{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:48:07Z","timestamp":1777891687745,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Mechanical ventilation and surfactants are the standard treatment of preterm respiratory distress syndrome (RDS). The effects of the primary ventilation model on bronchopulmonary dysplasia (BPD) and long-term neurodevelopment outcomes are controversial. The purpose of this study was to compare the efficacy and safety of high-frequency oscillatory ventilation (HFOV) and synchronized intermittent mandatory ventilation plus pressure support ventilation (SIMV-PSV) in preterm infants with severe RDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      A total of 366 eligible preterm infants were randomly assigned to treatment with HFOV (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 184) or SIMV-PSV (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 182). Surfactant was applied if P\n                      <jats:sub>\n                        aO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      \/F\n                      <jats:sub>\n                        IO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      was &lt; 200 mm Hg after 2 hours of ventilation. Primary outcomes were mortality or incidence of BPD. Secondary outcomes were duration of ventilation and hospitalization, surfactant requirements, pneumothorax, retinopathy of prematurity \u2265 stage 2, and neurodevelopment at 18 months of corrected age.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Survival and complete outcome data were available for 288 infants at 18 months of corrected age. The incidence of death or BPD was significantly higher in the SIMV-PSV group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001). The duration of mechanical ventilation and hospitalization was shorter and the incidence of surfactant requirement and retinopathy of prematurity was lower in the HFOV group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .002,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .04, respectively). Moderate or severe neurological disability was less frequent in the HFOV group than in the SIMV-PSV group at 18 months (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .03). The combination of HFOV and surfactant dramatically reduced negative outcomes in preterm infants with severe RDS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Initial ventilation with HFOV in preterm infants with severe RDS reduces the incidence of death and BPD, and improves long-term neurodevelopment outcomes. (ClinicalTrials.gov NCT01496508)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.02382","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T01:40:28Z","timestamp":1371174028000},"page":"159-169","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["High-Frequency Oscillatory Ventilation Versus Synchronized Intermittent Mandatory Ventilation Plus Pressure Support in Preterm Infants With Severe Respiratory Distress Syndrome"],"prefix":"10.1177","volume":"59","author":[{"given":"Huiqing","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China."},{"name":"Department of Pediatrics, Zhengzhou Children's Hospital, Zhengzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wengqing","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Zhengzhou Children's Hospital, Zhengzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Zhengzhou Children's Hospital, Zhengzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongchen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Zhengzhou Children's Hospital, Zhengzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Zhengzhou Children's Hospital, Zhengzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China."},{"name":"Henan Key Laboratory for Neonatal Brain Injury, Zhengzhou, China, and with the Perinatal Center, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changlian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China."},{"name":"Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,2,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2010.01126.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-11-22"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050701398413"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-010-1838-0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000297773"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60278-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01413.x"},{"issue":"3","key":"e_1_3_3_9_2","first-page":"144","article-title":"Benefits of high frequency oscillatory ventilation for premature infants","volume":"12","author":"Kessel I","year":"2010","unstructured":"Kessel I, , Waisman D, , Barnet-Grinnes O, , Ben Ari TZ, , Rotschild A. 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