{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:06:39Z","timestamp":1791320799275,"version":"4.3.1"},"reference-count":40,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T00:00:00Z","timestamp":1303171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>A simple method for effective bronchodilator aerosol delivery while administering continuing continuous positive airway pressure (CPAP) would be useful in patients with severe bronchial obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To assess the effectiveness of bronchodilator aerosol delivery during CPAP generated by the Boussignac CPAP system and its optimal humidification system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      First we assessed the relationship between flow and pressure generated in the mask with the Boussignac CPAP system. Next we measured the inspired-gas humidity during CPAP, with several humidification strategies, in 9 healthy volunteers. We then measured the bronchodilator aerosol particle size during CPAP, with and without heat-and-moisture exchanger, in a bench study. Finally, in 7 patients with acute respiratory failure and airway obstruction, we measured work of breathing and gas exchange after a \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      -agonist bronchodilator aerosol (terbutaline) delivered during CPAP or via standard nebulization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Optimal humidity was obtained only with the heat-and-moisture exchanger or heated humidifier. The heat-and-moisture exchanger had no influence on bronchodilator aerosol particle size. Work of breathing decreased similarly after bronchodilator via either standard nebulization or CPAP, but P\n                      <jats:sub>\n                        aO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      increased significantly only after CPAP aerosol delivery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>CPAP bronchodilator delivery decreases the work of breathing as effectively as does standard nebulization, but produces a greater oxygenation improvement in patients with airway obstruction. To optimize airway humidification, a heat-and-moisture exchanger could be used with the Boussignac CPAP system, without modifying aerosol delivery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.00847","type":"journal-article","created":{"date-parts":[[2011,10,3]],"date-time":"2011-10-03T12:23:12Z","timestamp":1317644592000},"page":"1526-1532","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Aerosol Delivery and Humidification With the Boussignac Continuous Positive Airway Pressure Device"],"prefix":"10.1177","volume":"56","author":[{"given":"Arnaud W","family":"Thille","sequence":"first","affiliation":[{"name":"Medical Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Henri Mondor Hospital, University of Paris Est, Cr\u00e9teil, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Bertholon","sequence":"additional","affiliation":[{"name":"Department of Respiratory Physiology, Assistance Publique-H\u00f4pitaux de Paris, Saint-Antoine Hospital, Paris, Pierre et Marie Curie University, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Becquemin","sequence":"additional","affiliation":[{"name":"Service d'Explorations Fonctionnelles Respiratoires, Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Roy","sequence":"additional","affiliation":[{"name":"Laboratoire de Granulom\u00e9trie et de D\u00e9p\u00f4t des A\u00e9rosols, Assistance Publique-H\u00f4pitaux de Paris, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aissam","family":"Lyazidi","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Henri Mondor Hospital, University of Paris Est, Cr\u00e9teil, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lellouche","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Henri Mondor Hospital, University of Paris Est, Cr\u00e9teil, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Pertusini","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Henri Mondor Hospital, University of Paris Est, Cr\u00e9teil, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Boussignac","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Henri Mondor Hospital, University of Paris Est, Cr\u00e9teil, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Ma\u00eetre","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Assistance Publique-H\u00f4pitaux de Paris, Henri Mondor Hospital, Cr\u00e9teil Intercommunal Hospital, University of Paris Est, Cr\u00e9teil, Cr\u00e9teil, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Brochard","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Assistance Publique-H\u00f4pitaux de Paris, Henri Mondor Hospital, University of Paris Est, Cr\u00e9teil, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2011,4,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199112263252601"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.24.3124"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.5.589"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.5.8173743"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.6.533"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.65.4.1488"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.2.281"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200007000-00016"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2007.06.488"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90126-8"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.6.9908115"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90679-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.4.1036"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.6.8004299"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.2.317"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.2.171"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(95)70003-X"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.6.2003069"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340101062"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200211000-00018"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.9902062"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.8.2101010"},{"issue":"5","key":"e_1_3_2_24_2","first-page":"788","article-title":"A simple method for assessing the validity of the esophageal balloon technique","volume":"126","author":"Baydur A","year":"1982","unstructured":"Baydur A, , Behrakis PK, , Zin WA, , Jaeger M, , Milic-Emili J. A simple method for assessing the validity of the esophageal balloon technique. Am Rev Respir Dis, 1982; 126(5):788\u2013791.","journal-title":"Am Rev Respir Dis"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/143.3.469"},{"issue":"1","key":"e_1_3_2_26_2","first-page":"166","article-title":"Occult positive end-expiratory pressure in mechanically ventilated patients with airflow obstruction: the auto-PEEP effect","volume":"126","author":"Pepe PE","year":"1982","unstructured":"Pepe PE, , Marini JJ. Occult positive end-expiratory pressure in mechanically ventilated patients with airflow obstruction: the auto-PEEP effect. Am Rev Respir Dis, 1982; 126(1):166\u2013170.","journal-title":"Am Rev Respir Dis"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.2.7842221"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.38.10.755"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.1.8680678"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1455-y"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1456-x"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200210-1167OC"},{"issue":"7","key":"e_1_3_2_33_2","first-page":"837","article-title":"Evaluation of aerosol generator devices at 3 locations in humidified and non-humidified circuits during adult mechanical ventilation","volume":"55","author":"Ari A","unstructured":"Ari A, , Areabi H, , Fink JB. Evaluation of aerosol generator devices at 3 locations in humidified and non-humidified circuits during adult mechanical ventilation. Respir Care; 55(7):837\u2013844.","journal-title":"Respir Care"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.019620"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.1.95"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.1.5"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.07.012"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.2.502"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.06.003"},{"issue":"3","key":"e_1_3_2_40_2","first-page":"397","article-title":"Pulmonary aerosol deposition in chronic bronchitis: intermittent positive pressure breathing versus quiet breathing","volume":"115","author":"Dolovich MB","year":"1977","unstructured":"Dolovich MB, , Killian D, , Wolff RK, , Obminski G, , Newhouse MT. Pulmonary aerosol deposition in chronic bronchitis: intermittent positive pressure breathing versus quiet breathing. Am Rev Respir Dis, 1977; 115(3):397\u2013402.","journal-title":"Am Rev Respir Dis"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05501438"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.00847","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.00847","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.00847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:01:04Z","timestamp":1777615264000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.00847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,19]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.4187\/respcare.00847"],"URL":"https:\/\/doi.org\/10.4187\/respcare.00847","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4,19]]}}}