{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:17:29Z","timestamp":1769599049834,"version":"3.49.0"},"reference-count":81,"publisher":"Informa UK Limited","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Cycle"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.4161\/cc.9.9.11544","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T17:21:48Z","timestamp":1274376108000},"page":"1839-1846","source":"Crossref","is-referenced-by-count":23,"title":["Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy"],"prefix":"10.1080","volume":"9","author":[{"given":"Stephen L.","family":"Abrams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda S.","family":"Steelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Shelton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Chappell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"B\u00e4secke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franca","family":"Stivala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Donia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Libra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto M.","family":"Martelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A","family":"McCubrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2014,10,28]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"7414","DOI":"10.1073\/pnas.82.21.7414","article-title":"Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors","volume":"82","author":"McKearn","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R2","first-page":"97","article-title":"Abrogation of factor-dependence in two IL-3-dependent cell lines can occur by two distinct mechanisms","volume":"4","author":"McCubrey","year":"1989","journal-title":"Oncogene Res"},{"key":"R3","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/leu.2008.26","article-title":"Contributions of the Raf\/MEK\/ERK, PI3K\/PTEN\/Akt\/mTOR and Jak\/STAT pathways to leukemia","volume":"22","author":"Steelman","year":"2008","journal-title":"Leukemia"},{"key":"R4","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/leu.2008.27","article-title":"Targeting survival cascades induced by activation of Ras\/Raf\/MEK\/ERK, PI3K\/PTEN\/Akt\/mTOR and Jak\/STAT pathways for effective leukemia therapy","volume":"22","author":"McCubrey","year":"2008","journal-title":"Leukemia"},{"key":"R5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/leu.2008.246","article-title":"Targeting the leukemic stem cell: the Holy Grail of leukemia therapy","volume":"23","author":"Misaghian","year":"2009","journal-title":"Leukemia"},{"key":"R6","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1182\/blood.V86.8.3139.3139","article-title":"Synergy between AUUUA motif disruption and enhancer insertion results in autocrine transformation of interleukin-3-dependent hematopoietic cells","volume":"86","author":"Mayo","year":"1995","journal-title":"Blood"},{"key":"R7","first-page":"487","article-title":"Malignant transformation induced by cytokine genes: a comparison of the abilities of germline and mutated interleukin 3 genes to transform hematopoietic cells by transcriptional and posttranscriptional mechanisms","volume":"7","author":"Wang","year":"1996","journal-title":"Cell Growth Differ"},{"key":"R8","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/sj.leu.2400793","article-title":"Differential effects of retroviral long terminal repeats on interleukin-3 gene expression and autocrine transformation","volume":"11","author":"Wang","year":"1997","journal-title":"Leukemia"},{"key":"R9","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1038\/sj.onc.1206321","article-title":"Effects of the RAF\/MEK\/ERK and PI3K\/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells","volume":"22","author":"Shelton","year":"2003","journal-title":"Oncogene"},{"key":"R10","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/sj.leu.2404217","article-title":"Synergy between an IGF-1R antibody and Raf\/MEK\/ERK and PI3K\/Akt\/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells","volume":"20","author":"Bertrand","year":"2006","journal-title":"Leukemia"},{"key":"R11","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1038\/leu.2008.207","article-title":"Involvement of p53 and Raf\/MEK\/ERK pathways in hematopoietic drug resistance","volume":"22","author":"McCubrey","year":"2008","journal-title":"Leukemia"},{"key":"R12","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.4161\/cc.8.18.9545","article-title":"p38MAPK inhibitors attenuate cytokine production by bone marrow stromal cells and reduce stroma-mediated proliferation of acute lymphoblastic leukemia cells","volume":"8","author":"Gaundar","year":"2009","journal-title":"Cell Cycle"},{"key":"R13","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.4161\/cc.7.17.6594","article-title":"Expanding role of cyclin dependent kinases in cytokine inducible gene expression","volume":"7","author":"Brasier","year":"2008","journal-title":"Cell Cycle"},{"key":"R14","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.4161\/cc.8.10.8381","article-title":"Defining pathways that enforce cell lineage specification in early development and stem cells","volume":"8","author":"Roper","year":"2009","journal-title":"Cell Cycle"},{"key":"R15","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.4161\/cc.8.13.8985","article-title":"Chronic inflammation, the tumor microenvironment and carcinogenesis","volume":"8","author":"Gonda","year":"2009","journal-title":"Cell Cycle"},{"key":"R16","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.4161\/cc.7.10.5954","article-title":"Cancer stem cells and survival pathways","volume":"7","author":"Hambardzumyan","year":"2008","journal-title":"Cell Cycle"},{"key":"R17","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.4161\/cbt.6.11.5167","article-title":"Cancer stem cell and cancer stemloids: from biology to therapy","volume":"6","author":"Blagosklonny","year":"2007","journal-title":"Cancer Biol Ther"},{"key":"R18","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.4161\/cc.8.9.8209","article-title":"The CML stem cell: evolution of the progenitor","volume":"8","author":"Stuart","year":"2009","journal-title":"Cell Cycle"},{"key":"R19","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.4161\/cc.8.7.8041","article-title":"Genomic instability en route to and from cancer stem cells","volume":"8","author":"Li","year":"2009","journal-title":"Cell Cycle"},{"key":"R20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4161\/cc.8.1.7533","article-title":"Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance","volume":"8","author":"Alvero","year":"2009","journal-title":"Cell Cycle"},{"key":"R21","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.4161\/cc.7.24.7214","article-title":"Stem cell aging: survival of the laziest?","volume":"7","author":"Muller-Sieburg","year":"2008","journal-title":"Cell Cycle"},{"key":"R22","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1182\/blood-2006-02-003475","article-title":"Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia","volume":"108","author":"Kornblau","year":"2006","journal-title":"Blood"},{"key":"R23","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.exphem.2007.07.001","article-title":"Establishing long-term cultures with self-renewing acute myeloid leukemia stem\/progenitor cells","volume":"35","author":"van Gosliga","year":"2007","journal-title":"Exp Hematol"},{"key":"R24","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1038\/sj.leu.2401903","article-title":"The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells","volume":"14","author":"Jordan","year":"2000","journal-title":"Leukemia"},{"key":"R25","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1182\/blood-2002-11-3429","article-title":"Survival of acute myeloid leukemia cells requires PI3 kinase activation","volume":"102","author":"Xu","year":"2003","journal-title":"Blood"},{"key":"R26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0092-8674(00)80674-1","article-title":"The multiple roles of PTEN in tumor suppression","volume":"100","author":"Di Cristofano","year":"2000","journal-title":"Cell"},{"key":"R27","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature04703","article-title":"Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells","volume":"441","author":"Yilmaz","year":"2006","journal-title":"Nature"},{"key":"R28","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature04747","article-title":"PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention","volume":"441","author":"Zhang","year":"2006","journal-title":"Nature"},{"key":"R29","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.4161\/cc.7.10.5953","article-title":"Cancer stem cells: Models, mechanisms and implications for improved treatment","volume":"7","author":"Zhou","year":"2008","journal-title":"Cell Cycle"},{"key":"R30","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.4161\/cc.8.19.9758","article-title":"Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models","volume":"8","author":"Sabisz","year":"2009","journal-title":"Cell Cycle"},{"key":"R31","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.bbamcr.2006.10.001","article-title":"Roles of the Raf\/MEK\/ERK pathway in cell growth, malignant transformation and drug resistance","volume":"1773","author":"McCubrey","year":"2007","journal-title":"Biochim Biophys Acta"},{"key":"R32","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.advenzreg.2009.10.016","article-title":"Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells","volume":"50","author":"McCubrey","year":"2010","journal-title":"Adv Enzyme Regul"},{"key":"R33","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.4161\/cc.8.9.8255","article-title":"PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches","volume":"8","author":"Ligresti","year":"2009","journal-title":"Cell Cycle"},{"key":"R34","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.4161\/cc.7.24.7244","article-title":"Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors","volume":"7","author":"Carracedo","year":"2008","journal-title":"Cell Cycle"},{"key":"R35","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4161\/cc.8.3.7555","article-title":"PI3K\/mTORC1 activation in hamartoma syndromes: therapeutic prospects","volume":"8","author":"Krymskaya","year":"2009","journal-title":"Cell Cycle"},{"key":"R36","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.4161\/cc.8.7.8044","article-title":"Targeting mTOR with rapamycin: one dose does not fit all","volume":"8","author":"Foster","year":"2009","journal-title":"Cell Cycle"},{"key":"R37","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.4161\/cc.7.12.6166","article-title":"Targeting prostate cancer based on signal transduction and cell cycle pathways","volume":"7","author":"Lee","year":"2008","journal-title":"Cell Cycle"},{"key":"R38","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1038\/onc.2008.49","article-title":"Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors","volume":"27","author":"Steelman","year":"2008","journal-title":"Oncogene"},{"key":"R39","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1038\/leu.2008.192","article-title":"c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia","volume":"22","author":"Lagadinou","year":"2008","journal-title":"Leukemia"},{"key":"R40","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.4161\/cc.7.20.6920","article-title":"Resist or die: FOXO transcription factors determine the cellular response to chemotherapy","volume":"7","author":"Gomes","year":"2008","journal-title":"Cell Cycle"},{"key":"R41","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.4161\/cc.7.18.6675","article-title":"Phosphoinositide 3-kinase signaling overrides a G2 phase arrest checkpoint and promotes aberrant cell cycling and death of hematopoietic cells after DNA damage","volume":"7","author":"Nimbalkar","year":"2008","journal-title":"Cell Cycle"},{"key":"R42","doi-asserted-by":"crossref","first-page":"965","DOI":"10.4161\/cc.7.8.5753","article-title":"The role of the PTEN\/AKT Pathway in NOTCH1-induced leukemia","volume":"7","author":"Palomero","year":"2008","journal-title":"Cell Cycle"},{"key":"R43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/sj.leu.2404980","article-title":"Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells","volume":"22","author":"Papa","year":"2008","journal-title":"Leukemia"},{"key":"R44","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/sj.leu.2404245","article-title":"Phosphoinositide 3-kinase\/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia","volume":"20","author":"Martelli","year":"2006","journal-title":"Leukemia"},{"key":"R45","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/sj.leu.2404643","article-title":"The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion","volume":"21","author":"Tazzari","year":"2007","journal-title":"Leukemia"},{"key":"R46","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.4161\/cc.6.18.4705","article-title":"Dual inhibition of PI3K\/Akt signaling and the DNA damage checkpoint in p53-deficient cells with strong survival signaling: implications for cancer therapy","volume":"6","author":"Skladanowski","year":"2007","journal-title":"Cell Cycle"},{"key":"R47","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.4161\/cc.8.9.8302","article-title":"Upregulation of the CDC25A phosphatase down-stream of the NPM\/ALK oncogene participates to anaplastic large cell lymphoma enhanced proliferation","volume":"8","author":"Fernandez-Vidal","year":"2009","journal-title":"Cell Cycle"},{"key":"R48","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1158\/0008-5472.CAN-08-4884","article-title":"Dual inhibition of class IA phosphatidylionsitol 3-kinase and mTOR as a new therapeutic option for T-cell acute lymphoblastic leukemia","volume":"69","author":"Chiarini","year":"2009","journal-title":"Cancer Res"},{"key":"R49","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1089\/rej.2008.0722","article-title":"Aging, stem cells and mammalian target of rapamycin: a prospect of pharmalogical rejuvenation of aging stem cells","volume":"11","author":"Blagosklonny","year":"2008","journal-title":"Rejuv Res"},{"key":"R50","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.4161\/cc.7.21.6965","article-title":"Aging: ROS or TOR","volume":"7","author":"Blagosklonny","year":"2008","journal-title":"Cell Cycle"},{"key":"R51","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.4161\/cc.7.17.6626","article-title":"Cancer and aging: more puzzles, more promises?","volume":"7","author":"Blagosklonny","year":"2008","journal-title":"Cell Cycle"},{"key":"R52","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1002\/jcb.21602","article-title":"Program-like aging and mitochondria: instead of random damage by free radicals","volume":"102","author":"Blagosklonny","year":"2007","journal-title":"J Cell Biochem"},{"key":"R53","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.4161\/cc.7.21.6919","article-title":"Growth stimulation leads to cellular senescence when the cell cycle is blocked","volume":"7","author":"Demidenko","year":"2008","journal-title":"Cell Cycle"},{"key":"R54","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.4161\/cc.8.12.8809","article-title":"Pharmacologic inhibition of MEK and PI-3K converges on the mTOR\/S6 pathway to decelerate cellular senescence","volume":"8","author":"Demidenko","year":"2009","journal-title":"Cell Cycle"},{"key":"R55","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.4161\/cc.8.12.8810","article-title":"At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence","volume":"8","author":"Demidenko","year":"2009","journal-title":"Cell Cycle"},{"key":"R56","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.4161\/cc.8.12.8606","article-title":"Rapamycin decelerates cellular senescence","volume":"8","author":"Demidenko","year":"2009","journal-title":"Cell Cycle"},{"key":"R57","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.4161\/cc.8.12.8815","article-title":"Aging-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration","volume":"8","author":"Blagosklonny","year":"2009","journal-title":"Cell Cycle"},{"key":"R58","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.4161\/cc.9.8.11487","article-title":"Dominant roles of the Raf\/MEK\/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs","volume":"9","author":"Steelman","year":"2010","journal-title":"Cell Cycle"},{"key":"R59","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.4161\/cc.9.9.11483","article-title":"The Raf\/MEK\/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy","volume":"9","author":"Abrams","year":"2010","journal-title":"Cell Cycle"},{"key":"R60","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/leu.2008.79","article-title":"The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism","volume":"22","author":"Chiarini","year":"2008","journal-title":"Leukemia"},{"key":"R61","doi-asserted-by":"crossref","first-page":"533","DOI":"10.4161\/cc.7.4.5660","article-title":"The c-Jun N-terminal kinase JNK functions upstream of Aurora B to promote entry into mitosis","volume":"7","author":"Oktay","year":"2008","journal-title":"Cell Cycle"},{"key":"R62","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.4161\/cc.7.21.6894","article-title":"Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK","volume":"7","author":"Nica","year":"2008","journal-title":"Cell Cycle"},{"key":"R63","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4161\/cc.7.2.5155","article-title":"Basal c-Jun N-terminal kinases promote mitotic progression through histone H3 phosphorylation","volume":"7","author":"Lee","year":"2008","journal-title":"Cell Cycle"},{"key":"R64","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nsmb.1564","article-title":"A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal","volume":"16","author":"Catalanotti","year":"2009","journal-title":"Nat Struct Mol Biol"},{"key":"R65","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1517\/14728210903282760","article-title":"Emerging MEK inhibitors","volume":"15","author":"McCubrey","year":"2010","journal-title":"Expert Opin Emerg Drugs"},{"key":"R66","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1128\/JVI.02020-07","article-title":"Early phosphatidylinositol 3-kinase\/Akt pathway activation limits poliovirus-induced JNK-mediated cell death","volume":"82","author":"Autret","year":"2008","journal-title":"J Virol"},{"key":"R67","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/sj.leu.2404523","article-title":"Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase\/Akt signal transduction network in human acute myelogenous leukemia blasts","volume":"21","author":"Tazzari","year":"2007","journal-title":"Leukemia"},{"key":"R68","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/sj.leu.2404855","article-title":"PI-PLCbeta-1 and activated Akt levels are linked to azacitidine responsiveness in high-risk myelodysplastic syndromes","volume":"22","author":"Follo","year":"2008","journal-title":"Leukemia"},{"key":"R69","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.4161\/cc.8.19.9627","article-title":"The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior","volume":"8","author":"Liu","year":"2009","journal-title":"Cell Cycle"},{"key":"R70","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.4161\/cc.8.17.9503","article-title":"Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy","volume":"8","author":"Choong","year":"2009","journal-title":"Cell Cycle"},{"key":"R71","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.4161\/cc.7.21.7014","article-title":"RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53","volume":"7","author":"Sohr","year":"2008","journal-title":"Cell Cycle"},{"key":"R72","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.4161\/cc.6420","article-title":"Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation","volume":"7","author":"Par\u00eds","year":"2008","journal-title":"Cell Cycle"},{"key":"R73","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.4161\/cc.7.13.6072","article-title":"BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death","volume":"7","author":"Wade","year":"2008","journal-title":"Cell Cycle"},{"key":"R74","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.4161\/cc.8.11.8596","article-title":"The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells","volume":"8","author":"Vaseva","year":"2009","journal-title":"Cell Cycle"},{"key":"R75","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.4161\/cc.7.11.5929","article-title":"Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation","volume":"7","author":"Xia","year":"2008","journal-title":"Cell Cycle"},{"key":"R76","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.4161\/cc.8.16.9382","article-title":"Mutant p53 rescue and modulation of p53 redox state","volume":"8","author":"Bykov","year":"2009","journal-title":"Cell Cycle"},{"key":"R77","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.4161\/cc.8.18.9539","article-title":"DNA damage-induced cell death is enhanced by progression through mitosis","volume":"8","author":"Varmark","year":"2009","journal-title":"Cell Cycle"},{"key":"R78","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.4161\/cc.8.20.9689","article-title":"Enhancement of cancer chemotherapy by simultaneously altering cell cycle progression and DNA-damage defenses through global modification of the serine\/threonine phospho-proteome","volume":"8","author":"Zhuang","year":"2009","journal-title":"Cell Cycle"},{"key":"R79","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.4161\/cc.8.9.8217","article-title":"Stem-cell driven cancer: \u201chands-off\u201d regulation of cancer development","volume":"8","author":"Vicente-Due\u00f1as","year":"2009","journal-title":"Cell Cycle"},{"key":"R80","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.4161\/cc.7.19.6760","article-title":"The insulin-like growth factor system as a potential therapeutic target in gastrointestinal stromal tumors","volume":"7","author":"Belinsky","year":"2008","journal-title":"Cell Cycle"},{"key":"R81","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.1038\/sj.onc.1204564","article-title":"p21Cip1 induced by Raf is associated with increased Cdk4 activity in hematopoietic cells","volume":"20","author":"Chang","year":"2001","journal-title":"Oncogene"}],"container-title":["Cell Cycle"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.4161\/cc.9.9.11544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T22:05:56Z","timestamp":1591308356000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/abs\/10.4161\/cc.9.9.11544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":81,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,10,28]]},"published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.4161\/cc.9.9.11544"],"URL":"https:\/\/doi.org\/10.4161\/cc.9.9.11544","relation":{},"ISSN":["1538-4101","1551-4005"],"issn-type":[{"value":"1538-4101","type":"print"},{"value":"1551-4005","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}