{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:57:54Z","timestamp":1779375474439,"version":"3.53.1"},"reference-count":25,"publisher":"Korean Society of Epidemiology","content-domain":{"domain":["e-epih.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol Health"],"abstract":"<jats:p>OBJECTIVES: Epidemiological evidence of associations between ambient particulate matter (PM) and tuberculosis (TB) risk is accumulating. Two previous studies in Korea found associations between air pollution\u2014especially sulfur dioxide (SO&lt;sub&gt;2&lt;\/sub&gt;)\u2014and TB. In this study, we conducted an annual time-series cross-sectional study to assess the effect of PM with an aerodynamic diameter less than 10 \u03bcm (PM&lt;sub&gt;10&lt;\/sub&gt;) on TB risk in seven major cities of Korea from 2010 to 2016, taking into account time lag and long-term cumulative exposure.METHODS: Age-standardized TB notification rates were derived using the Korea National TB Surveillance System. Annual average PM&lt;sub&gt;10&lt;\/sub&gt; concentrations were obtained from annual Korean air quality reports. We applied a generalized linear mixed model with unconstrained distributed lags of exposure to PM&lt;sub&gt;10&lt;\/sub&gt;. We adjusted for potential confounders such as age, health behaviors, and area-level characteristics.RESULTS: Both average annual PM&lt;sub&gt;10&lt;\/sub&gt; concentrations and age-standardized TB notification rates decreased over time. The association between cumulative exposure to PM&lt;sub&gt;10&lt;\/sub&gt; and TB incidence became stronger as a longer exposure duration was considered. An increase of one standard deviation (5.63 \u03bcg\/m&lt;sup&gt;3&lt;\/sup&gt;) in PM&lt;sub&gt;10&lt;\/sub&gt; exposure for six years was associated with a 1.20 (95% confidence interval, 1.17 to 1.22) times higher TB notification rate. The marginal association of exposure duration with the TB notification rate was highest at four and five years prior to TB notification. This association remained consistent even after adjusting it for exposure to SO&lt;sub&gt;2&lt;\/sub&gt;.CONCLUSIONS: The findings of this study suggest that cumulative exposure to PM&lt;sub&gt;10&lt;\/sub&gt; may affect TB risk, with a potential lag effect.<\/jats:p>","DOI":"10.4178\/epih.e2020012","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T07:06:52Z","timestamp":1583996812000},"page":"e2020012","update-policy":"https:\/\/doi.org\/10.4178\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effects of particulate air pollution on tuberculosis development in seven major cities of Korea from 2010 to 2016: methodological considerations involving long-term exposure and time lag"],"prefix":"10.4178","volume":"42","author":[{"given":"Honghyok","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2679","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"key":"ref1","first-page":"722","volume-title":"Historical statistics support a hypothesis linking tuberculosis and air pollution caused by coal","author":"Tremblay","year":"2007"},{"key":"ref2","first-page":"441","volume-title":"Cooking with biomass stoves and tuberculosis: a case control study","author":"P\u00e9rez-Padilla","year":"2001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040020"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2012.12.030"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2016.08.071"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2015-102995"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/09603123.2013.800959"},{"key":"ref8","first-page":"357","volume-title":"","author":"Holgate","year":"1999"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2014.29.2.183"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/09603123.2019.1566522"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.21489\/hass.2017.08.45.89"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrp.2016.08.002"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.11.210"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16020173"},{"key":"ref15","doi-asserted-by":"crossref","DOI":"10.1093\/oxfordhb\/9780199286546.003.0020","volume-title":"Time-series-cross-section methods","author":"Beck","year":"2008"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200005000-00016"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2009.03.041"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.99107149"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.09.004"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080\/019021402753570509"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00419-2016"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1408166"},{"key":"ref23","first-page":"41","volume-title":"Particulate matter is associated with sputum culture conversion in patients with culture-positive tuberculosis","author":"Chen","year":"2016"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108419"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1409111"}],"container-title":["Epidemiology and Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-epih.org\/upload\/pdf\/epih-42-e2020012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T13:34:25Z","timestamp":1666100065000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-epih.org\/journal\/view.php?doi=10.4178\/epih.e2020012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,12]]},"references-count":25,"URL":"https:\/\/doi.org\/10.4178\/epih.e2020012","relation":{},"ISSN":["2092-7193"],"issn-type":[{"value":"2092-7193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,12]]},"assertion":[{"value":"2019-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}