{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:34:58Z","timestamp":1789659298158,"version":"4.0.1"},"reference-count":87,"publisher":"Informa UK Limited","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["mAbs"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.4161\/mabs.2.6.13270","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T18:43:55Z","timestamp":1291142635000},"page":"670-681","source":"Crossref","is-referenced-by-count":28,"title":["Monoclonal antibody therapy in multiple sclerosis"],"prefix":"10.1080","volume":"2","author":[{"given":"Paulo","family":"Fontoura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2014,10,27]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61620-7"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-2010-6"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115707"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2008.06.008"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.2165\/0003495-200868170-00004"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.7.4.535"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000344417.42972.54"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b9c8f7"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.25.112701.142913"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2358"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.07.012"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.104"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c97ed3"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1177\/1352458508098268"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.8.10.1561"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2005.07.020"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70043-0"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1007\/BF00918689"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0016"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.6.1531"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200216030-00003"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099896"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141557"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-009-9188-9"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70173-X"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05070.x"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70110-8"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.8.3.433"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-009-0025-5"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct071462"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1097\/01.nrl.0000263760.53418.5b"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.07.004"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1038\/356063a0"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1752"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044397"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044396"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000158329.30470.D0"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.10.1383"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20858"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20859"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.12.noc80051"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.10.4.489"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70078-9"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70028-4"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000320512.21919.d2"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01614-08"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103492"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21782"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509347154"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601335103"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.16"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402653101"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.50"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70033-8"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0934-5"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)02429-0"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802670"},{"key":"R58","first-page":"2052","volume":"119","author":"Jones JL","year":"2009","journal-title":"J Clin Invest"},{"key":"R59","first-page":"1206","volume":"9","author":"Hutas G","year":"2008","journal-title":"Curr Opin Invest Dr"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1517\/13543780902832679"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70192-3"},{"key":"R62","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0901"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm038"},{"key":"R64","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh641"},{"key":"R65","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)00404-5"},{"key":"R66","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706383"},{"key":"R67","first-page":"1016","volume":"66","author":"Martin MP","year":"2009","journal-title":"Arch Neurol"},{"key":"R68","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21867"},{"key":"R69","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1019131"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.11.noc80069"},{"key":"R71","doi-asserted-by":"publisher","DOI":"10.1038\/nri2315"},{"key":"R72","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.10.6092"},{"key":"R73","doi-asserted-by":"publisher","DOI":"10.2217\/1750743X.1.2.181"},{"key":"R74","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-186999"},{"key":"R75","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.080708.082655"},{"key":"R76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2008.03.007"},{"key":"R77","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-007-0072-9"},{"key":"R78","doi-asserted-by":"publisher","DOI":"10.1086\/597117"},{"key":"R79","doi-asserted-by":"publisher","DOI":"10.1086\/344280"},{"key":"R80","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.11.007"},{"key":"R81","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.1.6.9884"},{"key":"R82","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70161-5"},{"key":"R83","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000327671.91357.96"},{"key":"R84","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.07.006"},{"key":"R85","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-008-0018-0"},{"key":"R86","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904267"},{"key":"R87","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70006-5"}],"container-title":["mAbs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.4161\/mabs.2.6.13270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,12,16]],"date-time":"2016-12-16T00:27:18Z","timestamp":1481848038000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/abs\/10.4161\/mabs.2.6.13270"}},"subtitle":["Paradigm shifts and emerging challenges"],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":87,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,10,27]]},"published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.4161\/mabs.2.6.13270"],"URL":"https:\/\/doi.org\/10.4161\/mabs.2.6.13270","relation":{},"ISSN":["1942-0862","1942-0870"],"issn-type":[{"value":"1942-0862","type":"print"},{"value":"1942-0870","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}