{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:37:03Z","timestamp":1765960623485,"version":"build-2065373602"},"reference-count":71,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.4158\/ep09083.rar","type":"journal-article","created":{"date-parts":[[2009,5,20]],"date-time":"2009-05-20T21:20:03Z","timestamp":1242854403000},"page":"475-482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Polycystic Ovary Syndrome, Depression, and Affective Disorders"],"prefix":"10.1016","volume":"15","author":[{"given":"Suzette C.","family":"Bishop","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Basch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Futterweit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.4158\/EP09083.RAR_bb0005","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population","volume":"89","author":"Azziz","year":"2004","journal-title":"J Clin Endocrinol Metab."},{"key":"10.4158\/EP09083.RAR_bb0010","first-page":"165","article-title":"Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women","volume":"84","author":"Legro","year":"1999","journal-title":"J Clin Endocrinol Metab."},{"key":"10.4158\/EP09083.RAR_bb0015","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2337\/diacare.22.1.141","article-title":"Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome","volume":"22","author":"Ehrmann","year":"1999","journal-title":"Diabetes Care."},{"key":"10.4158\/EP09083.RAR_bb0020","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.pop.2007.07.004","article-title":"Polycystic ovary syndrome: a common reproductive and metabolic disorder necessitating early recognition and treatment","volume":"34","author":"Futterweit","year":"2007","journal-title":"Prim Care."},{"key":"10.4158\/EP09083.RAR_bb0025","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/humrep\/15.4.785","article-title":"Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension and coronary artery disease in perimenopausal women with a history of the polycystic ovary syndrome","volume":"15","author":"Cibula","year":"2000","journal-title":"Hum Reprod."},{"key":"10.4158\/EP09083.RAR_bb0030","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/jc.2006-0178","article-title":"(Androgen Excess Society). Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome; an Androgen Excess Society guideline","volume":"91","author":"Azziz","year":"2006","journal-title":"J Clin Endocrinol Metab."},{"key":"10.4158\/EP09083.RAR_bb0035","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.fertnstert.2006.11.039","article-title":"Increased risk of depressive disorders in women with polycystic ovary syndrome","volume":"87","author":"Hollinrake","year":"2007","journal-title":"Fertil Steril."},{"key":"10.4158\/EP09083.RAR_bb0040","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.fertnstert.2007.11.022","article-title":"Risk of depression and other mental health disorders in women with polycystic ovary syndrome: a longitudinal study","volume":"91","author":"Kerchner","year":"2009","journal-title":"Fertil Steril."},{"key":"10.4158\/EP09083.RAR_bb0045","first-page":"356","article-title":"Androgens and mood dysfunction in women: comparison of women with polycystic ovarian syndrome to healthy controls","volume":"66","author":"Weiner","year":"2004","journal-title":"Psychosom Med."},{"key":"10.4158\/EP09083.RAR_bb0050","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.psyneuen.2008.06.003","article-title":"Women with polycystic ovary syndrome are often depressed or anxious\u2014a case control study","volume":"33","author":"M\u00e5nsson","year":"2008","journal-title":"Psychoneuroendocrinology."},{"key":"10.4158\/EP09083.RAR_bb0055","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0277-9536(01)00034-X","article-title":"\u201cThe thief of womanhood\u201d: women\u2019s experience of polycystic ovarian syndrome","volume":"54","author":"Kitzinger","year":"2002","journal-title":"Soc Sci Med."},{"key":"10.4158\/EP09083.RAR_bb0060","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.2337\/dc08-0175","article-title":"Depression: an important comorbidity with metabolic syndrome in a general population","volume":"31","author":"Dunbar","year":"2008","journal-title":"Diabetes Care."},{"key":"10.4158\/EP09083.RAR_bb0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Fertil Steril."},{"key":"10.4158\/EP09083.RAR_bb0070","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1126\/science.7638596","article-title":"Depression in women: implications for health care research","volume":"269","author":"Weissman","year":"1995","journal-title":"Science."},{"key":"10.4158\/EP09083.RAR_bb0075","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jad.2006.01.011","article-title":"Screening for bipolar disorder in women with polycystic ovary syndrome: a pilot study [published correction appears in J Affect Disord. 2007;97:277]","volume":"91","author":"Klipstein","year":"2006","journal-title":"J Affect Disord."},{"key":"10.4158\/EP09083.RAR_bb0080","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3109\/01674829309084434","article-title":"Polycystic ovary syndrome and psychiatric morbidity","volume":"14","author":"Bruce-Jones","year":"1993","journal-title":"J Psychosom Obstet Gynaecol."},{"key":"10.4158\/EP09083.RAR_bb0085","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1093\/humrep\/dem108","article-title":"Quality of life and psychological well being in polycystic ovary syndrome","volume":"22","author":"Barnard","year":"2007","journal-title":"Hum Reprod."},{"key":"10.4158\/EP09083.RAR_bb0090","series-title":"Contemporary Endocrinology: Androgen Excess Disorders in Women; Polycystic Ovary Syndrome and Other Disorders","first-page":"343","article-title":"Psychosocial and quality-of-life consequences of androgen excess and the polycystic ovary syndrome","author":"Janssen","year":"2006"},{"key":"10.4158\/EP09083.RAR_bb0095","doi-asserted-by":"crossref","first-page":"5801","DOI":"10.1210\/jc.2003-030562","article-title":"Quality of life, psychosocial well-being, and sexual satisfaction in women with polycystic ovary syndrome","volume":"88","author":"Elsenbruch","year":"2003","journal-title":"J Clin Endocrinol Metab."},{"key":"10.4158\/EP09083.RAR_bb0100","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/01.ogx.0000243772.33357.84","article-title":"Polycystic ovary syndrome and mental health: a review","volume":"61","author":"Himelein","year":"2006","journal-title":"Obstet Gynecol Surv."},{"key":"10.4158\/EP09083.RAR_bb0105","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/1359105306065021","article-title":"Depression and body image among women with polycystic ovary syndrome","volume":"11","author":"Himelein","year":"2006","journal-title":"J Health Psychol."},{"key":"10.4158\/EP09083.RAR_bb0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1055\/s-2007-992924","article-title":"Mood and sexual function in polycystic ovary syndrome","volume":"26","author":"Janssen","year":"2008","journal-title":"Semin Reprod Med."},{"key":"10.4158\/EP09083.RAR_bb0115","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2265.2007.02742.x","article-title":"Quality of life and psychological morbidity in women with polycystic ovary syndrome: body mass index, age and the provision of patient information are significant modifiers","volume":"66","author":"Ching","year":"2007","journal-title":"Clin Endocrinol (Oxf)."},{"key":"10.4158\/EP09083.RAR_bb0120","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1093\/humrep\/dei409","article-title":"Determinants of emotional distress in women with polycystic ovary syndrome","volume":"21","author":"Elsenbruch","year":"2006","journal-title":"Hum Reprod."},{"key":"10.4158\/EP09083.RAR_bb0125","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1067\/mob.2000.106580","article-title":"Validity and utility of the PRIME-MD Patient Health Questionnaire in assessment of 3000 obstetric-gynecologic patients: the PRIME-MD Patient Health Questionnaire Obstetrics-Gynecology Study","volume":"183","author":"Spitzer","year":"2000","journal-title":"Am J Obstet Gynecol."},{"key":"10.4158\/EP09083.RAR_bb0130","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0165-0327(02)00117-9","article-title":"Depression in women with polycystic ovary syndrome: clinical and biochemical correlates","volume":"74","author":"Rasgon","year":"2003","journal-title":"J Affect Disord."},{"key":"10.4158\/EP09083.RAR_bb0135","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/00365510802449642","article-title":"Use of combined oral contraceptives alters metabolic determinants and genetic regulation of C-reactive protein: the Cardiovascular Risk in Young Finns Study","volume":"69","author":"Haarala","year":"2009","journal-title":"Scand J Clin Lab Invest."},{"key":"10.4158\/EP09083.RAR_bb0140","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/AOG.0b013e31816a2476","article-title":"Effects of third-generation oral contraceptives on high-sensitivity C-reactive protein and homocysteine in young women","volume":"111","author":"Cauci","year":"2008","journal-title":"Obstet Gynecol."},{"key":"10.4158\/EP09083.RAR_bb0145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/humupd\/dmm030","article-title":"Health-related quality of life measurement in women with polycystic ovary syndrome: a systematic review","volume":"14","author":"Jones","year":"2008","journal-title":"Hum Reprod Update."},{"key":"10.4158\/EP09083.RAR_bb0150","first-page":"1976","article-title":"Development of a health-related quality-of-life questionnaire (PCOSQ) for women with polycystic ovary syndrome (PCOS)","volume":"83","author":"Cronin","year":"1998","journal-title":"J Clin Endocrinol Metab."},{"key":"10.4158\/EP09083.RAR_bb0155","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1530\/eje.1.02024","article-title":"Clinical and psychological correlates of quality-of-life in polycystic ovary syndrome","volume":"153","author":"Hahn","year":"2005","journal-title":"Eur J Endocrinol."},{"key":"10.4158\/EP09083.RAR_bb0160","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/eat.20527","article-title":"The prevalence of eating disorders in women with facial hirsutism: an epidemiological cohort study","volume":"41","author":"Morgan","year":"2008","journal-title":"Int J Eat Disord."},{"key":"10.4158\/EP09083.RAR_bb0165","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.fertnstert.2005.11.041","article-title":"Clinical and laboratory characteristics of adolescents with both polycystic ovary disease and anorexia nervosa","volume":"85","author":"Pinhas-Hamiel","year":"2006","journal-title":"Fertil Steril."},{"key":"10.4158\/EP09083.RAR_bb0170","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1080\/09513590600847421","article-title":"Polycystic ovary syndrome in bulimic women\u2014an evaluation based on the new diagnostic criteria","volume":"22","author":"Naess\u00e9n","year":"2006","journal-title":"Gynecol Endocrinol."},{"key":"10.4158\/EP09083.RAR_bb0175","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/09513590400002300","article-title":"Impaired cholecystokinin secretion and disturbed appetite regulation in women with polycystic ovary syndrome","volume":"19","author":"Hirschberg","year":"2004","journal-title":"Gynecol Endocrinol."},{"issue":"2 pt 1","key":"10.4158\/EP09083.RAR_bb0180","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0190-9622(92)70166-D","article-title":"Serum androgens and depression in women with facial hirsutism","volume":"27","author":"Shulman","year":"1992","journal-title":"J Am Acad Dermatol"},{"key":"10.4158\/EP09083.RAR_bb0185","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0306-4530(00)00023-8","article-title":"Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression","volume":"25","author":"Weber","year":"2000","journal-title":"Psychoneuroendocrinology."},{"key":"10.4158\/EP09083.RAR_bb0190","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1210\/jc.2007-1549","article-title":"Glucose intolerance in polycystic ovary syndrome\u2014a position statement of the Androgen Excess Society","volume":"92","author":"Salley","year":"2007","journal-title":"J Clin Endocrinol Metab."},{"key":"10.4158\/EP09083.RAR_bb0195","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1176\/ajp.145.3.325","article-title":"Insulin resistance after oral glucose tolerance testing in patients with major depression","volume":"145","author":"Winokur","year":"1988","journal-title":"Am J Psychiatry."},{"key":"10.4158\/EP09083.RAR_bb0200","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/bmj.38313.513310.F71","article-title":"Insulin resistance and depression: cross sectional study","volume":"330","author":"Timonen","year":"2005","journal-title":"BMJ."},{"key":"10.4158\/EP09083.RAR_bb0205","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1517\/14656566.8.11.1615","article-title":"Thiazolidinediones: novel treatments for cognitive deficits in mood disorders?","volume":"8","author":"McIntyre","year":"2007","journal-title":"Expert Opin Pharmacother."},{"key":"10.4158\/EP09083.RAR_bb0210","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/hup.946","article-title":"Is major depressive disorder a metabolic encephalopathy","volume":"23","author":"Harvey","year":"2008","journal-title":"Hum Psychopharmacol"},{"key":"10.4158\/EP09083.RAR_bb0215","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1053\/meta.2002.36301","article-title":"The relationship between psychological risk attributes and the metabolic syndrome in healthy women: antecedent or consequence?","volume":"51","author":"R\u00e4ikk\u00f6nen","year":"2002","journal-title":"Metabolism."},{"key":"10.4158\/EP09083.RAR_bb0220","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4088\/JCP.v69n0202","article-title":"Metabolic syndrome predisposes to depressive symptoms: a population-based 7-year follow-up study","volume":"69","author":"Koponen","year":"2008","journal-title":"J Clin Psychiatry."},{"key":"10.4158\/EP09083.RAR_bb0225","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/j.1742-1241.2007.01416.x","article-title":"Metabolic side effects of antipsychotic medication","volume":"61","author":"Tschoner","year":"2007","journal-title":"Int J Clin Pract."},{"key":"10.4158\/EP09083.RAR_bb0230","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.mcn.2007.05.009","article-title":"Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases","volume":"36","author":"Levkovitz","year":"2007","journal-title":"Mol Cell Neurosci."},{"key":"10.4158\/EP09083.RAR_bb0235","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00125-004-1641-y","article-title":"Prevalence of obesity, glucose homeostasis disorders and metabolic syndrome in psychiatric patients taking typical or atypical antipsychotic drugs: a cross-sectional study","volume":"48","author":"Mackin","year":"2005","journal-title":"Diabetologia."},{"key":"10.4158\/EP09083.RAR_bb0240","first-page":"126","article-title":"American Association of Clinical Endocrinologists position statement on metabolic and cardiovascular consequences of polycystic ovary syndrome","volume":"11","author":"American Association of Clinical Endocrinologists Polycystic Ovary Syndrome Writing Committee","year":"2005","journal-title":"Endocr Pract."},{"key":"10.4158\/EP09083.RAR_bb0245","doi-asserted-by":"crossref","first-page":"25","DOI":"10.7326\/0003-4819-137-1-200207020-00009","article-title":"Metformin: an update","volume":"137","author":"Kirpichnikov","year":"2002","journal-title":"Ann Intern Med."},{"key":"10.4158\/EP09083.RAR_bb0250","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ajog.2008.09.010","article-title":"Use of metformin in polycystic ovary syndrome","volume":"199","author":"Mathur","year":"2008","journal-title":"Am J Obstet Gynecol."},{"key":"10.4158\/EP09083.RAR_bb0255","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/humrep\/del069","article-title":"Metformin treatment of polycystic ovary syndrome improves health-related quality-of-life, emotional distress and sexuality","volume":"21","author":"Hahn","year":"2006","journal-title":"Hum Reprod."},{"key":"10.4158\/EP09083.RAR_bb0260","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1001\/jama.2007.56-b","article-title":"Lifestyle intervention and metformin for treatment of antipsychotic-induced weight gain: a randomized controlled trial","volume":"299","author":"Wu","year":"2008","journal-title":"JAMA."},{"key":"10.4158\/EP09083.RAR_bb0265","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1126\/science.1160794","article-title":"A stress signaling pathway in adipose tissue regulates hepatic insulin resistance","volume":"322","author":"Sabio","year":"2008","journal-title":"Science."},{"key":"10.4158\/EP09083.RAR_bb0270","first-page":"4","article-title":"Recent advances in the relationship between obesity, inflammation, and insulin resistance","volume":"17","author":"Bastard","year":"2006","journal-title":"Eur Cytokine Netw."},{"key":"10.4158\/EP09083.RAR_bb0275","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1126\/science.1167571","article-title":"Cell signaling: fat stress and liver resistance","volume":"322","author":"Ogawa","year":"2008","journal-title":"Science."},{"key":"10.4158\/EP09083.RAR_bb0280","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1139\/jpn.0902","article-title":"Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder","volume":"34","author":"Anisman","year":"2009","journal-title":"J Psychiatry Neurosci."},{"key":"10.4158\/EP09083.RAR_bb0285","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat Rev Neurosci."},{"key":"10.4158\/EP09083.RAR_bb0290","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.it.2005.11.006","article-title":"Cytokines sing the blues: inflammation and the pathogenesis of depression","volume":"27","author":"Raison","year":"2006","journal-title":"Trends Immunol."},{"key":"10.4158\/EP09083.RAR_bb0295","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbi.2008.08.006","article-title":"Norman Cousins lecture: mechanisms of cytokine-induced behavioral changes; psychoneuroimmunology at the translational interface","volume":"23","author":"Miller","year":"2008","journal-title":"Brain Behav Immun."},{"key":"10.4158\/EP09083.RAR_bb0300","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1365-2362.2006.01712.x","article-title":"Inflammatory and endothelial markers in women with polycystic ovary syndrome","volume":"36","author":"Diamanti-Kandarakis","year":"2006","journal-title":"Eur J Clin Invest."},{"key":"10.4158\/EP09083.RAR_bb0305","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0026-0495(99)90100-2","article-title":"Elevated serum levels of tumor necrosis factor alpha in normal-weight women with polycystic ovary syndrome","volume":"48","author":"Gonzalez","year":"1999","journal-title":"Metabolism"},{"key":"10.4158\/EP09083.RAR_bb0310","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1210\/jcem.86.6.7580","article-title":"Low grade chronic inflammation in women with polycystic ovarian syndrome","volume":"86","author":"Kelly","year":"2001","journal-title":"J Clin Endocrinol Metab."},{"key":"10.4158\/EP09083.RAR_bb0315","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbi.2007.07.003","article-title":"Obesity, depression, and chronic low-grade inflammation in women with polycystic ovary syndrome","volume":"22","author":"Benson","year":"2008","journal-title":"Brain Behav Immun."},{"key":"10.4158\/EP09083.RAR_bb0320","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1161\/01.ATV.0000201938.78044.75","article-title":"Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells","volume":"26","author":"Isoda","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"10.4158\/EP09083.RAR_bb0325","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/01.HYP.0000221429.94591.72","article-title":"Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells","volume":"47","author":"Hattori","year":"2006","journal-title":"Hypertension."},{"key":"10.4158\/EP09083.RAR_bb0330","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ijcard.2008.04.010","article-title":"Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL- 6 production in endothelial cells through PI3K-dependent AMPK phosphorylation","volume":"134","author":"Huang","year":"2009","journal-title":"Int J Cardiol."},{"key":"10.4158\/EP09083.RAR_bb0335","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1210\/jc.2002-021688","article-title":"Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome","volume":"88","author":"Morin-Papunen","year":"2003","journal-title":"J Clin Endocrinol Metab."},{"key":"10.4158\/EP09083.RAR_bb0340","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1093\/humrep\/del003","article-title":"Indices of low-grade chronic inflammation in polycystic ovary syndrome and the beneficial effect of metformin","volume":"21","author":"Diamanti-Kandarakis","year":"2006","journal-title":"Hum Reprod."},{"key":"10.4158\/EP09083.RAR_bb0345","doi-asserted-by":"crossref","first-page":"529.e1","DOI":"10.1016\/j.ajog.2008.04.013","article-title":"Comparison of metabolic and inflammatory outcomes in women who used oral contraceptives and the levonor-gestrel-releasing intrauterine device in a general population","volume":"199","author":"Morin-Papunen","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.4158\/EP09083.RAR_bb0350","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1093\/humrep\/dei072","article-title":"High neutrophil count in girls and women with hyperinsulinaemic hyperandrogenism: normalization with metformin and flutamide overcomes the aggravation by oral contraception","volume":"20","author":"Ib\u00e1\u00f1ez","year":"2005","journal-title":"Hum Reprod."},{"key":"10.4158\/EP09083.RAR_bb0355","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1210\/jc.2003-031281","article-title":"Ethinylestradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity","volume":"89","author":"Ib\u00e1\u00f1ez","year":"2004","journal-title":"J Clin Endocrinol Metab."}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20411796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20411796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/aace.metapress.com\/index\/VT1333JV67053885.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:50:15Z","timestamp":1761515415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X20411796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":71,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S1530891X20411796"],"URL":"https:\/\/doi.org\/10.4158\/ep09083.rar","relation":{},"ISSN":["1530-891X"],"issn-type":[{"type":"print","value":"1530-891X"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polycystic Ovary Syndrome, Depression, and Affective Disorders","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.4158\/EP09083.RAR","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}