{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:43:07Z","timestamp":1777891387152,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T00:00:00Z","timestamp":1303171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>We describe the case of a woman who presented to the intensive care unit with acute respiratory failure that required mechanical ventilation. She had severe pulmonary hypertension secondary to interstitial lung disease, and her history included sarcoidosis and tuberculosis. She was dependent on inhaled nitric oxide (INO) to maintain safe arterial oxygen saturation and could not be weaned from mechanical ventilation. Echocardiography revealed a patent foramen ovale with substantial right-to-left shunt, which probably contributed to her hypoxemia. Sildenafil enabled weaning from INO and substantially reduced the flow through the patent foramen ovale. She was successfully extubated and discharged home. To our knowledge, this is the first report of weaning from INO and mechanical ventilation in a patient with both severe secondary pulmonary hypertension and a right-to-left shunt through a patent foramen ovale.<\/jats:p>","DOI":"10.4187\/respcare.01147","type":"journal-article","created":{"date-parts":[[2011,10,3]],"date-time":"2011-10-03T12:23:12Z","timestamp":1317644592000},"page":"1611-1613","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Sildenafil to Facilitate Weaning From Inhaled Nitric Oxide and Mechanical Ventilation in a Patient With Severe Secondary Pulmonary Hypertension and a Patent Foramen Ovale"],"prefix":"10.1177","volume":"56","author":[{"given":"Shlomo","family":"Elias","sequence":"first","affiliation":[{"name":"Department of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigal","family":"Sviri","sequence":"additional","affiliation":[{"name":"Department of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efrat","family":"Orenbuch-Harroch","sequence":"additional","affiliation":[{"name":"Department of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakov","family":"Fellig","sequence":"additional","affiliation":[{"name":"Department of Pathology; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie","family":"Ben-Yehuda","sequence":"additional","affiliation":[{"name":"Department of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi G","family":"Fridlender","sequence":"additional","affiliation":[{"name":"Department of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Gilon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hebrew University-Hadassah Medical Center, Jerusalem, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abed","family":"Bayya","sequence":"additional","affiliation":[{"name":"Department of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,4,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.5.385"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00002607"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.44.2.151"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.5.1246"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.3.866"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.11.576"},{"issue":"4","key":"e_1_3_2_8_2","first-page":"70","article-title":"[Causes and mechanisms of the development of chronic cor pulmonale in patients with tuberculosis and chronic nonspecific diseases of the lungs]","author":"Mar'iandyshev AO","year":"1991","unstructured":"Mar'iandyshev AO. 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