{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:43:48Z","timestamp":1777891428415,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2011,10,13]],"date-time":"2011-10-13T00:00:00Z","timestamp":1318464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Pulmonary function, in HIV infected patients, has been associated with reduction in pulmonary ventilation parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We conducted a prospective cross sectional study to evaluate the pulmonary function of AIDS patients cared for in the infectious diseases ambulatory care clinic. Maximal inspiratory (P\n                      <jats:sub>Imax<\/jats:sub>\n                      ) and expiratory (P\n                      <jats:sub>Emax<\/jats:sub>\n                      ) pressures and spirometry were assessed. Clinical, demographic, and laboratory data were also evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      P\n                      <jats:sub>Imax<\/jats:sub>\n                      and P\n                      <jats:sub>Emax<\/jats:sub>\n                      were assessed in 73 and spirometry in 54 subjects. The mean time of HIV infection (in years) was similar for men (8.5 \u00b1 5.1 y) and women (10.4 \u00b1 4.2 y,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .13), and the mean time of use of antiretroviral therapy was 8.5 \u00b1 4.1 years for women and 7.7 \u00b1 4.1 years for men (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .46). P\n                      <jats:sub>Imax<\/jats:sub>\n                      and P\n                      <jats:sub>Emax<\/jats:sub>\n                      values were normal in 35 (48%) and 48 (66%) subjects, respectively. The use of tenofovir and presence of cough, by the time the test was performed, were independently associated with P\n                      <jats:sub>Emax<\/jats:sub>\n                      below the predicted value. Elevated creatine kinase values were associated with prolonged antiretroviral usage (9.6 \u00b1 4.1 y vs 7.4 \u00b1 3.9 y,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .05). FVC was reduced in 14 (26.4%) subjects and was independently associated with high and\/or intermediate cardiovascular risk (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .002), and those with reduced vesicular murmur in auscultation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .047). FEV\n                      <jats:sub>1<\/jats:sub>\n                      was significantly lower in subjects with prolonged time of smoking (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02) and high and\/or intermediate cardiovascular risk (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .003). Reduced FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC was associated with smoking (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .041).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>AIDS subjects, in our study, had reduced parameters of maximal respiratory pressures and spirometry. The frequent dysfunction of respiratory muscles might be due to the association of multiple factors and not a particular one; moreover, smoking was independently associated with abnormal airway function. Pulmonary function tests should be implemented as an essential part of the medical assistance to AIDS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.01362","type":"journal-article","created":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T08:18:21Z","timestamp":1326356301000},"page":"544-549","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Functional Respiratory Parameters in AIDS Patients Assisted in the Infectious Diseases Ambulatory Care Clinic of a Tertiary Care University Hospital in Brazil"],"prefix":"10.1177","volume":"57","author":[{"given":"Ana Isabela","family":"Morsch Passos","sequence":"first","affiliation":[{"name":"Post-Graduation Program of the Internal Medicine Department;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn Regina","family":"Couto","sequence":"additional","affiliation":[{"name":"Physiotherapy Division, Hospital and Clinics; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio Moraes","family":"de Rezende","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Faculty of Medical Sciences, State University of Campinas, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luiza","family":"Moretti","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Faculty of Medical Sciences, State University of Campinas, S\u00e3o Paulo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,10,13]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"451","article-title":"Effect of smoking on the clinical progression of HIV 1 infection","volume":"14","author":"Galai N","year":"1997","unstructured":"Galai N, , Lawrence PP, , Wesch J, , Visscher B, , Riddler S, , Margolick JB. Effect of smoking on the clinical progression of HIV 1 infection. Epidemiology, 1997; 14:451\u2013458.","journal-title":"Epidemiology"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2005.062745"},{"key":"e_1_3_2_4_2","volume-title":"Ano VII. N\u00famero 01","author":"Brasil","year":"2010","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. Departamento de DST, Aids e Hepatites virais. Boletim Epidemiol\u00f3gico DST e Aids 2010. Vers\u00e3o preliminar. Ano VII. N\u00famero 01. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade, 2010. Article in Portugese.."},{"key":"e_1_3_2_5_2","first-page":"91","article-title":"Medida das press\u00f5es respirat\u00f3rias m\u00e1ximas em indiv\u00edduos portadores de HIV","volume":"1","author":"Oliveira DZ","year":"2008","unstructured":"Oliveira DZ, , Damin S, , Skroch EOK. Medida das press\u00f5es respirat\u00f3rias m\u00e1ximas em indiv\u00edduos portadores de HIV. RUBS, 2008; 1:91\u201396. 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