{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:46:35Z","timestamp":1777891595476,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:00:00Z","timestamp":1367280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2013,11]]},"abstract":"\n BACKGROUND:<\/jats:title>\n \n Therapeutic gases and other modalities delivered by inhalation may affect the accuracy of capnographic measurements in 2 ways. First is the specificity of the measurement of CO\n 2<\/jats:sub>\n within the device, and second is the dilution effect of supplemental gases in the ambient air during CO\n 2<\/jats:sub>\n sampling by the device. Our goal was to determine if variables such as inhaled gas composition, gas flows delivered via non-rebreather mask, and mouth open or closed affect measurements of end-tidal CO\n 2<\/jats:sub>\n pressure (P\n \n ETCO\n 2<\/jats:sub>\n <\/jats:sub>\n ) measured with the Capnostream 20 capnograph.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n We measured P\n \n ETCO\n 2<\/jats:sub>\n <\/jats:sub>\n and breathing frequency by capnography in 20 adult normal subjects, with coaching to maintain respiratory frequency between 10 and 20 breaths\/min. S\n \n pO\n 2<\/jats:sub>\n <\/jats:sub>\n was monitored to detect hypoxemia. A 6 min wash-out period occurred between each 6 min level of testing.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n A mixed models analysis revealed that the mean \u00b1 SD P\n \n ETCO\n 2<\/jats:sub>\n <\/jats:sub>\n for all subjects and flows while breathing heliox (37 \u00b1 5 mm Hg) was not different (\n P<\/jats:italic>\n = .50) from the value while breathing room air (36 \u00b1 5 mm Hg). Repeated measurements with given subjects over 6 min periods of breathing spontaneously 0 L\/min, with 10 L\/min, and with 15 L\/min of either air or heliox showed no difference in P\n \n ETCO\n 2<\/jats:sub>\n <\/jats:sub>\n related to flow:\n P<\/jats:italic>\n = .97 for 0 L\/min vs 10 L\/min,\n P<\/jats:italic>\n = .87 for 0 L\/min vs 15 L\/min.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n In normal subjects, P\n \n ETCO\n 2<\/jats:sub>\n <\/jats:sub>\n measurements with the Capnostream 20 were not affected by heliox or gas flow at 10 or 15 L\/min through a non-rebreathing mask.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.02183","type":"journal-article","created":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T11:29:29Z","timestamp":1367407769000},"page":"1945-1948","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Heliox on End-Tidal CO\n 2<\/sub>\n Measurement in Healthy Adults"],"prefix":"10.1177","volume":"58","author":[{"given":"Jonathan B","family":"Waugh","sequence":"first","affiliation":[{"name":"Respiratory Therapy Program, Center for Teaching and Learning, University of Alabama, Birmingham, Alabama."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna D","family":"Gardner","sequence":"additional","affiliation":[{"name":"Department of Respiratory Care, School of Health Professions, University of Texas Health Science Center at San Antonio, San Antonio, Texas."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L","family":"Vines","sequence":"additional","affiliation":[{"name":"Department of Respiratory Care, College of Health Sciences, Rush University Medical Center, Chicago, Illinois."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,4,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2003.02963.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01618124"},{"key":"e_1_3_3_4_2","first-page":"255","article-title":"Carbon dioxide monitors","volume":"15","year":"1986","unstructured":"Carbon dioxide monitors. Health Dev, 1986; 15(Sep-Oct):255-285.","journal-title":"Health Dev"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.07520636"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06510613"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06510608"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1936.02770420011003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06510651"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.02183","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.02183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.02183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:06:55Z","timestamp":1777615615000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.02183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,30]]},"references-count":8,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.4187\/respcare.02183"],"URL":"https:\/\/doi.org\/10.4187\/respcare.02183","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4,30]]}}}