{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:41:16Z","timestamp":1791247276211,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.4158\/ep13318.ra","type":"journal-article","created":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T22:40:01Z","timestamp":1378507201000},"page":"853-863","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Testosterone Therapy in Older Men with Late-Onset Hypogonadism: A Counter-Rationale"],"prefix":"10.1016","volume":"19","author":[{"given":"Shehzad","family":"Basaria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.4158\/EP13318.RA_bb0010","doi-asserted-by":"crossref","first-page":"419","DOI":"10.5694\/j.1326-5377.2004.tb06364.x","article-title":"Trends and regional differences in testosterone prescribing in Australia, 1991-2001","volume":"181","author":"Handelsman","year":"2004","journal-title":"Med J Aust"},{"key":"10.4158\/EP13318.RA_bb0015","doi-asserted-by":"crossref","first-page":"e5469","DOI":"10.1136\/bmj.e5469","article-title":"Many men are receiving unnecessary testosterone prescriptions","volume":"345","author":"Gan","year":"2012","journal-title":"BMJ"},{"key":"10.4158\/EP13318.RA_bb0020","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1530\/EJE-08-0601","article-title":"Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations","volume":"159","author":"Wang","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP13318.RA_bb0025","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1210\/jc.2009-2354","article-title":"Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline","volume":"95","author":"Bhasin","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0030","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1210\/jc.2009-1796","article-title":"Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study","volume":"95","author":"Tajar","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0035","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1001\/jama.1935.92760440002009a","article-title":"A case of authenticated fertility in a man aged 94","volume":"18","author":"Seymour","year":"1935","journal-title":"JAMA"},{"key":"10.4158\/EP13318.RA_bb0040","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1210\/jcem.86.2.7219","article-title":"Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging","volume":"86","author":"Harman","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0045","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0026-0495(97)90057-3","article-title":"Longitudinal changes in testosterone, luteinizing hormone and follicle-stimulating hormone in healthy older men","volume":"46","author":"Morley","year":"1997","journal-title":"Metabolism"},{"key":"10.4158\/EP13318.RA_bb0050","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1210\/jcem.87.2.8201","article-title":"Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study","volume":"87","author":"Feldman","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0055","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1056\/NEJMoa0911101","article-title":"Identification of late-onset hypogonadism in middle-aged and elderly men","volume":"363","author":"Wu","year":"2010","journal-title":"N Engl J Med"},{"key":"10.4158\/EP13318.RA_bb0060","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1210\/jc.2003-031287","article-title":"Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry","volume":"89","author":"Wang","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0065","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1210\/jc.2008-1902","article-title":"The effect of diurnal variation on clinical measurement of serum testosterone and other sex hormone levels in men","volume":"94","author":"Brambilla","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0070","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1365-2265.2007.02976.x","article-title":"Intraindividual variation in levels of serum testosterone and other reproductive and adrenal hormones in men","volume":"67","author":"Brambilla","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP13318.RA_bb0075","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ecl.2013.02.012","article-title":"Reproductive aging in men","volume":"42","author":"Basaria","year":"2013","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.4158\/EP13318.RA_bb0080","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1210\/jc.2007-1245","article-title":"Prevalence of symptomatic androgen deficiency in men","volume":"92","author":"Araujo","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0085","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1210\/er.2004-0013","article-title":"The decline of androgen levels in elderly men and its clinical and therapeutic implications","volume":"26","author":"Kaufman","year":"2005","journal-title":"Endocr Rev"},{"key":"10.4158\/EP13318.RA_bb0090","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1161\/CIRCULATIONAHA.106.649426","article-title":"Anabolic deficiency in men with chronic heart failure: prevalence and detrimental impact on survival","volume":"114","author":"Jankowska","year":"2006","journal-title":"Circulation"},{"key":"10.4158\/EP13318.RA_bb0095","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0889-8529(18)30184-1","article-title":"Hypothalamo-pituitary gonadal axis in chronic renal failure","volume":"22","author":"Handelsman","year":"1993","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.4158\/EP13318.RA_bb0100","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1210\/jc.2010-2724","article-title":"Hypogonadotropic hypogonadism in type 2 diabetes and obesity","volume":"96","author":"Dandona","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0105","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1210\/jc.2006-1859","article-title":"The relative contributions of aging, health, and lifestyle factors to serum testosterone decline in men","volume":"92","author":"Travison","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0110","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1210\/jc.2008-0021","article-title":"Correlates of low testosterone and symptomatic androgen deficiency in a population-based sample","volume":"93","author":"Hall","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0115","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1210\/jc.2008-1598","article-title":"Effect of Roux-en-Y gastric bypass surgery on the sex steroids and quality of life in obese men","volume":"94","author":"Hammoud","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0120","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1462-8902.2004.00335.x","article-title":"Changes in sex hormone-binding globulin and testosterone during weight loss and weight-maintenance in abdominally obese men with the metabolic syndrome","volume":"6","author":"Niskanen","year":"2004","journal-title":"Diabetes Obes Metab"},{"key":"10.4158\/EP13318.RA_bb0125","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1210\/jcem-55-4-676","article-title":"Reproductive functions in young fathers and grandfathers","volume":"55","author":"Nieschlag","year":"1982","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0130","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1365-2265.2012.04432.x","article-title":"Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man study","volume":"77","author":"Sartorius","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP13318.RA_bb0135","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF01542116","article-title":"Changes in erectile responsiveness during androgen replacement therapy","volume":"12","author":"Bancroft","year":"1983","journal-title":"Arch Sex Behav"},{"key":"10.4158\/EP13318.RA_bb0140","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1210\/jc.2002-021058","article-title":"AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual function","volume":"88","author":"Steidle","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0145","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0025-6196(11)60963-4","article-title":"Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials","volume":"82","author":"Bolo\u00f1a","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"10.4158\/EP13318.RA_bb0150","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1365-2265.2005.02350.x","article-title":"Effects of testosterone on sexual function in men: results of a meta-analysis","volume":"63","author":"Isidori","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP13318.RA_bb0155","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1210\/jcem-71-4-963","article-title":"Secondary hypogonadism in older men: its relation to impotence","volume":"71","author":"Korenman","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0160","doi-asserted-by":"crossref","first-page":"681","DOI":"10.7326\/0003-4819-157-10-201211200-00004","article-title":"Effect of testosterone replacement on response to sildenafil citrate in men with erectile dysfunction: aparallel, randomized trial","volume":"157","author":"Spitzer","year":"2012","journal-title":"Ann Intern Med"},{"key":"10.4158\/EP13318.RA_bb0165","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1365-2265.2004.02108.x","article-title":"Type V phosphodiesterase inhibitor treatments for erectile dysfunction increase testosterone levels","volume":"61","author":"Carosa","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP13318.RA_bb0170","doi-asserted-by":"crossref","first-page":"E284","DOI":"10.1152\/ajpendo.00334.2001","article-title":"Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men","volume":"283","author":"Roy","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0175","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1210\/jc.2009-2680","article-title":"Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: the Framingham Offspring Study","volume":"95","author":"Krasnoff","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0180","doi-asserted-by":"crossref","first-page":"E601","DOI":"10.1152\/ajpendo.00362.2001","article-title":"Testosterone administration to older men improves muscle function: molecular and physiological mechanisms","volume":"282","author":"Ferrando","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0185","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1210\/jc.2004-1184","article-title":"Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle","volume":"90","author":"Bhasin","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0190","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1210\/jc.2009-1251","article-title":"Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study","volume":"95","author":"Srinivas-Shankar","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0195","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1093\/gerona\/glr100","article-title":"Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation","volume":"66","author":"Travison","year":"2011","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.4158\/EP13318.RA_bb0200","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1056\/NEJMoa1000485","article-title":"Adverse events associated with testosterone administration","volume":"363","author":"Basaria","year":"2010","journal-title":"N Engl J Med"},{"key":"10.4158\/EP13318.RA_bb0205","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.4088\/JCP.08m04478","article-title":"A randomized, double-blind, placebo-controlled study of testosterone treatment in hypogonadal older men with subthreshold depression (dysthymia or minor depression)","volume":"70","author":"Shores","year":"2009","journal-title":"J Clin Psychiatry"},{"key":"10.4158\/EP13318.RA_bb0210","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/JCP.0b013e3181a39137","article-title":"Effects of testosterone replacement in middle-aged men with dysthymia: a randomized, placebo-controlled clinical trial","volume":"29","author":"Seidman","year":"2009","journal-title":"J Clin Psychopharmacol"},{"key":"10.4158\/EP13318.RA_bb0215","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/JCP.0b013e3181d207ca","article-title":"Parallel-group placebo-controlled trial of testosterone gel in men with major depressive disorder displaying an incomplete response to standard antidepressant treatment","volume":"30","author":"Pope","year":"2010","journal-title":"J Clin Psychopharmacol"},{"key":"10.4158\/EP13318.RA_bb0220","doi-asserted-by":"crossref","first-page":"57","DOI":"10.64719\/pb.4089","article-title":"A systematic review of augmentation strategies for patients with major depressive disorder","volume":"42","author":"Fleurence","year":"2009","journal-title":"Psychopharmacol Bull"},{"key":"10.4158\/EP13318.RA_bb0225","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1210\/jc.2005-0247","article-title":"Dose-dependent effects of testosterone on sexual function, mood, and visuospatial cognition in older men","volume":"90","author":"Gray","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0230","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2164\/jandrol.107.002931","article-title":"Exogenous testosterone alone or with finasteride does not improve measurements of cognition in healthy older men with low serum testosterone","volume":"28","author":"Vaughan","year":"2007","journal-title":"J Androl"},{"key":"10.4158\/EP13318.RA_bb0235","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1212\/01.WNL.0000165995.98986.F1","article-title":"Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment","volume":"64","author":"Cherrier","year":"2005","journal-title":"Neurology"},{"key":"10.4158\/EP13318.RA_bb0240","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1001\/archneur.63.2.nct50002","article-title":"Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men","volume":"63","author":"Lu","year":"2006","journal-title":"Arch Neurol"},{"key":"10.4158\/EP13318.RA_bb0245","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1210\/jc.2006-1805","article-title":"Intramuscular testosterone treatment in elderly men: evidence of memory decline and altered brain function","volume":"92","author":"Maki","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0250","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.1210\/jc.2009-2635","article-title":"Sex steroid hormones in older men: longitudinal associations with 4.5-year change in hip bone mineral density-the osteoporotic fractures in men study","volume":"95","author":"Cauley","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0255","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1359\/JBMR.041228","article-title":"Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men","volume":"20","author":"Khosla","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.4158\/EP13318.RA_bb0260","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1210\/jc.2006-0036","article-title":"Testosterone use in men and its effects on bone health. A systematic review and meta-analysis of randomized placebo-controlled trials","volume":"91","author":"Tracz","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0265","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1210\/jc.2003-031110","article-title":"Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone","volume":"89","author":"Amory","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0270","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1210\/jc.2010-0266","article-title":"Clinical review: Why is androgen replacement in males controversial?","volume":"96","author":"Cunningham","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0275","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1210\/jc.2006-0822","article-title":"Differences in the apparent metabolic clearance rate of testosterone in young and older men with gonadotropin suppression receiving graded doses of testosterone","volume":"91","author":"Coviello","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0280","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1210\/jc.2007-1692","article-title":"Effects of graded doses of testosterone on erythropoiesis in healthy young and older men","volume":"93","author":"Coviello","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0285","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/BF03345745","article-title":"Androgens and erythropoiesis: past and present","volume":"32","author":"Shahani","year":"2009","journal-title":"J Endocrinol Invest"},{"key":"10.4158\/EP13318.RA_bb0290","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1210\/jc.2010-0864","article-title":"Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis","volume":"95","author":"Bachman","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0295","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1093\/gerona\/60.11.1451","article-title":"Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials","volume":"60","author":"Calof","year":"2005","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.4158\/EP13318.RA_bb0300","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1210\/jc.2009-2575","article-title":"Adverse effects of testosterone therapy in adult men: a systematic review and meta-analysis","volume":"95","author":"Fern\u00e1ndez-Balsells","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0305","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/0002-8703(94)90679-3","article-title":"Hematocrit and the risk of cardiovascular disease-the Framingham study: a 34-year follow-up","volume":"127","author":"Gagnon","year":"1994","journal-title":"Am Heart J"},{"key":"10.4158\/EP13318.RA_bb0310","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1046\/j.1365-2141.2003.04475.x","article-title":"Does sticky blood predict a sticky end? Associations of blood viscosity, haematocrit and fibrinogen with mortality in the West of Scotland","volume":"122","author":"Woodward","year":"2003","journal-title":"Br J Haematol"},{"key":"10.4158\/EP13318.RA_bb0315","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/jnci\/djm323","article-title":"Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies","volume":"100","author":"Roddam","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"10.4158\/EP13318.RA_bb0320","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1001\/jama.295.11.1288","article-title":"Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis","volume":"295","author":"Ding","year":"2006","journal-title":"JAMA"},{"key":"10.4158\/EP13318.RA_bb0325","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1210\/jc.2003-030611","article-title":"Endogenous sex hormones and cardiovascular disease in men","volume":"88","author":"Muller","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0330","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.jacc.2011.07.019","article-title":"High serum testosterone is associated with reduced risk of cardiovascular events in elderly men. The MrOS (Osteoporotic Fractures in Men) study in Sweden","volume":"58","author":"Ohlsson","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.4158\/EP13318.RA_bb0335","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1210\/er.2001-0025","article-title":"von Eckardstein A. Androgens and coronary artery disease","volume":"24","author":"Wu","year":"2003","journal-title":"Endocr Rev"},{"key":"10.4158\/EP13318.RA_bb0340","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0025-6196(11)60964-6","article-title":"Testosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials","volume":"82","author":"Haddad","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"10.4158\/EP13318.RA_bb0345","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1741-7015-11-108","article-title":"Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials","volume":"11","author":"Xu","year":"2013","journal-title":"BMC Med"},{"key":"10.4158\/EP13318.RA_bb0350","first-page":"108","article-title":"Need for standardizing adverse event reporting in testosterone trials","volume":"11","author":"Basaria","year":"2013","journal-title":"BMC Med"},{"key":"10.4158\/EP13318.RA_bb0355","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1210\/jc.2008-2338","article-title":"Testosterone and growth hormone improve body composition and muscle performance in older men","volume":"94","author":"Sattler","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0360","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/jc.2011-2591","article-title":"Testosterone treatment and mortality in men with low testosterone levels","volume":"97","author":"Shores","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP13318.RA_bb0365","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1210\/jc.2012-1977","article-title":"Caveat emptor: does testosterone treatment reduce mortality in men?","volume":"97","author":"Wu","year":"2012","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20446646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20446646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/aace.metapress.com\/index\/W150N23807479N31.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:54:48Z","timestamp":1761515688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X20446646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":72,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S1530891X20446646"],"URL":"https:\/\/doi.org\/10.4158\/ep13318.ra","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Testosterone Therapy in Older Men with Late-Onset Hypogonadism: A Counter-Rationale","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.4158\/EP13318.RA","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}