{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:41:16Z","timestamp":1777614076701,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.4158\/ep151183.or","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T16:50:01Z","timestamp":1459788601000},"page":"951-958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Trabecular Bone Score Change Differs with Regard to 25(OH)D Levels in Patients Treated for Adult-Onset Growth Hormone Deficiency"],"prefix":"10.1016","volume":"22","author":[{"given":"Martin","family":"Ku\u017ema","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Binkley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Bedn\u00e1rov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdenko","family":"Killinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Va\u0148uga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juraj","family":"Payer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.4158\/EP151183.OR_bb0010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2265.1994.tb02452.x","article-title":"Decreased psychological well-being in adult patients with growth hormone deficiency","volume":"40","author":"Ros\u00e9n","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP151183.OR_bb0015","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.yhbeh.2004.11.015","article-title":"Long-term growth hormone treatment preserves GH-induced memory and mood improvements: a 10-year follow-up study in GH-deficient adult men","volume":"47","author":"Arwert","year":"2005","journal-title":"Horm Behav"},{"key":"10.4158\/EP151183.OR_bb0020","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ghir.2013.12.001","article-title":"Impact of the growth hormone replacement on bone status in growth hormone deficient adults","volume":"24","author":"Ku\u017ema","year":"2014","journal-title":"Growth Horm IGF Res"},{"key":"10.4158\/EP151183.OR_bb0025","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1530\/EJE-08-0436","article-title":"Treatment for 24 months with recombinant human GH has a beneficial effect on bone mineral density in young adults with childhood-onset GH deficiency","volume":"160","author":"Conway","year":"2009","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP151183.OR_bb0030","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1530\/EJE-11-0886","article-title":"Effects of 3-year GH replacement therapy on bone mineral density in younger and elderly adults with adult-onset GH deficiency","volume":"166","author":"Elbornsson","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP151183.OR_bb0035","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/BF03345574","article-title":"Bone density and turnover in young adult patients with growth hormone deficiency after 2-year growth hormone replacement according with gender","volume":"31","author":"Rota","year":"2008","journal-title":"J Endocrinol Invest"},{"key":"10.4158\/EP151183.OR_bb0040","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1210\/jc.2015-1757","article-title":"Effect of Growth Hormone Treatment on Fractures and Quality of Life in Postmenopausal Osteoporosis: A 10-Year Follow-Up Study","volume":"100","author":"Krantz","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP151183.OR_bb0045","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S2213-8587(15)00098-4","article-title":"Fracture risk in adult patients treated with growth hormone replacement therapy for growth hormone deficiency: a prospective observational cohort study","volume":"3","author":"Mo","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.4158\/EP151183.OR_bb0050","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/cen.12493","article-title":"Effects of up to 15 years of recombinant human GH (rhGH) replacement on bone metabolism in adults with growth hormone deficiency (GHD): the Leiden Cohort Study","volume":"81","author":"Appelman-Dijkstra","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP151183.OR_bb0055","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1210\/jc.2013-3921","article-title":"Effects of recombinant human growth hormone therapy on bone mineral density in adults with growth hormone deficiency: a meta-analysis","volume":"99","author":"Barake","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP151183.OR_bb0060","first-page":"1671","article-title":"Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses","volume":"77","author":"Amato","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP151183.OR_bb0065","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1530\/eje.0.1330180","article-title":"Reduced bone mineral density in adults with growth hormone (GH) deficiency: increased bone turnover during 12 months of GH substitution therapy","volume":"133","author":"Degerblad","year":"1995","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP151183.OR_bb0070","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ghir.2011.01.001","article-title":"Favorable long-term effects of growth hormone replacement therapy on quality of life, bone metabolism, body composition and lipid levels in patients with adult-onset growth hormone deficiency","volume":"21","author":"J\u00f8rgensen","year":"2011","journal-title":"Growth Horm IGF Res"},{"key":"10.4158\/EP151183.OR_bb0075","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1530\/EJE-11-1072","article-title":"Fifteen years of GH replacement increases bone mineral density in hypopituitary patients with adult-onset GH deficiency","volume":"166","author":"Elbornsson","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP151183.OR_bb0080","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1365-2265.2004.01935.x","article-title":"Growth hormone replacement in adults and bone mineral density: a systematic review and meta-analysis","volume":"60","author":"Davidson","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP151183.OR_bb0085","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.1365-2265.2001.01284.x","article-title":"Effects of 6 years of growth hormone (GH) treatment on bone mineral density in GH-deficient adults","volume":"55","author":"Clanget","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP151183.OR_bb0090","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1210\/jcem.86.7.7669","article-title":"Additional beneficial effects of alendronate in growth hormone (GH)-deficient adults with osteoporosis receiving long-term recombinant human GH replacement therapy: a randomized controlled trial","volume":"86","author":"Biermasz","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP151183.OR_bb0095","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1359\/JBMR.050613","article-title":"Effect of long-term growth hormone treatment on bone mass and bone metabolism in growth hormone-deficient men","volume":"20","author":"Bravenboer","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.4158\/EP151183.OR_bb0100","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1359\/jbmr.2003.18.7.1308","article-title":"Morphological determinants of femoral strength in growth hormone-deficient transgenic growth-retarded (Tgr) rats","volume":"18","author":"Evans","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.4158\/EP151183.OR_bb0105","doi-asserted-by":"crossref","first-page":"294965","DOI":"10.1155\/2012\/294965","article-title":"Microarchitecture, but not bone mechanical properties, is rescued with growth hormone treatment in a mouse model of growth hormone deficiency","volume":"2012","author":"Kristensen","year":"2012","journal-title":"Int J Endocrinol"},{"key":"10.4158\/EP151183.OR_bb0110","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jocd.2011.05.005","article-title":"Correlations between trabecular bone score, measured using anteroposterior dual-energy X-ray absorptiometry acquisition, and 3-dimensional parameters of bone microarchitecture: an experimental study on human cadaver vertebrae","volume":"14","author":"Hans","year":"2011","journal-title":"J Clin Densitom"},{"key":"10.4158\/EP151183.OR_bb0115","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bone.2013.07.040","article-title":"Added value of trabecular bone score to bone mineral density for prediction of osteoporotic fractures in postmenopausal women: the OPUS study","volume":"57","author":"Briot","year":"2013","journal-title":"Bone"},{"key":"10.4158\/EP151183.OR_bb0120","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00198-012-2188-2","article-title":"Trabecular bone score improves fracture risk prediction in non-osteoporotic women: the OFELY study","volume":"24","author":"Boutroy","year":"2013","journal-title":"Osteoporos Int"},{"key":"10.4158\/EP151183.OR_bb0125","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/jbmr.2176","article-title":"Trabecular bone score: a noninvasive analytical method based upon the DXA image","volume":"29","author":"Silva","year":"2014","journal-title":"J Bone Miner Res"},{"key":"10.4158\/EP151183.OR_bb0130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4274\/jcrpe.v2i1.17","article-title":"Circulating insulin-like growth factor binding protein-4 (IGFBP-4) is not regulated by parathyroid hormone and vitamin D in vivo: evidence from children with rickets","volume":"2","author":"Bereket","year":"2010","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"10.4158\/EP151183.OR_bb0135","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.metabol.2007.08.011","article-title":"Linear growth in relation to the circulating concentrations of insulin-like growth factor I, parathyroid hormone, and 25-hydroxy vitamin D in children with nutritional rickets before and after treatment: endocrine adaptation to vitamin D deficiency","volume":"57","author":"Soliman","year":"2008","journal-title":"Metabolism"},{"key":"10.4158\/EP151183.OR_bb0140","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1055\/s-2004-814103","article-title":"Relationship between 25-(OH) D3, the IGF-I system, leptin, anthropometric and body composition variables in a healthy, randomly selected population","volume":"36","author":"G\u00f3mez","year":"2004","journal-title":"Horm Metab Res"},{"key":"10.4158\/EP151183.OR_bb0145","first-page":"e200","article-title":"Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects","volume":"34","author":"Bogazzi","year":"2011","journal-title":"J Endocrinol Invest"},{"key":"10.4158\/EP151183.OR_bb0150","first-page":"89","article-title":"Patients with Active Acromegaly are at High Risk of 25(OH)D Deficiency","volume":"6","author":"Halupczok-\u017by\u0142a","year":"2015","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.4158\/EP151183.OR_bb0155","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1530\/EJE-13-0510","article-title":"Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency","volume":"169","author":"Ameri","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP151183.OR_bb0160","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1359\/jbmr.071117","article-title":"Effects of growth hormone administration on bone mineral metabolism, PTH sensitivity and PTH secretory rhythm in postmenopausal women with established osteoporosis","volume":"23","author":"Joseph","year":"2008","journal-title":"J Bone Miner Res"},{"key":"10.4158\/EP151183.OR_bb0165","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1210\/jc.2005-2227","article-title":"Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society Clinical Practice Guideline","volume":"91","author":"Molitch","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP151183.OR_bb0170","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1056\/NEJM199202273260904","article-title":"Osteopenia in men with a history of delayed puberty","volume":"326","author":"Finkelstein","year":"1992","journal-title":"N Engl J Med"},{"key":"10.4158\/EP151183.OR_bb0175","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1530\/eje.0.1370240","article-title":"Increased fracture frequency in adult patients with hypopituitarism and GH deficiency","volume":"137","author":"Ros\u00e9n","year":"1997","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP151183.OR_bb0180","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1210\/jc.2005-0897","article-title":"A densitometric and morphometric analysis of the skeleton in adults with varying degrees of growth hormone deficiency","volume":"91","author":"Murray","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP151183.OR_bb0185","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1046\/j.1365-2265.2003.01905.x","article-title":"GH treatment and its effect on bone mineral density, bone maturation and growth in short children born small for gestational age: 3-year results of a randomized, controlled GH trial","volume":"59","author":"Arends","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP151183.OR_bb0190","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/8756-3282(96)00069-5","article-title":"Histomorphometric analysis of bone mass and bone metabolism in growth hormone deficient adult men","volume":"18","author":"Bravenboer","year":"1996","journal-title":"Bone"},{"key":"10.4158\/EP151183.OR_bb0195","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/cen.12268","article-title":"Interactions between vitamin D and IGF-I: from physiology to clinical practice","volume":"79","author":"Ameri","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP151183.OR_bb0200","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s00198-014-3010-0","article-title":"Can vitamin D metabolite measurements facilitate a \u201ctreat-to-target\u201d paradigm to guide vitamin D supplementation?","volume":"26","author":"Binkley","year":"2015","journal-title":"Osteoporosis Int"},{"key":"10.4158\/EP151183.OR_bb0205","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20391916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20391916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:02:13Z","timestamp":1761516133000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X20391916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S1530891X20391916"],"URL":"https:\/\/doi.org\/10.4158\/ep151183.or","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trabecular Bone Score Change Differs with Regard to 25(OH)D Levels in Patients Treated for Adult-Onset Growth Hormone Deficiency","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.4158\/EP151183.OR","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}