{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:50:06Z","timestamp":1777891806664,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T00:00:00Z","timestamp":1398729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>\n                    Noninvasive ventilation (NIV) in severe acute asthma is controversial but may benefit this population by preventing intubation. We report on a 35-year-old male asthma patient who presented to our emergency department via emergency medical services. The patient was responsive, diaphoretic, and breathing at 35 breaths\/min on 100% oxygen with bag-mask assistance, with S\n                    <jats:sub>\n                      pO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    88%, heart rate 110\u2013120 beats\/min, blood pressure 220\/110 mm Hg, and temperature 35.8\u00b0C. NIV at 12\/5 cm H\n                    <jats:sub>2<\/jats:sub>\n                    O and F\n                    <jats:sub>\n                      IO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    0.40 was applied, and albuterol at 40 mg\/h was initiated. Admission arterial blood gas revealed a pH of 6.95, P\n                    <jats:sub>\n                      aCO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    126 mm Hg, and P\n                    <jats:sub>\n                      aO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    316 mm Hg. After 90 min of therapy, P\n                    <jats:sub>\n                      aCO\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:sub>\n                    was 63 mm Hg. Improvement continued, and NIV was stopped 4 h following presentation. NIV tolerance was supported with low doses of lorazepam. The patient was transferred to the ICU, moved to general care the next morning, and discharged 3 days later. We attribute our success to close monitoring in a critical care setting and the titration of lorazepam.\n                  <\/jats:p>","DOI":"10.4187\/respcare.02730","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T00:53:43Z","timestamp":1398819223000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Noninvasive Ventilation in Severe Acute Asthma"],"prefix":"10.1177","volume":"59","author":[{"given":"Jhaymie L","family":"Cappiello","sequence":"first","affiliation":[{"name":"Respiratory Care Services, Duke University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B","family":"Hocker","sequence":"additional","affiliation":[{"name":"Division of Emergency Medicine, Duke University Medical Center, Durham, North Carolina."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,4,29]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000284587.36541.7F"},{"key":"e_1_3_2_3_2","first-page":"CD004360","article-title":"Non-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbations of asthma","volume":"12","author":"Lim W","year":"2012","unstructured":"Lim W, , Mohammed Akram R, , Carson K, , Mysore S, , Labiszewski N, , Wedzicha J, et al. Non-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbations of asthma. 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