{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:39:59Z","timestamp":1773779999090,"version":"3.50.1"},"reference-count":49,"publisher":"Informa UK Limited","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Cycle"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.4161\/cc.24757","type":"journal-article","created":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:08:42Z","timestamp":1370045322000},"page":"1679-1687","source":"Crossref","is-referenced-by-count":101,"title":["Oncogenic miR-181a\/b affect the DNA damage response in aggressive breast cancer"],"prefix":"10.1080","volume":"12","author":[{"given":"Andrea","family":"BISSO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Faleschini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Zampa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Capaci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"De Santa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libero","family":"Santarpia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvano","family":"Piazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Cappelletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariagrazia","family":"Daidone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reuven","family":"Agami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giannino","family":"Del Sal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2014,11,3]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nature05327","article-title":"Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication","volume":"444","author":"Di Micco","year":"2006","journal-title":"Nature"},{"key":"R2","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nature03482","article-title":"DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis","volume":"434","author":"Bartkova","year":"2005","journal-title":"Nature"},{"key":"R3","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1038\/sj.onc.1209873","article-title":"ATM and breast cancer susceptibility","volume":"25","author":"Ahmed","year":"2006","journal-title":"Oncogene"},{"key":"R4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrc3181","article-title":"BRCA1 and BRCA2: different roles in a common pathway of genome protection","volume":"12","author":"Roy","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"R5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/bcr557","article-title":"Regulation of BRCA1 expression and its relationship to sporadic breast cancer","volume":"5","author":"Mueller","year":"2003","journal-title":"Breast Cancer Res"},{"key":"R6","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1038\/sj.onc.1210885","article-title":"The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1\/BRCA2-deficient and ER\/PR\/ERBB2-triple-negative breast cancer","volume":"27","author":"Tommiska","year":"2008","journal-title":"Oncogene"},{"key":"R7","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/jnci\/92.7.564","article-title":"Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors","volume":"92","author":"Esteller","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"R8","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1128\/MCB.23.7.2225-2238.2003","article-title":"Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma","volume":"23","author":"Baldassarre","year":"2003","journal-title":"Mol Cell Biol"},{"key":"R9","doi-asserted-by":"crossref","first-page":"e25454","DOI":"10.1371\/journal.pone.0025454","article-title":"miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase","volume":"6","author":"Song","year":"2011","journal-title":"PLoS ONE"},{"key":"R10","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1073\/pnas.0907763107","article-title":"ATM is down-regulated by N-Myc-regulated microRNA-421","volume":"107","author":"Hu","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"R11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/emmm.201100136","article-title":"Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers","volume":"3","author":"Garcia","year":"2011","journal-title":"EMBO Mol Med"},{"key":"R12","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.molcel.2010.12.005","article-title":"miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors","volume":"41","author":"Moskwa","year":"2011","journal-title":"Mol Cell"},{"key":"R13","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nrc1457","article-title":"Hallmarks of \u2018BRCAness\u2019 in sporadic cancers","volume":"4","author":"Turner","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"R14","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1093\/carcin\/bgs232","article-title":"The rebel angel: mutant p53 as the driving oncogene in breast cancer","volume":"33","author":"Walerych","year":"2012","journal-title":"Carcinogenesis"},{"key":"R15","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nrc3342","article-title":"The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance","volume":"12","author":"Bouwman","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"R16","first-page":"702","article-title":"BRCA mutations in the management of breast cancer: the state of the art. Nature reviews","volume":"7","author":"Narod","year":"2010","journal-title":"Clin Oncol"},{"key":"R17","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nature10760","article-title":"The DNA damage response and cancer therapy","volume":"481","author":"Lord","year":"2012","journal-title":"Nature"},{"key":"R18","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nrg2634","article-title":"Causes and consequences of microRNA dysregulation in cancer","volume":"10","author":"Croce","year":"2009","journal-title":"Nat Rev Genet"},{"key":"R19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"R20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrm2619","article-title":"Revisiting the principles of microRNA target recognition and mode of action","volume":"10","author":"Brodersen","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"R21","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2007.10.054","article-title":"let-7 regulates self renewal and tumorigenicity of breast cancer cells","volume":"131","author":"Yu","year":"2007","journal-title":"Cell"},{"key":"R22","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/emmm.201201483","article-title":"miR-10b*, a master inhibitor of the cell cycle, is down-regulated in human breast tumours","volume":"4","author":"Biagioni","year":"2012","journal-title":"EMBO Mol Med"},{"key":"R23","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.cell.2010.05.017","article-title":"A MicroRNA targeting dicer for metastasis control","volume":"141","author":"Martello","year":"2010","journal-title":"Cell"},{"key":"R24","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1073\/pnas.0510565103","article-title":"A microRNA expression signature of human solid tumors defines cancer gene targets","volume":"103","author":"Volinia","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"R25","doi-asserted-by":"crossref","first-page":"e20980","DOI":"10.1371\/journal.pone.0020980","article-title":"Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer","volume":"6","author":"Roth\u00e9","year":"2011","journal-title":"PLoS ONE"},{"key":"R26","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1261\/rna.1034808","article-title":"MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis","volume":"14","author":"Yan","year":"2008","journal-title":"RNA"},{"key":"R27","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrm2514","article-title":"Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer","volume":"9","author":"Lavin","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"R28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nrm2858","article-title":"Genomic instability--an evolving hallmark of cancer","volume":"11","author":"Negrini","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"R29","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1126\/science.286.5442.1162","article-title":"Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks","volume":"286","author":"Cortez","year":"1999","journal-title":"Science"},{"key":"R30","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature03445","article-title":"Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy","volume":"434","author":"Farmer","year":"2005","journal-title":"Nature"},{"key":"R31","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1200\/JCO.2007.14.4147","article-title":"Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer","volume":"26","author":"Liedtke","year":"2008","journal-title":"J Clin Oncol"},{"key":"R32","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nature10933","article-title":"The clonal and mutational evolution spectrum of primary triple-negative breast cancers","volume":"486","author":"Shah","year":"2012","journal-title":"Nature"},{"key":"R33","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/onc.2010.531","article-title":"Transforming growth factor-beta regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM","volume":"30","author":"Wang","year":"2011","journal-title":"Oncogene"},{"key":"R34","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1172\/JCI64946","article-title":"TGF-\u03b2 upregulates miR-181a expression to promote breast cancer metastasis","volume":"123","author":"Taylor","year":"2013","journal-title":"J Clin Invest"},{"key":"R35","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.molcel.2010.07.023","article-title":"STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer","volume":"39","author":"Iliopoulos","year":"2010","journal-title":"Mol Cell"},{"key":"R36","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1038\/onc.2009.468","article-title":"TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3","volume":"29","author":"Wang","year":"2010","journal-title":"Oncogene"},{"key":"R37","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1128\/MCB.01395-06","article-title":"A microRNA signature of hypoxia","volume":"27","author":"Kulshreshtha","year":"2007","journal-title":"Mol Cell Biol"},{"key":"R38","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2045-3701-1-4","article-title":"Wnt\/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma","volume":"1","author":"Ji","year":"2011","journal-title":"Cell Biosci"},{"key":"R39","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1177\/1947601910366860","article-title":"Identification of a New Pathway for Tumor Progression: MicroRNA-181b Up-Regulation and CBX7 Down-Regulation by HMGA1 Protein","volume":"1","author":"Mansueto","year":"2010","journal-title":"Genes Cancer"},{"key":"R40","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1128\/MCB.01971-08","article-title":"miR-181a regulates cap-dependent translation of p27(kip1) mRNA in myeloid cells","volume":"29","author":"Cuesta","year":"2009","journal-title":"Mol Cell Biol"},{"key":"R41","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cell.2011.09.032","article-title":"In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma","volume":"147","author":"Karreth","year":"2011","journal-title":"Cell"},{"key":"R42","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nbt0511-373","article-title":"PARP inhibitors stumble in breast cancer","volume":"29","author":"Guha","year":"2011","journal-title":"Nat Biotechnol"},{"key":"R43","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1158\/0008-5472.CAN-09-3112","article-title":"miR-181a and miR-630 regulate cisplatin-induced cancer cell death","volume":"70","author":"Galluzzi","year":"2010","journal-title":"Cancer Res"},{"key":"R44","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1158\/1078-0432.CCR-11-2425","article-title":"A phase I combination study of olaparib with cisplatin and gemcitabine in adults with solid tumors","volume":"18","author":"Rajan","year":"2012","journal-title":"Clin Cancer Res"},{"key":"R45","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1200\/JCO.2009.22.4725","article-title":"Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer","volume":"28","author":"Silver","year":"2010","journal-title":"J Clin Oncol"},{"key":"R46","doi-asserted-by":"crossref","first-page":"e23271","DOI":"10.1371\/journal.pone.0023271","article-title":"Prognostic significance of miR-181b and miR-21 in gastric cancer patients treated with S-1\/Oxaliplatin or Doxifluridine\/Oxaliplatin","volume":"6","author":"Jiang","year":"2011","journal-title":"PLoS ONE"},{"key":"R47","first-page":"317","article-title":"Non-coding MicroRNAs hsa-let-7g and hsa-miR-181b are Associated with Chemoresponse to S-1 in Colon Cancer","volume":"3","author":"Nakajima","year":"2006","journal-title":"Cancer Genomics Proteomics"},{"key":"R48","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nrc3166","article-title":"Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy","volume":"11","author":"Kasinski","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"R49","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrd3179","article-title":"Targeting microRNAs in cancer: rationale, strategies and challenges","volume":"9","author":"Garzon","year":"2010","journal-title":"Nat Rev Drug Discov"}],"container-title":["Cell Cycle"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.4161\/cc.24757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T05:41:53Z","timestamp":1563082913000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/abs\/10.4161\/cc.24757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":49,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,3]]},"published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.4161\/cc.24757"],"URL":"https:\/\/doi.org\/10.4161\/cc.24757","relation":{},"ISSN":["1538-4101","1551-4005"],"issn-type":[{"value":"1538-4101","type":"print"},{"value":"1551-4005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}