{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:49:23Z","timestamp":1792205363363,"version":"4.4.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T00:00:00Z","timestamp":1331596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>Heated and humidified high flow nasal cannula oxygen therapy (HFNC) represents a new alternative to conventional oxygen therapy that has not been evaluated in the emergency department (ED). We aimed to study its feasibility and efficacy in patients exhibiting acute respiratory failure presenting to the ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Prospective, observational study in a university hospital's ED. Patients with acute respiratory failure requiring &gt; 9 L\/min oxygen or with ongoing clinical signs of respiratory distress despite oxygen therapy were included. The device of oxygen administration was then switched from non-rebreathing mask to HFNC. Dyspnea, rated by the Borg scale and a visual analog scale, respiratory rate, and S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      were collected before and 15, 30, and 60 min after beginning HFNC. Feasibility was assessed through caregivers' acceptance of the device in terms of practicality and perceived effect on the subjects, evaluated by questionnaire.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Seventeen subjects, median age 64 y (46\u201384.7 y), were studied. Pneumonia was the most common reason for oxygen therapy (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 9). HFNC was associated with a significant decrease in both dyspnea scores: Borg scale from 6 (5\u20137) to 3 (2\u20134) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and visual analog scale from 7 (5\u20138) to 3 (1\u20135) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .01). Respiratory rate decreased from 28 breaths\/min (25\u201332 breaths\/min) to 25 breaths\/min (21\u201328 breaths\/min) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001), and S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      increased from 90% (88.5\u201394%) to 97% (92.5\u2013100%) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). Fewer subjects exhibited clinical signs of respiratory distress (10\/17 vs 3\/17,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .03). HFNC was well tolerated and no adverse event was noted. Altogether, 76% of healthcare givers declared preferring HFNC, as compared to conventional oxygen therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>HFNC is possible in the ED, and it alleviated dyspnea and improved respiratory parameters in subjects with acute hypoxemic respiratory failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.01575","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T14:32:17Z","timestamp":1338906737000},"page":"1873-1878","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":172,"title":["Humidified High Flow Nasal Oxygen During Respiratory Failure in the Emergency Department: Feasibility and Efficacy"],"prefix":"10.1177","volume":"57","author":[{"given":"Hugo","family":"Lenglet","sequence":"first","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris (APHP), Service de R\u00e9animation M\u00e9dicale; and"},{"name":"Service d'Accueil des Urgences, H\u00f4pital Louis Mourier, F-92700, Colombes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Sztrymf","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris (APHP), Service de R\u00e9animation M\u00e9dicale; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Leroy","sequence":"additional","affiliation":[{"name":"Service d'Accueil des Urgences, H\u00f4pital Louis Mourier, F-92700, Colombes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Brun","sequence":"additional","affiliation":[{"name":"Service d'Accueil des Urgences, H\u00f4pital Louis Mourier, F-92700, Colombes, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Dreyfuss","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris (APHP), Service de R\u00e9animation M\u00e9dicale; and"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, F-75018, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Damien","family":"Ricard","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris (APHP), Service de R\u00e9animation M\u00e9dicale; and"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, F-75018, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,3,13]]},"reference":[{"issue":"6","key":"e_1_3_3_2_2","first-page":"717","article-title":"AARC Clinical Practice Guideline: oxygen therapy for adults in the acute care facility: 2002 revision & update","volume":"47","author":"Kallstrom TJ","year":"2002","unstructured":"Kallstrom TJ. AARC Clinical Practice Guideline: oxygen therapy for adults in the acute care facility: 2002 revision & update. Respir Care, 2002; 47(6):717\u2013720.","journal-title":"Respir Care"},{"issue":"6","key":"e_1_3_3_3_2","first-page":"vi1","article-title":"BTS guideline for emergency oxygen use in adult patients","volume":"63","author":"O'Driscoll BR","year":"2008","unstructured":"O'Driscoll BR, , Howard LS, , Davison AG. BTS guideline for emergency oxygen use in adult patients. Thorax, 2008; 63(6):vi1\u201368.","journal-title":"Thorax"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7161.798"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05500604"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1456-x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1457-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2010.01.001"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21051"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04490902"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.10550408"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.00801"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2354-6"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2011.07.075"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01250"},{"issue":"8","key":"e_1_3_3_16_2","first-page":"723","article-title":"High-flow therapy via nasal cannula in acute heart failure","volume":"64","author":"Carratala Perales JM","year":"2011","unstructured":"Carratala Perales JM, , Llorens P, , Brouzet B, , Albert Jimenez AR, , Fernandez-Canadas JM, , Carbajosa Dalmau J, et al. High-flow therapy via nasal cannula in acute heart failure. 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Non-invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary edema. Cochrane Database Syst Rev, 2008;(3):CD005351.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02600071"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9572(02)00100-4"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2008.tb01825.x"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.01575","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.01575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.01575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:04:25Z","timestamp":1777615465000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.01575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,13]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.4187\/respcare.01575"],"URL":"https:\/\/doi.org\/10.4187\/respcare.01575","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3,13]]}}}