{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:03:50Z","timestamp":1779930230175,"version":"3.53.1"},"reference-count":63,"publisher":"XMLink","issue":"3","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-aair.org"],"crossmark-restriction":false},"short-container-title":["Allergy Asthma Immunol Res"],"DOI":"10.4168\/aair.2026.18.3.339","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:46:33Z","timestamp":1779925593000},"page":"339","update-policy":"https:\/\/doi.org\/10.4168\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hen\u2019s Egg Allergy: Immunological Mechanisms, Epidemiology, and Predictors of Persistence in Childhood"],"prefix":"10.4168","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8022-6959","authenticated-orcid":false,"given":"Ya An","family":"Tsai","sequence":"first","affiliation":[{"name":"China Medical University Hospital, School of Medicine, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4966-6583","authenticated-orcid":false,"given":"Chen Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"China Medical University Hospital, School of Medicine, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3860-975X","authenticated-orcid":false,"given":"Xiao-Ling","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Center of Allergy, Immunology and Microbiome (A.I.M.), China Medical University Hospital, China Medical University, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5175-908X","authenticated-orcid":false,"given":"Su Boon","family":"Yong","sequence":"additional","affiliation":[{"name":"Research Center of Allergy, Immunology and Microbiome (A.I.M.), China Medical University Hospital, China Medical University, Taichung, Taiwan."},{"name":"Department of Allergy and Immunology, China Medical University Children\u2019s Hospital, China Medical University, Taichung, Taiwan."},{"name":"Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4540-9822","authenticated-orcid":false,"given":"Jiu-Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center of Allergy, Immunology and Microbiome (A.I.M.), China Medical University Hospital, China Medical University, Taichung, Taiwan."},{"name":"Department of Allergy and Immunology, China Medical University Children\u2019s Hospital, China Medical University, Taichung, Taiwan."},{"name":"Department of Medicine, College of Medicine, China Medical University, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","published-online":{"date-parts":[[2026]]},"reference":[{"key":"10.4168\/aair.2026.18.3.339_ref1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/cea.14596","volume":"55","author":"Leung","year":"2025","journal-title":"Clin Exp Allergy"},{"key":"10.4168\/aair.2026.18.3.339_ref2","doi-asserted-by":"crossref","first-page":"100479","DOI":"10.1016\/j.waojou.2020.100479","volume":"13","author":"Yamamoto-Hanada","year":"2020","journal-title":"World Allergy Organ J"},{"key":"10.4168\/aair.2026.18.3.339_ref3","doi-asserted-by":"crossref","first-page":"e70188","DOI":"10.1111\/pai.70188","volume":"36","author":"Leung","year":"2025","journal-title":"Pediatr Allergy Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref4","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.5415\/apallergy.2022.12.e31","volume":"12","author":"Lee","year":"2022","journal-title":"Asia Pac Allergy"},{"key":"10.4168\/aair.2026.18.3.339_ref5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4168\/aair.2014.6.2.131","volume":"6","author":"Park","year":"2014","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.4168\/aair.2026.18.3.339_ref6","doi-asserted-by":"crossref","first-page":"410","DOI":"10.4168\/aair.2017.9.5.410","volume":"9","author":"Kim","year":"2017","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.4168\/aair.2026.18.3.339_ref7","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1016\/j.jaip.2020.04.058","volume":"8","author":"Samady","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.4168\/aair.2026.18.3.339_ref8","doi-asserted-by":"crossref","first-page":"e185630","DOI":"10.1001\/jamanetworkopen.2018.5630","volume":"2","author":"Gupta","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.4168\/aair.2026.18.3.339_ref9","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jaip.2020.07.039","volume":"9","author":"Singer","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.4168\/aair.2026.18.3.339_ref10","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1111\/all.15801","volume":"78","author":"Spolidoro","year":"2023","journal-title":"Allergy"},{"key":"10.4168\/aair.2026.18.3.339_ref11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jaci.2017.02.019","volume":"140","author":"Peters","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref12","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jaci.2018.07.023","volume":"143","author":"Botha","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref13","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2147\/ITT.S284821","volume":"10","author":"Zhang","year":"2021","journal-title":"Immunotargets Ther"},{"key":"10.4168\/aair.2026.18.3.339_ref14","volume-title":"StatPearls [Internet]","author":"Abbas","year":"2024"},{"key":"10.4168\/aair.2026.18.3.339_ref15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1159\/000527481","volume":"31","author":"Vitte","year":"2022","journal-title":"Med Princ Pract"},{"key":"10.4168\/aair.2026.18.3.339_ref16","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3389\/fimmu.2014.00569","volume":"5","author":"Moon","year":"2014","journal-title":"Front Immunol"},{"issue":"Suppl 2","key":"10.4168\/aair.2026.18.3.339_ref17","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.jaci.2009.11.017","volume":"125","author":"Stone","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref18","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000375416","volume":"101","author":"Urisu","year":"2015","journal-title":"Chem Immunol Allergy"},{"key":"10.4168\/aair.2026.18.3.339_ref19","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/ACI.0000000000000441","volume":"18","author":"Sato","year":"2018","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref20","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.aller.2013.03.005","volume":"41","author":"Martorell","year":"2013","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.4168\/aair.2026.18.3.339_ref21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.iac.2014.09.004","volume":"35","author":"Savage","year":"2015","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.4168\/aair.2026.18.3.339_ref22","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/all.12015","volume":"67","author":"Koplin","year":"2012","journal-title":"Allergy"},{"key":"10.4168\/aair.2026.18.3.339_ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2010.04139.x","volume":"160","author":"Okada","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref24","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1365-2567.2004.01925.x","volume":"112","author":"Romagnani","year":"2004","journal-title":"Immunology"},{"key":"10.4168\/aair.2026.18.3.339_ref25","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1002\/eji.200940045","volume":"40","author":"Palomares","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref26","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1034\/j.1399-3038.2000.00077.x","volume":"11","author":"Tariq","year":"2000","journal-title":"Pediatr Allergy Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2332\/allergolint.10-RAI-0270","volume":"60","author":"Osawa","year":"2011","journal-title":"Allergol Int"},{"key":"10.4168\/aair.2026.18.3.339_ref28","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.jaci.2014.07.033","volume":"134","author":"Venkataraman","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3390\/jcm10020233","volume":"10","author":"Astolfi","year":"2021","journal-title":"J Clin Med"},{"key":"10.4168\/aair.2026.18.3.339_ref30","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.jaci.2022.05.018","volume":"150","author":"Kalb","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref31","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.jaci.2023.08.029","volume":"152","author":"Chu","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref32","first-page":"CD013534","volume":"2","author":"Kelleher","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"10.4168\/aair.2026.18.3.339_ref33","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1364\/BOE.2.003363","volume":"2","author":"Gonz\u00e1lez","year":"2011","journal-title":"Biomed Opt Express"},{"key":"10.4168\/aair.2026.18.3.339_ref34","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.anai.2025.01.010","volume":"134","author":"Puppels","year":"2025","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/joim.13422","volume":"291","author":"Tedner","year":"2022","journal-title":"J Intern Med"},{"key":"10.4168\/aair.2026.18.3.339_ref36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jaci.2017.11.003","volume":"141","author":"Sicherer","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref37","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.anai.2012.09.012","volume":"109","author":"Taylor-Black","year":"2012","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref38","doi-asserted-by":"crossref","first-page":"e2318162","DOI":"10.1001\/jamanetworkopen.2023.18162","volume":"6","author":"Jiang","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.4168\/aair.2026.18.3.339_ref39","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2217\/imt-2020-0123","volume":"12","author":"Schworer","year":"2020","journal-title":"Immunotherapy"},{"key":"10.4168\/aair.2026.18.3.339_ref40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.18176\/jiaci.0212","volume":"28","author":"Garc\u00eda-Lirio","year":"2018","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref41","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.jaci.2015.12.1316","volume":"137","author":"Jones","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref42","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jaci.2020.05.040","volume":"146","author":"Kim","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref43","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1056\/NEJMoa1200435","volume":"367","author":"Burks","year":"2012","journal-title":"N Engl J Med"},{"key":"10.4168\/aair.2026.18.3.339_ref44","first-page":"1067","volume":"8","author":"Tsuge","year":"2021","journal-title":"Children (Basel)"},{"key":"10.4168\/aair.2026.18.3.339_ref45","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12887-016-0673-z","volume":"16","author":"Hill","year":"2016","journal-title":"BMC Pediatr"},{"key":"10.4168\/aair.2026.18.3.339_ref46","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jaci.2015.10.049","volume":"137","author":"Tsakok","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref47","first-page":"234","volume":"8","author":"Mo","year":"2023","journal-title":"Clin Pediatr"},{"key":"10.4168\/aair.2026.18.3.339_ref48","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/WOX.0b013e3181abe7cb","volume":"2","author":"Salehi","year":"2009","journal-title":"World Allergy Organ J"},{"issue":"Suppl","key":"10.4168\/aair.2026.18.3.339_ref49","first-page":"S1","volume":"126","author":"Boyce","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref50","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/pai.12815","volume":"28","author":"Christiansen","year":"2017","journal-title":"Pediatr Allergy Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref51","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1440-1754.2007.00996.x","volume":"43","author":"Allen","year":"2007","journal-title":"J Paediatr Child Health"},{"issue":"Suppl 1","key":"10.4168\/aair.2026.18.3.339_ref52","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1097\/MCG.0b013e3181e102a7","volume":"44","author":"del Giudice","year":"2010","journal-title":"J Clin Gastroenterol"},{"key":"10.4168\/aair.2026.18.3.339_ref53","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.anai.2015.08.012","volume":"115","author":"Arik Yilmaz","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref54","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jaci.2022.04.008","volume":"150","author":"Peters","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.4168\/aair.2026.18.3.339_ref55","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.5415\/apallergy.2021.11.e41","volume":"11","author":"Ngai","year":"2021","journal-title":"Asia Pac Allergy"},{"key":"10.4168\/aair.2026.18.3.339_ref56","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/all.13572","volume":"74","author":"Dang","year":"2019","journal-title":"Allergy"},{"key":"10.4168\/aair.2026.18.3.339_ref57","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1038\/s41467-018-05608-4","volume":"9","author":"Martino","year":"2018","journal-title":"Nat Commun"},{"key":"10.4168\/aair.2026.18.3.339_ref58","unstructured":"Taiwan Academy of Asthma, Allergy and Clinical Immunology. 2024 food allergy diagnosis and management guidelines [Internet]. Taipei. Taiwan Academy of Asthma, Allergy and Clinical Immunology. 2024. cited 2025 Aug 20. Available from: https:\/\/www.taaaci.org.tw\/upfile\/down\/249231349372024%20%E9%A3%9F%E7%89%A9%E9%81%8E%E6%95%8F%E8%A8%BA%E7%99%82%E6%8C%87%E5%BC%95.pdf"},{"key":"10.4168\/aair.2026.18.3.339_ref59","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0140-6736(16)31418-0","volume":"389","author":"Natsume","year":"2017","journal-title":"Lancet"},{"issue":"Suppl_7","key":"10.4168\/aair.2026.18.3.339_ref60","doi-asserted-by":"crossref","first-page":"890S","DOI":"10.1093\/ajcn\/nqy220","volume":"109","author":"Obbagy","year":"2019","journal-title":"Am J Clin Nutr"},{"key":"10.4168\/aair.2026.18.3.339_ref61","doi-asserted-by":"crossref","first-page":"e20190281","DOI":"10.1542\/peds.2019-0281","volume":"143","author":"Greer","year":"2019","journal-title":"Pediatrics"},{"key":"10.4168\/aair.2026.18.3.339_ref62","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1016\/S0140-6736(22)00687-0","volume":"399","author":"Skjerven","year":"2022","journal-title":"Lancet"},{"key":"10.4168\/aair.2026.18.3.339_ref63","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/jamapediatrics.2023.0142","volume":"177","author":"Scarpone","year":"2023","journal-title":"JAMA Pediatr"}],"container-title":["Allergy, Asthma & Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/e-aair.org\/pdf\/10.4168\/aair.2026.18.3.339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/e-aair.org\/DOIx.php?id=10.4168\/aair.2026.18.3.339","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/e-aair.org\/DOIx.php?id=10.4168\/aair.2026.18.3.339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:07:32Z","timestamp":1779926852000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-aair.org\/DOIx.php?id=10.4168\/aair.2026.18.3.339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":63,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4168\/aair.2026.18.3.339","relation":{},"ISSN":["2092-7355","2092-7363"],"issn-type":[{"value":"2092-7355","type":"print"},{"value":"2092-7363","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"2025-10-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"Copyright \u00a9 2026 The Korean Academy of Asthma, Allergy and Clinical Immunology \u2022 The Korean Academy of Pediatric Allergy and Respiratory Disease","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}