{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T22:00:53Z","timestamp":1771797653107,"version":"3.50.1"},"reference-count":17,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.4158\/ep13316.cr","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T23:07:42Z","timestamp":1384816062000},"page":"e38-e41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Tablet Levothyroxine (L-T4) Malabsorption Induced by Proton Pump Inhibitor; A Problem that was Solved by Switching to L-T4 in Soft Gel Capsule"],"prefix":"10.1016","volume":"20","author":[{"given":"Roberto","family":"Vita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Benvenga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.4158\/EP13316.CR_bb0005","series-title":"Thyroid Diseases","first-page":"482","article-title":"Thyroid and drugs","author":"Benvenga","year":"2012"},{"key":"10.4158\/EP13316.CR_bb0010","unstructured":"http:\/\/www.pharmacytimes.com\/publications\/issue\/2012\/July2012\/Top-200-Drugs-of-2011. Accessed July 16, 2013."},{"key":"10.4158\/EP13316.CR_bb0015","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4158\/EP.13.4.345","article-title":"Effect of proton pump inhibitors on serum thyroid-stimulating hormone level in euthyroid patients treated with levothyroxine for hypothyroidism","volume":"13","author":"Sachmechi","year":"2007","journal-title":"Endocr Pract."},{"key":"10.4158\/EP13316.CR_bb0020","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1046\/j.1365-2036.2000.00829.x","article-title":"Proton pump inhibitors: better acid suppression when taken before a meal than without a meal","volume":"14","author":"Hatlebakk","year":"2000","journal-title":"Aliment Pharmacol Ther."},{"key":"10.4158\/EP13316.CR_bb0025","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1210\/jc.2009-0860","article-title":"Timing of levothyroxine administration affects serum thyrotropin concentration","volume":"94","author":"Bach-Huynh","year":"2009","journal-title":"J Clin Endocrinol Metab."},{"key":"10.4158\/EP13316.CR_bb0030","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1089\/thy.1995.5.249","article-title":"Delayed intestinal absorption of levothyroxine","volume":"5","author":"Benvenga","year":"1995","journal-title":"Thyroid."},{"key":"10.4158\/EP13316.CR_bb0035","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/thy.1994.4.55","article-title":"Human thyroxine absorption: age effects and methodological analyses","volume":"4","author":"Hays","year":"1994","journal-title":"Thyroid."},{"key":"10.4158\/EP13316.CR_bb0040","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1056\/NEJMoa043903","article-title":"Thyroxine in goiter, Helicobacter pylori infection, and chronic gastritis","volume":"354","author":"Centanni","year":"2006","journal-title":"N Engl J Med."},{"key":"10.4158\/EP13316.CR_bb0045","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejpb.2008.10.008","article-title":"A comparative pH-dissolution profile study of selected commercial levothyroxine products using inductively coupled plasma mass spectrometry","volume":"72","author":"Pabla","year":"2009","journal-title":"Eur J Pharm Biopharm."},{"issue":"S1","key":"10.4158\/EP13316.CR_bb0050","first-page":"A50","article-title":"Effect of proton pump inhibitors (PPIs) on the relative bioavailability of levothyroxine (L-T4) in soft gel capsules and in tablets","volume":"22","author":"Benvenga","year":"2012","journal-title":"Thyroid"},{"key":"10.4158\/EP13316.CR_bb0055","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jpeds.2010.08.050","article-title":"Celiac disease in children, adolescents, and young adults with autoimmune thyroid disease","volume":"158","author":"Sattar","year":"2011","journal-title":"J Pediatr"},{"key":"10.4158\/EP13316.CR_bb0060","first-page":"123","article-title":"Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease","author":"Boelaert","year":"2010","journal-title":"Am J Med"},{"key":"10.4158\/EP13316.CR_bb0065","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1530\/EJE-10-1172","article-title":"Clustering of additional autoimmunity behaves differently in Hashimoto\u2019s patients compared with Graves\u2019 patients","volume":"164","author":"Wiebolt","year":"2011","journal-title":"Eur J Endocrinol."},{"key":"10.4158\/EP13316.CR_bb0070","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s12020-012-9772-2","article-title":"A novel formulation of L-thyroxine (L-T4) reduces the problem of L-T4 malabsorption by coffee observed with traditional tablet formulations","volume":"43","author":"Vita","year":"2013","journal-title":"Endocrine."},{"key":"10.4158\/EP13316.CR_bb0075","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1517\/17425247.2012.701616","article-title":"Myo-inositol soft gel capsules may prevent the risk of coffee-induced neural tube defects","volume":"9","author":"De Grazia","year":"2012","journal-title":"Expert Opin Drug Deliv."},{"key":"10.4158\/EP13316.CR_bb0080","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1089\/thy.2006.16.1047","article-title":"Impaired enteral levothyroxine absorption in hypothyroidism refractory to oral therapy after thyroid ablation for papillary thyroid cancer: case report and kinetic studies","volume":"16","author":"T\u00f6njes","year":"2006","journal-title":"Thyroid."},{"key":"10.4158\/EP13316.CR_bb0085","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/MAJ.0b013e31817ee556","article-title":"Isolated thyroxine malabsorption treated with intramuscular thyroxine injections","volume":"337","author":"Anderson","year":"2009","journal-title":"Am J Med Sci."}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20432525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20432525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/aace.metapress.com\/index\/14563106143U1531.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:56:09Z","timestamp":1761515769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X20432525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S1530891X20432525"],"URL":"https:\/\/doi.org\/10.4158\/ep13316.cr","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tablet Levothyroxine (L-T4) Malabsorption Induced by Proton Pump Inhibitor; A Problem that was Solved by Switching to L-T4 in Soft Gel Capsule","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.4158\/EP13316.CR","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}