{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:19:24Z","timestamp":1790482764515,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T00:00:00Z","timestamp":1369094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The \u201chospital-at-home\u201d model may provide adequate care without an adverse effect on clinical outcome, and is generally well received by users. Our objective was to compare hospital-at-home and in-patient hospital care for neuromuscular disease (NMD) patients with respiratory tract infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We conducted a prospective randomized controlled trial in a university teaching hospital offering secondary care service to a population of approximately 500,000. We recruited selected NMD patients with respiratory tract infection for whom hospital admission had been recommended after medical assessment. Hospital-at-home was provided as an alternative to in-patient admission. The main outcome measures were need for hospitalization, treatment failure, time to recovery, death during the first 3 months following exacerbation, and cost of patient care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among 59 consecutive NMD patients eligible for the study, 53 met the criteria for hospital-at-home. Twenty-six subjects were randomized to home care and 27 to hospital care. No significant differences were found in treatment failure (8\/26 vs 13\/27,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .19), time to recovery (8.9 \u00b1 4.6 vs 9 \u00b1 8.9 d,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .21), or mortality at 3 months (3\/26 vs 4\/27 deaths,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .42) between the groups. Hospital-at-home failure was independently correlated with type of NMD (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .004) with an odds ratio of failure of 17.3 (95% CI 2.1 to infinity) for subjects with amyotrophic lateral sclerosis. The total and daily direct cost of patient healthcare was significantly lower for the subjects who were successfully treated at home, compared to the hospitalized individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Hospital-at-home is an effective alternative to hospital admission for selected NMD patients with respiratory tract infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.02501","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T21:40:26Z","timestamp":1369172426000},"page":"2061-2068","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["\u201cHospital at Home\u201d for Neuromuscular Disease Patients With Respiratory Tract Infection: A Pilot Study"],"prefix":"10.1177","volume":"58","author":[{"given":"Andrea","family":"Vianello","sequence":"first","affiliation":[{"name":"Department of Respiratory Pathophysiology and the Intensive Care Unit, City Hospital of Padova, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Savoia","sequence":"additional","affiliation":[{"name":"Department of Respiratory Pathophysiology and the Intensive Care Unit, City Hospital of Padova, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Pipitone","sequence":"additional","affiliation":[{"name":"Department of Formative Sciences, University of Modena and Reggio Emilia, Modena, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Nordio","sequence":"additional","affiliation":[{"name":"Respiratory Home Care Service, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Gallina","sequence":"additional","affiliation":[{"name":"Unione Italiana Lotta Alla Distrofia Muscolare Rehabilitation Centre, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Paladini","sequence":"additional","affiliation":[{"name":"Department of Respiratory Pathophysiology and the Intensive Care Unit, City Hospital of Padova, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Concas","sequence":"additional","affiliation":[{"name":"Department of Respiratory Pathophysiology and the Intensive Care Unit, City Hospital of Padova, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Arcaro","sequence":"additional","affiliation":[{"name":"Department of Respiratory Pathophysiology and the Intensive Care Unit, City Hospital of Padova, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Gallan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Pathophysiology and the Intensive Care Unit, City Hospital of Padova, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pegoraro","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of Padova, Padova, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,5,21]]},"reference":[{"issue":"3","key":"e_1_3_2_2_2","first-page":"CD000356","article-title":"Hospital at home versus in-patient hospital care","author":"Shepperd S","year":"2005","unstructured":"Shepperd S, , Iliffe S. Hospital at home versus in-patient hospital care. Cochrane Database Syst Rev, 2005;(3):CD000356. DOI: 10.1002\/14651858.CD000356.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-7-130"},{"issue":"4","key":"e_1_3_2_4_2","first-page":"CD003573","article-title":"Hospital at home for acute exacerbations of chronic obstructive pulmonary disease","author":"Ram FSF","year":"2003","unstructured":"Ram FSF, , Wedzicha JA, , Wright JJ, , Greenstone M. Hospital at home for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev, 2003;(4):CD003573. DOI: 10.1002\/14651858.CD003573.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.319.7224.1547"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/14.4.285"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.09.030"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PHM.0000151941.97266.96"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.5.1390"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3181d89760"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5337(02)00033-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.5.1538"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.5.1553"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp061493"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/511159"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1987.10478547"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.phm.0000184097.17189.93"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.207"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340051171"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.6.752"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70244-2"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.11.907"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/1479972309104279"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02679-9"},{"key":"e_1_3_2_25_2","unstructured":"Centers for Medicare & Medicaid Services. National health expenditure data. https:\/\/www.cms.gov\/NationalHealthExpendData. Accessed September 20 2013. Last modified April 11 2012."},{"key":"e_1_3_2_26_2","volume-title":"The National Survey of Attendant Service Programs in the United States","author":"Litvak S","year":"1987","unstructured":"Litvak S, , Heumann JE. Attending to America: personal assistance for independent living. The National Survey of Attendant Service Programs in the United States. Berkeley, CA: World Institute on Disability; 1987."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.2.428"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.1.26"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.02501","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.02501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.02501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:08:15Z","timestamp":1777615695000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.02501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,21]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.4187\/respcare.02501"],"URL":"https:\/\/doi.org\/10.4187\/respcare.02501","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5,21]]}}}