{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:06:40Z","timestamp":1791320800638,"version":"4.3.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:00:00Z","timestamp":1367280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To examine the effect of nebulized furosemide as an adjunct to the conventional treatment of patients with COPD exacerbation in an emergency department.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      In this randomized double-blinded clinical trial, patients with COPD exacerbation were randomized to receive 40 mg nebulized furosemide or placebo as an adjunct to the conventional treatments. We recorded changes in dyspnea severity (measured with a visual analog scale), FEV\n                      <jats:sub>1<\/jats:sub>\n                      , arterial blood gas measurements, blood pressure, heart rate, and breathing frequency at baseline and 1 hour after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      We randomized 100 patients, whose mean age was 73.1 \u00b1 8.7 y. The measured variables all improved significantly in both groups. FEV\n                      <jats:sub>1<\/jats:sub>\n                      , dyspnea, pH, mean blood pressure, and heart rate improved significantly more in the furosemide group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Nebulized furosemide benefits patients with COPD exacerbation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.02160","type":"journal-article","created":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T11:29:29Z","timestamp":1367407769000},"page":"1873-1877","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["The Adjunctive Effect of Nebulized Furosemide in COPD Exacerbation: A Randomized Controlled Clinical Trial"],"prefix":"10.1177","volume":"58","author":[{"given":"Hojat","family":"Sheikh Motahar Vahedi","sequence":"first","affiliation":[{"name":"Emergency Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Mahshidfar","sequence":"additional","affiliation":[{"name":"Emergency Department, Hazrat-E-Rasoul Hospital, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helaleh","family":"Rabiee","sequence":"additional","affiliation":[{"name":"Trauma and Surgery Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheil","family":"Saadat","sequence":"additional","affiliation":[{"name":"Trauma and Surgery Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Shokoohi","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, George Washington University, Washington, DC."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Chardoli","sequence":"additional","affiliation":[{"name":"Emergency Department, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vafa","family":"Rahimi-Movaghar","sequence":"additional","affiliation":[{"name":"Trauma and Surgery Research Center"},{"name":"Research Centre for Neural Repair, University of Tehran, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-456SO"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2008.01807.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328334a728"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107680710000512"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0b013e328338c1c6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200504-033SR"},{"issue":"3","key":"e_1_3_3_8_2","first-page":"289","article-title":"Palliative management of refractory dyspnea in COPD","volume":"1","author":"Uronis HE","year":"2006","unstructured":"Uronis HE, , Currow DC, , Abernethy AP. 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