{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:27:27Z","timestamp":1768292847034,"version":"3.49.0"},"reference-count":34,"publisher":"Korean Society of Epidemiology","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002597","name":"Kyung Hee University","doi-asserted-by":"publisher","award":["KHU-20230913"],"award-info":[{"award-number":["KHU-20230913"]}],"id":[{"id":"10.13039\/501100002597","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-epih.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol Health"],"abstract":"<jats:p>OBJECTIVES: Proteinuria is widely used to predict cardiovascular risk. However, there is insufficient evidence to predict how changes in proteinuria may affect the incidence of cardiovascular disease.METHODS: The study included 265,236 Korean adults who underwent health checkups in 2003-2004 and 2007-2008. They were categorized into 4 groups based on changes in proteinuria (negative: negative \u2192 negative; resolved: proteinuria \u22651+ \u2192 negative; incident: negative \u2192 proteinuria \u22651+; persistent: proteinuria \u22651+ \u2192 proteinuria \u22651+). We conducted 6 years of follow-up to identify the risks of developing ischemic heart disease (IHD), acute myocardial infarction (AMI), and angina pectoris according to changes in proteinuria. A multivariate Cox proportional-hazards model was used to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for incident IHD, AMI, and angina pectoris.RESULTS: The IHD risk (expressed as HR [95% CI]) was the highest for persistent proteinuria, followed in descending order by incident and resolved proteinuria, compared with negative proteinuria (negative: reference, resolved: 1.211 [95% CI, 1.104 to 1.329], incident: 1.288 [95% CI, 1.184 to 1.400], and persistent: 1.578 [95% CI, 1.324 to 1.881]). The same pattern was associated with AMI (negative: reference, resolved: 1.401 [95% CI, 1.048 to 1.872], incident: 1.606 [95% CI, 1.268 to 2.035], and persistent: 2.069 [95% CI, 1.281 to 3.342]) and angina pectoris (negative: reference, resolved: 1.184 [95% CI, 1.065 to 1.316], incident: 1.275 [95% CI, 1.160 to 1.401], and persistent: 1.554 [95% CI, 1.272 to 1.899]).CONCLUSIONS: Experiencing proteinuria increased the risks of IHD, AMI, and angina pectoris even after proteinuria resolved.<\/jats:p>","DOI":"10.4178\/epih.e2023088","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T06:09:24Z","timestamp":1696918164000},"page":"e2023088","update-policy":"https:\/\/doi.org\/10.4178\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Changes in proteinuria and the associated risks of ischemic heart disease, acute myocardial infarction,\nand angina pectoris in Korean population"],"prefix":"10.4178","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4703-9917","authenticated-orcid":true,"given":"Sung Keun","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7921-6549","authenticated-orcid":true,"given":"Ju Young","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4909-2308","authenticated-orcid":true,"given":"Min-Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5709-9350","authenticated-orcid":true,"given":"Chang-Mo","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-3858","authenticated-orcid":true,"given":"Eunhee","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-1695","authenticated-orcid":true,"given":"Eun Hye","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-5668","authenticated-orcid":true,"given":"Hyo Choon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3304-526X","authenticated-orcid":true,"given":"Soonsu","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0231-8330","authenticated-orcid":true,"given":"Woo Yeon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5943-7715","authenticated-orcid":true,"given":"Sangho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1478-5895","authenticated-orcid":true,"given":"So Youn","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-1426","authenticated-orcid":true,"given":"Jae-Hong","family":"Ryoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2679","published-online":{"date-parts":[[2023,9,30]]},"reference":[{"key":"ref1","volume-title":""},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.26"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)61682-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.111"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12104"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2009.11"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws447"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(10)60674-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050207"},{"key":"ref10","first-page":"S3","volume-title":"Slowing nephropathy progression: focus on proteinuria reduction","author":"Bakris","year":"2008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-016-0420-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv272"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0586-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2010091001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.01.065"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1646"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv319"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123893"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.39"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2015.07.009"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/bf00285287"},{"key":"ref22","first-page":"13","volume-title":"Proteinuria and its relation to cardiovascular disease","author":"Currie","year":"2013"},{"key":"ref23","first-page":"1157","volume-title":"Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: progressive, interrelated, and independently associated with risk of death","author":"Stehouwer","year":"2002"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2007040461"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1177\/2048872612441582"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8227(97)01384-3"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/bf02374497"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.5.793"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.23.6.681"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.02870316"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(15)00469-6"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2018.10.014"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.12.026"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-006-0458-z"}],"container-title":["Epidemiology and Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-epih.org\/upload\/pdf\/epih-45-e2023088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-epih.org\/journal\/view.php?doi=10.4178\/epih.e2023088","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-epih.org\/upload\/pdf\/epih-45-e2023088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T05:00:51Z","timestamp":1708405251000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-epih.org\/journal\/view.php?doi=10.4178\/epih.e2023088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,30]]},"references-count":34,"URL":"https:\/\/doi.org\/10.4178\/epih.e2023088","relation":{},"ISSN":["2092-7193"],"issn-type":[{"value":"2092-7193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,30]]},"assertion":[{"value":"2022-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-30","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}}]}}