{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:50:25Z","timestamp":1789512625912,"version":"build-2803163510"},"reference-count":78,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.4158\/ep11061.ra","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T21:22:22Z","timestamp":1310160142000},"page":"941-948","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["The Glucocorticoid Receptor and its Expression in the Anterior Pituitary and the Adrenal Cortex: A Source of Variation in Hypothalamic-Pituitary-Adrenal Axis Function; Implications for Pituitary and Adrenal Tumors"],"prefix":"10.1016","volume":"17","author":[{"given":"George","family":"Briassoulis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetozar","family":"Damjanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Xekouki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Lefebvre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine A.","family":"Stratakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.4158\/EP11061.RA_bb0010","first-page":"173","article-title":"The pituitary corticotroph is not the rate limiting step in the postoperative recovery of the hypothalamic-pituitary-adrenal axis in patients with Cushing syndrome","volume":"77","author":"Gomez","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0015","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1371\/journal.pgen.0030094","article-title":"Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor","volume":"3","author":"So","year":"2007","journal-title":"PLoS Genet"},{"key":"10.4158\/EP11061.RA_bb0020","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1196\/annals.1321.008","article-title":"The origin and functions of multiple human glucocorticoid receptor isoforms","volume":"1024","author":"Lu","year":"2004","journal-title":"Ann NY Acad Sci"},{"key":"10.4158\/EP11061.RA_bb0025","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1210\/er.2003-0031","article-title":"11beta-Hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response","volume":"25","author":"Tomlinson","year":"2004","journal-title":"Endocr Rev"},{"key":"10.4158\/EP11061.RA_bb0030","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1210\/me.2008-0101","article-title":"Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by hexamethylene bisacetamide-inducible protein 1","volume":"22","author":"Shimizu","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.4158\/EP11061.RA_bb0035","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(03)01078-X","article-title":"Regulation of RNA polymerase II transcription by sequence-specific DNA binding factors","volume":"116","author":"Kadonaga","year":"2004","journal-title":"Cell"},{"key":"10.4158\/EP11061.RA_bb0040","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1172\/JCI116898","article-title":"Corticotropin-releasing hormone, proopiomelanocortin, and glucocorticoid receptor gene expression in adrenocorticotropin-producing tumors in vitro","volume":"92","author":"Suda","year":"1993","journal-title":"J Clin Invest"},{"key":"10.4158\/EP11061.RA_bb0045","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0303-7207(02)00280-0","article-title":"Glucocorticoid receptors and Cushing's disease","volume":"197","author":"Lamberts","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"10.4158\/EP11061.RA_bb0050","first-page":"4490","article-title":"Expression of type 2 11beta-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in early human fetal life","volume":"83","author":"Condon","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0055","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1055\/s-2005-873007","article-title":"Expression of the glucocorticoid receptor in the human adrenal cortex","volume":"114","author":"Paust","year":"2006","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.4158\/EP11061.RA_bb0060","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1210\/jc.2002-022001","article-title":"Primary pigmented nodular adrenocortical disease: paradoxical responses of cortisol secretion to dexamethasone occur in vitro and are associated with increased expression of the glucocorticoid receptor","volume":"88","author":"Bourdeau","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0065","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1210\/jc.2009-0546","article-title":"The glucocorticoid receptor is overexpressed in malignant adrenocortical tumors","volume":"94","author":"Tacon","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0070","first-page":"647","article-title":"The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states","volume":"19","author":"Newell-Price","year":"1998","journal-title":"Endocr Rev"},{"key":"10.4158\/EP11061.RA_bb0075","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1210\/jc.2008-0125","article-title":"The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline","volume":"93","author":"Nieman","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0080","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1210\/jc.2003-030207","article-title":"The low-dose dexamethasone suppression test: a reevaluation in patients with Cushing's syndrome","volume":"89","author":"Findling","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0085","doi-asserted-by":"crossref","first-page":"e575","DOI":"10.1542\/peds.2006-2402","article-title":"Diagnostic tests for children referred for the investigation of Cushing syndrome","volume":"120","author":"Batista","year":"2007","journal-title":"Pediatrics"},{"key":"10.4158\/EP11061.RA_bb0090","doi-asserted-by":"crossref","first-page":"585","DOI":"10.7326\/0003-4819-131-8-199910190-00006","article-title":"Paradoxical response to dexamethasone in the diagnosis of primary pigmented nodular adrenocortical disease","volume":"131","author":"Stratakis","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.4158\/EP11061.RA_bb0095","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1210\/jcem-48-4-660","article-title":"Virilizing adrenal adenoma stimulated by dexamethasone in a middle-aged woman","volume":"48","author":"Yotsumoto","year":"1979","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0100","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1365-2265.1989.tb01270.x","article-title":"Virilizing adrenal adenoma in an adult with the Beckwith-Wiedemann syndrome: paradoxical response to dexamethasone","volume":"31","author":"Clouston","year":"1989","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP11061.RA_bb0105","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1172\/JCI115046","article-title":"Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance","volume":"87","author":"Hurley","year":"1991","journal-title":"J Clin Invest"},{"key":"10.4158\/EP11061.RA_bb0110","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1749-6632.1994.tb39257.x","article-title":"Glucocorticosteroid resistance in humans: elucidation of the molecular mechanisms and implications for pathophysiology [with discussion]","volume":"746","author":"Stratakis","year":"1994","journal-title":"Ann NY Acad Sci"},{"key":"10.4158\/EP11061.RA_bb0115","first-page":"683","article-title":"Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene","volume":"76","author":"Karl","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0120","first-page":"124","article-title":"Nelson's syndrome associated with a somatic frame shift mutation in the glucocorticoid receptor gene","volume":"81","author":"Karl","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0125","first-page":"296","article-title":"Cushing's disease preceded by generalized glucocorticoid resistance: clinical consequences of a novel, dominant-negative glucocorticoid receptor mutation","volume":"108","author":"Karl","year":"1996","journal-title":"Proc Assoc Am Physicians"},{"key":"10.4158\/EP11061.RA_bb0130","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1530\/EJE-09-0100","article-title":"A corticotroph pituitary adenoma as the initial presentation of familial glucocorticoid deficiency","volume":"161","author":"Benoit","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP11061.RA_bb0135","first-page":"917","article-title":"Human adrenocorticotropin-secreting pituitary adenomas show frequent loss of heterozygosity at the glucocorticoid receptor gene locus","volume":"83","author":"Huizenga","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0140","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/humu.10213","article-title":"Variations of the human glucocorticoid receptor gene (NR3C1): pathological and in vitro mutations and polymorphisms","volume":"21","author":"Bray","year":"2003","journal-title":"Hum Mutat"},{"key":"10.4158\/EP11061.RA_bb0145","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s004390050425","article-title":"Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance","volume":"99","author":"Koper","year":"1997","journal-title":"Hum Genet"},{"key":"10.4158\/EP11061.RA_bb0150","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1046\/j.1365-2265.2002.01639.x","article-title":"Glucocorticoid receptor gene polymorphisms in ACTH-secreting pituitary tumours","volume":"57","author":"Antonini","year":"2002","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP11061.RA_bb0155","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1365-2265.1998.00520.x","article-title":"Low level of glucocorticoid receptor messenger ribonucleic acid in pituitary adenomas manifesting Cushing's disease with resistance to a high dose-dexamethasone suppression test","volume":"49","author":"Mu","year":"1998","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP11061.RA_bb0160","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1530\/EJE-07-0428","article-title":"Differential gene expression in ACTH-secreting and non-functioning pituitary tumors","volume":"157","author":"Tateno","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP11061.RA_bb0165","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1530\/EJE-10-0076","article-title":"Clinical, hormonal and molecular characterization of pituitary ACTH adenomas without (silent corticotroph adenomas) and with Cushing's disease","volume":"163","author":"Raverot","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP11061.RA_bb0170","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s12022-008-9052-0","article-title":"Immunohistochemical analysis of 11-beta-hydroxysteroid dehydrogenase type 2 and glucocorticoid receptor in subclinical Cushing's disease due to pituitary macroadenoma","volume":"19","author":"Ebisawa","year":"2008","journal-title":"Endocr Pathol"},{"key":"10.4158\/EP11061.RA_bb0175","first-page":"2728","article-title":"Expression of 11 beta-hydroxysteroid dehydrogenase isoenzymes in the human pituitary: induction of the type 2 enzyme in corticotropinomas and other pituitary tumors","volume":"86","author":"Korbonits","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0180","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1038\/sj.onc.1206293","article-title":"Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation","volume":"22","author":"Rabbitt","year":"2003","journal-title":"Oncogene"},{"key":"10.4158\/EP11061.RA_bb0185","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0960-0760(03)00224-3","article-title":"11beta-Hydroxysteroid dehydrogenases, cell proliferation and malignancy","volume":"85","author":"Rabbitt","year":"2003","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.4158\/EP11061.RA_bb0190","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1002\/j.1460-2075.1993.tb06112.x","article-title":"A human homologue of Saccharomyces cerevisiae SNF2\/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor","volume":"12","author":"Muchardt","year":"1993","journal-title":"EMBO J"},{"key":"10.4158\/EP11061.RA_bb0195","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1101\/gad.1444606","article-title":"Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease","volume":"20","author":"Bilodeau","year":"2006","journal-title":"Genes Dev"},{"key":"10.4158\/EP11061.RA_bb0200","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.febslet.2009.03.072","article-title":"XAP2 inhibits glucocorticoid receptor activity in mammalian cells","volume":"583","author":"Laenger","year":"2009","journal-title":"FEBS Lett"},{"key":"10.4158\/EP11061.RA_bb0205","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.tem.2010.02.007","article-title":"Clinical, genetic and molecular characterization of patients with familial isolated pituitary adenomas (FIPA)","volume":"21","author":"Chahal","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0210","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0079-6123(10)82010-2","article-title":"Molecular genetics of the AIP gene in familial pituitary tumorigenesis","volume":"182","author":"Tahir","year":"2010","journal-title":"Prog Brain Res"},{"key":"10.4158\/EP11061.RA_bb0215","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1126\/science.1126100","article-title":"Pituitary adenoma predisposition caused by germline mutations in the AIP gene","volume":"312","author":"Vierimaa","year":"2006","journal-title":"Science"},{"key":"10.4158\/EP11061.RA_bb0220","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1399-0004.2010.01406.x","article-title":"The role of germline AIP, MEN1, PRKAR1A, CDKN1B and CDKN2C mutations in causing pituitary adenomas in a large cohort of children, adolescents, and patients with genetic syndromes","volume":"78","author":"Stratakis","year":"2010","journal-title":"Clin Genet"},{"key":"10.4158\/EP11061.RA_bb0225","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1210\/endo-107-1-137","article-title":"Demonstration of glucocorticoid receptors in the adrenal cortex: evidence for a direct dexamethasone suppressive effect on the rat adrenal gland","volume":"107","author":"Loose","year":"1980","journal-title":"Endocrinology"},{"key":"10.4158\/EP11061.RA_bb0230","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1210\/jcem-60-2-283","article-title":"Glucocorticoid receptors and responsiveness of normal and neoplastic human adrenal cortex","volume":"60","author":"Kontula","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0235","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/cpt1970115711","article-title":"Effects of a single large intravenous dose of methylprednisolone sodium succinate","volume":"11","author":"Novak","year":"1970","journal-title":"Clin Pharmacol Ther"},{"key":"10.4158\/EP11061.RA_bb0240","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1210\/jcem-48-5-861","article-title":"Direct inhibitory effect of dexamethasone on steroidogenesis of human adrenal in vivo","volume":"48","author":"Saito","year":"1979","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0245","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1210\/jcem-25-5-602","article-title":"Adrenal response to infused corticotropin in subjects receiving glucocorticoids","volume":"25","author":"Landon","year":"1965","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0250","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1471-4159.1983.tb11291.x","article-title":"Glucocorticoids increase catecholamine synthesis and storage in PC12 pheochromocytoma cell cultures","volume":"40","author":"Tischler","year":"1983","journal-title":"J Neurochem"},{"key":"10.4158\/EP11061.RA_bb0255","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1056\/NEJM196809052791007","article-title":"Dexamethasone-suppressible adrenocortical tumor","volume":"279","author":"Kendall","year":"1968","journal-title":"N Engl J Med"},{"key":"10.4158\/EP11061.RA_bb0260","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1056\/NEJM197103182841108","article-title":"ACTH-responsive, dexamethasone-suppressible adrenocortical carcinoma","volume":"284","author":"Rayfield","year":"1971","journal-title":"N Engl J Med"},{"key":"10.4158\/EP11061.RA_bb0265","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.steroids.2010.04.008","article-title":"Expression of glucocorticoid receptor isoforms in human adrenocortical adenomas","volume":"75","author":"Boyle","year":"2010","journal-title":"Steroids"},{"key":"10.4158\/EP11061.RA_bb0270","doi-asserted-by":"crossref","first-page":"e13563","DOI":"10.1371\/journal.pone.0013563","article-title":"Familial glucocorticoid receptor haploinsufficiency by non-sense mediated mRNA decay, adrenal hyperplasia and apparent mineralocorticoid excess","volume":"5","author":"Bouligand","year":"2010","journal-title":"PLoS One"},{"key":"10.4158\/EP11061.RA_bb0275","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/ncpendmet0648","article-title":"Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias","volume":"3","author":"Stratakis","year":"2007","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0280","first-page":"5308","article-title":"Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity","volume":"63","author":"Bertherat","year":"2003","journal-title":"Cancer Res"},{"key":"10.4158\/EP11061.RA_bb0285","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/79238","article-title":"Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex","volume":"26","author":"Kirschner","year":"2000","journal-title":"Nat Genet"},{"key":"10.4158\/EP11061.RA_bb0290","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1093\/hmg\/9.20.3037","article-title":"Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with Carney complex","volume":"9","author":"Kirschner","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.4158\/EP11061.RA_bb0295","doi-asserted-by":"crossref","first-page":"11893","DOI":"10.1073\/pnas.220413297","article-title":"Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-kappa B and the glucocorticoid receptor","volume":"97","author":"Doucas","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.4158\/EP11061.RA_bb0300","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1210\/jc.2006-0188","article-title":"PRKAR1A mutations and protein kinase A interactions with other signaling pathways in the adrenal cortex","volume":"91","author":"Robinson-White","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0305","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/hmg\/ddg160","article-title":"Protein kinase A activity in PRKAR1A-mutant cells, and regulation of mitogen-activated protein kinases ERK1\/2","volume":"12","author":"Robinson-White","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.4158\/EP11061.RA_bb0310","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1210\/jc.2009-0031","article-title":"The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits","volume":"94","author":"Louiset","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0315","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1530\/EJE-07-0458","article-title":"Mifepristone (RU 486) in Cushing's syndrome","volume":"157","author":"Johanssen","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP11061.RA_bb0320","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jmb.2009.11.011","article-title":"Molecular switch in the glucocorticoid receptor: active and passive antagonist conformations","volume":"395","author":"Schoch","year":"2010","journal-title":"J Mol Biol"},{"key":"10.4158\/EP11061.RA_bb0325","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.steroids.2007.03.012","article-title":"The glucocorticoid agonist activities of mifepristone (RU486) and progesterone dependent on glucocorticoid receptor levels but not on EC50 values","volume":"72","author":"Zhang","year":"2007","journal-title":"Steroids"},{"key":"10.4158\/EP11061.RA_bb0330","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0039-128X(94)00001-S","article-title":"The two faces of a steroid antagonist: when an antagonist isn't","volume":"60","author":"Nordeen","year":"1995","journal-title":"Steroids"},{"key":"10.4158\/EP11061.RA_bb0335","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1210\/me.2005-0461","article-title":"Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex","volume":"20","author":"Gummow","year":"2006","journal-title":"Mol Endocrinol"},{"key":"10.4158\/EP11061.RA_bb0340","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0167-4781(96)00175-3","article-title":"Promoter of the gene encoding the bovine catalytic subunit of cAMP-dependent protein kinase isoform C beta 2","volume":"1309","author":"Wiemann","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"10.4158\/EP11061.RA_bb0345","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0167-4889(83)90028-9","article-title":"Glucocorticoid control of steroidogenesis in isolated rat adrenocortical cells","volume":"763","author":"Carsia","year":"1983","journal-title":"Biochim Biophys Acta"},{"key":"10.4158\/EP11061.RA_bb0350","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1210\/jc.2009-0881","article-title":"ACTH-independent Cushing's syndrome with bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma","volume":"95","author":"Louiset","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0355","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.mce.2005.11.012","article-title":"Non-genomic glucocorticoid effects to provide the basis for new drug developments","volume":"246","author":"Song","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"10.4158\/EP11061.RA_bb0360","doi-asserted-by":"crossref","first-page":"8811","DOI":"10.1158\/0008-5472.CAN-04-3620","article-title":"Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors","volume":"64","author":"Griffin","year":"2004","journal-title":"Cancer Res"},{"key":"10.4158\/EP11061.RA_bb0365","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1136\/jmg.2004.028043","article-title":"A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions","volume":"41","author":"Griffin","year":"2004","journal-title":"J Med Genet"},{"key":"10.4158\/EP11061.RA_bb0370","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1081\/ERC-200044145","article-title":"A mouse model for Carney complex","volume":"30","author":"Griffin","year":"2004","journal-title":"Endocr Res"},{"key":"10.4158\/EP11061.RA_bb0375","first-page":"348","article-title":"The dexamethasone-suppressed corticotropin-releasing hormone stimulation test differentiates mild Cushing's disease from normal physiology","volume":"83","author":"Yanovski","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0380","first-page":"47","article-title":"Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals","volume":"83","author":"Huizenga","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0385","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1210\/jc.2006-0066","article-title":"Overrepresentation of the N363S variant of the glucocorticoid receptor gene in patients with bilateral adrenal incidentalomas","volume":"91","author":"Majnik","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0390","first-page":"14","article-title":"Normocortisolemic Cushing's syndrome initially presenting with increased glucocorticoid receptor numbers","volume":"85","author":"Newfield","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP11061.RA_bb0395","first-page":"57","article-title":"Absence of cushingoid phenotype in a patient with Cushing's disease due to defective cortisone to cortisol conversion","volume":"87","author":"Tomlinson","year":"2002","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X2043277X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X2043277X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/aace.metapress.com\/index\/VK432K452546768V.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:53:14Z","timestamp":1761515594000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X2043277X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":78,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S1530891X2043277X"],"URL":"https:\/\/doi.org\/10.4158\/ep11061.ra","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Glucocorticoid Receptor and its Expression in the Anterior Pituitary and the Adrenal Cortex: A Source of Variation in Hypothalamic-Pituitary-Adrenal Axis Function; Implications for Pituitary and Adrenal Tumors","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.4158\/EP11061.RA","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}