{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:28:43Z","timestamp":1792650523183,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T00:00:00Z","timestamp":1381190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Thoracoscopic pleural biopsy increases the diagnostic yield of pleural effusions undiagnosed after thoracentesis and is superior to closed pleural biopsy. Medical thoracoscopy can be performed using the rigid thoracoscope or the semirigid thoracoscope (pleuroscope). In this randomized trial, we compare the efficacy and safety of the 2 thoracoscopes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Subjects with undiagnosed exudative pleural effusions were randomly assigned to undergo pleural biopsy with either the rigid or the semirigid thoracoscope. The primary outcome was the diagnostic yield of the procedure, while the secondary outcomes were requirement of sedative\/analgesic agents, scar size, biopsy sample size, and the operator's view of the procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Of the 145 screened subjects with exudative pleural effusions, 90 were randomized to undergo thoracoscopy with the 2 thoracoscopes (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 45 each). The diagnostic yield of rigid thoracoscopy was superior to semirigid thoracoscopy (97.8% vs 73.3%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .002) on an intention-to-treat analysis but was similar (100% vs 94.3%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .18) in those with successful biopsy. The requirement of sedative\/analgesic agents was higher in the rigid thoracoscopy arm. The scar size was slightly larger (mean \u00b1 SD, 23.1 \u00b1 4 vs 18.7 \u00b1 3.2 mm,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .0001), whereas the biopsy sample size was distinctly larger in the rigid arm (mean \u00b1 SD, 13.9 \u00b1 4.4 vs 4.4 \u00b1 1.4 mm,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001). The operator-rated visual analog scale score for the ease of taking a biopsy sample was significantly higher with the rigid instrument (mean \u00b1 SD, visual analog scale 86 \u00b1 12 vs 79 \u00b1 12 mm,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01), while the quality of image was superior in the semirigid arm (mean \u00b1 SD, visual analog scale 88 \u00b1 7 vs 92 \u00b1 5 mm,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .002). The number of complications were similar in the 2 groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Rigid thoracoscopy was found to be superior to semirigid thoracoscopy overall, but the diagnostic yield was similar if pleural biopsy could be successfully performed. Due to the small sample size, a larger study is required to define the usefulness and choice between the 2 procedures. (ClinicalTrials.gov registration NCT01726556)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.02738","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T21:53:59Z","timestamp":1381269239000},"page":"756-764","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":112,"title":["A Randomized Trial Comparing the Diagnostic Yield of Rigid and Semirigid Thoracoscopy in Undiagnosed Pleural Effusions"],"prefix":"10.1177","volume":"59","author":[{"given":"Sahajal","family":"Dhooria","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh N","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dheeraj","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,10,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.11010213"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.58.suppl_2.ii8"},{"issue":"5","key":"e_1_3_2_4_2","first-page":"196","article-title":"Blind pleural biopsy using a Tru-cut needle in moderate to large pleural effusion\u2014an experience","volume":"39","author":"Christopher DJ","year":"1998","unstructured":"Christopher DJ, , Peter JV, , Cherian AM. 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