{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:46:36Z","timestamp":1777891596553,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T00:00:00Z","timestamp":1363651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      The RAD-57 pulse CO-oximeter is a lightweight device allowing noninvasive measurement of blood carboxyhemoglobin (S\n                      <jats:sub>pCO<\/jats:sub>\n                      ). We assessed the diagnostic value of pulse CO-oximetry, comparing S\n                      <jats:sub>pCO<\/jats:sub>\n                      values from the RAD-57 to standard laboratory blood carboxyhemoglobin (COHb) measurement in emergency department patients with suspected carbon monoxide (CO) poisoning.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      This was a prospective, diagnostic accuracy study according to the Standards for the Reporting of Diagnostic Accuracy Studies criteria in consecutive adult emergency department patients with suspected CO poisoning. S\n                      <jats:sub>pCO<\/jats:sub>\n                      was measured with the RAD-57 simultaneously with blood sampling for laboratory blood gas analysis. We made no changes to our standard management of CO poisoning. Blood COHb &gt; 5% for non-smokers, and &gt; 10% for smokers were applied as the reference standard.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      We included 93 subjects: 37 smokers and 56 non-smokers. CO poisoning was diagnosed in 26 subjects (28%). The S\n                      <jats:sub>pCO<\/jats:sub>\n                      values ranged from 1% to 30%, with a median of 4% (IQR 2.7\u20137.3%). The COHb values ranged from 0% to 34%, with a median of 5% (IQR 2\u20139%). The mean differences between the COHb and S\n                      <jats:sub>pCO<\/jats:sub>\n                      values were \u22120.2% \u00b1 3.3% (95% limits of agreement of \u22126.7% and 6.3%) for the whole cohort, \u22120.7% (limits of agreement \u22127.7% and 6.2%) for the non-smokers, and 0.6% (limits of agreement \u22125.0% and 6.2%) for the smokers. The optimal thresholds for detecting CO poisoning were S\n                      <jats:sub>pCO<\/jats:sub>\n                      of 9% and 6% for smokers and non-smokers, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      S\n                      <jats:sub>pCO<\/jats:sub>\n                      measured with the RAD-57 was not a substitute for standard blood COHb measurement. However, noninvasive pulse CO-oximetry could be useful as a first-line screening test, enabling rapid detection and management of CO-poisoned patients in the emergency department.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.02313","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T20:22:43Z","timestamp":1363724563000},"page":"1614-1620","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Emergency Department Management of Suspected Carbon Monoxide Poisoning: Role of Pulse CO-Oximetry"],"prefix":"10.1177","volume":"58","author":[{"given":"Mustapha","family":"Sebbane","sequence":"first","affiliation":[{"name":"D\u00e9partement des Urgences, Centre Hospitalier R\u00e9gional Universitaire Lapeyronie, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-G\u00e9raud","family":"Claret","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Urgences, H\u00f4pital Universitaire Car\u00e9meau, Nimes, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e9goire","family":"Mercier","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Information M\u00e9dicale"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Urgences, Centre Hospitalier R\u00e9gional Universitaire Lapeyronie, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Th\u00e9ry","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Urgences, Centre Hospitalier R\u00e9gional Universitaire Lapeyronie, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Dumont","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Urgences, Centre Hospitalier R\u00e9gional Universitaire Lapeyronie, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Maill\u00e9","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Urgences, Centre Hospitalier R\u00e9gional Universitaire Lapeyronie, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Richard","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Urgences, Centre Hospitalier R\u00e9gional Universitaire Lapeyronie, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Jacques","family":"Eledjam","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Urgences, Centre Hospitalier R\u00e9gional Universitaire Lapeyronie, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Emmanuel","family":"de La Coussaye","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Urgences, H\u00f4pital Universitaire Car\u00e9meau, Nimes, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,3,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(99)00217-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2011.03.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1991.9934405"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811263392206"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2005.09.010"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2007.10.005"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201207-1284CI"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0808891"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2010.05.025"},{"issue":"2","key":"e_1_3_3_11_2","first-page":"107","article-title":"Reliability of new pulse CO-oximeter in victims of carbon monoxide poisoning","volume":"35","author":"Coulange M","year":"2008","unstructured":"Coulange M, , Barthelemy A, , Hug F, , Thierry AL, , De Haro L. Reliability of new pulse CO-oximeter in victims of carbon monoxide poisoning. Undersea Hyperb Med, 2008; 35(2):107\u2013111.","journal-title":"Undersea Hyperb Med"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2007.12.004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/08958370902839754"},{"issue":"2","key":"e_1_3_3_14_2","first-page":"75","article-title":"[Carbon monoxide pulse oximetry vs direct spectrophotometry for early detection of CO poisoning]","volume":"40","author":"Kot J","year":"2008","unstructured":"Kot J, , Si\u0107ko Z, , G\u00f3ralczyk P. [Carbon monoxide pulse oximetry vs direct spectrophotometry for early detection of CO poisoning]. Anestezjol Intens Ter, 2008; 40(2):75\u201378. 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