{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:47:48Z","timestamp":1777891668972,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2014,2]]},"abstract":"\n BACKGROUND:<\/jats:title>\n \n The use of \u03b2\n 2<\/jats:sub>\n agonist as an intervention for acute lung injury (ALI) and ARDS patients is controversial, so we performed a systematic review and meta-analysis of the published randomized controlled trials of using \u03b2\n 2<\/jats:sub>\n agonists to improve outcomes (mortality and ventilator free days) among patients with ALI\/ARDS.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n \n A comprehensive search of 7 major databases (Ovid MEDLINE In-Process and other non-indexed citations, Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials (CENTRAL), Ovid Cochrane Database of Systematic Reviews, Web of Science, and Scopus) for randomized controlled trials using \u03b2\n 2<\/jats:sub>\n agonists for ALI from their origin to March 2013 was conducted. The effect size was measured by relative risk for dichotomous outcomes, and mean difference for continuous outcomes, with 95% CI. The statistical heterogeneity between the studies was assessed with the Cochran Q test and I\n 2<\/jats:sup>\n statistic. The heterogeneity of > 50% was considered significant for the analysis. The Cochrane risk of bias tool was used to ascertain the quality of the included studies.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Out of 219 studies screened, 3 randomized controlled trials reported mortality and ventilator-free days, in 646 ALI\/ARDS subjects. Of the 646 subjects, 334 (51.7%) received \u03b2\n 2<\/jats:sub>\n agonist and 312 (48.3%) received placebo. There was no significant decrease in 28-day mortality or hospital mortality in the \u03b2\n 2<\/jats:sub>\n -agonist group: relative risk 1.04, 95% CI 0.50\u20132.16, and relative risk 1.22, 95% CI 0.95\u20131.56, respectively. The ventilator-free days and organ-failure-free days were significantly lower for the ALI subjects who received \u03b2\n 2<\/jats:sub>\n agonists: mean difference \u22122.19 days (95% CI \u22123.68 to \u22121.99 d) and mean difference \u22122.04 days (95% CI \u22123.74 to \u22120.35 d), respectively.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \n In subjects with ALI\/ARDS, \u03b2\n 2<\/jats:sub>\n agonists were not only nonbeneficial in improving the survival, but were harmful and increased morbidity (reduced organ-failure-free days and ventilator-free days). The current evidence discourages the use of \u03b2\n 2<\/jats:sub>\n agonist in ALI\/ARDS patients. (International Prospective Register of Systematic Reviews,\n http:\/\/www.crd.york.ac.uk\/prospero<\/jats:ext-link>\n , 2012:CRD42012002616.)\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4187\/respcare.02571","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T21:23:20Z","timestamp":1371590600000},"page":"288-296","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["\u03b2\n 2<\/sub>\n Agonist for the Treatment of Acute Lung Injury: A Systematic Review and Meta-analysis"],"prefix":"10.1177","volume":"59","author":[{"given":"Balwinder","family":"Singh","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhilesh Kumar","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care, National University Hospital, Singapore."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuljit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Division of Medicine, Queen Elizabeth Hospital, Adelaide South Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon K","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of General Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adil","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia J","family":"Erwin","sequence":"additional","affiliation":[{"name":"Mayo Medical Libraries, Mayo Clinic, Rochester, Minnesota."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo Moreno","family":"Franco","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota."},{"name":"Division of Transplant Critical Care Service, Department of Medicine, Mayo Clinic, Jacksonville, Florida."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8627(03)00020-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013183"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00003.2002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.6.2004035"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000129489.34416.0E"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc8171"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc3971"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc11221"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc2417"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201105-0852ED"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201106-1115ED"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199301000-00016"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050291"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a5506c"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.059410"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61623-1"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201012-2090OC"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200508-1302OC"},{"issue":"12","key":"e_1_3_2_20_2","first-page":"100","article-title":"Beta-2-agonist in the treatment of acute lung injury: a meta-analysis (abstract)","volume":"40","author":"Singh B","year":"2012","unstructured":"Singh B, , Erwin PJ, , Moreno-Franco P. 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