabolic syndrome: metabolic changes with vascular consequences","volume":"37","author":"Wassink","year":"2007","journal-title":"Eur J Clin Invest."},{"key":"10.4158\/EP.13.3.300_bb0030","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00125-006-0165-z","article-title":"Mitochondrial dysfunction in adipocytes: the culprit in type 2 diabetes?","volume":"49","author":"Maassen","year":"2006","journal-title":"Diabetologia."},{"key":"10.4158\/EP.13.3.300_bb0035","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/hep.20466","article-title":"Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity","volume":"40","author":"Browning","year":"2004","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0040","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1542\/peds.2006-1212","article-title":"Prevalence of fatty liver in children and adolescents","volume":"118","author":"Schwimmer","year":"2006","journal-title":"Pediatrics."},{"key":"10.4158\/EP.13.3.300_bb0045","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N Engl J Med."},{"key":"10.4158\/EP.13.3.300_bb0050","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0002-9343(99)00271-5","article-title":"Association of nonalcoholic fatty liver disease with insulin resistance","volume":"107","author":"Marchesini","year":"1999","journal-title":"Am J Med."},{"key":"10.4158\/EP.13.3.300_bb0055","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2337\/diabetes.49.5.749","article-title":"Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients","volume":"49","author":"Ryysy","year":"2000","journal-title":"Diabetes."},{"key":"10.4158\/EP.13.3.300_bb0060","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1365-2265.2006.02527.x","article-title":"Associations between plasma adiponectin concentrations and liver histology in patients with nonalcoholic fatty liver disease","volume":"64","author":"Targher","year":"2006","journal-title":"Clin Endocrinol (Oxf)."},{"key":"10.4158\/EP.13.3.300_bb0065","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1053\/gast.2001.27126","article-title":"Nonalcoholic steatohepatitis","volume":"121","author":"Reid","year":"2001","journal-title":"Gastroenterology."},{"key":"10.4158\/EP.13.3.300_bb0070","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/gast.2001.25540","article-title":"Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese","volume":"121","author":"Dixon","year":"2001","journal-title":"Gastroenterology."},{"key":"10.4158\/EP.13.3.300_bb0075","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/hep.510300604","article-title":"Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis","volume":"30","author":"Angulo","year":"1999","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0080","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00042737-200602000-00010","article-title":"Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease","volume":"18","author":"Aygun","year":"2006","journal-title":"Eur J Gastroenterol Hepatol."},{"key":"10.4158\/EP.13.3.300_bb0085","first-page":"58","article-title":"Prevalence of non-alcoholic steatohepatitis: comparative study with diabetic patients [article in Spanish]","volume":"65","author":"Bernal-Reyes","year":"2000","journal-title":"Rev Gastroenterol Mex."},{"key":"10.4158\/EP.13.3.300_bb0090","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/hep.510270121","article-title":"Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis","volume":"27","author":"Weltman","year":"1998","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0095","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","article-title":"Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radic Biol Med."},{"issue":"3 Suppl 1","key":"10.4158\/EP.13.3.300_bb0100","first-page":"S17","article-title":"Pathophysiology of nonalcoholic steato-hepatitis","volume":"40","author":"McCullough","year":"2006","journal-title":"J Clin Gastroenterol."},{"key":"10.4158\/EP.13.3.300_bb0105","series-title":"Fatty Liver Disease: NASH and Related Disorders","first-page":"23","article-title":"The epidemiology and risk factors of NASH","author":"McCullough","year":"2005"},{"key":"10.4158\/EP.13.3.300_bb0110","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0016-5085(99)70506-8","article-title":"Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity","volume":"116","author":"Matteoni","year":"1999","journal-title":"Gastroenterology."},{"key":"10.4158\/EP.13.3.300_bb0115","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/jhep.2003.50320","article-title":"Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C","volume":"38","author":"Hui","year":"2003","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0120","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1053\/jhep.2002.33324","article-title":"Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis","volume":"35","author":"Ratziu","year":"2002","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0125","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S1542-3565(04)00014-X","article-title":"Nonalcoholic fatty liver disease in patients with type 2 diabetes [erratum in Clin Gastroenterol Hepatol. 2004;2:522]","volume":"2","author":"Younossi","year":"2004","journal-title":"Clin Gastroenterol Hepatol."},{"key":"10.4158\/EP.13.3.300_bb0130","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/hep.20672","article-title":"Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy","volume":"41","author":"Javor","year":"2005","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0135","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1111\/j.1572-0241.2001.04667.x","article-title":"Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease","volume":"96","author":"Willner","year":"2001","journal-title":"Am J Gastroenterol."},{"key":"10.4158\/EP.13.3.300_bb0140","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/hep.1840120505","article-title":"Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors","volume":"12","author":"Wanless","year":"1990","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0145","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jhep.2004.09.012","article-title":"The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies","volume":"42","author":"Adams","year":"2005","journal-title":"J Hepatol."},{"key":"10.4158\/EP.13.3.300_bb0150","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1053\/j.gastro.2005.04.014","article-title":"The natural history of nonalcoholic fatty liver disease: a population-based cohort study","volume":"129","author":"Adams","year":"2005","journal-title":"Gastroenterology."},{"key":"10.4158\/EP.13.3.300_bb0155","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/hep.20092","article-title":"Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized trial","volume":"39","author":"Lindor","year":"2004","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0160","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S1542-3565(04)00462-8","article-title":"Treatment of nonalcoholic steatohepatitis: antioxidants or insulin sensitizers?","volume":"2","author":"Adams","year":"2004","journal-title":"Clin Gastroenterol Hepatol."},{"key":"10.4158\/EP.13.3.300_bb0165","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0002-9343(03)00449-2","article-title":"Is weight reduction an effective therapy for nonalcoholic fatty liver? A systematic review","volume":"115","author":"Wang","year":"2003","journal-title":"Am J Med."},{"key":"10.4158\/EP.13.3.300_bb0170","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa060326","article-title":"A placebocontrolled trial of pioglitazone in subjects with nonalcoholic steatohepatitis","volume":"355","author":"Belfort","year":"2006","journal-title":"N Engl J Med."},{"key":"10.4158\/EP.13.3.300_bb0175","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/sj.ijo.0800571","article-title":"Liver abnormalities in severely obese subjects: effect of drastic weight loss after gastroplasty","volume":"22","author":"Luyckx","year":"1998","journal-title":"Int J Obes Relat Metab Disord."},{"key":"10.4158\/EP.13.3.300_bb0180","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/0168-8278(91)90942-5","article-title":"Hepatic effects of dietary weight loss in morbidly obese subjects","volume":"12","author":"Andersen","year":"1991","journal-title":"J Hepatol."},{"key":"10.4158\/EP.13.3.300_bb0185","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nm1421","article-title":"CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis","volume":"12","author":"Teixeira-Clerc","year":"2006","journal-title":"Nat Med."},{"key":"10.4158\/EP.13.3.300_bb0190","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0140-6736(01)06042-1","article-title":"Metformin in non-alcoholic steatohepatitis","volume":"358","author":"Marchesini","year":"2001","journal-title":"Lancet."},{"key":"10.4158\/EP.13.3.300_bb0195","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2036.2004.02025.x","article-title":"Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial","volume":"20","author":"Nair","year":"2004","journal-title":"Aliment Pharmacol Ther."},{"key":"10.4158\/EP.13.3.300_bb0200","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1056\/NEJMe068232","article-title":"Thiazolidinediones for nonalcoholic steatohepatitis\u2014promising but not ready for prime time","volume":"355","author":"McCullough","year":"2006","journal-title":"N Engl J Med."},{"key":"10.4158\/EP.13.3.300_bb0205","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/hep.20012","article-title":"A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis","volume":"39","author":"Promrat","year":"2004","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0210","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0168-8278(03)00027-8","article-title":"Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity, amino-transferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis","volume":"38","author":"Neuschwander-Tetri","year":"2003","journal-title":"J Hepatol."},{"key":"10.4158\/EP.13.3.300_bb0215","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S1542-3565(04)00457-4","article-title":"A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis","volume":"2","author":"Sanyal","year":"2004","journal-title":"Clin Gastroenterol Hepatol."},{"key":"10.4158\/EP.13.3.300_bb0220","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.2337\/diabetes.53.8.2169","article-title":"Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes","volume":"53","author":"Tiikkainen","year":"2004","journal-title":"Diabetes."},{"key":"10.4158\/EP.13.3.300_bb0225","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bbrc.2004.01.038","article-title":"Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet","volume":"315","author":"Kawaguchi","year":"2004","journal-title":"Biochem Biophys Res Commun."},{"issue":"Suppl 2","key":"10.4158\/EP.13.3.300_bb0230","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1365-2036.2005.02596.x","article-title":"Review article: non-alcoholic fatty liver disease and hepatitis C\u2014risk factors and clinical implications","volume":"22","author":"Sanyal","year":"2005","journal-title":"Aliment Pharmacol Ther."},{"key":"10.4158\/EP.13.3.300_bb0235","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1002\/hep.21429","article-title":"Fibrosis in genotype 3 chronic hepatitis C and nonalcoholic fatty liver disease: role of insulin resistance and hepatic steatosis","volume":"44","author":"Bugianesi","year":"2006","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0240","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1136\/gut.2004.050302","article-title":"Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C","volume":"54","author":"Fartoux","year":"2005","journal-title":"Gut."},{"key":"10.4158\/EP.13.3.300_bb0245","first-page":"135","article-title":"Non-alcoholic fatty liver disease and hepatitis C infection","volume":"52","author":"Bondini","year":"2006","journal-title":"Minerva Gastroenterol Dietol."},{"issue":"6B","key":"10.4158\/EP.13.3.300_bb0250","doi-asserted-by":"crossref","first-page":"2S","DOI":"10.1016\/S0002-9343(99)00373-3","article-title":"Epidemiology of hepatitis C in the United States","volume":"107","author":"Williams","year":"1999","journal-title":"Am J Med."},{"key":"10.4158\/EP.13.3.300_bb0255","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.2337\/diacare.28.10.2548","article-title":"Hepatitis C virus infection: evidence for an association with type 2 diabetes","volume":"28","author":"Antonelli","year":"2005","journal-title":"Diabetes Care."},{"key":"10.4158\/EP.13.3.300_bb0260","doi-asserted-by":"crossref","first-page":"592","DOI":"10.7326\/0003-4819-133-8-200010170-00009","article-title":"Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States","volume":"133","author":"Mehta","year":"2000","journal-title":"Ann Intern Med."},{"key":"10.4158\/EP.13.3.300_bb0265","first-page":"335","article-title":"Changes in glucose tolerance after interferon-alpha therapy in patients with chronic hepatitis C","volume":"28","author":"Tanaka","year":"1997","journal-title":"J Med."},{"key":"10.4158\/EP.13.3.300_bb0270","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.510290235","article-title":"Association of diabetes mellitus and chronic hepatitis C virus infection","volume":"29","author":"Mason","year":"1999","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0275","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0168-8227(99)00135-7","article-title":"Increased frequency of HCV and HBV infection in type 2 diabetic patients","volume":"48","author":"Sangiorgio","year":"2000","journal-title":"Diabetes Res Clin Pract."},{"key":"10.4158\/EP.13.3.300_bb0280","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/hep.510300416","article-title":"Further evidence for an association between non-insulin-dependent diabetes mellitus and chronic hepatitis C virus infection","volume":"30","author":"Caronia","year":"1999","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/qjmed\/hci001","article-title":"TNF-{alpha}, chronic hepatitis C and diabetes: a novel triad","volume":"98","author":"Knobler","year":"2005","journal-title":"QJM."},{"key":"10.4158\/EP.13.3.300_bb0290","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2337\/diacare.27.5.1171","article-title":"High prevalence of glucose abnormalities in patients with hepatitis C virus infection: a multivariate analysis considering the liver injury","volume":"27","author":"Lecube","year":"2004","journal-title":"Diabetes Care."},{"key":"10.4158\/EP.13.3.300_bb0295","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jinf.2004.06.001","article-title":"Prevalence of diabetes mellitus and dyslipidemia among antiretroviral naive patients co-infected with hepatitis C virus (HCV) and HIV-1 compared to patients without co-infection","volume":"50","author":"Visnegarwala","year":"2005","journal-title":"J Infect."},{"key":"10.4158\/EP.13.3.300_bb0300","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S0168-8278(05)80631-2","article-title":"Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population","volume":"21","author":"Allison","year":"1994","journal-title":"J Hepatol."},{"key":"10.4158\/EP.13.3.300_bb0305","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1365-2893.1996.tb00081.x","article-title":"Autoimmunity in hepatitis C and D virus infection","volume":"3","author":"Strassburg","year":"1996","journal-title":"J Viral Hepat."},{"key":"10.4158\/EP.13.3.300_bb0310","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1464-5491.2005.01412.x","article-title":"Hepatitis C virus infection-related type 1 diabetes mellitus","volume":"22","author":"Chen","year":"2005","journal-title":"Diabet Med."},{"key":"10.4158\/EP.13.3.300_bb0315","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-2893.2005.00669.x","article-title":"Hepatitis C and steatosis: a reappraisal","volume":"13","author":"Lonardo","year":"2006","journal-title":"J Viral Hepat."},{"key":"10.4158\/EP.13.3.300_bb0320","first-page":"125","article-title":"Steatosis, insulin resistance and fibrosis progression in chronic hepatitis C","volume":"52","author":"Castera","year":"2006","journal-title":"Minerva Gastroenterol Dietol."},{"key":"10.4158\/EP.13.3.300_bb0325","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1185\/030079905X38141","article-title":"Elevated serum tumor necrosis factor alpha and ferritin may contribute to the insulin resistance found in HCV positive Egyptian patients","volume":"21","author":"Elsammak","year":"2005","journal-title":"Curr Med Res Opin."},{"key":"10.4158\/EP.13.3.300_bb0330","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1182\/asheducation-2006.1.36","article-title":"Current approaches to the management of hemochromatosis","author":"Brissot","year":"2006","journal-title":"Hematology Am Soc Hematol Educ Program."},{"key":"10.4158\/EP.13.3.300_bb0335","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1182\/asheducation-2006.1.29","article-title":"Hepcidin and its role in regulating systemic iron metabolism","author":"Ganz","year":"2006","journal-title":"Hematology Am Soc Hematol Educ Program."},{"key":"10.4158\/EP.13.3.300_bb0340","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00062752-200503000-00001","article-title":"Anemia of inflammation: the hepcidin link","volume":"12","author":"Roy","year":"2005","journal-title":"Curr Opin Hematol."},{"key":"10.4158\/EP.13.3.300_bb0345","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S1542-3565(05)00607-5","article-title":"Hemochromatosis: genetic testing and clinical practice","volume":"3","author":"Zoller","year":"2005","journal-title":"Clin Gastroenterol Hepatol."},{"key":"10.4158\/EP.13.3.300_bb0350","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1055\/s-2005-923310","article-title":"Clinical aspects of hemochromatosis","volume":"25","author":"O\u2019Neil","year":"2005","journal-title":"Semin Liver Dis."},{"key":"10.4158\/EP.13.3.300_bb0355","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s00125-006-0200-0","article-title":"High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis","volume":"49","author":"McClain","year":"2006","journal-title":"Diabetologia."},{"key":"10.4158\/EP.13.3.300_bb0360","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1007\/s00125-006-0445-7","article-title":"Increased insulin secretory capacity but decreased insulin sensitivity after correction of iron overload by phlebotomy in hereditary haemochromatosis","volume":"49","author":"Abraham","year":"2006","journal-title":"Diabetologia."},{"key":"10.4158\/EP.13.3.300_bb0365","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/BF00262217","article-title":"Hyperinsulinaemia in non-cirrhotic haemochromatosis: impaired hepatic insulin degradation?","volume":"26","author":"Niederau","year":"1984","journal-title":"Diabetologia."},{"key":"10.4158\/EP.13.3.300_bb0370","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0140-6736(96)06034-5","article-title":"A new syndrome of liver iron overload with normal transferrin saturation","volume":"349","author":"Moirand","year":"1997","journal-title":"Lancet."},{"key":"10.4158\/EP.13.3.300_bb0375","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/hep.1840180411","article-title":"Genetic predispositions for the immunological features of chronic active hepatitis","volume":"18","author":"Czaja","year":"1993","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0380","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0016-5085(98)70484-6","article-title":"Two cytochromes P450 are major hepatocellular autoantigens in autoimmune polyglandular syndrome type 1","volume":"114","author":"Clemente","year":"1998","journal-title":"Gastroenterology."},{"key":"10.4158\/EP.13.3.300_bb0385","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/S0016-5085(00)70034-5","article-title":"Hepatogenous diabetes: reduced insulin sensitivity and increased awareness","volume":"119","author":"Blendis","year":"2000","journal-title":"Gastroenterology."},{"key":"10.4158\/EP.13.3.300_bb0390","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1007\/BF01300198","article-title":"Insulin resistance is the main determinant of impaired glucose tolerance in patients with liver cirrhosis","volume":"32","author":"Marchesini","year":"1987","journal-title":"Dig Dis Sci."},{"key":"10.4158\/EP.13.3.300_bb0395","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/hep.510310320","article-title":"Contribution of reduced insulin sensitivity and secretion to the pathogenesis of hepatogenous diabetes: effect of liver transplantation","volume":"31","author":"Perseghin","year":"2000","journal-title":"Hepatology."},{"key":"10.4158\/EP.13.3.300_bb0400","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1365-2265.1984.tb01408.x","article-title":"Hyperinsulinaemia and insulin resistance of cirrhosis: the importance of insulin hypersecretion","volume":"21","author":"Proietto","year":"1984","journal-title":"Clin Endocrinol (Oxf)."},{"key":"10.4158\/EP.13.3.300_bb0405","first-page":"265","article-title":"Low insulin secretion in decompensated liver cirrhosis with diabetes mellitus","volume":"31","author":"Sampelean","year":"1993","journal-title":"Rom J Intern Med."},{"key":"10.4158\/EP.13.3.300_bb0410","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF00400692","article-title":"Insulin sensitivity, insulin secretion and glucose effectiveness in diabetic and non-diabetic cirrhotic patients","volume":"36","author":"Kruszynska","year":"1993","journal-title":"Diabetologia."},{"key":"10.4158\/EP.13.3.300_bb0415","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1097\/00007890-200006150-00043","article-title":"Liver transplantation improves cirrhosis-associated impaired oral glucose tolerance","volume":"69","author":"Shetty","year":"2000","journal-title":"Transplantation."},{"key":"10.4158\/EP.13.3.300_bb0420","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1007\/BF02071404","article-title":"Prevalence of gallbladder disease in diabetes mellitus","volume":"41","author":"Chapman","year":"1996","journal-title":"Dig Dis Sci."},{"key":"10.4158\/EP.13.3.300_bb0425","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0301-5629(89)90185-3","article-title":"Gallbladder emptying in diabetic patients and control subjects assessed by real-time ultrasonography and cholescintigraphy: a methodological comparison","volume":"15","author":"Kronert","year":"1989","journal-title":"Ultrasound Med Biol."},{"key":"10.4158\/EP.13.3.300_bb0430","first-page":"981","article-title":"Gallbladder function and plasma cholecystokinin levels in diabetes mellitus","volume":"85","author":"Mitsukawa","year":"1990","journal-title":"Am J Gastroenterol."},{"key":"10.4158\/EP.13.3.300_bb0435","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archinte.1993.00410090019003","article-title":"Management of gallstones in diabetic patients","volume":"153","author":"Aucott","year":"1993","journal-title":"Arch Intern Med."},{"key":"10.4158\/EP.13.3.300_bb0440","first-page":"945","article-title":"Diabetes mellitus and primary hepatocellular carcinoma","volume":"61","author":"Lawson","year":"1986","journal-title":"Q J Med."},{"key":"10.4158\/EP.13.3.300_bb0445","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1093\/jnci\/88.20.1472","article-title":"Excess risk of primary liver cancer in patients with diabetes mellitus","volume":"88","author":"Adami","year":"1996","journal-title":"J Natl Cancer Inst."},{"key":"10.4158\/EP.13.3.300_bb0450","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1093\/jnci\/89.18.1360","article-title":"Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark","volume":"89","author":"Wideroff","year":"1997","journal-title":"J Natl Cancer Inst."},{"key":"10.4158\/EP.13.3.300_bb0455","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/dmrr.214","article-title":"Prospective study of diabetes mellitus and liver cancer in Japan","volume":"17","author":"Fujino","year":"2001","journal-title":"Diabetes Metab Res Rev."},{"key":"10.4158\/EP.13.3.300_bb0460","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1053\/j.gastro.2003.10.065","article-title":"Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma","volume":"126","author":"El-Serag","year":"2004","journal-title":"Gastroenterology."},{"key":"10.4158\/EP.13.3.300_bb0465","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1136\/gut.2004.052167","article-title":"Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study","volume":"54","author":"Davila","year":"2005","journal-title":"Gut."},{"key":"10.4158\/EP.13.3.300_bb0470","first-page":"1986","article-title":"Concerted nonsyntenic allelic losses in hyperploid hepatocellular carcinoma as determined by a high-resolution allelotype","volume":"57","author":"Boige","year":"1997","journal-title":"Cancer Res."},{"key":"10.4158\/EP.13.3.300_bb0475","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00125-005-0074-6","article-title":"Troglitazone: the lesson that nobody learned?","volume":"49","author":"Gale","year":"2006","journal-title":"Diabetologia."},{"key":"10.4158\/EP.13.3.300_bb0480","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2337\/diacare.25.5.815","article-title":"Evaluation of liver function in type 2 diabetic patients during clinical trials: evidence that rosiglitazone does not cause hepatic dysfunction","volume":"25","author":"Lebovitz","year":"2002","journal-title":"Diabetes Care."},{"key":"10.4158\/EP.13.3.300_bb0485","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.2337\/diacare.22.12.2067","article-title":"Frequency of liver disease in type 2 diabetic patients treated with oral antidiabetic agents","volume":"22","author":"Jick","year":"1999","journal-title":"Diabetes Care."},{"key":"10.4158\/EP.13.3.300_bb0490","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/BF02582093","article-title":"Favorable effects of glibenclamide in a patient exhibiting idiosyncratic hepatotoxic reactions to both chlorpropamide and tolbutamide","volume":"21","author":"Rumboldt","year":"1984","journal-title":"Acta Diabetol Lat."},{"key":"10.4158\/EP.13.3.300_bb0495","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/BF02093822","article-title":"Granulomatous hepatitis associated with glyburide","volume":"41","author":"Saw","year":"1996","journal-title":"Dig Dis Sci"},{"key":"10.4158\/EP.13.3.300_bb0500","first-page":"306","article-title":"Hypersensitivity vasculitis and granulomatous hepatitis induced by glibenclamide: a case report [author\u2019s translation] [article in Spanish]","volume":"75","author":"Ingelmo","year":"1980","journal-title":"Med Clin (Barc)"},{"key":"10.4158\/EP.13.3.300_bb0505","first-page":"305","article-title":"Glyburide-induced cholestatic hepatitis and liver failure: case-report and review of the literature","volume":"40","author":"van Basten","year":"1992","journal-title":"Neth J Med."},{"key":"10.4158\/EP.13.3.300_bb0510","doi-asserted-by":"crossref","first-page":"931","DOI":"10.7326\/0003-4819-124-10-199605150-00030","article-title":"Hepatic injury caused by acarbose","volume":"124","author":"Andrade","year":"1996","journal-title":"Ann Intern Med."},{"key":"10.4158\/EP.13.3.300_bb0515","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.2337\/diacare.21.11.2029","article-title":"Acarbose-associated hepatotoxicity","volume":"21","author":"Andrade","year":"1998","journal-title":"Diabetes Care."},{"key":"10.4158\/EP.13.3.300_bb0520","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0140-6736(05)78337-9","article-title":"Acarbose-induced hepatic injury","volume":"351","author":"Fujimoto","year":"1998","journal-title":"Lancet."},{"key":"10.4158\/EP.13.3.300_bb0525","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0140-6736(05)60134-1","article-title":"Acarbose-induced acute severe hepatotoxicity","volume":"349","author":"Carrascosa","year":"1997","journal-title":"Lancet."},{"key":"10.4158\/EP.13.3.300_bb0530","first-page":"1398","article-title":"Acarbose-induced acute hepatitis [article in French]","volume":"23","author":"Mennecier","year":"1999","journal-title":"Gastroenterol Clin Biol."}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20418403?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20418403?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/aace.metapress.com\/index\/274721023V710X37.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:47:44Z","timestamp":1761515264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X20418403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":106,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S1530891X20418403"],"URL":"https:\/\/doi.org\/10.4158\/ep.13.3.300","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Multifaceted Associations of Hepatobiliary Disease and Diabetes","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.4158\/EP.13.3.300","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}