{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:10:45Z","timestamp":1773076245192,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["aacejournalendocrinepractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Endocrine Practice"],"published-print":{"date-parts":[[2016]]},"DOI":"10.4158\/ep15990.or","type":"journal-article","created":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T13:27:08Z","timestamp":1467293228000},"page":"1088-1095","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Asymmetric Dimethylarginine Levels and Atherosclerosis Markers in Cushing Syndrome"],"prefix":"10.1016","volume":"22","author":[{"given":"Cemile Gulbas","family":"Ozsurekci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mujde","family":"Akturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cigdem","family":"Ozkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Gulbahar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alev Eroglu","family":"Altinova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhittin","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emre","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fusun","family":"Toruner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.4158\/EP15990.OR_bb0010","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2265.1994.tb02486.x","article-title":"Morbidity and mortality in Cushing's disease: an epidemiological approach","volume":"40","author":"Etxabe","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.4158\/EP15990.OR_bb0015","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1210\/jc.2012-3754","article-title":"Hypercortisolism is associated with increased coronary arterial atherosclerosis: analysis of noninvasive coronary angiography using multidetector computerized tomography","volume":"98","author":"Neary","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP15990.OR_bb0020","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.carpath.2006.04.006","article-title":"C-reactive protein: a non traditional serum marker of cardiovascular risk","volume":"16","author":"de Ferranti","year":"2007","journal-title":"Cardiovasc Pathol"},{"key":"10.4158\/EP15990.OR_bb0025","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.phrs.2009.07.001","article-title":"Asymmetricdimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality--an update on patient populations with a wide range of cardiovascular risk","volume":"60","author":"B\u00f6ger","year":"2009","journal-title":"Pharmacol Res"},{"key":"10.4158\/EP15990.OR_bb0030","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1155\/2013\/432136","article-title":"Lipoprotein-associated phospholipase A2 (Lp-PLA(2)): a novel and promising biomarker for cardiovascular risks assessment","volume":"34","author":"Cai","year":"2013","journal-title":"Dis Markers"},{"key":"10.4158\/EP15990.OR_bb0035","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.2174\/092986712800493039","article-title":"Clinical utility of biomarkers in premature atherosclerosis","volume":"19","author":"Kampoli","year":"2012","journal-title":"Curr Med Chem"},{"key":"10.4158\/EP15990.OR_bb0040","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2174\/157340310791162659","article-title":"The role of asymmetric dimethylarginine (ADMA) in endothelial dysfunction and cardiovascular disease","volume":"6","author":"Sibal","year":"2010","journal-title":"Curr Cardiol Rev"},{"key":"10.4158\/EP15990.OR_bb0045","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.thromres.2014.05.025","article-title":"Relationship between homocysteine and coronary artery disease. Results from a large prospective cohort study","volume":"134","author":"Schaffer","year":"2014","journal-title":"Thromb Res"},{"key":"10.4158\/EP15990.OR_bb0050","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1161\/hc4601.098514","article-title":"Homocysteine impairs the nitric oxide synthase pathway: role of asymmetricdimethylarginine","volume":"104","author":"St\u00fchlinger","year":"2001","journal-title":"Circulation"},{"key":"10.4158\/EP15990.OR_bb0055","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/01.ATV.0000160551.21962.a7","article-title":"Role of lipoprotein-associated-phospholipase A2 in atherosclerosis: biology, epidemiology, and possible therapeutic target","volume":"25","author":"Zalewski","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"suppl","key":"10.4158\/EP15990.OR_bb0060","first-page":"S108","article-title":"Inflammation and atherosclerosis: the value of the high-sensitivity C-reactive protein assay as a risk marker","volume":"116","author":"Jialal","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"10.4158\/EP15990.OR_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2013.01.025","article-title":"Carotid intima-media thickness for cardiovascular risk assessment: systematic review and meta-analysis","volume":"228","author":"van den Oord","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.4158\/EP15990.OR_bb0070","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3949\/ccjm.79a.11154","article-title":"Using the ankle-brachial index to diagnose peripheral artery disease and assess cardiovascular risk","volume":"79","author":"Kim","year":"2012","journal-title":"Cleve Clin J Med"},{"key":"10.4158\/EP15990.OR_bb0075","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1210\/jcem-57-3-619","article-title":"Plasma lipoproteins, lipolytic enzymes, and very low density lipoprotein triglyceride turnover in Cushing's syndrome","volume":"57","author":"Taskinen","year":"1983","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP15990.OR_bb0080","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1210\/jc.2002-021558","article-title":"Cardiovascular risk factors and common carotid artery caliber and stiffness in patients with Cushing's disease during active disease and 1 year after disease remission","volume":"88","author":"Faggiano","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP15990.OR_bb0085","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1210\/jc.2004-0079","article-title":"Hyperhomocysteinemia in patients with Cushing's syndrome","volume":"89","author":"Terzolo","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.4158\/EP15990.OR_bb0090","doi-asserted-by":"crossref","first-page":"734","DOI":"10.4158\/EP14408.OR","article-title":"Conditioning factors for high cardiovascular risk in patients with Cushing syndrome","volume":"21","author":"Boero","year":"2015","journal-title":"Endocr Pract"},{"key":"10.4158\/EP15990.OR_bb0095","doi-asserted-by":"crossref","first-page":"286","DOI":"10.4158\/EP14399.OR","article-title":"Increased soluble TNF receptor-1 and glutathione peroxidase may predict carotid intima media thickness in females with Cushing syndrome","volume":"21","author":"Shivaprasad","year":"2015","journal-title":"Endocr Pract"},{"key":"10.4158\/EP15990.OR_bb0100","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1210\/jc.2008-0125","article-title":"The diagnosis of Cushing's syndrome: an Endocrine Society clinical practice guideline","volume":"93","author":"Nieman","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"suppl","key":"10.4158\/EP15990.OR_bb0105","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.2337\/dc15-S005","article-title":"Classification and diagnosis of diabetes","volume":"3","author":"American Diabetes Association","year":"2015","journal-title":"Diabetes Care"},{"key":"10.4158\/EP15990.OR_bb0110","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"key":"10.4158\/EP15990.OR_bb0115","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (AdultTreatment Panel III) final report","volume":"106","author":"National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (AdultTreatment Panel III)","year":"2002","journal-title":"Circulation"},{"issue":"suppl","key":"10.4158\/EP15990.OR_bb0120","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.jvs.2006.12.037","article-title":"Inter-society consensus for the management of peripheral arterial disease (TASC II)","volume":"45","author":"Norgren","year":"2007","journal-title":"J Vasc Surg"},{"key":"10.4158\/EP15990.OR_bb0125","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1573399810666140214093600","article-title":"Assessment of pancreatic \u03b2-cell function: review of methods and clinical applications","volume":"10","author":"Cersosimo","year":"2014","journal-title":"Curr Diabetes Rev"},{"key":"10.4158\/EP15990.OR_bb0130","doi-asserted-by":"crossref","first-page":"H3227","DOI":"10.1152\/ajpheart.00998.2007","article-title":"Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems","volume":"293","author":"Palm","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.4158\/EP15990.OR_bb0135","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1161\/01.HYP.23.1.25","article-title":"Glucocorticoid increases angiotensin II type 1 receptor and its gene expression","volume":"23","author":"Sato","year":"1994","journal-title":"Hypertension"},{"key":"10.4158\/EP15990.OR_bb0140","first-page":"159","article-title":"Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy","volume":"58","author":"Be\u0142towski","year":"2006","journal-title":"Pharmacol Rep"},{"key":"10.4158\/EP15990.OR_bb0145","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12933-014-0156-1","article-title":"Asymmetric dimethylarginine and long-term adverse cardiovascular events in patients with type 2 diabetes: relation with the glycemic control","volume":"13","author":"Hsu","year":"2014","journal-title":"Cardiovasc Diabetol"},{"key":"10.4158\/EP15990.OR_bb0150","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s00125-002-0975-6","article-title":"Asymmetric dimethylarginine (ADMA): a potential link between endothelial dysfunction and cardiovascular diseases in insulin resistance syndrome?","volume":"45","author":"Chan","year":"2002","journal-title":"Diabetologia"},{"key":"10.4158\/EP15990.OR_bb0155","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/BF03346383","article-title":"Biochemical markers for cardiovascular risk following treatment in endogenous Cushing's syndrome","volume":"31","author":"Kristo","year":"2008","journal-title":"J Endocrinol Invest"},{"key":"10.4158\/EP15990.OR_bb0160","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1055\/s-2006-944545","article-title":"Patients with Cushing's syndrome have increased intimal media thickness at different vascular levels: comparison with a population matched for similar cardiovascular risk factors","volume":"38","author":"Albiger","year":"2006","journal-title":"Horm Metab Res"},{"key":"10.4158\/EP15990.OR_bb0165","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.jacc.2008.02.034","article-title":"Lipoprotein management in patients with cardio metabolic risk: consensus conference report from the American Diabetes Association and the American College of Cardiology Foundation","volume":"51","author":"Brunzell","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.4158\/EP15990.OR_bb0170","unstructured":"RosensonRS, KangDS.Overview of homocysteine July 2014. Available at: http:\/\/www.uptodate.com\/contents\/overview-of-homocysteine. Accessed July 12, 2016."},{"key":"10.4158\/EP15990.OR_bb0175","first-page":"427","article-title":"Normal value correlates of carotid intima-media thickness and affecting parameters in healthy adults [in Turkish]","volume":"12","author":"Be\u015fir","year":"2012","journal-title":"Anadolu Kardiyol Derg"},{"issue":"suppl 1","key":"10.4158\/EP15990.OR_bb0180","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000314294","article-title":"Management of dyslipidemia in Cushing's syndrome","volume":"92","author":"Greenman","year":"2010","journal-title":"Neuroendocrinology"},{"key":"10.4158\/EP15990.OR_bb0185","doi-asserted-by":"crossref","first-page":"963","DOI":"10.33549\/physiolres.931842","article-title":"Plasma concentrations of adipocyte fatty acid binding protein in patients with Cushing's syndrome","volume":"59","author":"Durovcov\u00e1","year":"2010","journal-title":"Physiol Res"},{"issue":"suppl 1","key":"10.4158\/EP15990.OR_bb0190","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000314213","article-title":"Pathophysiology of dyslipidemia in Cushing's syndrome","volume":"92","author":"Arnaldi","year":"2010","journal-title":"Neuroendocrinology"},{"key":"10.4158\/EP15990.OR_bb0195","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/art.21329","article-title":"Glucocorticoid use and serum lipid levels in US adults: the Third National Health and Nutrition Examination Survey","volume":"53","author":"Choi","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.4158\/EP15990.OR_bb0200","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mce.2007.05.015","article-title":"Glucocorticoids, metabolism and metabolic diseases","volume":"275","author":"Vegiopoulos","year":"2007","journal-title":"Mol Cell Endocrinol"},{"key":"10.4158\/EP15990.OR_bb0205","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1365-2265.2004.02168.x","article-title":"High cardiovascular risk in patients with Cushing's syndrome according to 1999 WHO\/ISH guidelines","volume":"61","author":"Mancini","year":"2004","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["Endocrine Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20416830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1530891X20416830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:02:03Z","timestamp":1761516123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1530891X20416830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016]]}},"alternative-id":["S1530891X20416830"],"URL":"https:\/\/doi.org\/10.4158\/ep15990.or","relation":{},"ISSN":["1530-891X"],"issn-type":[{"value":"1530-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Asymmetric Dimethylarginine Levels and Atherosclerosis Markers in Cushing Syndrome","name":"articletitle","label":"Article Title"},{"value":"Endocrine Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.4158\/EP15990.OR","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}