{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:15:56Z","timestamp":1761743756356,"version":"build-2065373602"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1996,1,1]],"date-time":"1996-01-01T00:00:00Z","timestamp":820454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1996,1,1]],"date-time":"1996-01-01T00:00:00Z","timestamp":820454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[1996,1]]},"DOI":"10.4158\/ep.2.1.4","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T23:23:44Z","timestamp":1365204224000},"page":"4-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Hypogonadism and Methadone: Hypothalamic Hypogonadism after Long-Term use of High-Dose Methadone"],"prefix":"10.1016","volume":"2","author":[{"given":"Raymond E.","family":"de la Rosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James V.","family":"Hennessey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.4158\/EP.2.1.4_bb0005","first-page":"1970","article-title":"Methadone maintained patients","volume":"74","author":"Cushman","year":"1974","journal-title":"N Y State J Med."},{"key":"10.4158\/EP.2.1.4_bb0010","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000180040","article-title":"Effects of dopamine receptor stimulation on opiate-induced modifications of pituitary-gonadal function","volume":"21","author":"Vescovi","year":"1985","journal-title":"Horm Res."},{"key":"10.4158\/EP.2.1.4_bb0015","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0376-8716(81)90066-1","article-title":"Hormone levels in methadone treated drug addicts","volume":"8","author":"Lafisca","year":"1981","journal-title":"Drug Alcohol Depend."},{"key":"10.4158\/EP.2.1.4_bb0020","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1176\/ajp.137.8.909","article-title":"Opiate use and sexual function","volume":"137","author":"Mirin","year":"1980","journal-title":"Am J Psychiatry."},{"key":"10.4158\/EP.2.1.4_bb0025","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1001\/archpsyc.1973.01750320112017","article-title":"Methadone-a reevaluation","volume":"28","author":"Martin","year":"1973","journal-title":"Arch Gen Psychiatry."},{"key":"10.4158\/EP.2.1.4_bb0030","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2605.1988.tb00984.x","article-title":"Gonadal function in male heroin and methadone addicts","volume":"11","author":"Ragni","year":"1988","journal-title":"Int J Androl."},{"key":"10.4158\/EP.2.1.4_bb0035","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1056\/NEJM197504242921703","article-title":"Function of the male sex organs in heroin and methadone users","volume":"292","author":"Cicero","year":"1975","journal-title":"N Engl J Med."},{"key":"10.4158\/EP.2.1.4_bb0040","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1056\/NEJM197411142912003","article-title":"Plasma testosterone levels before, during and after chronic marijuana smoking","volume":"291","author":"Mendelson","year":"1974","journal-title":"N Engl J Med."},{"key":"10.4158\/EP.2.1.4_bb0045","first-page":"1193","article-title":"Further studies on the effects of heroin addiction on the hypothalamic-pituitary-gonadal function in man","volume":"16","author":"Celani","year":"1984","journal-title":"Pharmacol Res."},{"key":"10.4158\/EP.2.1.4_bb0050","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-3565(25)30047-9","article-title":"Plasma testosterone levels in heroin addiction and during methadone maintenance","volume":"192","author":"Mendelson","year":"1975","journal-title":"J Pharmacol Exp Ther."},{"key":"10.4158\/EP.2.1.4_bb0055","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000123558","article-title":"Differential effects of opiate peptides and alkaloids on anterior pituitary hormone secretion","volume":"37","author":"Delitalia","year":"1983","journal-title":"Neuroendocrinology."},{"key":"10.4158\/EP.2.1.4_bb0060","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0022-3565(25)23334-1","article-title":"Effect of chronic methadone administration on neuroendocrine function in young adult rats","volume":"234","author":"Kuhn","year":"1985","journal-title":"J Pharmacol Exp Ther."},{"key":"10.4158\/EP.2.1.4_bb0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1210\/edrv-9-1-3","article-title":"Contemporary aspects of discrete peak-detection algorithms. I. The paradigm of the luteinizing hormone pulse signal in men","volume":"9","author":"Urban","year":"1988","journal-title":"Endocr Rev."},{"key":"10.4158\/EP.2.1.4_bb0070","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0306-4530(87)90080-1","article-title":"Acute ethanol administration enhances plasma testosterone levels following gonadotropin stimulation in men","volume":"12","author":"Phipps","year":"1987","journal-title":"Psychoneuroendocrinology."},{"key":"10.4158\/EP.2.1.4_bb0075","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0025-6196(12)61397-4","article-title":"Laboratory diagnosis of hypopituitarism","volume":"61","author":"Abboud","year":"1986","journal-title":"Mayo Clin Proc."},{"key":"10.4158\/EP.2.1.4_bb0080","first-page":"46","article-title":"Effects of marijuana in the male: preclinical studies","volume":"44","author":"Harclerode","year":"1984","journal-title":"NIDA Res Monogr."},{"key":"10.4158\/EP.2.1.4_bb0085","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/bmj.295.6595.403","article-title":"Mechanisms leading to hypogonadism in men with burn injuries","volume":"295","author":"Semple","year":"1987","journal-title":"BMJ."},{"key":"10.4158\/EP.2.1.4_bb0090","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000180803","article-title":"Central hypogonadism in burned men","volume":"27","author":"Plymate","year":"1987","journal-title":"Horm Res."},{"key":"10.4158\/EP.2.1.4_bb0095","series-title":"Williams Textbook of Endocrinology","first-page":"158","article-title":"Neuroendocrinology","author":"Reichlin","year":"1992"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20412686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20412686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/aace.metapress.com\/index\/86WGYC5AFV1G0R1T.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:17:00Z","timestamp":1761517020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X20412686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["S1530891X20412686"],"URL":"https:\/\/doi.org\/10.4158\/ep.2.1.4","relation":{},"ISSN":["1530-891X"],"issn-type":[{"type":"print","value":"1530-891X"}],"subject":[],"published":{"date-parts":[[1996,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypogonadism and Methadone: Hypothalamic Hypogonadism after Long-Term use of High-Dose Methadone","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.4158\/EP.2.1.4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1996 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}