{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:15:21Z","timestamp":1791288921073,"version":"4.3.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.4158\/ep15756.or","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T15:17:43Z","timestamp":1438010263000},"page":"1152-1160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Germline Deletion of Armc5 In Familial Primary Macronodular Adrenal Hyperplasia"],"prefix":"10.1016","volume":"21","author":[{"given":"Sawako","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Tatsuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Oohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitoshi","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Komai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akina","family":"Shiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Takiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichiro","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikki","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Mayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Koide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Nakatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Imamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koutaro","family":"Yokote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.4158\/EP15756.OR_bb0010","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.beem.2008.10.011","article-title":"ACTH-independent macronodular adrenal hyperplasia","volume":"23","author":"Lacroix","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.4158\/EP15756.OR_bb0015","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1046\/j.1365-2265.2003.01963.x","article-title":"Vasopressin responsiveness of subclinical Cushing's syndrome due to ACTH-independent macronodular adrenocortical hyperplasia","volume":"60","author":"Tatsuno","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP15756.OR_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2265.2009.03689.x","article-title":"Aberrant G-protein coupled receptor expression in relation to adrenocortical overfunction","volume":"73","author":"Lacroix","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP15756.OR_bb0025","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1056\/NEJMoa1304603","article-title":"ARMC5 mutations in macronodular adrenal hyperplasia with Cushing's syndrome","volume":"369","author":"Assi\u00e9","year":"2013","journal-title":"N Engl J Med"},{"key":"10.4158\/EP15756.OR_bb0030","doi-asserted-by":"crossref","first-page":"E926","DOI":"10.1210\/jc.2014-4204","article-title":"ARMC5 mutations in a large cohort of primary macronodular adrenal hyperplasia: clinical and functional consequences","volume":"100","author":"Espiard","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP15756.OR_bb0035","doi-asserted-by":"crossref","first-page":"E1113","DOI":"10.1210\/jc.2013-4280","article-title":"Macronodular adrenal hyperplasia due to mutations in an armadillo repeat containing 5 (ARMC5) gene: a clinical and genetic investigation","volume":"99","author":"Faucz","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP15756.OR_bb0040","first-page":"115","article-title":"Vasopressin responders have a high prevalence of hypertension and insulin resistance in spite of a lower secretion of cortisol in subclinical Cushing's syndrome","volume":"2","author":"Suzuki","year":"2009","journal-title":"Mol Med Report"},{"key":"10.4158\/EP15756.OR_bb0045","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1210\/jc.2003-030871","article-title":"Diagnosis and complications of Cushing's syndrome: a consensus statement","volume":"88","author":"Arnaldi","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP15756.OR_bb0050","first-page":"119","article-title":"Clinical and subclinical ACTH-independent macronodular adrenal hyperplasia and aberrant hormone receptors","volume":"64","author":"Christopoulos","year":"2005","journal-title":"Horm Res"},{"key":"10.4158\/EP15756.OR_bb0055","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0140-6736(06)68699-6","article-title":"Cushing's syndrome","volume":"367","author":"Newell-Price","year":"2006","journal-title":"Lancet"},{"key":"10.4158\/EP15756.OR_bb0060","first-page":"215","article-title":"ACTH-independent macronodular adrenocortical hyperplasia: immunohistochemical and in situ hybridization studies of steroidogenic enzymes","volume":"7","author":"Sasano","year":"1994","journal-title":"Mod Pathol"},{"key":"10.4158\/EP15756.OR_bb0065","doi-asserted-by":"crossref","first-page":"E1501","DOI":"10.1210\/jc.2013-4237","article-title":"ARMC5 mutations are a frequent cause of primary macronodular adrenal hyperplasia","volume":"99","author":"Alencar","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP15756.OR_bb0070","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.humpath.2014.03.013","article-title":"Analysis of BRCA2 loss of heterozygosity in tumor tissue using droplet digital polymerase chain reaction","volume":"45","author":"Cochran","year":"2014","journal-title":"Hum Pathol"},{"key":"10.4158\/EP15756.OR_bb0075","doi-asserted-by":"crossref","first-page":"8604","DOI":"10.1021\/ac202028g","article-title":"High-throughput droplet digital PCR system for absolute quantitation of DNA copy number","volume":"83","author":"Hindson","year":"2011","journal-title":"Anal Chem"},{"key":"10.4158\/EP15756.OR_bb0080","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.1073\/pnas.1002459107","article-title":"Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species","volume":"107","author":"Suzuki","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.4158\/EP15756.OR_bb0085","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1385\/ENDO:19:3:319","article-title":"Inherited adrenocorticotropin- independent macronodular adrenal hyperplasia with abnormal cortisol secretion by vasopressin and catecholamines: detection of the aberrant hormone receptors on adrenal gland","volume":"19","author":"Miyamura","year":"2002","journal-title":"Endocrine"},{"key":"10.4158\/EP15756.OR_bb0090","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1365-2265.2005.02387.x","article-title":"Ectopic expression of vasopressin V1b and V2 receptors in the adrenal glands of familial ACTH-independent macronodular adrenal hyperplasia","volume":"63","author":"Lee","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP15756.OR_bb0095","first-page":"189","article-title":"Familial adrenocorticotropin-independent Cushing's syndrome with bilateral macronodular adrenal hyperplasia","volume":"76","author":"Findlay","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP15756.OR_bb0100","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1046\/j.1365-2265.1996.682504.x","article-title":"ACTH independent Cushing's syndrome occurring in siblings","volume":"44","author":"Minami","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP15756.OR_bb0105","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1055\/s-2002-34590","article-title":"Familial ACTH-independent Cushing's syndrome with bilateral macronodular adrenal hyperplasia clinically affecting only female family members","volume":"110","author":"Nies","year":"2002","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.4158\/EP15756.OR_bb0110","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1530\/eje.1.02324","article-title":"Familial adrenocorticotropin- independent macronodular adrenal hyperplasia with aberrant serotonin and vasopressin adrenal receptors","volume":"156","author":"Vezzosi","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"10.4158\/EP15756.OR_bb0115","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1365-2265.2008.03471.x","article-title":"Familial vasopressin-sensitive ACTH-independent macronodular adrenal hyperplasia (VPs-AIMAH): clinical studies of three kindreds","volume":"70","author":"Gagliardi","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP15756.OR_bb0120","doi-asserted-by":"crossref","first-page":"E1784","DOI":"10.1210\/jc.2014-1265","article-title":"ARMC5 mutations are common in familial bilateral macronodular adrenal hyperplasia","volume":"99","author":"Gagliardi","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP15756.OR_bb0125","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12881-014-0106-5","article-title":"Mapping the deletion endpoints in individuals with 22q11.2 deletion syndrome by droplet digital PCR","volume":"15","author":"Hwang","year":"2014","journal-title":"BMC Med Genet"},{"key":"10.4158\/EP15756.OR_bb0130","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1158\/1078-0432.CCR-12-3768","article-title":"Noninvasive detection of HER2 amplification with plasma DNA digital PCR","volume":"19","author":"Gevensleben","year":"2013","journal-title":"Clin Cancer Res"},{"key":"10.4158\/EP15756.OR_bb0135","doi-asserted-by":"crossref","first-page":"e0117983","DOI":"10.1371\/journal.pone.0117983","article-title":"The use of a two-tiered testing strategy for the simultaneous detection of small EGFR mutations and EGFR amplification in lung cancer","volume":"10","author":"Lewandowska","year":"2015","journal-title":"PLoS One"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20355324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20355324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:59:27Z","timestamp":1761515967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X20355324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1530891X20355324"],"URL":"https:\/\/doi.org\/10.4158\/ep15756.or","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Germline Deletion of Armc5 In Familial Primary Macronodular Adrenal Hyperplasia","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.4158\/EP15756.OR","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}