{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:40:29Z","timestamp":1793212829755,"version":"4.5.0"},"reference-count":68,"publisher":"XMLink","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergy Asthma Immunol Res"],"DOI":"10.4168\/aair.2021.13.5.684","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T01:38:23Z","timestamp":1630546703000},"page":"684","source":"Crossref","is-referenced-by-count":80,"title":["Arachidonic Acid 15-Lipoxygenase: Effects of Its Expression, Metabolites, and Genetic and Epigenetic Variations on Airway Inflammation"],"prefix":"10.4168","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3744-6394","authenticated-orcid":false,"given":"Xu","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8066-4648","authenticated-orcid":false,"given":"Jingyun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China."},{"name":"Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1080-4267","authenticated-orcid":false,"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China."},{"name":"Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China."},{"name":"Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-9884","authenticated-orcid":false,"given":"Luo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China."},{"name":"Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China."},{"name":"Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","published-online":{"date-parts":[[2021]]},"reference":[{"key":"10.4168\/aair.2021.13.5.684_ref1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(19)31147-X","volume":"394","author":"Huang","year":"2019","journal-title":"Lancet"},{"key":"10.4168\/aair.2021.13.5.684_ref2","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/all.12874","volume":"71","author":"Wang","year":"2016","journal-title":"Allergy"},{"key":"10.4168\/aair.2021.13.5.684_ref3","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.2147\/COPD.S161555","volume":"13","author":"Zhu","year":"2018","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.4168\/aair.2021.13.5.684_ref4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.plipres.2018.09.002","volume":"72","author":"Kuhn","year":"2018","journal-title":"Prog Lipid Res"},{"key":"10.4168\/aair.2021.13.5.684_ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2015.07.073","volume":"573","author":"Ivanov","year":"2015","journal-title":"Gene"},{"key":"10.4168\/aair.2021.13.5.684_ref6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.plipres.2018.11.001","volume":"73","author":"Singh","year":"2019","journal-title":"Prog Lipid Res"},{"key":"10.4168\/aair.2021.13.5.684_ref7","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.plefa.2017.12.003","volume":"128","author":"Markworth","year":"2018","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.4168\/aair.2021.13.5.684_ref8","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.bbalip.2017.04.001","volume":"1862","author":"Kutzner","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.4168\/aair.2021.13.5.684_ref9","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.4049\/jimmunol.1302795","volume":"193","author":"Ramon","year":"2014","journal-title":"J Immunol"},{"key":"10.4168\/aair.2021.13.5.684_ref10","doi-asserted-by":"crossref","first-page":"31649","DOI":"10.1038\/srep31649","volume":"6","author":"Kumar","year":"2016","journal-title":"Sci Rep"},{"key":"10.4168\/aair.2021.13.5.684_ref11","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1432-1033.1979.tb13068.x","volume":"96","author":"Rapoport","year":"1979","journal-title":"Eur J Biochem"},{"key":"10.4168\/aair.2021.13.5.684_ref12","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s00125-005-1673-y","volume":"48","author":"Chen","year":"2005","journal-title":"Diabetologia"},{"key":"10.4168\/aair.2021.13.5.684_ref13","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1172\/JCI78490","volume":"125","author":"Rothe","year":"2015","journal-title":"J Clin Invest"},{"key":"10.4168\/aair.2021.13.5.684_ref14","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12974-019-1438-z","volume":"16","author":"Quan","year":"2019","journal-title":"J Neuroinflammation"},{"key":"10.4168\/aair.2021.13.5.684_ref15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.prostaglandins.2015.04.010","volume":"121","author":"Brunnstr\u00f6m","year":"2015","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.4168\/aair.2021.13.5.684_ref16","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1165\/ajrcmb.18.5.2985","volume":"18","author":"Hill","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.4168\/aair.2021.13.5.684_ref17","doi-asserted-by":"crossref","first-page":"14246","DOI":"10.1073\/pnas.1018075108","volume":"108","author":"Zhao","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.4168\/aair.2021.13.5.684_ref18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/43686","volume":"401","author":"Yeung","year":"1999","journal-title":"Nature"},{"key":"10.4168\/aair.2021.13.5.684_ref19","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1128\/MCB.23.11.3918-3928.2003","volume":"23","author":"Xu","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.4168\/aair.2021.13.5.684_ref20","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.1073\/pnas.94.12.6148","volume":"94","author":"Brash","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.4168\/aair.2021.13.5.684_ref21","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3389\/fphar.2019.00719","volume":"10","author":"Snodgrass","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.4168\/aair.2021.13.5.684_ref22","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.3389\/fimmu.2018.01906","volume":"9","author":"Snodgrass","year":"2018","journal-title":"Front Immunol"},{"key":"10.4168\/aair.2021.13.5.684_ref23","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1067\/mai.2000.105122","volume":"105","author":"Profita","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2021.13.5.684_ref24","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1046\/j.1365-2222.2002.01477.x","volume":"32","author":"Chu","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.4168\/aair.2021.13.5.684_ref25","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/srep01540","volume":"3","author":"Mabalirajan","year":"2013","journal-title":"Sci Rep"},{"key":"10.4168\/aair.2021.13.5.684_ref26","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41586-018-0449-8","volume":"560","author":"Ordovas-Montanes","year":"2018","journal-title":"Nature"},{"key":"10.4168\/aair.2021.13.5.684_ref27","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12931-018-0968-8","volume":"20","author":"Sridhar","year":"2019","journal-title":"Respir Res"},{"key":"10.4168\/aair.2021.13.5.684_ref28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12931-017-0559-0","volume":"18","author":"Kolsum","year":"2017","journal-title":"Respir Res"},{"key":"10.4168\/aair.2021.13.5.684_ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1165\/rcmb.2016-0141PS","volume":"55","author":"Wenzel","year":"2016","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.4168\/aair.2021.13.5.684_ref30","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.jaci.2016.06.008","volume":"138","author":"Choy","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2021.13.5.684_ref31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.prostaglandins.2018.05.005","volume":"137","author":"Kolmert","year":"2018","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.4168\/aair.2021.13.5.684_ref32","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-pathol-052016-100401","volume":"12","author":"Schleimer","year":"2017","journal-title":"Annu Rev Pathol"},{"key":"10.4168\/aair.2021.13.5.684_ref33","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/all.13411","volume":"73","author":"Liao","year":"2018","journal-title":"Allergy"},{"key":"10.4168\/aair.2021.13.5.684_ref34","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.jaci.2005.02.029","volume":"115","author":"P\u00e9rez-Novo","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2021.13.5.684_ref35","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.jaci.2019.06.037","volume":"144","author":"Li","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2021.13.5.684_ref36","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1034\/j.1399-3003.2000.16a08.x","volume":"16","author":"Sanak","year":"2000","journal-title":"Eur Respir J"},{"key":"10.4168\/aair.2021.13.5.684_ref37","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0091-6749(03)01716-0","volume":"112","author":"Kowalski","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2021.13.5.684_ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000355949","volume":"163","author":"Neighbour","year":"2014","journal-title":"Int Arch Allergy Immunol"},{"key":"10.4168\/aair.2021.13.5.684_ref39","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jaci.2020.04.031","volume":"147","author":"Stevens","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2021.13.5.684_ref40","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.jaci.2019.06.037","volume":"144","author":"Li","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2021.13.5.684_ref41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1189\/jlb.0212074","volume":"94","author":"Provost","year":"2013","journal-title":"J Leukoc Biol"},{"key":"10.4168\/aair.2021.13.5.684_ref42","doi-asserted-by":"crossref","first-page":"L196","DOI":"10.1152\/ajplung.00036.2008","volume":"297","author":"Liu","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.4168\/aair.2021.13.5.684_ref43","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/alr.21943","volume":"7","author":"Kuhar","year":"2017","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.4168\/aair.2021.13.5.684_ref44","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1164\/rccm.200811-1744OC","volume":"179","author":"Zhao","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.4168\/aair.2021.13.5.684_ref45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12931-015-0218-2","volume":"16","author":"Li","year":"2015","journal-title":"Respir Res"},{"key":"10.4168\/aair.2021.13.5.684_ref46","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1165\/rcmb.2012-0150OC","volume":"48","author":"Johansson","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.4168\/aair.2021.13.5.684_ref47","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1165\/rcmb.2017-0031OC","volume":"57","author":"Zhao","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.4168\/aair.2021.13.5.684_ref48","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1242\/dev.00966","volume":"131","author":"Wan","year":"2004","journal-title":"Development"},{"key":"10.4168\/aair.2021.13.5.684_ref49","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/alr.22243","volume":"9","author":"Yan","year":"2019","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.4168\/aair.2021.13.5.684_ref50","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/humu.20273","volume":"27","author":"Wittwer","year":"2006","journal-title":"Hum Mutat"},{"key":"10.4168\/aair.2021.13.5.684_ref51","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/hmg\/ddp530","volume":"19","author":"Fairfax","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.4168\/aair.2021.13.5.684_ref52","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jaci.2008.05.049","volume":"122","author":"Tremblay","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2021.13.5.684_ref53","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/ng.3985","volume":"49","author":"Ferreira","year":"2017","journal-title":"Nat Genet"},{"key":"10.4168\/aair.2021.13.5.684_ref54","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41588-018-0314-6","volume":"51","author":"Kristjansson","year":"2019","journal-title":"Nat Genet"},{"key":"10.4168\/aair.2021.13.5.684_ref55","doi-asserted-by":"crossref","first-page":"23920","DOI":"10.1074\/jbc.M110.211821","volume":"286","author":"Schurmann","year":"2011","journal-title":"J Biol Chem"},{"key":"10.4168\/aair.2021.13.5.684_ref56","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.atherosclerosis.2007.09.003","volume":"198","author":"Assimes","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.4168\/aair.2021.13.5.684_ref57","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.jaci.2016.07.036","volume":"139","author":"Yang","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2021.13.5.684_ref58","doi-asserted-by":"crossref","first-page":"e85085","DOI":"10.1371\/journal.pone.0085085","volume":"9","author":"Han","year":"2014","journal-title":"PLoS One"},{"key":"10.4168\/aair.2021.13.5.684_ref59","doi-asserted-by":"crossref","first-page":"31341","DOI":"10.1074\/jbc.M803729200","volume":"283","author":"Zuo","year":"2008","journal-title":"J Biol Chem"},{"key":"10.4168\/aair.2021.13.5.684_ref60","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10555-018-9738-9","volume":"37","author":"Orafaie","year":"2018","journal-title":"Cancer Metastasis Rev"},{"key":"10.4168\/aair.2021.13.5.684_ref61","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.3390\/nu5062128","volume":"5","author":"Tanaka","year":"2013","journal-title":"Nutrients"},{"key":"10.4168\/aair.2021.13.5.684_ref62","doi-asserted-by":"crossref","first-page":"874","DOI":"10.3892\/etm.2017.4569","volume":"14","author":"Li","year":"2017","journal-title":"Exp Ther Med"},{"key":"10.4168\/aair.2021.13.5.684_ref63","first-page":"818","volume":"41","author":"Yang","year":"2018","journal-title":"Int J Mol Med"},{"key":"10.4168\/aair.2021.13.5.684_ref64","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.12659\/MSM.915080","volume":"25","author":"Hua","year":"2019","journal-title":"Med Sci Monit"},{"key":"10.4168\/aair.2021.13.5.684_ref65","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1073\/pnas.0508946103","volume":"103","author":"Spencer","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.4168\/aair.2021.13.5.684_ref66","doi-asserted-by":"crossref","first-page":"914","DOI":"10.5114\/aoms.2017.65239","volume":"13","author":"Jaworski","year":"2017","journal-title":"Arch Med Sci"},{"key":"10.4168\/aair.2021.13.5.684_ref67","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s11882-007-0010-6","volume":"7","author":"Steinke","year":"2007","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.4168\/aair.2021.13.5.684_ref68","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S2213-2600(18)30466-1","volume":"7","author":"Forno","year":"2019","journal-title":"Lancet Respir Med"}],"container-title":["Allergy, Asthma & Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/e-aair.org\/pdf\/10.4168\/aair.2021.13.5.684","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/e-aair.org\/DOIx.php?id=10.4168\/aair.2021.13.5.684","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/e-aair.org\/DOIx.php?id=10.4168\/aair.2021.13.5.684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T01:38:58Z","timestamp":1630546738000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-aair.org\/DOIx.php?id=10.4168\/aair.2021.13.5.684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":68,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4168\/aair.2021.13.5.684","relation":{},"ISSN":["2092-7355","2092-7363"],"issn-type":[{"value":"2092-7355","type":"print"},{"value":"2092-7363","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}