{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:33:32Z","timestamp":1791023612938,"version":"4.1.0"},"reference-count":54,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prion"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.4161\/pri.23581","type":"journal-article","created":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T17:41:06Z","timestamp":1360950066000},"page":"76-84","source":"Crossref","is-referenced-by-count":50,"title":["Neuronal Ca<sup>2+<\/sup>dyshomeostasis in Huntington disease"],"prefix":"10.1080","volume":"7","author":[{"given":"Marta","family":"Giacomello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Oliveros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Naranjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Carafoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2014,10,27]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2011.12.013","article-title":"Protein aggregates in Huntington\u2019s disease","volume":"238","author":"Arrasate","year":"2012","journal-title":"Exp Neurol"},{"key":"R2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1471-4159.2004.02692.x","article-title":"Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions","volume":"91","author":"Nagaoka","year":"2004","journal-title":"J Neurochem"},{"key":"R3","doi-asserted-by":"crossref","first-page":"9932","DOI":"10.1523\/JNEUROSCI.3355-05.2005","article-title":"Dysfunction of the cholesterol biosynthetic pathway in Huntington\u2019s disease","volume":"25","author":"Valenza","year":"2005","journal-title":"J Neurosci"},{"key":"R4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00041.2009","article-title":"Molecular mechanisms and potential therapeutical targets in Huntington\u2019s disease","volume":"90","author":"Zuccato","year":"2010","journal-title":"Physiol Rev"},{"key":"R5","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.1074\/jbc.M110.156521","article-title":"Early and late events induced by polyQ-expanded proteins: identification of a common pathogenic property of polYQ-expanded proteins","volume":"286","author":"Bertoni","year":"2011","journal-title":"J Biol Chem"},{"key":"R6","doi-asserted-by":"crossref","first-page":"44512","DOI":"10.1074\/jbc.M111.307587","article-title":"In vitro and in vivo aggregation of a fragment of huntingtin protein directly causes free radical production","volume":"286","author":"Hands","year":"2011","journal-title":"J Biol Chem"},{"key":"R7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/1531-8249(200001)47:1<80::AID-ANA13>3.0.CO;2-K","article-title":"Mitochondrial dysfunction and free radical damage in the Huntington R6\/2 transgenic mouse","volume":"47","author":"Tabrizi","year":"2000","journal-title":"Ann Neurol"},{"key":"R8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/ana.410430321","article-title":"Complex I defect in muscle from patients with Huntington\u2019s disease","volume":"43","author":"Arenas","year":"1998","journal-title":"Ann Neurol"},{"key":"R9","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/emmm.201000102","article-title":"Mitochondrial fission and cristae disruption increase the response of cell models of Huntington\u2019s disease to apoptotic stimuli","volume":"2","author":"Costa","year":"2010","journal-title":"EMBO Mol Med"},{"key":"R10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/biof.162","article-title":"Huntington\u2019s disease, calcium, and mitochondria","volume":"37","author":"Giacomello","year":"2011","journal-title":"Biofactors"},{"key":"R11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10541-005-0100-9","article-title":"A historical review of cellular calcium handling, with emphasis on mitochondria","volume":"70","author":"Saris","year":"2005","journal-title":"Biochemistry (Mosc)"},{"key":"R12","doi-asserted-by":"crossref","first-page":"31674","DOI":"10.1074\/jbc.R112.384982","article-title":"Ca2+-dependent transcriptional control of Ca2+ homeostasis","volume":"287","author":"Naranjo","year":"2012","journal-title":"J Biol Chem"},{"key":"R13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0022-2828(74)90077-7","article-title":"The release of calcium from heart mitochondria by sodium","volume":"6","author":"Carafoli","year":"1974","journal-title":"J Mol Cell Cardiol"},{"key":"R14","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/sj.cdd.4402147","article-title":"Mitochondrial Ca2+ as a key regulator of cell life and death","volume":"14","author":"Giacomello","year":"2007","journal-title":"Cell Death Differ"},{"key":"R15","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00019052-199512000-00014","article-title":"Effects of chronic MPTP and 3-nitropropionic acid in nonhuman primates","volume":"8","author":"Brouillet","year":"1995","journal-title":"Curr Opin Neurol"},{"key":"R16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0896-6273(03)00366-0","article-title":"Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1","volume":"39","author":"Tang","year":"2003","journal-title":"Neuron"},{"key":"R17","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/hmg\/11.17.1911","article-title":"Dysregulation of gene expression in the R6\/2 model of polyglutamine disease: parallel changes in muscle and brain","volume":"11","author":"Luthi-Carter","year":"2002","journal-title":"Hum Mol Genet"},{"key":"R18","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1046\/j.0953-816x.2001.01767.x","article-title":"Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene","volume":"14","author":"Hansson","year":"2001","journal-title":"Eur J Neurosci"},{"key":"R19","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn884","article-title":"Early mitochondrial calcium defects in Huntington\u2019s disease are a direct effect of polyglutamines","volume":"5","author":"Panov","year":"2002","journal-title":"Nat Neurosci"},{"key":"R20","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/hmg\/ddh162","article-title":"Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release","volume":"13","author":"Choo","year":"2004","journal-title":"Hum Mol Genet"},{"key":"R21","doi-asserted-by":"crossref","first-page":"34785","DOI":"10.1074\/jbc.M603845200","article-title":"Mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences","volume":"281","author":"Milakovic","year":"2006","journal-title":"J Biol Chem"},{"key":"R22","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1111\/j.1471-4159.2005.03036.x","article-title":"Age-dependent changes in the calcium sensitivity of striatal mitochondria in mouse models of Huntington\u2019s Disease","volume":"93","author":"Brustovetsky","year":"2005","journal-title":"J Neurochem"},{"key":"R23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1471-4159.2006.04361.x","article-title":"Mitochondrial dysfunction in Huntington\u2019s disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice","volume":"101","author":"Oliveira","year":"2007","journal-title":"J Neurochem"},{"key":"R24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2202-9-38","article-title":"Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts","volume":"9","author":"Zhang","year":"2008","journal-title":"BMC Neurosci"},{"key":"R25","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1474-9726.2012.00858.x","article-title":"Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2","volume":"11","author":"Kipanyula","year":"2012","journal-title":"Aging Cell"},{"key":"R26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bbrc.2011.10.096","article-title":"Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation","volume":"416","author":"Bauer","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"R27","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1093\/hmg\/ddm217","article-title":"Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity","volume":"16","author":"Atwal","year":"2007","journal-title":"Hum Mol Genet"},{"key":"R28","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1093\/hmg\/ddi340","article-title":"Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington\u2019s disease","volume":"14","author":"Benn","year":"2005","journal-title":"Hum Mol Genet"},{"key":"R29","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/ng1503","article-title":"Polyglutamine expansion of huntingtin impairs its nuclear export","volume":"37","author":"Cornett","year":"2005","journal-title":"Nat Genet"},{"key":"R30","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.chembiol.2011.04.012","article-title":"Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington\u2019s disease treatment","volume":"18","author":"Wu","year":"2011","journal-title":"Chem Biol"},{"key":"R31","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.mcn.2005.07.016","article-title":"Crosstalk between huntingtin and syntaxin 1A regulates N-type calcium channels","volume":"30","author":"Swayne","year":"2005","journal-title":"Mol Cell Neurosci"},{"key":"R32","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1073\/pnas.93.10.5037","article-title":"Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin","volume":"93","author":"Bao","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R33","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fnmol.2012.00092","article-title":"The Neuronal Functions of EF-Hand Ca2+-Binding Proteins","volume":"5","author":"Kreutz","year":"2012","journal-title":"Front Mol Neurosci"},{"key":"R34","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1750-3639.2008.00258.x","article-title":"Neuroprotective effects of calmodulin peptide 76-121aa: disruption of calmodulin binding to mutant huntingtin","volume":"20","author":"Dudek","year":"2010","journal-title":"Brain Pathol"},{"key":"R35","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/NEN.0b013e31816a9e60","article-title":"Protective effects of interrupting the binding of calmodulin to mutant huntingtin","volume":"67","author":"Dudek","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"R36","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1471-4159.2012.07919.x","article-title":"Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity","volume":"123","author":"Dong","year":"2012","journal-title":"J Neurochem"},{"key":"R37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/hmg\/ddl440","article-title":"The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis","volume":"16","author":"Rockabrand","year":"2007","journal-title":"Hum Mol Genet"},{"key":"R38","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/hmg\/ddl013","article-title":"Regional and cellular gene expression changes in human Huntington\u2019s disease brain","volume":"15","author":"Hodges","year":"2006","journal-title":"Hum Mol Genet"},{"key":"R39","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.nbd.2011.07.001","article-title":"What have we learned from gene expression profiles in Huntington\u2019s disease?","volume":"45","author":"Seredenina","year":"2012","journal-title":"Neurobiol Dis"},{"key":"R40","doi-asserted-by":"crossref","first-page":"10820","DOI":"10.1073\/pnas.0800658105","article-title":"Huntington\u2019s disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies","volume":"105","author":"Savas","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R41","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.expneurol.2010.10.012","article-title":"Altered microRNA regulation in Huntington\u2019s disease models","volume":"227","author":"Lee","year":"2011","journal-title":"Exp Neurol"},{"key":"R42","doi-asserted-by":"crossref","first-page":"e41152","DOI":"10.1371\/journal.pone.0041152","article-title":"Promoters are differentially sensitive to N-terminal mutant huntingtin-mediated transcriptional repression","volume":"7","author":"Hogel","year":"2012","journal-title":"PLoS One"},{"key":"R43","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1126\/science.1056784","article-title":"Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity","volume":"291","author":"Nucifora","year":"2001","journal-title":"Science"},{"key":"R44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng882","article-title":"Disruption of CREB function in brain leads to neurodegeneration","volume":"31","author":"Mantamadiotis","year":"2002","journal-title":"Nat Genet"},{"key":"R45","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","article-title":"Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration","volume":"127","author":"Cui","year":"2006","journal-title":"Cell"},{"key":"R46","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2004.09.013","article-title":"Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice","volume":"119","author":"Lin","year":"2004","journal-title":"Cell"},{"key":"R47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1124\/jpet.110.167551","article-title":"Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments","volume":"335","author":"Gambazzi","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"R48","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1750-3639.2007.00111.x","article-title":"Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington\u2019s disease","volume":"18","author":"Zuccato","year":"2008","journal-title":"Brain Pathol"},{"key":"R49","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1093\/emboj\/cdf440","article-title":"Ca2+-dependent block of CREB-CBP transcription by repressor DREAM","volume":"21","author":"Ledo","year":"2002","journal-title":"EMBO J"},{"key":"R50","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1038\/sj.emboj.7600810","article-title":"Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression","volume":"24","author":"Savignac","year":"2005","journal-title":"EMBO J"},{"key":"R51","doi-asserted-by":"crossref","first-page":"8398","DOI":"10.1523\/JNEUROSCI.0618-06.2006","article-title":"Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections","volume":"26","author":"Kashani","year":"2006","journal-title":"J Neurosci"},{"key":"R52","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.molcel.2010.04.003","article-title":"Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels","volume":"38","author":"Giacomello","year":"2010","journal-title":"Mol Cell"},{"key":"R53","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.molcel.2010.06.029","article-title":"Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface","volume":"39","author":"Csord\u00e1s","year":"2010","journal-title":"Mol Cell"},{"key":"R54","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0076-6879(06)11009-5","article-title":"TM4 microarray software suite","volume":"411","author":"Saeed","year":"2006","journal-title":"Methods Enzymol"}],"container-title":["Prion"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.4161\/pri.23581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T20:14:03Z","timestamp":1562703243000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/abs\/10.4161\/pri.23581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,10,27]]},"published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.4161\/pri.23581"],"URL":"https:\/\/doi.org\/10.4161\/pri.23581","relation":{},"ISSN":["1933-6896","1933-690X"],"issn-type":[{"value":"1933-6896","type":"print"},{"value":"1933-690X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}