{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:28:14Z","timestamp":1791250094609,"version":"4.1.0"},"reference-count":89,"publisher":"Informa UK Limited","issue":"24","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Cell Cycle"],"published-print":{"date-parts":[[2014,12,15]]},"DOI":"10.4161\/15384101.2014.987627","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T13:16:21Z","timestamp":1416316581000},"page":"3798-3807","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":24,"title":["Guilty as CHARGED: p53's expanding role in disease"],"prefix":"10.1080","volume":"13","author":[{"given":"Jeanine L","family":"Van Nostrand","sequence":"first","affiliation":[{"name":"Division of Radiation and Cancer Biology; Department of Radiation Oncology; Stanford School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D","family":"Attardi","sequence":"additional","affiliation":[{"name":"Division of Radiation and Cancer Biology; Department of Radiation Oncology; Stanford School of Medicine","place":["Stanford, USA"]},{"name":"Department of Genetics; Stanford School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2015,1,3]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/356215a0"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00002-6"},{"key":"e_1_3_4_4_1","first-page":"603","article-title":"Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene","volume":"9","author":"Purdie C","year":"1994","unstructured":"Purdie C, Harrison D, Peter A, Dobbie L, White S, Howie S, Salter D, Bird C, Wyllie A, Hooper M, et\u00a0al. Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene. Oncogene 1994; 9:603-9; PMID:8290271","journal-title":"Oncogene"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2011.07.003"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc864"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.04.037"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07986"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.064501"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.03.149"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc992"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.15.5527-5538.2002"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng714"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/378203a0"},{"key":"e_1_3_4_15_1","first-page":"3221","article-title":"mdmx is a negative regulator of p53 activity in vivo","volume":"62","author":"Finch RA","year":"2002","unstructured":"Finch RA, Donoviel DB, Potter D, Shi M, Fan A, Freed DD, Wang CY, Zambrowicz BP, Ramirez-Solis R, Sands AT, et\u00a0al. mdmx is a negative regulator of p53 activity in vivo. Cancer Res 2002; 62:3221-5; PMID:12036937","journal-title":"Cancer Res"},{"key":"e_1_3_4_16_1","first-page":"8664","article-title":"Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets","volume":"63","author":"Chavez-Reyes A","year":"2003","unstructured":"Chavez-Reyes A, Parant JM, Amelse LL, de Oca Luna RM, Korsmeyer SJ, Lozano G. Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets. Cancer Res 2003; 63:8664-9; PMID:14695178","journal-title":"Cancer Res"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/378206a0"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.13.7.4107-4114.1993"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90644-R"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401912"},{"key":"e_1_3_4_21_1","first-page":"88","article-title":"MDM2 and MDMX: alone and together in regulation of p53","volume":"1","author":"Shadfan M","year":"2012","unstructured":"Shadfan M, Lopez-Pajares V, Yuan Z-M. MDM2 and MDMX: alone and together in regulation of p53. Transla Cancer Res 2012; 1:88-99; PMID:23002429","journal-title":"Transla Cancer Res"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.01.009"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.1.192-198.2006"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200508130"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-013656"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4077"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.053645"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2014.01.009"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.02.007"},{"key":"e_1_3_4_30_1","first-page":"3226","volume-title":"Proc Natl Acad Sci U S A","author":"Xiong S","year":"2006","unstructured":"Xiong S, Van Pelt CS, Elizondo-Fraire AC, Liu G, Lozano G. Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Proc Natl Acad Sci U S A 2006; 103:3226-31"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.03.035"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1498"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201244"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.21.13030"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202539"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13585"},{"key":"e_1_3_4_37_1","first-page":"17123","volume-title":"Proc Natl Acad Sci","author":"Jiang D","year":"2011","unstructured":"Jiang D, Brady CA, Johnson TM, Lee EY, Park EJ, Scott MP, Attardi LD. Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proc Natl Acad Sci 2011; 108:17123-8"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.10.1235"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.24.5080"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289803700302"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30559"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22086"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.087106"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi375"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-006-0107-6"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2011.08.005"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.036160"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08733"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420310303"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24156"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904280106"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.04.014"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq265"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1725"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2010.01446.x"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1831"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.188"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.052"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq189"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2063"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.188"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advenzreg.2011.09.008"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-132290"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2022-3"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.03.006"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-259705"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-295238"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.05.028"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2013.09.002"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80762-X"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-351460"},{"key":"e_1_3_4_72_1","first-page":"3587","volume-title":"Dev (Cambridge, England)","author":"Zhang Z","year":"2006","unstructured":"Zhang Z, Huynh T, Baldini A. Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Dev (Cambridge, England) 2006; 133:3587-95; PMID:16914493"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-013-0384-6"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1401923111"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mod.2008.07.003"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.969302"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21211"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029379"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.224386.113"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2100"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00555-06"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2238"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.2.462-473.2003"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1378506"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/415045a"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1162404"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf595"},{"key":"e_1_3_4_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.16.4657"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0695-175"},{"key":"e_1_3_4_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(95)00183-7"}],"container-title":["Cell Cycle"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.4161\/15384101.2014.987627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T23:32:30Z","timestamp":1770939150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.4161\/15384101.2014.987627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,15]]},"references-count":89,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2014,12,15]]}},"alternative-id":["10.4161\/15384101.2014.987627"],"URL":"https:\/\/doi.org\/10.4161\/15384101.2014.987627","relation":{},"ISSN":["1538-4101","1551-4005"],"issn-type":[{"value":"1538-4101","type":"print"},{"value":"1551-4005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,15]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kccy20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=kccy20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2014-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}