{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T10:29:31Z","timestamp":1779013771550,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.4158\/ep14603.or","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T15:37:00Z","timestamp":1447774620000},"page":"396-405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Trends In Growth Hormone Stimulation Testing And Growth Hormone Dosing In Adult Growth Hormone Deficiency Patients: Results From The Answer Program"],"prefix":"10.1016","volume":"22","author":[{"given":"MurrayB.","family":"Gordon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RichardA.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert.","family":"Gut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John.","family":"Germak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.4158\/EP14603.OR_bb0010","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1210\/jc.2011-0179","article-title":"Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Molitch","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP14603.OR_bb0015","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1210\/jc.2011-1215","article-title":"Does growth hormone replacement therapy reduce mortality in adults with growth hormone deficiency? Data from the Dutch national registry of growth hormone treatment in adults","volume":"96","author":"van Bunderen","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP14603.OR_bb0020","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1210\/er.2004-0022","article-title":"The influence of growth hormone status on physical impairments, functional limitations, and health-related quality of life in adults","volume":"27","author":"Woodhouse","year":"2006","journal-title":"Endocr Rev"},{"key":"10.4158\/EP14603.OR_bb0025","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/MED.0b013e32833b6bc7","article-title":"The diagnosis and treatment of growth hormone deficiency in adults","volume":"17","author":"Clemmons","year":"2010","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"10.4158\/EP14603.OR_bb0030","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1210\/jcem.83.2.4594","article-title":"Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee","volume":"83","author":"Carroll","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 2","key":"10.4158\/EP14603.OR_bb0035","first-page":"1","article-title":"American Association of Clinical Endocrinologists medical guidelines for clinical practice for growth hormone use in growth hormone-deficient adults and transition patients - 2009 update","volume":"15","author":"American Association of Clinical Endocrinologists","year":"2009","journal-title":"Endocr Pract"},{"key":"10.4158\/EP14603.OR_bb0040","first-page":"2013","article-title":"Serum levels of insulin-like growth factor I in 152 patients with growth hormone deficiency, aged 19\u201382 years, in relation to those in healthy subjects","volume":"84","author":"Hilding","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP14603.OR_bb0045","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1210\/jcem.87.2.8216","article-title":"Which patients do not require a GH stimulation test for the diagnosis of adult GH deficiency?","volume":"87","author":"Hartman","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP14603.OR_bb0050","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1210\/jc.2010-0295","article-title":"Comparative validation of the growth hormone-releasing hormone and arginine test for the diagnosis of adult growth hormone deficiency using a growth hormone assay conforming to recent international recommendations","volume":"95","author":"Chanson","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP14603.OR_bb0055","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1210\/jc.2009-0299","article-title":"Clinical review: is lack of recombinant growth hormone (GH)- releasing hormone in the United States a setback or time to consider glucagon testing for adult GH deficiency?","volume":"94","author":"Yuen","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP14603.OR_bb0060","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1530\/eje.1.01967","article-title":"The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index","volume":"153","author":"Corneli","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP14603.OR_bb0065","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1210\/jc.2002-021094","article-title":"The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time interval","volume":"88","author":"Darzy","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"10.4158\/EP14603.OR_bb0070","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1530\/EJE-09-0273","article-title":"Etiology, baseline characteristics, and biochemical diagnosis of GH deficiency in the adult: are there regional variations?","volume":"161","author":"Brabant","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP14603.OR_bb0075","series-title":"Norditropin cartridges (somatropin &lsqb;rDNA origin] injection) for subcutaneous use &lsqb;package insert]","year":"2010"},{"key":"10.4158\/EP14603.OR_bb0080","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2147\/CLEP.S42602","volume":"5","author":"Hoybye","year":"2013","journal-title":"Clin Epidemiol"},{"key":"10.4158\/EP14603.OR_bb0085","first-page":"53","article-title":"Serum insulin-like growth factor I reference values for an automated chemiluminescence immunoassay system: results from a multicenter study","volume":"60","author":"Brabant","year":"2003","journal-title":"Horm Res"},{"key":"10.4158\/EP14603.OR_bb0090","unstructured":"Stratum Medical. Products for clinical use: GHRH diagnostic for GHRH\/arg stimulation testing. Available at: http:\/\/stratummedical.com\/products\/. Accessed August 8, 2014."},{"key":"10.4158\/EP14603.OR_bb0095","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1210\/jcem.87.5.8509","article-title":"Sensitivity and specificity of six tests for the diagnosis of adult GH deficiency","volume":"87","author":"Biller","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"10.4158\/EP14603.OR_bb0100","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1530\/EJE-09-0328","article-title":"From isolated GH deficiency to multiple pituitary hormone deficiency: an evolving continuum - a KIMS analysis","volume":"161","author":"Klose","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP14603.OR_bb0105","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1530\/EJE-10-0914","article-title":"Dutch national registry of GH treatment in adults: patient characteristics and diagnostic test procedures","volume":"164","author":"van Nieuwpoort","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP14603.OR_bb0110","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ghir.2014.11.002","article-title":"Potential risks of glucagon stimulation test in elderly people","volume":"25","author":"Tavares","year":"2015","journal-title":"Growth Horm IGF Res"},{"key":"10.4158\/EP14603.OR_bb0115","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s11102-012-0407-7","article-title":"Clinical characteristics, timing of peak responses and safety aspects of two dosing regimens of the glucagon stimulation test in evaluating growth hormone and cortisol secretion in adults","volume":"16","author":"Yuen","year":"2013","journal-title":"Pituitary"},{"key":"10.4158\/EP14603.OR_bb0120","unstructured":"U.S. Food and Drug Administration. Current drug shortages. Available at: http:\/\/www.marylandinjurylawyersblogcom\/Drug%20Shortages%20FDA.pdf. Accessed August 8, 2014."},{"key":"10.4158\/EP14603.OR_bb0125","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1210\/jc.2008-0713","article-title":"Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database","volume":"94","author":"Webb","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 3","key":"10.4158\/EP14603.OR_bb0130","first-page":"619","article-title":"Diagnostic growth hormone deficiency testing practices among patients in the NCGS\/NCSS databases","volume":"16","author":"Levy","year":"2003","journal-title":"J Pediatr Endocrinol Metab"},{"key":"10.4158\/EP14603.OR_bb0135","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4158\/EP11168.RA","article-title":"Transition care of patients with growth hormone deficiency from pediatric endocrinologists to adult endocrinologists","volume":"18","author":"Chamberlain","year":"2012","journal-title":"Endocr Pract"},{"key":"10.4158\/EP14603.OR_bb0140","first-page":"3956","article-title":"Route of estrogen administration helps to determine growth hormone (GH) replacement dose in GH-deficient adults","volume":"84","author":"Cook","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP14603.OR_bb0145","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1046\/j.1365-2265.1996.728550.x","article-title":"Decreased plasma and extracellular volume in growth hormone deficient adults and the acute and prolonged effects of GH administration: a controlled experimental study","volume":"44","author":"M\u00f8ller","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP14603.OR_bb0150","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1210\/jc.2014-2830","article-title":"Overweight\/Obese adults with pituitary disorders require lower peak growth hormone cutoff values on glucagon stimulation testing to avoid overdiagnosis of growth hormone deficiency","volume":"99","author":"Dichtel","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP14603.OR_bb0155","unstructured":"HamrahianAH, YuenKCJ, GordonMB, Pulaski-libertKJ, BenaJ, BillerBMK.Revised GH cut-point needed for the glucagon stimulation test (GST) in the evaluation of adult growth hormone deficiency (GHD): results from a prospective randomized multicenter study. Poster presented at: 97th Annual Meeting & Expo of The Endocrine Society; March 5\u20138, 2015; San Diego, CA."}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20393150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20393150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:01:00Z","timestamp":1761516060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X20393150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S1530891X20393150"],"URL":"https:\/\/doi.org\/10.4158\/ep14603.or","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trends In Growth Hormone Stimulation Testing And Growth Hormone Dosing In Adult Growth Hormone Deficiency Patients: Results From The Answer Program","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.4158\/EP14603.OR","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}